Bio


I am originally from Towson, Maryland, and did my undergraduate at Brown University in Providence, Rhode Island. I like baseball, running, and playing the piano!

Institute Affiliations


Education & Certifications


  • BS, Brown University, Mechanical Engineering (2019)

Current Research and Scholarly Interests


Engineering research with applications to energy/environmental sustainability.

All Publications


  • A Modular Framework for Implicit 3D-0D Coupling in Cardiac Mechanics. Computer methods in applied mechanics and engineering Brown, A. L., Salvador, M., Shi, L., Pfaller, M. R., Hu, Z., Harold, K. E., Hsiai, T., Vedula, V., Marsden, A. L. 2024; 421

    Abstract

    In numerical simulations of cardiac mechanics, coupling the heart to a model of the circulatory system is essential for capturing physiological cardiac behavior. A popular and efficient technique is to use an electrical circuit analogy, known as a lumped parameter network or zero-dimensional (0D) fluid model, to represent blood flow throughout the cardiovascular system. Due to the strong physical interaction between the heart and the blood circulation, developing accurate and efficient numerical coupling methods remains an active area of research. In this work, we present a modular framework for implicitly coupling three-dimensional (3D) finite element simulations of cardiac mechanics to 0D models of blood circulation. The framework is modular in that the circulation model can be modified independently of the 3D finite element solver, and vice versa. The numerical scheme builds upon a previous work that combines 3D blood flow models with 0D circulation models (3D fluid - 0D fluid). Here, we extend it to couple 3D cardiac tissue mechanics models with 0D circulation models (3D structure - 0D fluid), showing that both mathematical problems can be solved within a unified coupling scheme. The effectiveness, temporal convergence, and computational cost of the algorithm are assessed through multiple examples relevant to the cardiovascular modeling community. Importantly, in an idealized left ventricle example, we show that the coupled model yields physiological pressure-volume loops and naturally recapitulates the isovolumic contraction and relaxation phases of the cardiac cycle without any additional numerical techniques. Furthermore, we provide a new derivation of the scheme inspired by the Approximate Newton Method of Chan (1985), explaining how the proposed numerical scheme combines the stability of monolithic approaches with the modularity and flexibility of partitioned approaches.

    View details for DOI 10.1016/j.cma.2024.116764

    View details for PubMedID 38523716

    View details for PubMedCentralID PMC10956732

  • A modular framework for implicit 3D-0D coupling in cardiac mechanics COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING Brown, A. L., Salvador, M., Shi, L., Pfaller, M. R., Hu, Z., Harold, K. E., Hsiai, T., Vedula, V., Marsden, A. L. 2024; 421
  • Recent advances in quantifying the mechanobiology of cardiac development via computational modeling. Current opinion in biomedical engineering Brown, A. L., Gerosa, F. M., Wang, J., Hsiai, T., Marsden, A. L. 2023; 25

    Abstract

    Mechanical forces are essential for coordinating cardiac morphogenesis, but much remains to be discovered about the interactions between mechanical forces and the mechanotransduction pathways they activate. Due to the elaborate and fundamentally multi-physics and multi-scale nature of cardiac mechanobiology, a complete understanding requires multiple experimental and analytical techniques. We identify three fundamental tools used in the field to probe these interactions: high resolution imaging, genetic and molecular analysis, and computational modeling. In this review, we focus on computational modeling and present recent studies employing this tool to investigate the mechanobiological pathways involved with cardiac development. These works demonstrate that understanding the detailed spatial and temporal patterns of biomechanical forces is crucial to building a comprehensive understanding of mechanobiology during cardiac development, and that computational modeling is an effective and efficient tool for obtaining such detail. In this context, multidisciplinary studies combining all three tools present the most compelling results.

    View details for DOI 10.1016/j.cobme.2022.100428

    View details for PubMedID 36583220

    View details for PubMedCentralID PMC9794182