Post-Doctoral Scholar and Research Scientist, Department of Radiology, Stanford University (June 2020-present)
Post-Doctoral Scholar and Research Scientist, Department of Radiology, John Hopkins University (August 2018 - May 2020)
Honors & Awards
Certificate of Recognition, Shiraz University of Medical Sciences (SUMS) (2018)
Best thesis award for M.D. degree, Hormozagan University of Medical Sciences (HUMS) (2014)
Bronze medal winner, National Medical Students Scientific Olympiad (2014)
Graduated as top 1% in the class of 2014, Hormozagan University of Medical Sciences (HUMS) (2014)
University select top student, Hormozagan University of Medical Sciences (HUMS) (2011-2014)
Doctor of Medicine, Hormozgan University of Medical Sciences (HUMS), Iran (2014)
Heike Daldrup-Link, Postdoctoral Faculty Sponsor
Evidence-based use of clinical examination, ultrasonography, and MRI for diagnosing ulnar collateral ligament tears of the metacarpophalangeal joint of the thumb: systematic review and meta-analysis.
To determine the performances of clinical examination, ultrasonography, and MRI for diagnosing non-displaced and displaced ulnar collateral ligament (UCL) tears.Based on a literature search of Medline, ISI Web of Science, Embase, and Scopus between January 1990 and December 2019, all published original articles which met the inclusion criteria were included. We determined the pooled sensitivities, specificities, and accuracies of clinical examination, ultrasonography, and MRI using a meta-analysis based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses-Diagnostic Test Accuracy (PRISMA-DTA) guidelines.A total of 17 studies with 519 subjects reporting diagnostic performances of clinical examination (8), ultrasonography (12), and MRI (5) met the inclusion criteria. For ruling out UCL tears, the pooled sensitivities were similarly high for clinical examination (97% (95% confidence interval [CI], 93-99%)), ultrasonography (96% (95% CI, 94-98%)), and MRI (99% (95% CI, 92-100%)) (p = 0.3). For ruling in UCL tears, the pooled specificities were higher for MRI (100% (95% CI, 87-100%)) when compared to ultrasonography (91% (95% CI, 86-95%)) (p = 0.1) and clinical examination (85% (95% CI, 78-91%)) (p = 0.04). For the diagnosis of displaced UCL tears, MRI had a higher specificity (92% (95% CI, 73-99%)) than ultrasonography (72% (95% CI, 63-80%)) (p = 0.2).Clinical examination, ultrasonography, and MRI have similarly high sensitivities for ruling out UCL tears in patients presenting with a thumb injury. MRI and ultrasonography have high specificities to confirm the presence of suspected UCL tears. MRI performs best for differentiating non-displaced from displaced UCL tears.• Clinical examination followed by ultrasonography is the most appropriate test for ruling out ulnar collateral ligament (UCL) tears of the thumb. • MRI and ultrasonography both have high specificities to confirm the presence of a suspected UCL tear. • MRI outperforms ultrasonography for differentiating non-displaced from displaced UCL tears.
View details for DOI 10.1007/s00330-020-07666-z
View details for PubMedID 33459856
How to stop using gadolinium chelates for magnetic resonance imaging: clinical-translational experiences with ferumoxytol.
Gadolinium chelates have been used as standard contrast agents for clinical MRI for several decades. However, several investigators recently reported that rare Earth metals such as gadolinium are deposited in the brain for months or years. This is particularly concerning for children, whose developing brain is more vulnerable to exogenous toxins compared to adults. Therefore, a search is under way for alternative MR imaging biomarkers. The United States Food and Drug Administration (FDA)-approved iron supplement ferumoxytol can solve this unmet clinical need: ferumoxytol consists of iron oxide nanoparticles that can be detected with MRI and provide significant T1- and T2-signal enhancement of vessels and soft tissues. Several investigators including our research group have started to use ferumoxytol off-label as a new contrast agent for MRI. This article reviews the existing literature on the biodistribution of ferumoxytol in children and compares the diagnostic accuracy of ferumoxytol- and gadolinium-chelate-enhanced MRI. Iron oxide nanoparticles represent a promising new class of contrast agents for pediatric MRI that can be metabolized and are not deposited in the brain.
View details for DOI 10.1007/s00247-021-05098-5
View details for PubMedID 34046709
Ferumoxytol magnetic resonance imaging detects joint and pleural infiltration of bone sarcomas in pediatric and young adult patients.
The diagnosis of joint infiltration by a malignant bone tumor affects surgical management. The specificity of standard magnetic resonance imaging (MRI) for diagnosing joint infiltration is limited. During our MRI evaluations with ferumoxytol nanoparticles of pediatric and young adult patients with bone sarcomas, we observed a surprising marked T1 enhancement of joint and pleural effusions in some patients but not in others.To evaluate if nanoparticle extravasation differed between joints and pleura with and without tumor infiltration.We retrospectively identified 15 pediatric and young adult patients (mean age: 16±4 years) with bone sarcomas who underwent 18 MRI scans at 1 h (n=7) or 24 h (n=11) after intravenous ferumoxytol infusion. Twelve patients also received a gadolinium-enhanced MRI. We determined tumor invasion into the joint or pleural space based on histology (n=11) and imaging findings (n=4). We compared the signal-to-noise ratios (SNR) and contrast-to-noise ratios (CNR) of the joint or pleural fluid for tumors with and without invasion using a Mann-Whitney U test.MRI scans 24 h after intravenous ferumoxytol infusion demonstrated a positive T1 enhancement of the effusion in all joints and pleural spaces with tumor infiltration and no joint or pleural space without infiltration. Corresponding SNR (P=0.004) and CNR (P=0.004) values were significantly higher for joints and pleural spaces with tumor infiltration than without. By contrast, unenhanced MRI, gadolinium-enhanced MRI and 1-h post-contrast ferumoxytol MRI did not show any enhancement of the joint or pleural effusion, with or without tumor infiltration.This pilot study suggests that 24-h post-contrast ferumoxytol MRI scans can noninvasively differentiate between joints with and without tumor infiltration.
View details for DOI 10.1007/s00247-021-05156-y
View details for PubMedID 34410452
Increasing Diversity in Radiology and Molecular Imaging: Current Challenges.
Molecular imaging and biology
This paper summarizes the 2020 Diversity in Radiology and Molecular Imaging: What We Need to Know Conference, a three-day virtual conference held September 9-11, 2020. The World Molecular Imaging Society (WMIS) and Stanford University jointly organized this event to provide a forum for WMIS members and affiliates worldwide to openly discuss issues pertaining to diversity in science, technology, engineering, and mathematics (STEM). The participants discussed three main conference themes, "racial diversity in STEM," "women in STEM," and "global health," which were discussed through seven plenary lectures, twelve scientific presentations, and nine roundtable discussions, respectively. Breakout sessions were designed to flip the classroom and seek input from attendees on important topics such as increasing the representation of underrepresented minority (URM) members and women in STEM, generating pipeline programs in the fields of molecular imaging, supporting existing URM and women members in their career pursuits, developing mechanisms to effectively address microaggressions, providing leadership opportunities for URM and women STEM members, improving global health research, and developing strategies to advance culturally competent healthcare.
View details for DOI 10.1007/s11307-021-01610-3
View details for PubMedID 33903986
Five-Minute Five-Sequence Knee MRI Using Combined Simultaneous Multislice and Parallel Imaging Acceleration: Comparison with 10-Minute Parallel Imaging Knee MRI.
Background Rapid knee MRI using combined simultaneous multislice (SMS) technique and parallel imaging (PI) acceleration can add value through reduced acquisition time but requires validation of clinical efficacy. Purpose To evaluate the performance of clinical fourfold SMS-PI-accelerated, 5-minute, five-sequence, multicontrast knee MRI protocols compared with standard twofold PI-accelerated, 10-minute knee MRI protocols. Materials and Methods Adults with painful knee conditions were prospectively enrolled from April 2018 to October 2019. Participants underwent fourfold SMS-PI-accelerated, 5-minute, turbo spin-echo (TSE) knee MRI and standard-of-care twofold PI-accelerated, 10-minute, TSE knee MRI at either 1.5 T or 3.0 T. Three radiologists independently evaluated the knee MRI studies for meniscal, tendinous, ligamentous, and osseocartilaginous injuries. Statistical analyses included k-based intermethod agreements and diagnostic performance testing. P < .05 was considered indicative of a statistically significant difference. Results A total of 252 adults were evaluated (mean age ± standard deviation, 47 years ± 17; 134 men). Among the participants, 104 (mean age, 42 years 5 18; 57 women) were in the 1.5-T arm and 148 (mean age, 46 years 5 17; 87 men) were in the 3.0-T arm. Twenty-nine participants (mean age, 38 years 5 12; 15 men) in the 1.5-T arm and 42 (mean age, 41 years 5 16; 24 men) in the 3.0-T arm underwent arthroscopy a mean of 45 days 5 31 and 45 days 5 22 after MRI, respectively. Intermethod agreements were good at 1.5 T (κ >0.71 [95% CI: 0.56, 0.83]) and very good at 3.0 T (κ >0.85 [95% CI: 0.69, 0.96]). The diagnostic performances of corresponding 5-minute and 10-minute MRI protocols were similar for 1.5 T, with areas under the receiver operating characteristic curve (AUCs) greater than 0.78 (95% CI: 0.71, 0.84) (P > .32), and 3.0 T, with AUCs greater than 0.83 (95% CI: 0.78, 0.88) (P > .32). Conclusion Comparisons of 5-minute five-sequence simultaneous multislice- and parallel imaging (PI)-accelerated and 10-minute five-sequence PI-accelerated turbo spin-echo MRI of the knee suggest similar performances at 1.5 and 3.0 T. © RSNA, 2021 Online supplemental material is available for this article. See also the editorial by Subhas in this issue.
View details for DOI 10.1148/radiol.2021203655
View details for PubMedID 33825510
Cryoanalgesia of the anterior femoral cutaneous nerve (AFCN) for the treatment of neuropathy-mediated anterior thigh pain: anatomy and technical description.
View details for DOI 10.1007/s00256-020-03650-2
- Advanced Imaging of the Shoulder and Elbow Orthopedic Knowledge Update Shoulder and Elbow Wolters Kluwer. 2020; 5: 655–670
- Teaching NeuroImages: Intracranial DICER1-associated spindle cell sarcoma. Neurology 2020
Image-guided Sports Medicine and Musculoskeletal Tumor Interventions: A Patient-Centered Model.
Seminars in musculoskeletal radiology
2020; 24 (3): 290–309
The spectrum of effective musculoskeletal (MSK) interventions is broadening and rapidly evolving. Increasing demands incite a perpetual need to optimize services and interventions by maximizing the diagnostic and therapeutic yield, reducing exposure to ionizing radiation, increasing cost efficiency, as well as identifying and promoting effective procedures to excel in patient satisfaction ratings and outcomes. MSK interventions for the treatment of oncological conditions, and conditions related to sports injury can be performed with different imaging modalities; however, there is usually one optimal image guidance modality for each procedure and individual patient. We describe our patient-centered workflow as a model of care that incorporates state-of-the-art imaging techniques, up-to-date evidence, and value-based practices with the intent of optimizing procedural success and outcomes at a patient-specific level. This model contrasts interventionalist- and imaging modality-centered practices, where procedures are performed based on local preference and selective availability of imaging modality or interventionalists. We discuss rationales, benefits, and limitations of fluoroscopy, ultrasound, computed tomography, and magnetic resonance imaging procedure guidance for a broad range of image-guided MSK interventions to diagnose and treat sports and tumor-related conditions.
View details for DOI 10.1055/s-0040-1710065
View details for PubMedID 32987427
Evaluation of Demographic Characteristics and Factors Associated with Poisoning in Children Attending the Koodakan Hospital of Bandar Abbas
Acta HealthMedica Journal
2018; 3 (2): 263-267
View details for DOI 10.19082/ah263
Frequency of Congenital Hypothyroidism in Hormozgan Province, Iran
Acta HealthMedica Journal
2018; 3 (2): 253-258
View details for DOI 10.19082/ah253
- Antifungal effect of essential oil of Bunium persicum on Candida albicans, In vitro study Hormozgan Medical Journal 2014; 17 (3): 37-44