Independent Labs, Institutes, and Centers (Dean of Research)


Showing 1-10 of 12 Results

  • Gianluca Iaccarino

    Gianluca Iaccarino

    Professor of Mechanical Engineering

    Current Research and Scholarly InterestsComputing and data for energy, health and engineering

    Challenges in energy sciences, green technology, transportation, and in general, engineering design and prototyping are routinely tackled using numerical simulations and physical testing. Computations barely feasible two decades ago on the largest available supercomputers, have now become routine using turnkey commercial software running on a laptop. Demands on the analysis of new engineering systems are becoming more complex and multidisciplinary in nature, but exascale-ready computers are on the horizon. What will be the next frontier? Can we channel this enormous power into an increased ability to simulate and, ultimately, to predict, design and control? In my opinion two roadblocks loom ahead: the development of credible models for increasingly complex multi-disciplinary engineering applications and the design of algorithms and computational strategies to cope with real-world uncertainty.
    My research objective is to pursue concerted innovations in physical modeling, numerical analysis, data fusion, probabilistic methods, optimization and scientific computing to fundamentally change our present approach to engineering simulations relevant to broad areas of fluid mechanics, transport phenomena and energy systems. The key realization is that computational engineering has largely ignored natural variability, lack of knowledge and randomness, targeting an idealized deterministic world. Embracing stochastic scientific computing and data/algorithms fusion will enable us to minimize the impact of uncertainties by designing control and optimization strategies that are robust and adaptive. This goal can only be accomplished by developing innovative computational algorithms and new, physics-based models that explicitly represent the effect of limited knowledge on the quantity of interest.

    Multidisciplinary Teaching

    I consider the classical boundaries between disciplines outdated and counterproductive in seeking innovative solutions to real-world problems. The design of wind turbines, biomedical devices, jet engines, electronic units, and almost every other engineering system requires the analysis of their flow, thermal, and structural characteristics to ensure optimal performance and safety. The continuing growth of computer power and the emergence of general-purpose engineering software has fostered the use of computational analysis as a complement to experimental testing in multiphysics settings. Virtual prototyping is a staple of modern engineering practice! I have designed a new undergraduate course as an introduction to Computational Engineering, covering theory and practice across multidisciplanary applications. The emphasis is on geometry modeling, mesh generation, solution strategy and post-processing for diverse applications. Using classical flow/thermal/structural problems, the course develops the essential concepts of Verification and Validation for engineering simulations, providing the basis for assessing the accuracy of the results.

  • Andrei Iagaru

    Andrei Iagaru

    Professor of Radiology (Nuclear Medicine)

    Current Research and Scholarly InterestsCurrent research projects include:
    1) PET/MRI and PET/CT for Early Cancer Detection
    2) Targeted Radionuclide Therapy
    3) Clinical Translation of Novel PET Radiopharmaceuticals;

  • Juliana Idoyaga

    Juliana Idoyaga

    Assistant Professor of Microbiology and Immunology

    Current Research and Scholarly InterestsThe Idoyaga Lab is focused on the function and biology of dendritic cells, which are specialized antigen-presenting cells that initiate and modulate our body’s immune responses. Considering their importance in orchestrating the quality and quantity of immune responses, dendritic cells are an indisputable target for vaccines and therapies.

    Dendritic cells are not one cell type, but a network of cells comprised of many subsets or subpopulations with distinct developmental pathways and tissue localization. It is becoming apparent that each dendritic cell subset is different in its capacity to induce and modulate specific types of immune responses; however, there is still a lack of resolution and deep understanding of dendritic cell subset functional specialization. This gap in knowledge is an impediment for the rational design of immune interventions. Our research program focuses on advancing our understanding of mouse and human dendritic cell subsets, revealing their endowed capacity to induce distinct types of immune responses, and designing novel strategies to exploit them for vaccines and therapies.

  • Yusuke Iguchi

    Yusuke Iguchi

    Sr Res Scientist-Physical

    Current Research and Scholarly InterestsHis research specialties are in experimental condensed matter physics, magnetic excitations in microwave region, magnetic scanning probe microscopy, multiferroics, and unconventional superconductors. Currently his interest is in the unconventional superconductors such as heavy fermion and iron based ones.

  • Gentaro Ikeda

    Gentaro Ikeda

    Instructor, Medicine - Cardiovascular Medicine

    BioDr. Ikeda is a physician-scientist who develops innovative diagnostic and therapeutic modalities for patients with cardiovascular disease. Based on his clinical experience as a cardiologist, he has become aware of major clinical shortcomings, specifically in the current pharmaceutical therapies for myocardial infarction (MI) and chronic heart failure (HF). Some evidence-based drug therapies, including β-blockers, ivabradine, and renin-angiotensin-aldosterone antagonists are difficult to apply to critical patients due to adverse side effects. Drugs that have shown efficacy in basic animal experiments have failed to show significant benefits in clinical trials. To address these problems, he moved to academia to conduct translational research. During his graduate training in the Egashira Lab, he focused on drug delivery systems (DDS) that target mitochondria in animal models of MI. He obtained advanced skills in molecular biology, mitochondrial bioenergetics, and animal surgery. He realized the importance of translational research and the great potential of DDS to overcome many clinical problems. He developed nanoparticle-mediated DDS containing cyclosporine for the treatment of patients with MI. He published a first-author paper and received academic awards for his novel science. Since becoming a postdoctoral fellow in the Yang Lab, he has continued to build upon his previous training in translational research. He is currently developing an innovative therapy, namely, extracellular vesicles-mediated mitochondrial transfer for mitochondria-related diseases such as heart failure and mitochondrial disease.

  • Daniel Imler

    Daniel Imler

    Clinical Associate Professor, Emergency Medicine
    Clinical Associate Professor, Pediatrics

    Current Research and Scholarly InterestsI am interested in understanding the impact of smart, agile clinical pathways to drive behavior change among providers.

  • John P.A. Ioannidis

    John P.A. Ioannidis

    Professor of Medicine (Stanford Prevention Research), of Epidemiology and Population Health and by courtesy, of Statistics and of Biomedical Data Science

    Current Research and Scholarly InterestsMeta-research
    Evidence-based medicine
    Clinical and molecular epidemiology
    Human genome epidemiology
    Research design
    Reporting of research
    Empirical evaluation of bias in research
    Randomized trials
    Statistical methods and modeling
    Meta-analysis and large-scale evidence
    Prognosis, predictive, personalized, precision medicine and health
    Sociology of science