Nicole Irgens-Moller
Clinical Assistant Professor, Emergency Medicine
Clinical Assistant Professor (By courtesy), Pediatrics
Clinical Focus
- Pediatric Emergency Medicine
Academic Appointments
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Clinical Assistant Professor, Emergency Medicine
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Clinical Assistant Professor (By courtesy), Pediatrics
Honors & Awards
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Global Health Faculty Fellow, Center for Innovation in Global Health (CIGH) (Sept 2024- Present)
Professional Education
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Fellowship: Yale New Haven Hospital Pediatric Emergency Department (2024) CT
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Board Certification: American Board of Pediatrics, Pediatrics (2021)
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Residency: Cohen Children's Hospital Pediatric Residency (2021) NY
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Medical Education: Virginia Commonwealth University School of Medicine Registrar (2018) VA
Community and International Work
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University of Global Health Equity, Kigali, Rwanda
Topic
Pediatric Emergency
Partnering Organization(s)
Partners In Health
Location
International
Ongoing Project
Yes
Opportunities for Student Involvement
Yes
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Pediatric Emergency Medicine in Resource Limited Settings (PEMiRLS)
Topic
Pediatric Emergency
Populations Served
International trainees
Location
International
Ongoing Project
Yes
Opportunities for Student Involvement
Yes
Research Interests
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Immigrants and Immigration
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Lifelong Learning
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Poverty and Inequality
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Race and Ethnicity
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Sociology
Current Research and Scholarly Interests
Association of Race and Insurance on Social Work Consults and Child Protective Services Reports following Ingestions in Young Children. [Platform Presentation]. Ray E. Helfer Society Conference, 2024, Savannah, GA, United States
All Publications
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Complications of Long-Acting Reversible Contraceptive Modalities.
Pediatric emergency care
2023; 39 (6): 443-449
Abstract
Long-acting reversible contraception has risen in popularity in recent decades and is becoming one of the more common modalities of contraception in the United States, with a growing adolescent population among its users. The 2 modalities of long-acting reversible contraception-intrauterine devices and subcutaneous hormonal implants/etonogestrel implants (referred to as Nexplanon in the US)-are beneficial for their excellent effectiveness, ease of use, and safety profile. This article reviews the pharmacology of these modalities, common complications and their presentations, and the initial evaluation and management in the pediatric emergency department setting. Where applicable, attention will be paid to problems unique to the adolescent population.
View details for DOI 10.1097/PEC.0000000000002970
View details for PubMedID 37256282
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MARCH1 protects the lipid raft and tetraspanin web from MHCII proteotoxicity in dendritic cells.
The Journal of cell biology
2018; 217 (4): 1395-1410
Abstract
Dendritic cells (DCs) produce major histocompatibility complex II (MHCII) in large amounts to function as professional antigen presenting cells. Paradoxically, DCs also ubiquitinate and degrade MHCII in a constitutive manner. Mice deficient in the MHCII-ubiquitinating enzyme membrane-anchored RING-CH1, or the ubiquitin-acceptor lysine of MHCII, exhibit a substantial reduction in the number of regulatory T (Treg) cells, but the underlying mechanism was unclear. Here we report that ubiquitin-dependent MHCII turnover is critical to maintain homeostasis of lipid rafts and the tetraspanin web in DCs. Lack of MHCII ubiquitination results in the accumulation of excessive quantities of MHCII in the plasma membrane, and the resulting disruption to lipid rafts and the tetraspanin web leads to significant impairment in the ability of DCs to engage and activate thymocytes for Treg cell differentiation. Thus, ubiquitin-dependent MHCII turnover represents a novel quality-control mechanism by which DCs maintain homeostasis of membrane domains that support DC's Treg cell-selecting function.
View details for DOI 10.1083/jcb.201611141
View details for PubMedID 29371232
View details for PubMedCentralID PMC5881489