Zhi Huang received his Bachelor of Science degree in Automation (BS--MS straight entrance class) from Xi'an Jiaotong University School of Electronic and Information Engineering in June 2015. In August 2021, He received a Ph.D. degree from Purdue University, majoring in Electrical and Computer Engineering (ECE).
His background is in the area of Machine and Deep Learning, Computational Pathology, Computational Biology, and Bioinformatics.
From May 2019 to August 2019, he was at Philips Research North America as a Research Intern.
Doctor of Philosophy, Purdue University (2021)
Master of Science, Indiana-Purdue University Indianapolis (2016)
Bachelor of Science, Xi'An Jiaotong University (2015)
Systematic pan-cancer analysis of mutation-treatment interactions using large real-world clinicogenomics data.
Quantifying the effectiveness of different cancer therapies in patients with specific tumor mutations is critical for improving patient outcomes and advancing precision medicine. Here we perform a large-scale computational analysis of 40,903 US patients with cancer who have detailed mutation profiles, treatment sequences and outcomes derived from electronic health records. We systematically identify 458 mutations that predict the survival of patients on specific immunotherapies, chemotherapy agents or targeted therapies across eight common cancer types. We further characterize mutation-mutation interactions that impact the outcomes of targeted therapies. This work demonstrates how computational analysis of large real-world data generates insights, hypotheses and resources to enable precision oncology.
View details for DOI 10.1038/s41591-022-01873-5
View details for PubMedID 35773542