Ana Carolina Boncompagni

All Publications

• A case of iatrogenic Cushing syndrome and subsequent adrenal insufficiency from a hidden ingredient in the supplement Artri Ajo King. Journal of the American College of Emergency Physicians open Boncompagni, A. C., Ruiz, E., Rider, A. C. 2023; 4 (4): e13007

  Abstract

  Dietary supplement use is common in the United States. Supplements are regulated by the US Food and Drug Administration (FDA) under a separate set of guidelines from typical food and drug products. This case report describes a patient who presented to the emergency department (ED) with abdominal pain, vomiting, and generalized weakness. On detailed history, we learned that he had been taking a supplement called Artri Ajo King for 18 months, followed by recent abrupt cessation before his ED presentation. He was subsequently found to have a low serum cortisol level and was diagnosed with secondary adrenal insufficiency by a cosyntropin stimulation test. Ultimately, he was started on hydrocortisone with resolution of his symptoms. This case illustrates the consequence of allowing dietary supplements to be sold before FDA evaluation as well as the importance of physicians eliciting history of supplement use and offering a culturally competent discussion with their patients regarding supplement use.

  View details for DOI 10.1002/emp2.13007

  View details for PubMedID 37440790

  View details for PubMedCentralID PMC10334111

• The association of anxiety and insomnia on blood pressure parameters in pregnancy: a pilot study Miller, H. E., Simpson, S. L., Hurtado, J., Boncompagni, A. C., Chueh, J., Druzin, M. L., Panelli, D. M. MOSBY-ELSEVIER. 2023: S483-S484

  View details for Web of Science ID 000909337401305

• Evaluating the Impact of the Covid-19 Pandemic on Emergency Medicaid Programs: Have Insurance Rates Improved among Trauma Patients? Handley, T. J., Boncompagni, A., Arnow, K. D., Sasnal, M., Trickey, A. W., Morris, A. M., Knowlton, L. LIPPINCOTT WILLIAMS & WILKINS. 2022: S88

  View details for Web of Science ID 000867877000219

• Predictive Value of Clinical Complete Response after Chemoradiation for Rectal Cancer Liu, C., Boncompagni, A. A., Perrone, K., Agarwal, A., Hur, D. G., Lopez, I., Sheth, V., Morris, A. M. LIPPINCOTT WILLIAMS & WILKINS. 2022: S51-S52

  View details for DOI 10.1097/01.XCS.0000893308.54894.46

  View details for Web of Science ID 000867889300080

• Regional Control of Hairless versus Hair-Bearing Skin by Dkk2 CELL REPORTS Song, Y., Boncompagni, A. C., Kim, S., Gochnauer, H. R., Zhang, Y., Loots, G. G., Wu, D., Li, Y., Xu, M., Millar, S. E. 2018; 25 (11): 2981-+

  Abstract

  Haired skin is a defining characteristic of mammals. However, some specialized skin regions, such as human palms, soles and ventral wrist, and mouse plantar foot, are entirely hairless. Using mouse plantar skin as a model system, we show that the endogenous secreted Wnt inhibitor DKK2 suppresses plantar hair follicle development and permits the formation of hairless skin. Plantar skin retains all of the mechanistic components needed for hair follicle development, as genetic deletion of Dkk2 permits formation of fully functional plantar hair follicles that give rise to external hair, contain sebaceous glands and a stem cell compartment, and undergo regenerative growth. In the absence of Dkk2, Wnt/β-catenin signaling activity is initially broadly elevated in embryonic plantar skin and gradually becomes patterned, mimicking follicular development in normally haired areas. These data provide a paradigm in which regionally restricted expression of a Wnt inhibitor underlies specification of hairless versus hairy skin.

  View details for DOI 10.1016/j.celrep.2018.11.017

  View details for Web of Science ID 000452895100007

  View details for PubMedID 30509557

  View details for PubMedCentralID PMC6345517