All Publications


  • Cortical layer-specific critical dynamics triggering perception. Science (New York, N.Y.) Marshel, J. H., Kim, Y. S., Machado, T. A., Quirin, S., Benson, B., Kadmon, J., Raja, C., Chibukhchyan, A., Ramakrishnan, C., Inoue, M., Shane, J. C., McKnight, D. J., Yoshizawa, S., Kato, H. E., Ganguli, S., Deisseroth, K. 2019

    Abstract

    Perceptual experiences may arise from neuronal activity patterns in mammalian neocortex. We probed mouse neocortex during visual discrimination using a red-shifted channelrhodopsin (ChRmine, discovered through structure-guided genome mining) alongside multiplexed multiphoton-holography (MultiSLM), achieving control of individually-specified neurons spanning large cortical volumes with millisecond precision. Stimulating a critical number of stimulus-orientation-selective neurons drove widespread recruitment of functionally-related neurons, a process enhanced by (but not requiring) orientation-discrimination task learning. Optogenetic targeting of orientation-selective ensembles elicited correct behavioral discrimination. Cortical layer specific-dynamics were apparent, as emergent neuronal activity asymmetrically propagated from layer-2/3 to layer-5, and smaller layer-5 ensembles were as effective as larger layer-2/3 ensembles in eliciting orientation discrimination behavior. Population dynamics emerging after optogenetic stimulation both correctly predicted behavior and resembled natural neural representations of visual stimuli.

    View details for DOI 10.1126/science.aaw5202

    View details for PubMedID 31320556

  • Channeling and radiation experiments at SLAC Wienands, U., Gessner, S., Hogan, M. J., Markiewicz, T. W., Smith, T., Sheppard, J., Uggerhoj, U. I., Hansen, J. L., Wistisen, T. N., Bagli, E., Bandiera, L., Germogli, G., Mazzolari, A., Guidi, V., Sytov, A., Holtzapple, R. L., McArdle, K., Tucker, S., Benson, B. ELSEVIER SCIENCE BV. 2017: 11–15
  • Hand-powered ultralow-cost paper centrifuge NATURE BIOMEDICAL ENGINEERING Bhamla, M., Benson, B., Chai, C., Katsikis, G., Johri, A., Prakash, M. 2017; 1 (1)
  • Channeling, volume reflection, and volume capture study of electrons in a bent silicon crystal PHYSICAL REVIEW ACCELERATORS AND BEAMS Wistisen, T. N., Uggerhoj, U. I., Wienands, U., Markiewicz, T. W., Noble, R. J., Benson, B. C., Smith, T., Bagli, E., Bandiera, L., Germogli, G., Guidi, V., Mazzolari, A., Holtzapple, R., Tucker, S. 2016; 19 (7)