All Publications


  • Necrotizing myopathy with elevated anti-HMGCR antibodies following exposure to the supplement Bacopa. Muscle & nerve Yaworski, A. M., Blyumin, M., Chang, T., Mammen, A. L., Greene, M. 2022

    View details for DOI 10.1002/mus.27758

    View details for PubMedID 36416249

  • Pediatric Encephalopathy and Complex Febrile Seizures CLINICAL PEDIATRICS Yaworski, A., Alobaidi, R., Liu, N., Mailo, J., Kassiri, J. 2022: 99228221084422

    View details for DOI 10.1177/00099228221084422

    View details for Web of Science ID 000776593100001

    View details for PubMedID 35352986

  • Intrinsic peripheral nerve and root tumor and pseudotumoral lesions at a tertiary care pediatric hospital. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery Yaworski, A., Koujok, K., Cheung, K., Ying, Y., McMillan, H. J. 2021; 37 (4): 1229-1236

    Abstract

    Tumors affecting peripheral nerves in children are rare. Accurate diagnosis ensures that management is appropriate and timely. A review of intrinsic nerve tumors was completed to differentiate common peripheral nerve lesions based on clinical characteristics and investigations.A retrospective review was conducted for children (< 18 years old) diagnosed with an intrinsic tumor affecting peripheral nerve(s) or roots at the Children's Hospital of Eastern Ontario (CHEO) from 2009 to 2019.We report 14 children with perineurioma (N = 6), neurofibroma (N = 4), intraneural ganglion cyst (N = 2), or lipomatosis (N = 2). Mean age of symptom onset was 8.2 years (range 0.3 to 17.3 years). Presenting symptoms included muscle weakness (7/14), painless muscle wasting (2/14), contracture (1/14), pain (1/14), or the identification of a painless mass (3/14). Nerve conduction studies (NCS) or electromyography (EMG) were performed in 11/14 patients. MRI was useful at differentiating between these pediatric nerve tumors. Biopsies were performed in nine patients with additional surgical management pursued in four patients.The rare nature of peripheral nerve tumors in children can pose diagnostic challenges. NCS/EMG are important to assist with localization, and MRI is useful to distinguish more benign tumors. Key MRI, clinical, and NCS features can in some cases guide management, potentially avoiding the need for invasive procedures.

    View details for DOI 10.1007/s00381-020-04995-8

    View details for PubMedID 33404726

  • Improved care and management of paediatric neurological patients evaluated at a paediatric Rapid Access Neurology clinic: A pilot study JOURNAL OF PAEDIATRICS AND CHILD HEALTH Yaworski, A. M., Yager, J. Y., Richer, L., Mailo, J., Rajapakse, T., Kassiri, J. 2021; 57 (6): 908-912

    Abstract

    Referral wait times for paediatric neurological patients are increasing, leading to an increased burden on the emergency department (ED). The paediatric Rapid Access Neurology (pRAN) clinic was created for paediatric patients who are clinically stable, but require an urgent paediatric neurology consultation. The objectives were to evaluate the pathways of referral, accuracy of referring diagnoses, adherence to clinic appointments, impact of clinic visitation on ED visits and patient satisfaction.Data were collected from the pRAN clinic from March 2018 until April 2019. Information was obtained from patient charts including the referring and final diagnosis, management plan and the number of visits made to the ED before and after visiting the pRAN clinic.Of the 256 referred patients, 91 met inclusion criteria. The most frequent referral diagnosis was a seizure. Referring physicians and pRAN clinic neurologists differed significantly in the level of diagnostic agreement for patients <2 years of age (P = 0.03; 95% confidence interval (CI) -0.294, 0.373). There was a significant reduction in visits to the ED made by patients 3 months after the pRAN appointment compared with before the visit (P < 0.001; 95% CI -0.9070, -0.4088). The majority of patients felt that the clinic had high value and were satisfied with their follow-up plan.This pilot study showed that a pRAN clinic can improve the accuracy of neurological diagnoses and management, especially for children <2 years of age. In addition, pRAN clinic patients make fewer subsequent visits to the ED and express high satisfaction with their care.

    View details for DOI 10.1111/jpc.15352

    View details for Web of Science ID 000608361100001

    View details for PubMedID 33460255

  • Research Consent Models Used in Prospective Studies of Neurologically Deceased Organ Donors: A Systematic Review. Journal of empirical research on human research ethics : JERHRE D'Aragon, F., Burns, K. E., Yaworski, A., Lucas, A., Arseneau, E., Belley-Cote, E., Dhanani, S., Frenette, A. J., Lamontagne, F., Lauzier, F., Akhtar, A., Oczkowski, S., Rochwerg, B., Meade, M. O. 2020; 15 (4): 244-251

    Abstract

    Research to inform the care of neurologically deceased organ donors is complicated by a lack of standards for research consent. In this systematic review, we aim to describe current practices of soliciting consent for participation in prospective studies of neurologically deceased donors, including the frequency and justification for these various models of consent. Among the 74 studies included, 14 did not report on any regulatory review, and 13 did not report on the study consent procedures. Of the remaining 47 studies, 24 utilized a waiver of research consent. The most common justification for a waiver of research consent related to the fact that neurologically deceased donors are not considered human subjects. In conclusion, among studies of neurologically deceased donors, research consent models vary and are inconsistently reported. Consensus and standardization in the application of research consent models will help to advance this emerging field of research.

    View details for DOI 10.1177/1556264620904627

    View details for PubMedID 32052700

  • Developmental delay and neuropsychiatric comorbidities associated with Duchenne and Becker muscular dystrophy. Muscle & nerve Yaworski, A. M., McMillan, H. J. 2020; 61 (2): 127-128

    View details for DOI 10.1002/mus.26775

    View details for PubMedID 31811661