Showing 1-50 of 53 Results
Assistant Professor of Education
Current Research and Scholarly InterestsI use AI models of of exploratory and social learning in order to better understand early human learning and development, and conversely, I use our understanding of early human learning to make robust AI models that learn in exploratory and social ways. Based on this, I develop AI-powered learning tools for children, geared in particular towards the education of those with developmental issues such as the Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder, in the mold of my work on the Autism Glass Project. My formal graduate training in pure mathematics involved extending partial differential equation theory in cases involving the propagation of waves through complex media such as the space around a black hole. Since then, I have transitioned to the use of machine learning in developing both learning tools for children with developmental disorders and AI and cognitive models of learning.
Aida Habtezion MD MSc.
Associate Professor of Medicine (Gastroenterology and Hepatology)
Current Research and Scholarly InterestsLeukocyte recruitment & immune responses in diseases affecting digestive organs
Paul S. and Billie Achilles Professor in Environmental Biology, Senior Fellow at the Woods Institute for the Environment and Professor, by courtesy, of Geological Sciences
Current Research and Scholarly InterestsElizabeth Hadly and her lab probe how perturbations such as climatic change and human modification of the environment influence the evolution and ecology of animals.
Professor of Pediatrics (Neonatology) at the Lucile Packard Children's Hospital and, by courtesy, of Obstetrics and Gynecology at the Stanford University Medical Center
Current Research and Scholarly Interests1. development of hospital operations centers coupled with sophisticated simulation capabilities
2. re-creation of near misses and adverse events
3. optimizing human and system performance during resuscitation
4. optimizing pattern recognition and situational awareness at the bedside
5. evaluation and optimization of debriefing
6. patient simulator design
Professor of Psychiatry and Behavioral Sciences
Current Research and Scholarly InterestsPrincipal Investigator
Infrastructure to facilitate discovery of autism genes
The purpose of this project is to facilitate the discovery of the genes that contribute autism by maintaining an infrastructure which research groups studying the genetics of autism can work collaboratively. This will be
accomplished through workshops, a Virtual Private Network, and access to a database that includes phenotype and genotype data from all participating groups.
A California Population-Based Twin Study of Autism
This will address several fundamental questions: (1) What is the heritability of autism (2) What is the contribution of genetic factors to variation in symptom dimensions? (3) Is there a continuum between the quantitative neurocognitive traits and clinical disorder? (4) What proportion of the variance in the neurocognitive traits is accounted for by genetic and non-genetic factors?
Center for Integrating Ethics in Genetics Research(Cho)
The goal of this project is to serve as a center of excellence in neurogenetics research, to develop a national model for bench, to bedside research ethics consultation, and to provide training opportunity in biomedical ethics.
Gene, Brain and Behavior in Turner Syndrome(Reiss)
The primary objective of this project is to use advanced, multi-modal magnetic resonance imaging (MRI) techniques, analyses of X chromosome parent-of-origin and cognitive-behavioral assessment to elucidate the effects of monosomy and X-linked imprinting on neurodevelopment and neural function in a large cohort of young girls with Turner syndrome, pre-estrogen replacement.
Project F: Genomic Analysis in narcolepsy cataplexy
The goal of the project is to locate genes outside the HLA region that influence susceptibility to narcolepsy. In order to localize these genes we will carry out a linkage and association study in the most extensive world-wide collection of DNAs from well-characterized patients with narcolepsy and their families.
Casey H. Halpern, MD
Assistant Professor of Neurosurgery and, by courtesy, of Neurology and of Psychiatry and Behavioral Sciences at the Stanford University Medical Center
Current Research and Scholarly InterestsWe are currently investigating the effects of deep brain stimulation in obesity using mouse models of human behavior. Many obese individuals exhibit behavioral disinhibition, a clinical feature of many neurologic and psychiatric conditions. We are dissecting the mesocorticolimbic circuit with novel techniques including optogenetics.
May Han, MD
Associate Professor of Neurology at the Stanford University Medical Center
Current Research and Scholarly InterestsMultiple sclerosis
Autoimmune CNS disorders
Assistant Professor (Research) of Neurosurgery and of Medicine (Biomedical Informatics)
Current Research and Scholarly InterestsMy current research focuses on understanding the genetic and environmental etiology of complex disease and developing and evaluating efficient screening strategies based on etiological understanding. The areas of my research interests include statistical genetics, molecular epidemiology, cancer screening, health policy modeling, and risk prediction modeling. I have developed various statistical methods to analyze high-dimensional data to identify genetic and environmental risk factors and their interactions for complex disease.
Philip C. Hanawalt
Dr. Morris Herzstein Professor in Biology, Emeritus
Current Research and Scholarly InterestsOur current research focuses in two principal areas:
1. The molecular basis for diseases in which the pathway of transcription-coupled DNA repair is defective, including Cockyne syndrome (CS) and UV-sensitive syndrome (UVSS). Patients are severely sensitive to sunlight but get no cancers. See Hanawalt & Spivak, 2008, for review.
2. Transcription arrest by guanine-rich DNA sequences and non-canonical secondary structures. Transcription collisions with replication forks.
Associate Professor of Biochemistry
Current Research and Scholarly InterestsScientific breakthroughs often come on the heels of technological advances; advances that expose hidden truths of nature, and provide tools for engineering the world around us. Examples include the telescope (heliocentrism), the Michelson interferometer (relativity) and recombinant DNA (molecular evolution). Our lab explores innovative experimental approaches to problems in molecular biochemistry, focusing on technologies with the potential for broad impact.
Antonio Hardan, M.D.
Professor of Psychiatry and Behavioral Sciences at the Stanford University Medical Center
Current Research and Scholarly InterestsThe neurobiology of autism
Neuroimaging in individuals with autism
Psychopharmacological treatment of children and adults with autism and/or developmental disorders
The neurobiology and innovative interventions of several neurogenic disorders including DiGeorge Syndrome (Velocardiofacial syndrome; 22q11.2 mutations), PTEN mutations, and Phelan McDermid Syndrome (22q13 mutations).
Brian A. Hargreaves
Professor of Radiology (Radiological Sciences Laboratory) and, by courtesy, of Electrical Engineering and of Bioengineering
Current Research and Scholarly InterestsI am interested in magnetic resonance imaging (MRI) applications and augmented reality applications in medicine. These include abdominal, breast and musculoskeletal imaging, which require development of faster, quantitative, and more efficient MRI methods that provide improved diagnostic contrast compared with current methods. My work includes novel excitation schemes, efficient imaging methods and reconstruction tools and augmented reality in medicine.
Assistant Professor of Neurobiology
Current Research and Scholarly InterestsOur laboratory studies the mechanisms by which highly complex behaviors are mediated at the neuronal level, mainly focusing on the example of dynamic social interactions and the neural circuits that drive them. From dyadic interactions to group dynamics and collective decision making, the lab seeks a mechanistic understanding for the fundamental building blocks of societies, such as cooperation, empathy, fairness and reciprocity.
James and Elenor Chesebrough Professor in the School of Engineering, Emeritus
BioHarris utilizes molecular beam epitaxy (MBE) of III-V compound semiconductor materials to investigate new materials for electronic and optoelectronic devices. He utilizes heterojunctions, superlattices, quantum wells, and three-dimensional self-assembled quantum dots to create metastable engineered materials with novel or improved properties for electronic and optoelectronic devices. He has recently focused on three areas: 1) integration of photonic devices and micro optics for creation of new minimally invasive bio and medical systems for micro-array and neural imaging and 2) application of nanostructures semiconductors for the acceleration of electrons using light, a dielectric Laser Accelerator (DLA), and 3) novel materials and nano structuring for high efficiency solar cells and photo electrochemical water splitting for the generation of hydrogen.
John A. Overdeck Professor, Professor of Statistics and of Biomedical Data Sciences
Current Research and Scholarly InterestsFlexible statistical modeling for prediction and representation of data arising in biology, medicine, science or industry. Statistical and machine learning tools have gained importance over the years. Part of Hastie's work has been to bridge the gap between traditional statistical methodology and the achievements made in machine learning.
Melanie Hayden Gephart
Associate Professor of Neurosurgery and, by courtesy, of Neurology at the Stanford University Medical Center
BioI am a brain tumor neurosurgeon, treating patients with malignant and benign tumors, including glioma, brain metastases, meningioma, vestibular schwannoma, and pituitary adenomas. Our lab seeks greater understanding of the genetic and epigenetic mechanisms driving tumorigenesis and disease progression in malignant brain tumors. We currently study the capacity of cellular and cell-free nucleic acids to inform cancer biology and response to therapy. We also use single cell and cell subtype-specific transcriptomics to identify and target infiltrating glioblastoma. We use these techniques to identify mechanisms of tumor migration, and to stop tumor growth. Our laboratory is a unique and collaborative working environment, engaged in a dynamic research environment at Stanford. Our laboratory space lies at the heart of the Stanford campus between the core campus and the medical facilities, emblematic of the translational aspects of our work.
Assistant Professor (Research) of Neurology and of Medicine (BMIR)
BioDr. He received his PhD from the University of Michigan in 2016. Following a postdoctoral training in biostatistics at Columbia University, he joined Stanford University as an assistant professor of neurology and of medicine in 2018. His research is concentrated in the area of statistical genetics and integrative analysis of omics data, with the aim of developing novel statistical and computational methodologies for the identification and interpretation of complex biological pathways involved in human diseases, particularly neurological disorders. His methodology interest includes high-dimensional data analysis, correlated (longitudinal, familial) data analysis and machine learning algorithms.
Associate Professor of Materials Science and Engineering and, by courtesy, of Chemical Engineering and of Bioengineering
Current Research and Scholarly InterestsProtein engineering
Jeremy J. Heit, MD, PhD
Assistant Professor of Radiology (Neuroimaging and Neurointervention) and, by courtesy, of Neurosurgery at the Stanford University Medical Center
Current Research and Scholarly InterestsOur research seeks to advance our understanding of cerebrovascular disease and to develop new minimally invasive treatments for these diseases. We study ischemic and hemorrhagic stroke, cerebral aneurysms, delayed cerebral ischemia, cerebral arteriovenous malformations (AVMs), dural arteriovenous fistulae, and other vascular diseases of the brain. We use state-of-the-art neuroimaging techniques to non-invasively study these diseases, and we are developing future endovascular technologies to advance neurointerventional surgery.
H. Craig Heller
Lorry I. Lokey/Business Wire Professor
Current Research and Scholarly InterestsNeurobiology of sleep, circadian rhythms, regulation of body temperature, mammalian hibernation, and human exercise physiology. Currently applying background in sleep and circadian neurobiology the understanding and correcting the learning disability of Down Syndrome.
Edward C. and Amy H. Sewall Professor in the School of Medicine
Current Research and Scholarly InterestsOur research focuses on the inner ear, from its earliest manifestation as one of the cranial placodes until it has developed into a mature and functioning organ. We are interested how the sensory epithelia of the inner ear that harbor the sensory hair cells develop, how the cells mature, and how these epithelia respond to toxic insults. The overarching goal of this research is to find was to regenerate lost sensory hair cells in mammals.
Professor of Surgery (Plastic & Reconstructive Surgery)
Current Research and Scholarly InterestsDr. Helms' research interests center around regenerative medicine and craniofacial development.
Jaimie Henderson, MD
John and Jene Blume - Robert and Ruth Halperin Professor, Professor of Neurosurgery and, by courtesy, of Neurology at the Stanford University Medical Center
Current Research and Scholarly InterestsMy research interests encompass several areas of stereotactic and functional neurosurgery, including frameless stereotactic approaches for therapy delivery to deep brain nuclei; cortical physiology and its relationship to normal and pathological movement; brain-computer interfaces; and the development of novel neuromodulatory techniques for the treatment of movement disorders, epilepsy, pain, and other neurological diseases.
Professor of Surgery, Emeritus
Current Research and Scholarly Interests1. Nerve regeneration and repair, evaluation of repair methods, modalities to enhance peripheral nerve regeneration, development of improved methods to analyze nerve regeneration.
2. Implementation of functional neuromuscular stimulation to paralytic deformities.
3. Computer modeling of upper limb function.
Associate Professor (Research) of Medicine (Biomedical Informatics), of Biomedical Data Science and of Surgery
Current Research and Scholarly InterestsMy background and expertise is in the field of computational biology, with concentration in health services research. A key focus of my research is to apply novel methods and tools to large clinical datasets for hypothesis generation, comparative effectiveness research, and the evaluation of quality healthcare delivery. My research involves managing and manipulating big data, which range from administrative claims data to electronic health records, and applying novel biostatistical techniques to innovatively assess clinical and policy related research questions at the population level. This research enables us to create formal, statistically rigid, evaluations of healthcare data using unique combinations of large datasets.
Professor of Biochemistry and, by courtesy, of Chemical Engineering and of Chemistry
Current Research and Scholarly InterestsOur research is aimed at understanding the chemical and physical behavior underlying biological macromolecules and systems, as these behaviors define the capabilities and limitations of biology. Toward this end we study folding and catalysis by RNA, as well as catalysis by protein enzymes.
Professor of Electrical Engineering and, by courtesy, of Applied Physics
BioHesselink's research encompasses nano-photonics, ultra high density optical data storage, nonlinear optics, optical super-resolution, materials science, three-dimensional image processing and graphics, and Internet technologies.
Shaul Hestrin, PhD
Professor of Comparative Medicine
Current Research and Scholarly InterestsThe main interest of my lab is to understand how the properties of neocortical neurons, the circuits they form and the inputs they receive give rise to neuronal activity and behavior. Our approach includes behavioral studies, two-photon calcium imaging, in vivo whole cell recording in behaving animals and optogenetic methods to activate or to silence the activity of cortical neurons.
Assistant Professor of Cardiothoracic Surgery (Adult Cardiac Surgery) at the Stanford University Medical Center
BioDr. William Hiesinger is an assistant professor in the Department of Cardiothoracic Surgery at Stanford University. There, he serves as the Surgical Director of the Mechanical Circulatory Support (MCS) Program, where he leads and directs the surgical implantation of ventricular assist devices (VADs) in patients with end-stage heart failure. In addition, he runs a basic science laboratory investigating bioengineered devices and the application of angiogenic cytokine therapy and tissue engineering for the treatment of ischemic heart failure. Originally from Philadelphia, PA, Dr. Hiesinger was an undergraduate at Dartmouth College, where he received his B.A. in Psychological and Brain Sciences. He went on to receive his medical degree from the University of Pennsylvania School of Medicine and remained on at the Hospital of the University of Pennsylvania for both his general surgery and cardiothoracic surgery trainings. He has received research fundings from the National Institutes of Health (NIH) and the Thoracic Surgery Foundation (TSF).
Professor of Pathology at the Stanford University Medical Center
Current Research and Scholarly InterestsI work as a diagnostic surgical pathologist doing translational research in renal neoplasia and medical renal disease and neoplastic and medical liver disease. Subspecialty areas of clinical interest include diagnostic immunohistochemistry, renal, hepatic and transplant pathology.
Professor of Civil and Environmental Engineering
BioLynn Hildemann's current research areas include the sources and dispersion of indoor aerosols, the physicochemical properties of organic aerosols, and assessment of human exposure to PM.
Prof. Hildemann received BS, MS, and PhD degrees in environmental engineering science from the California Institute of Technology. She is an author on >90 peer-reviewed publications, including two with over 1000 citations each, and another 6 with over 500 citations each. She has been honored with Young Investigator Awards from NSF and ONR, the Kenneth T. Whitby Award from the AAAR (1998), and Stanford's Gores Award for Teaching Excellence (2013); she also was a co-recipient of Atmospheric Environment’s Haagen-Smit Outstanding Paper Award (2001).
She has served on advisory committees for the Bay Area Air Quality Management District and for the California Air Resources Board. She has been an Associate Editor for Environmental Science & Technology, and Aerosol Science and Technology, and has served on the advisory board for the journal Environmental Science & Technology.
At Stanford, Prof. Hildemann is currently chair of the Department of Civil & Environmental Engineering. She has served as an elected member of the Faculty Senate, and chaired the School of Engineering Library Committee, the University Committee on Judicial Affairs, and the University Breadth Governance Board..
David Mulvane Ehrsam and Edward Curtis Franklin Professor of Chemistry and Professor of Photon Science at SLAC
BioCombining inorganic, biophysical and structural chemistry, Professor Keith Hodgson investigates how structure at molecular and macromolecular levels relates to function. Studies in the Hodgson lab have pioneered the use of synchrotron x-radiation to probe the electronic and structural environment of biomolecules. Recent efforts focus on the applications of x-ray diffraction, scattering and absorption spectroscopy to examine metalloproteins that are important in Earth’s biosphere, such as those that convert nitrogen to ammonia or methane to methanol.
Keith O. Hodgson was born in Virginia in 1947. He studied chemistry at the University of Virginia (B.S. 1969) and University of California, Berkeley (Ph.D. 1972), with a postdoctoral year at the ETH in Zurich. He joined the Stanford Chemistry Department faculty in 1973, starting up a program of fundamental research into the use of x-rays to study chemical and biological structure that made use of the unique capabilities of the Stanford Synchrotron Radiation Lightsource (SSRL). His lab carried out pioneering x-ray absorption and x-ray crystallographic studies of proteins, laying the foundation for a new field now in broad use worldwide. In the early eighties, he began development of one of the world's first synchrotron-based structural molecular biology research and user programs, centered at SSRL. He served as SSRL Director from 1998 to 2005, and SLAC National Accelerator Laboratory (SLAC) Deputy Director (2005-2007) and Associate Laboratory Director for Photon Science (2007-2011).
Today the Hodgson research group investigates how molecular structure at different organizational levels relates to biological and chemical function, using a variety of x-ray absorption, diffraction and scattering techniques. Typical of these molecular structural studies are investigations of metal ions as active sites of biomolecules. His research group develops and utilizes techniques such as x-ray absorption and emission spectroscopy (XAS and XES) to study the electronic and metrical details of a given metal ion in the biomolecule under a variety of natural conditions.
A major area of focus over many years, the active site of the enzyme nitrogenase is responsible for conversion of atmospheric di-nitrogen to ammonia. Using XAS studies at the S, Fe and Mo edge, the Hodgson group has worked to understand the electronic structure as a function of redox in this cluster. They have developed new methods to study long distances in the cluster within and outside the protein. Studies are ongoing to learn how this cluster functions during catalysis and interacts with substrates and inhibitors. Other components of the protein are also under active study.
Additional projects include the study of iron in dioxygen activation and oxidation within the binuclear iron-containing enzyme methane monooxygenase and in cytochrome oxidase. Lab members are also investigating the role of copper in electron transport and in dioxygen activation. Other studies include the electronic structure of iron-sulfur clusters in models and enzymes.
The research group is also focusing on using the next generation of x-ray light sources, the free electron laser. Such a light source, called the LCLS, is also located at SLAC. They are also developing new approaches using x-ray free electron laser radiation to image noncrystalline biomolecules and study chemical reactivity on ultrafast time scales.
Andrew R. Hoffman
Professor of Medicine (Endocrinology)
Current Research and Scholarly InterestsMechanism of genomic imprinting of insulin like growth factor-2 and other genes.Long range chromatin interactions Role of histone modifications and DNA methylation in gene expression.
Professor of Statistics
Current Research and Scholarly InterestsOur lab has been developing tools for the analyses of complex data structures, extending work on multivariate data to structured multitable table that include graphs, networks and trees as well as categorical and continuous measurements.
We created and support the Bioconductor package phyloseq for the analyses of microbial ecology data from the microbiome. We have specialized in developing interactive graphical visualization tools for doing reproducible research in biology.
Professor of Medicine (Infectious Diseases) at the Palo Alto Veterans Affairs Health Care System
Current Research and Scholarly InterestsMy research program is currently focused in three areas: 1) Translational research (HCV/HIV viral evolution and antiviral resistance prevalence and development), 2) Clinical trials (diagnostic assay/medical device, antimicrobials and immunomodulators), and 3) Health services research focusing on cost effectiveness of antiviral utilization and clincal outcomes.
Assistant Professor of Materials Science and Engineering
BioGuosong Hong's research aims to bridge materials science and neuroscience, and blur the distinction between the living and non-living worlds by developing novel neuroengineering tools to interrogate and manipulate the brain in a minimally invasive way.
Guosong received his Ph.D. degree in chemistry from Stanford University in 2014 under the advice of Prof. Hongjie Dai. His Ph.D. research focused on the development of a new fluorescence imaging method in the second near-infrared window (NIR-II window, 1,000-1,700 nm) to afford deep-tissue penetration in the brain and other biological tissues. During his postdoctoral training at Harvard University with Prof. Charles Lieber, Guosong developed tissue-like mesh electronics neural probes to interrogate the brain and the retina with chronic stability, and is a recipient of the American Heart Association (AHA) Postdoctoral Fellowship and the NIH Pathway to Independence Award (K99/R00). Guosong joined the Stanford faculty in September 2018, and is an assistant professor of Materials Science and Engineering, and the Wu Tsai Neurosciences Institute.
Yahoo! Founders Professor in the School of Engineering and Professor of Computer Science
BioProfessor Horowitz's initially focused on designing high-performance digital systems by combining work in computer-aided design tools, circuit design, and system architecture. During this time, he built a number of early RISC microprocessors, and contributed to the design of early distributed shared memory multiprocessors. In 1990, Dr. Horowitz took leave from Stanford to help start Rambus Inc., a company designing high-bandwidth memory interface technology. After returning in 1991, he research group pioneered many innovations in high-speed link design, and many of today’s high speed link designs are designed by his former students or colleagues from Rambus.
In the 2000s he started a long collaboration with Prof Levoy on computation photography, that included work that led to the Lytro camera. Dr. Horowitz's current research interests are quite broad and span using EE and CS analysis methods to problems in neuro and molecular biology to creating new agile design methodologies for analog and digital VLSI circuits. He remains interested in learning new things, and building interdisciplinary teams.
SM Hadi Hosseini
Assistant Professor (Research) of Psychiatry and Behavioral Sciences (Interdisciplinary Brain Science Research)
Current Research and Scholarly InterestsOur lab’s research portfolio crosses multiple disciplines including computational neuropsychiatry, cognitive neuroscience, multimodal neuroimaging and neurocognitive rehabilitation. Our computational neuropsychiatry research mainly involves investigating alterations in the organization of connectome in various neurodevelopmental and neurocognitive disorders using state of the art neuroimaging techniques (fMRI, sMRI, DWI, functional NIRS) combined with novel computational methods (graph theoretical and multivariate pattern analyses).
The ultimate goal of our research is to translate the findings from computational neuropsychiatry research toward developing personalized interventions. We have been developing personalized interventions that integrate computerized cognitive rehabilitation, real-time functional brain imaging and neurofeedback, as well as virtual reality (VR) tailored toward targeted rehabilitation of the affected brain networks in patients with neurocognitive disorders.
David Hovsepian, MD
Clinical Professor, Radiology
Current Research and Scholarly InterestsI am interested in the diagnosis and treatment of vascular malformations in both children and adults; all aspects of gynecological intervention, especially uterine fibroid embolization; and in the developing sciences of quality, safety, and radiology informatics.
William E. Ayer Professor in Electrical Engineering
BioDesign and fabrication of sensors and actuators using micro and nanotechnologies, with applications to information processing and energy conversion.
Assistant Professor of Pathology at the Stanford University Medical Center
BioDr. Howitt is a gynecologic and sarcoma pathologist, with academic interests in gynecologic mesenchymal tumors and morphologic and clinical correlates of molecular alterations in gynecologic neoplasia.
Michael Richard Howitt
Assistant Professor of Pathology
Current Research and Scholarly InterestsOur lab is broadly interested in how intestinal microbes shape our immune system to promote both health and disease. Recently we discovered that a type of intestinal epithelial cell, called tuft cells, act as sentinels stationed along the lining of the gut. Tuft cells respond to microbes, including parasites, to initiate type 2 immunity, remodel the epithelium, and alter gut physiology. Surprisingly, these changes to the intestine rely on the same chemosensory pathway found in oral taste cells. Currently, we aim to 1) elucidate the role of specific tuft cell receptors in microbial detection. 2) To understand how protozoa and bacteria within the microbiota impact host immunity. 3) Discover how tuft cells modulate surrounding cells and tissue.
Associate Professor of Radiation Oncology (Radiation Physics) at the Stanford University Medical Center
Current Research and Scholarly InterestsDevelopment and integration of X-ray, MRI and US imaging technologies for radiation therapy guidance; Design of synergistic approaches to radiation therapy delivery; Treatment planning optimization and modeling.
Professor of Obstetrics and Gynecology (Reproductive and Stem Cell Biology)
Current Research and Scholarly InterestsHormonal regulation of ovarian function; gonadotropin receptors and related genes, bioinformatic ananlyses of polypeptide hormones and receptors, follicle recruitment and GDF-9; analysis of oocyte and ovarian-expressed genes.
Yang Hu, MD, PhD
Assistant Professor of Ophthalmology
Current Research and Scholarly InterestsThe ultimate goal of the laboratory is to develop efficient therapeutic strategies to achieve CNS neural repair, through promoting neuroprotection, axon regeneration and functional recovery.
More specifically, we study retinal ganglion cell (RGC) and optic nerve in various optic neuropathies including traumatic, glaucomatous and inflammatory optic nerve injuries to fully understand the molecular mechanisms of CNS neurodegeneration and axon regeneration failure.
Professor of Bioengineering and of Microbiology and Immunology
Current Research and Scholarly InterestsHow do cells determine their shape and grow?
How do molecules inside cells get to the right place at the right time?
Our group tries to answer these questions using a systems biology approach, in which we integrate interacting networks of protein and lipids with the physical forces determined by the spatial geometry of the cell. We use theoretical and computational techniques to make predictions that we can verify experimentally using synthetic, chemical, or genetic perturbations.
Ngan F. Huang
Assistant Professor of Cardiothoracic Surgery (Cardiothoracic Surgery Research)
Current Research and Scholarly InterestsDr. Huang's laboratory aims to understand the chemical and mechanical interactions between extracellular matrix (ECM) proteins and pluripotent stem cells that regulate vascular and myogenic differentiation. The fundamental insights of cell-matrix interactions are applied towards stem cell-based therapies with respect to improving cell survival and regenerative capacity, as well as engineered vascularized tissues for therapeutic transplantation.
Assistant Professor of Bioengineering
Current Research and Scholarly InterestsProtein design: molecular engineering, method development and novel therapeutics
Andrew D. Huberman
Associate Professor of Neurobiology and of Ophthalmology
Current Research and Scholarly Interests1) We study the mechanisms of neural degeneration and regeneration with the specific goal of developing treatments to prevent and reverse vision loss. (e.g., Laha and Huberman, Science, 2017; Lim et al., Nature Neuroscience, 2016).
2) We study the neural circuits that merge visual perceptions with internal states, to drive adaptive behavioral decisions. We are parsing the neural circuits related to anxiety, and visually-driven autonomic arousal (e.g., Salay et al., Nature, 2018).