Showing 1-20 of 48 Results
Current Research and Scholarly InterestsThe Dabiri Lab conducts research at the intersection of fluid mechanics, energy and environment, and biology.
Associate Professor of Radiology (Pediatric Radiology)
Current Research and Scholarly InterestsUltrasonic beamforming, imaging methods, systems, and devices.
The J.G. Jackson and C.J. Wood Professor in Chemistry
BioProfessor Dai’s research spans chemistry, physics, and materials and biomedical sciences, leading to materials with properties useful in electronics, energy storage and biomedicine. Recent developments include near-infrared-II fluorescence imaging, ultra-sensitive diagnostic assays, a fast-charging aluminum battery and inexpensive electrocatalysts that split water into oxygen and hydrogen fuels.
Born in 1966 in Shaoyang, China, Hongjie Dai began his formal studies in physics at Tsinghua U. (B.S. 1989) and applied sciences at Columbia U. (M.S. 1991). He obtained his Ph.D. from Harvard U and performed postdoctoral research with Dr. Richard Smalley. He joined the Stanford faculty in 1997, and in 2007 was named Jackson–Wood Professor of Chemistry. Among many awards, he has been recognized with the ACS Pure Chemistry Award, APS McGroddy Prize for New Materials, Julius Springer Prize for Applied Physics and Materials Research Society Mid-Career Award. He has been elected to the American Academy of Arts and Sciences, National Academy of Sciences (NAS), National Academy of Medicine (NAM) and Foreign Member of Chinese Academy of Sciences.
The Dai Laboratory has advanced the synthesis and basic understanding of carbon nanomaterials and applications in nanoelectronics, nanomedicine, energy storage and electrocatalysis.
The Dai Lab pioneered some of the now-widespread uses of chemical vapor deposition for carbon nanotube (CNT) growth, including vertically aligned nanotubes and patterned growth of single-walled CNTs on wafer substrates, facilitating fundamental studies of their intrinsic properties. The group developed the synthesis of graphene nanoribbons, and of nanocrystals and nanoparticles on CNTs and graphene with controlled degrees of oxidation, producing a class of strongly coupled hybrid materials with advanced properties for electrochemistry, electrocatalysis and photocatalysis. The lab’s synthesis of a novel plasmonic gold film has enhanced near-infrared fluorescence up to 100-fold, enabling ultra-sensitive assays of disease biomarkers.
Nanoscale Physics and Electronics
High quality nanotubes from his group’s synthesis are widely used to investigate the electrical, mechanical, optical, electro-mechanical and thermal properties of quasi-one-dimensional systems. Lab members have studied ballistic electron transport in nanotubes and demonstrated nanotube-based nanosensors, Pd ohmic contacts and ballistic field effect transistors with integrated high-kappa dielectrics.
Nanomedicine and NIR-II Imaging
Advancing biological research with CNTs and nano-graphene, group members have developed π–π stacking non-covalent functionalization chemistry, molecular cellular delivery (drugs, proteins and siRNA), in vivo anti-cancer drug delivery and in vivo photothermal ablation of cancer. Using nanotubes as novel contrast agents, lab collaborations have developed in vitro and in vivo Raman, photoacoustic and fluorescence imaging. Lab members have exploited the physics of reduced light scattering in the near-infrared-II (1000-1700nm) window and pioneered NIR-II fluorescence imaging to increase tissue penetration depth in vivo. Video-rate NIR-II imaging can measure blood flow in single vessels in real time. The lab has developed novel NIR-II fluorescence agents, including CNTs, quantum dots, conjugated polymers and small organic dyes with promise for clinical translation.
Electrocatalysis and Batteries
The Dai group’s nanocarbon–inorganic particle hybrid materials have opened new directions in energy research. Advances include electrocatalysts for oxygen reduction and water splitting catalysts including NiFe layered-double-hydroxide for oxygen evolution. Recently, the group also demonstrated an aluminum ion battery with graphite cathodes and ionic liquid electrolytes, a substantial breakthrough in battery science.
Professor of Radiology (General Radiology) and, by courtesy, of Pediatrics (Hematology/Oncology)
Current Research and Scholarly InterestsAs a physician-scientist involved in the care of pediatric patients and developing novel pediatric molecular imaging technologies, my goal is to link the fields of nanotechnology and medical imaging towards more efficient diagnoses and image-guided therapies. Our research team develops novel imaging techniques for improved cancer diagnosis, for image-guided-drug delivery and for in vivo monitoring of cell therapies in children and young adults.
Professor (Research) of Computer Science and of Electrical Engineering
BioDally develops efficient hardware for demanding information processing problems and sustainable energy systems. His current projects include domain-specific accelerators for deep learning, bioinformatics, and SAT solving; redesigning memory systems for the data center; developing efficient methods for video perception; and developing efficient sustainable energy systems. His research involves demonstrating novel concepts with working systems. Previous systems include the MARS Hardware Accelerator, the Torus Routing Chip, the J-Machine, M-Machine, the Reliable Router, the Imagine signal and image processor, the Merrimac supercomputer, and the ELM embedded processor. His work on stream processing led to GPU computing. His group has pioneered techniques including fast capability-based addressing, processor coupling, virtual channel flow control, wormhole routing, link-level retry, message-driven processing, deadlock-free routing, pruning neural networks, and quantizing neural networks.
Ronald L. Dalman MD
Walter Clifford Chidester and Elsa Rooney Chidester Professor of Surgery
Current Research and Scholarly InterestsVascular biology, arterial remodeling, aneurysm development; innovative treatment strategies for AAA, animal models of arterial disease, arterial remodeling and flow changes in spinal cord injury, genetic regulation of arterial aneurysm formation
Professor of Radiology (Body Imaging) and, by courtesy, of Bioengineering
Current Research and Scholarly Interests1. MRI of Breast Cancer, particularly new techniques. Currently being explored are techniques including ultra high spatial resolution MRI and contrast-agent-free detection of breast tumors.
2. MRI-guided interventions, especially MRI-compatible remote manipulation and haptics
3. Medical Mixed Reality. Currently being explored are methods of fusing patients and their images to potentially improve breast conserving surgery, and other conditions.
Professor (Teaching) of Pediatrics (Neonatology) and, by courtesy, of Obstetrics and Gynecology
BioGary L. Darmstadt, MD, MS, is Associate Dean for Maternal and Child Health, and Professor of Neonatal and Developmental Pediatrics in the Department of Pediatrics at the Stanford University School of Medicine. Previously Dr. Darmstadt was Senior Fellow in the Global Development Program at the Bill & Melinda Gates Foundation (BMGF), where he led a cross-foundation initiative on Women, Girls and Gender, assessing how addressing gender inequalities and empowering women and girls leads to improved gender equality as well as improved health and development outcomes. Prior to this role, he served as BMGF Director of Family Health, leading strategy development and implementation across nutrition, family planning and maternal, newborn and child health.
Darmstadt was formerly Associate Professor and Founding Director of the International Center for Advancing Neonatal Health in the Department of International Health at the Johns Hopkins Bloomberg School of Public Health. He has trained in Pediatrics at Johns Hopkins University, in Dermatology at Stanford University, and in Pediatric Infectious Disease as a fellow at the University of Washington, Seattle, where he was Assistant Professor in the Departments of Pediatrics and Medicine. Dr. Darmstadt left the University of Washington to serve as Senior Research Advisor for the Saving Newborn Lives program of Save the Children-US, where he led the development and implementation of the global research strategy for newborn health and survival, before joining Johns Hopkins.
Professor of Mechanical Engineering
Current Research and Scholarly InterestsProfessor Darve's research is focused on the development of numerical methods for high-performance scientific computing, numerical linear algebra, fast algorithms, parallel computing, and machine learning with applications in engineering.
Associate Professor of Biochemistry
Current Research and Scholarly InterestsOur lab seeks an agile and predictive understanding of how nucleic acids and proteins code for information processing in living systems. We develop new computational & chemical tools to enable the precise modeling, regulation, and design of RNA and RNA/protein machines.
Rajesh Dash, MD PhD; Director of SSATHI & CardioClick
Associate Professor of Medicine (Cardiovascular Medicine) at the Stanford University Medical Center
Current Research and Scholarly InterestsI have two research areas:
1) Heart disease in South Asians - genetic, metabolic, & behavioral underpinnings of an aggressive phenotype.
2) Imaging cell injury & recovery in the heart. Using Cardiac MRI to visualize signals of early injury and facilitating preventive medical therapy. Optimizing new imaging methods for viable cells to delineate live heart cells or transplanted stem cells.
Laura M.K. Dassama
Assistant Professor of Chemistry
BioThe Dassama laboratory at Stanford performs research directed at understanding and mitigating bacterial multidrug resistance (MDR). Described as an emerging crisis, MDR often results from the misuse of antibiotics and the genetic transfer of resistance mechanisms by microbes. Efforts to combat MDR involve two broad strategies: understanding how resistance is acquired in hopes of mitigating it, and identifying new compounds that could serve as potent antibiotics. The successful implementation of both strategies relies heavily on an interdisciplinary approach, as resistance mechanisms must be elucidated on a molecular level, and formation of new drugs must be developed with precision before they can be used. The laboratory uses both strategies to contribute to current MDR mitigation efforts.
One area of research involves integral membrane proteins called multidrug and toxin efflux (MATE) pumps that have emerged as key players in MDR because their presence enables bacteria to secrete multiple drugs.The genes encoding these proteins are present in many bacterial genomes. However, the broad substrate range and challenges associated with membrane protein handling have hindered efforts to elucidate and exploit transport mechanisms of MATE proteins. To date, substrates identified for MATE proteins are small and ionic drugs, but recent reports have implicated these proteins in efflux of novel natural product substrates. The group’s approach will focus on identifying the natural product substrates of some of these new MATE proteins, as well as obtaining static and dynamic structures of the proteins during efflux. These efforts will define the range of molecules that can be recognized and effluxed by MATE proteins and reveal how their transport mechanisms can be exploited to curtail drug efflux.
Another research direction involves the biosynthesis of biologically active natural products. Natural products are known for their therapeutic potential, and those that derive from modified ribosomal peptides are an important emerging class. These ribosomally produced and post-translationally modified peptidic (RiPP) natural products have the potential to substantially diversify the chemical composition of known molecules because the peptides they derive from can tolerate sequence variance, and modifying enzymes can be selected to install specific functional groups. With an interest in producing new antimicrobial and anticancer compounds, the laboratory will exploit the versatility of RiPP natural product biosynthesis. Specifically, efforts in the laboratory will revolve around elucidating the reaction mechanisms of particular biosynthetic enzymes and leveraging that understanding to design and engineer new natural products with desired biological activities.
Ruth G. and William K. Bowes Professor in the School of Engineering and Professor, by courtesy, of Surgery
BioDauskardt and his group have worked extensively on integrating new materials into emerging technologies including thin-film structures for nanoscience and energy technologies, high-performance composite and laminates for aerospace, and on biomaterials and soft tissues in bioengineering. His group has pioneered methods for characterizing adhesion and cohesion of thin films used extensively in device technologies. His research on wound healing has concentrated on establishing a biomechanics framework to quantify the mechanical stresses and biologic responses in healing wounds and define how the mechanical environment affects scar formation. Experimental studies are complimented with a range of multiscale computational capabilities. His research includes interaction with researchers nationally and internationally in academia, industry, and clinical practice.
Professor of Civil and Environmental Engineering and Senior Fellow at the Woods Institute for the Environment
Current Research and Scholarly InterestsProfessor Davis’ research and teaching deals broadly with the role that water and sanitation services play in promoting public health and economic development, with particular emphasis on low- and middle-income countries. Her group conducts applied research that utilizes theory and analytical methods from public and environmental health, engineering, microeconomics, and planning. They have conducted field research in more than 20 countries, most recently including Zambia, Bangladesh, and Kenya.
Assistant Professor of Pediatrics (Hematology/Oncology) at the Lucile Salter Packard Children's Hospital
Current Research and Scholarly InterestsChildhood cancers can be considered aberrations of normal tissue development. We are interested in understanding childhood cancers through the lens of normal development. Further, individual tumors are composed of heterogeneous cell populations, not all cells being equal in their ability to respond to treatment or to repopulate a tumor. Thus, we take single cell approach to determine populations of clinical relevance.
Mark M. Davis
Director, Stanford Institute for Immunity, Transplantation and Infection and the Burt and Marion Avery Family Professor
Current Research and Scholarly InterestsMolecular mechanisms of lymphocyte recognition and differentiation; Systems immunology and human immunology; vaccination and infection.
Ronald W. Davis
Professor of Biochemistry and of Genetics
Current Research and Scholarly InterestsWe are using Saccharomyces cerevisiae and Human to conduct whole genome analysis projects. The yeast genome sequence has approximately 6,000 genes. We have made a set of haploid and diploid strains (21,000) containing a complete deletion of each gene. In order to facilitate whole genome analysis each deletion is molecularly tagged with a unique 20-mer DNA sequence. This sequence acts as a molecular bar code and makes it easy to identify the presence of each deletion.
Vinicio de Jesus Perez MD
Associate Professor of Medicine (Pulmonary and Critical Care Medicine)
Current Research and Scholarly InterestsMy work is aimed at understanding the molecular mechanisms involved in the development and progression of pulmonary arterial hypertension (PAH). I am interested in understanding the role that the BMP and Wnt pathways play in regulating functions of pulmonary endothelial and smooth muscle cells both in health and disease.
Adam de la Zerda
Associate Professor of Structural Biology and, by courtesy, of Electrical Engineering
Current Research and Scholarly InterestsMolecular imaging technologies for studying cancer biology in vivo
Luis de Lecea
Professor of Psychiatry and Behavioral Sciences (Major Laboratories and Clinical and Translational Neurosciences Incubator)On Leave from 03/09/2020 To 10/18/2020
Current Research and Scholarly InterestsMy lab uses molecular, optogenetic, anatomical and behavioral methods to identify and manipulate the neuronal circuits underlying brain arousal, with particular attention to sleep and wakefulness transitions. We are also interested in the changes that occur in neuronal circuits in conditions of hyperarousal such as stress and drug addiction.