Dr. Gonzalez-Montoro's research interests involve the development of novel Positron Emission Tomography (PET) instrumentation for an accurate in vivo imaging of the metabolic processes and the study of diseasses in humans and small animals.
In addition to obtain a high efficiency of PET scanners when combined with MRI or CT scanners, my research focusses on instrumentation projects related to enhance the sensitivity and 3D spatial, and/or temporal resolutions.
Honors & Awards
Ronald J. Jaszczak Graduate Award, IEEE Nuclear & Plasma Sciences Society (2020)
Bachelor of Science, Universidad De Valencia (2014)
Master of Science, Universidad De Valencia (2015)
Doctor of Philosophy, Universidad De Valencia (2019)
Scalable electronic readout design for a 100 ps coincidence time resolution TOF-PET system.
Physics in medicine and biology
We have developed a scalable detector readout design for a 100 ps coincidence time resolution (CTR) time of flight (TOF) positron emission tomography (PET) detector technology. The basic scintillation detectors studied in this paper are based on 2×4 arrays of 3×3×10 mm³ "fast- LGSO:Ce" scintillation crystals side- coupled to 6×4 arrays of 3×3 mm² silicon photomultipliers (SiPMs). We employed a novel mixed-signal front-end electronic configuration and a low timing jitter Field Programming Gate Array (FPGA)-based time to digital converter (TDC) for data acquisition. Using a 22 Na point source, >10,000 coincidence events were experimentally acquired for several SiPM bias voltages, leading edge time-pickoff thresholds, and timing channels. CTR of 102.03 ± 1.9 ps full-width-at-half-maximum (FWHM) was achieved using single 3×3×10 mm³ "fast- LGSO" crystal elements, wrapped in Teflon tape and side coupled to a linear array of 3 SiPMs. In addition, the measured average CTR was 113.4 ± 0.7 ps for the side- coupled 2×4 crystal array. The readout architecture presented in this work is designed to be scalable to large area module detectors with a goal to create the first TOF-PET system with 100 ps FWHM CTR.
View details for DOI 10.1088/1361-6560/abf1bc
View details for PubMedID 33761476
- Novel method to measure the intrinsic spatial resolution in PET detectors based on monolithic crystals NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT 2019; 920: 58–67
- TOF studies for dedicated PET with open geometries IOP PUBLISHING LTD. 2019
- PET detector block with accurate 4D capabilities ELSEVIER SCIENCE BV. 2018: 132–36
- Detector block performance based on a monolithic LYSO crystal using a novel signal multiplexing method ELSEVIER SCIENCE BV. 2018: 372–77
Feasibility Study of a Small Animal PET Insert Based on a Single LYSO Monolithic Tube
FRONTIERS IN MEDICINE
2018; 5: 328
There are drawbacks with using a Positron Emission Tomography (PET) scanner design employing the traditional arrangement of multiple detectors in an array format. Typically PET systems are constructed with many regular gaps between the detector modules in a ring or box configuration, with additional axial gaps between the rings. Although this has been significantly reduced with the use of the compact high granularity SiPM photodetector technology, such a scanner design leads to a decrease in the number of annihilation photons that are detected causing lower scanner sensitivity. Moreover, the ability to precisely determine the line of response (LOR) along which the positron annihilated is diminished closer to the detector edges because the spatial resolution there is degraded due to edge effects. This happens for both monolithic based designs, caused by the truncation of the scintillation light distribution, but also for detector blocks that use crystal arrays with a number of elements that are larger than the number of photosensors and, therefore, make use of the light sharing principle. In this report we present a design for a small-animal PET scanner based on a single monolithic annulus-like scintillator that can be used as a PET insert in high-field Magnetic Resonance systems. We provide real data showing the performance improvement when edge-less modules are used. We also describe the specific proposed design for a rodent scanner that employs facetted outside faces in a single LYSO tube. In a further step, in order to support and prove the proposed edgeless geometry, simulations of that scanner have been performed and lately reconstructed showing the advantages of the design.
View details for DOI 10.3389/fmed.2018.00328
View details for Web of Science ID 000451693300002
View details for PubMedID 30547030
View details for PubMedCentralID PMC6279866
- A scintillator geometry suitable for very small PET gantries IOP PUBLISHING LTD. 2017
- Highly improved operation of monolithic BGO-PET blocks IOP PUBLISHING LTD. 2017
- Performance Study of a Large Monolithic LYSO PET Detector With Accurate Photon DOI Using Retroreflector Layers IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES 2017; 1 (3): 229–37
- PETIROC2 based readout electronics optimization for Gamma Cameras and PET detectors JOURNAL OF INSTRUMENTATION 2017; 12
- Performance study of a PET scanner based on monolithic scintillators for different DoI-dependent methods JOURNAL OF INSTRUMENTATION 2016; 11
- Pilot tests of a PET detector using the TOF-PET ASIC based on monolithic crystals and SiPMs JOURNAL OF INSTRUMENTATION 2016; 11
- Analysis of the Statistical Moments of the Scintillation Light Distribution With dSiPMs IEEE TRANSACTIONS ON NUCLEAR SCIENCE 2015; 62 (5): 1981–88