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Current Research and Scholarly Interests


Computational drug discovery

All Publications


  • Lighting up sugars: fluorescent BODIPY-gluco-furanose and -septanose conjugates linked by direct B-O-C bonds ORGANIC & BIOMOLECULAR CHEMISTRY Liu, B., Novikova, N., Simpson, M. C., Timmer, M. S., Stocker, B. L., Sohnel, T., Ware, D. C., Brothers, P. J. 2016; 14 (23): 5205-5209

    Abstract

    We report the first O-BODIPY-glucose conjugates, in which the sugar is directly attached to the BODIPY boron through covalent B-O-C bonds. The reaction of Cl-BODIPY with glucose in acetonitrile produced the 1 : 1 α-glucofuranose BODIPY (1), 1 : 2 α-glucofuranose BODIPY (2) and 1 : 2 α-glucoseptanose BODIPY (3) esters. Compound 3 is a rare instance of the unnatural septanose form of glucose, and the first example of a septanose borate.

    View details for DOI 10.1039/c6ob00726k

    View details for Web of Science ID 000378512400002

    View details for PubMedID 27205874