My passion is to create medical devices that make a difference in quality of life for patients worldwide. Currently, I am a Postdoctoral Fellow at Stanford in Prof. Zhenan Bao's lab developing flexible electronic devices for physiologic status monitoring. I received my Ph.D. in Chemical Engineering from MIT working under Profs. Robert Langer and Giovanni Traverso, where my research focused on developing ingestible robotic capsules for oral biologic drug delivery. I am passionate about mentorship as well as entrepreneurship, and I volunteer locally to support STEM innovation in my community. Check out my website in the links section for more information in my research.
Ingestible transiently anchoring electronics for microstimulation and conductive signaling
2020; 6 (35): eaaz0127
Ingestible electronic devices enable noninvasive evaluation and diagnosis of pathologies in the gastrointestinal (GI) tract but generally cannot therapeutically interact with the tissue wall. Here, we report the development of an orally administered electrical stimulation device characterized in ex vivo human tissue and in in vivo swine models, which transiently anchored itself to the stomach by autonomously inserting electrically conductive, hooked probes. The probes provided stimulation to the tissue via timed electrical pulses that could be used as a treatment for gastric motility disorders. To demonstrate interaction with stomach muscle tissue, we used the electrical stimulation to induce acute muscular contractions. Pulses conductively signaled the probes' successful anchoring and detachment events to a parenterally placed device. The ability to anchor into and electrically interact with targeted GI tissues controlled by the enteric nervous system introduces opportunities to treat a multitude of associated pathologies.
View details for DOI 10.1126/sciadv.aaz0127
View details for Web of Science ID 000580595700003
View details for PubMedID 32923616
View details for PubMedCentralID PMC7455191