
Bin Zhao
Postdoctoral Research Fellow, Biology
Bio
genome engineering
Professional Education
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Doctor of Philosophy, Fudan University (2018)
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Bachelor of Engineering, Qingdao University of Science and Technology (2009)
Stanford Advisors
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Hunter Fraser, Postdoctoral Faculty Sponsor
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Hunter Fraser, Postdoctoral Research Mentor
All Publications
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DNMT3A reads and connects histone H3K36me2 to DNA methylation
PROTEIN & CELL
2020; 11 (2): 150–54
View details for DOI 10.1007/s13238-019-00672-y
View details for Web of Science ID 000511863400009
View details for PubMedID 31758527
View details for PubMedCentralID PMC6954886
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H3K14me3 genomic distributions and its regulation by KDM4 family demethylases.
Cell research
2018; 28 (11): 1118–20
View details for DOI 10.1038/s41422-018-0095-6
View details for PubMedID 30337684
View details for PubMedCentralID PMC6218439
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Tet3 CXXC Domain and Dioxygenase Activity Cooperatively Regulate Key Genes for Xenopus Eye and Neural Development
CELL
2012; 151 (6): 1200–1213
Abstract
Ten-Eleven Translocation (Tet) family of dioxygenases dynamically regulates DNA methylation and has been implicated in cell lineage differentiation and oncogenesis. Yet their functions and mechanisms of action in gene regulation and embryonic development are largely unknown. Here, we report that Xenopus Tet3 plays an essential role in early eye and neural development by directly regulating a set of key developmental genes. Tet3 is an active 5mC hydroxylase regulating the 5mC/5hmC status at target gene promoters. Biochemical and structural studies further demonstrate that the Tet3 CXXC domain is critical for specific Tet3 targeting. Finally, we show that the enzymatic activity and CXXC domain are both crucial for Tet3's biological function. Together, these findings define Tet3 as a transcription regulator and reveal a molecular mechanism by which the 5mC hydroxylase and DNA binding activities of Tet3 cooperate to control target gene expression and embryonic development.
View details for DOI 10.1016/j.cell.2012.11.014
View details for Web of Science ID 000311999900011
View details for PubMedID 23217707
View details for PubMedCentralID PMC3705565