Independent Labs, Institutes, and Centers (Dean of Research)


Showing 1-10 of 209 Results

  • Raya Saab

    Raya Saab

    Lindhard Family Professor of Pediatric Cancer Biology

    BioOur laboratory focuses on investigating molecular mechanisms of oncogene-induced tumorigenesis and tumor suppressor pathways, and oncogenic signaling in the pediatric solid tumor rhabdomyosarcoma. Our earlier work identified the tumor suppressors p53 and p18Ink4c as inhibitors of Cyclin D1-driven tumorigenesis in a pineoblastoma model, through senescence induction, and highlighted distinct roles for the the RB and p53 pathways in induction and maintenance of oncogene-induced senescence. We also identified CDK2 as a potential target for inducing senescence in premalignant lesions to inhibit tumor progression.
    Our current focus is on studying oncogenic signaling and tumor suppression in the childhood tumor rhabdomyosarcoma, to identify key mediators of invasion and metastasis, which is the most common cause of treatment failure clinically. We use preclinical in vitro and in vivo models, including murine and human cell lines, and mouse models of disease.
    We have recently uncovered a paracrine role for rhabdomyosarcoma-secreted exosomes in impacting biology of stromal cells. Rhabdomyosarcoma-derived exosomes carry specific miRNA cargo that imparts an invasive and migratory phenotype on normal recipient fibroblasts, and proteomic analysis revealed specific and unique pathways relevant to the two different molecular rhabdomyosarcoma subtypes that are driven by distinct oncogenic pathways. We identified that the driver oncogene in fusion-positive rhabdomyosarcoma, PAX3-FOXO1, modulates exosome cargo to promote invasion, migration, and angiogenic properties, and identified specific microRNA and protein cargo acting as effectors of PAX3-FOXO1 exosome-mediated signaling, including modulation of oxidative stress response and cell survival signaling.
    Our ongoing work is focused on interrogating specific paracrine signaling pathways and molecular mechanisms of metastatic disease progression in rhabdomyosarcoma, for potential therapeutic targeting.

  • Chiara Sabatti

    Chiara Sabatti

    Professor of Biomedical Data Science and of Statistics

    Current Research and Scholarly InterestsStatistical models and reasoning are key to our understanding of the genetic basis of human traits. Modern high-throughput technology presents us with new opportunities and challenges. We develop statistical approaches for high dimensional data in the attempt of improving our understanding of the molecular basis of health related traits.

  • Amin Saberi

    Amin Saberi

    Professor of Management Science and Engineering

    BioAmin Saberi is Professor of Management Science and Engineering at Stanford University. He received his B.Sc. from Sharif University of Technology and his Ph.D. from Georgia Institute of Technology in Computer Science. His research interests include algorithms, design and analysis of social networks, and applications. He is a recipient of the Terman Fellowship, Alfred Sloan Fellowship and several best paper awards.
    Amin was the founding CEO and chairman of NovoEd Inc., a social learning environment designed in his research lab and used by universities such as Stanford as well as non-profit and for-profit institutions for offering courses to hundreds of thousands of learners around the world.

  • Debra Safer

    Debra Safer

    Associate Professor of Psychiatry and Behavioral Sciences (General Psychiatry and Psychology-Adult)

    Current Research and Scholarly InterestsPrimary research interests include the nature and treatment of eating disorders
    (particularly bulimia nervosa and binge eating disorder), the development and treatment of obesity, and the development and treatment of problematic eating patterns in patients following bariatric surgery.

  • Marc R. Safran, MD

    Marc R. Safran, MD

    Professor of Orthopaedic Surgery

    Current Research and Scholarly InterestsDr. Safran’s practice focuses on arthroscopic management of hip problems as well as articular cartilage regeneration, shoulder surgery and athletic shoulder and elbow problems. He is actively involved in research in these areas.

  • Scott D. Sagan

    Scott D. Sagan

    Caroline S. G. Munro Memorial Professor of Political Science and Senior Fellow at the Freeman Spogli Institute for International Studies

    Current Research and Scholarly InterestsJust War doctrine and the development of norms concerning the use of force; public attitudes in the U.S., U.K., France, and Israel about the use of nuclear weapons and non-combatant casualties; organizations and management of insider threats; the management of hazardous technology; security of nuclear materials, the proliferation of weapons of mass destruction and the Non-Proliferation Treaty.

  • Julien Sage

    Julien Sage

    Elaine and John Chambers Professor of Pediatric Cancer and Professor of Genetics

    Current Research and Scholarly InterestsWe investigate the mechanisms by which normal cells become tumor cells, and we combine genetics, genomics, and proteomics approaches to investigate the differences between the proliferative response in response to injury and the hyperproliferative phenotype of cancer cells and to identify novel therapeutic targets in cancer cells.

  • Manish Saggar

    Manish Saggar

    Assistant Professor (Research) of Psychiatry and Behavioral Sciences (Interdisciplinary Brain Science Research)

    Current Research and Scholarly InterestsWe are a computational neuropsychiatry lab dedicated to developing computational methods to better understand brain’s overall dynamical organization in healthy and patient populations. We employ algorithms from a wide range of fields, including Applied Mathematics, Econometrics, Machine Learning, Biophysics, and Network Science.