Bio-X
Showing 701-750 of 1,063 Results
-
Teresa Nicolson, PhD
Edward C. and Amy H. Sewall Professor
Current Research and Scholarly InterestsOur aim is to understand the molecular basis of hearing and balance. We use zebrafish as our model system, which offers distinct advantages for imaging auditory/vestibular and lateral line hair cells in intact animals. Our experiments focus on the function of deafness genes isolated from forward genetic screens and developmental aspects of sensory hair-cell activity and synaptogenesis.
-
Dwight Nishimura
Addie and Al Macovski Professor, Emeritus
Current Research and Scholarly Interestsmedical imaging, magnetic resonance imaging
-
Julia E. Noel, MD
Clinical Assistant Professor (Affiliated), OHNS/Head & Neck Surgery Divisions
Staff, OHNS/Otolaryngology/Head & Neck SurgeryBioDr. Noel is a head and neck surgeon with fellowship training in endocrine surgery and board certification in otolaryngology. She is an assistant professor in the Department of Otolaryngology — Head & Neck Surgery at Stanford University School of Medicine.
She specializes in surgery of the thyroid and parathyroid glands and lymph nodes. She has additional expertise and training in minimally invasive treatment approaches and ultrasound-guided techniques performed in the office, such as Radiofrequency Ablation (RFA) and alcohol ablation.
Among the many conditions she treats are thyroid cancer, thyroid nodules, hyperthyroidism, hyperparathyroidism, hypercalcemia, Grave’s disease, and goiter.
For every patient, Dr. Noel prepares a personalized care plan that is comprehensive and compassionate. Her goal is to educate and empower each patient to achieve the best possible health and quality of life. Patient reviews praise her clinical expertise as well as her skills as a listener and communicator.
Dr. Noel conducts a robust research program to advance patient care. She has published extensively on the diagnosis, appropriate management, and optimization of outcomes for patients with thyroid and parathyroid disorders. Her articles have appeared in JAMA Otolaryngology Head and Neck Surgery, Nature Communications, Endocrine Practice, and many more peer-reviewed journals. She has co-authored numerous guideline and consensus statements, including an international statement on the use of RFA in benign and malignant thyroid nodules.
She serves as associate editor of the endocrine section for the journal Laryngoscope Investigative Otolaryngology. She is additionally an editorial board member for VideoEndocrinology, a video journal covering leading-edge diagnostic and treatment techniques and technologies.
Dr. Noel has made presentations to her peers at national and international meetings of the American Academy of Otolaryngology, Head & Neck Surgery, American Thyroid Association, American Head & Neck Society, and the World Congress of Thyroid Cancer. She also has shared her insights into the future of thyroid surgery at the International Thyroid Cancer Survivors’ Conference.
She is a member of the American Academy of Otolaryngology and Head and Neck Surgery, American Head and Neck Society, American Thyroid Association, American Association of Clinical Endocrinologists, and American College of Surgeons. -
Hae Young Noh
Associate Professor of Civil and Environmental Engineering
On Partial Leave from 01/01/2024 To 06/30/2024BioHae Young Noh is an associate professor in the Department of Civil and Environmental Engineering. Her research introduced the new concept of “structures as sensors” to enable physical structures (e.g., buildings and vehicle frames) to be user- and environment-aware. In particular, these structures indirectly sense humans and surrounding environments through their structural responses (i.e., vibrations) by inferring the desired information (e.g., human behaviors, environmental conditions, heating and cooling system performance), instead of directly measuring the sensing targets with additional dedicated sensors (e.g., cameras, motion sensors). This concept brought a paradigm shift in how we view these structures and how the structures interact with us.
Traditionally, structures that we inhabit (such as buildings or vehicles) are considered as passive and unchanging objects that we need to monitor and control, utilizing a dense set of sensors to collect information. This has often been complicated by “noise” caused by the occupants and environments. For example, building vibrations induced by indoor and outdoor environmental and operational conditions (e.g., people walking around, traffic outside, heating system running, etc.), have been often seen as noise that needs to be removed in traditional building science and structural engineering; however, they are a rich source of information about structure, users, environment, and resources. Similarly, in vehicle engineering, researchers and engineers have been investigating control and dynamics to reduce vehicle vibration for safety and comfort. However, vibrations measured inside vehicles contain information about transportation infrastructure, vehicle itself, and driver.
Noh's work utilizes this “noise” to empower the structures with the ability to perceive and understand the information about users and surroundings using their own responses, and actively adopt and/or interact to enhance their sustainability and the occupants’ quality of life. Since she utilizes the structure itself as a sensing medium, information collection involves a simpler set of hardware that can be easily maintained throughout the structural lifetime. However, the analysis of data to separate the desired information becomes more challenging. This challenge is addressed through high-rate dynamic sensing and multi-source inferencing. Ultimately, her work aims to allow structural systems to become general sensing platforms that are easier and more practical to deploy and maintain in a long-term.
At Stanford University, Noh received her PhD and MS degrees in the CEE department and her second MS degree in Electrical Engineering. Noh earned her BS in Mechanical and Aerospace Engineering at Cornell University. -
Garry Nolan
Rachford and Carlota Harris Professor
Current Research and Scholarly InterestsDr. Nolan's group uses high throughput single cell analysis technology cellular biochemistry to study autoimmunity, cancer, virology (influenza & Ebola), as well as understanding normal immune system function. Using advanced flow cytometric techniques such as Mass Cytometry, MIBI (ion beam imaging), CODEX and computational biology approaches, we focus on understanding disease processes at the single cell level. We have a strong interest in cancer immunotherapy and pathogen-host interactions.
-
Anthony Norcia
Professor (Research) of Psychology
Current Research and Scholarly InterestsVision, development, functional imaging, systems analysis
-
Roeland Nusse
Virginia and Daniel K. Ludwig Professor of Cancer Research
Current Research and Scholarly InterestsOur laboratory studies Wnt signaling in development and disease. We found recently that Wnt proteins are unusual growth factors, because they are lipid-modified. We discovered that Wnt proteins promote the proliferation of stem cells of various origins. Current work is directed at understanding the function of the lipid on the Wnt, using Wnt proteins as factors the expand stem cells and on understanding Wnt signaling during repair and regeneration after tissue injury.
-
Paul Nuyujukian
Assistant Professor of Bioengineering and of Neurosurgery and, by courtesy, of Electrical Engineering
Current Research and Scholarly InterestsOur group explores neuroengineering and its application to both basic and clinical neuroscience. Our goal is to develop brain-machine interfaces as a platform technology for a variety of brain-related medical conditions including stroke and epilepsy.
-
Dáibhid Ó Maoiléidigh, PhD
Assistant Professor of Otolaryngology - Head & Neck Surgery (OHNS)
Current Research and Scholarly InterestsThe Ó Maoiléidigh group employs mathematical and computational approaches to better understand normal hearing and hearing impairment. Because complete restoration of auditory function by artificial devices or regenerative treatments will only be possible when experiments and computational modeling align, we work closely with experimental laboratories. Our goal is to understand contemporary experimental observations, to make experimentally testable predictions, and to motivate new experiments. We are pursuing several projects.
Hair-Bundle Mechanics
Auditory and balance organs rely on hair cells to convert mechanical vibrations into electrical signals for transmission to the brain. In response to the quietest sounds we can hear, the hair cell's mechanical sensor, the hair bundle, moves by less than one-billionth of a meter. To determine how this astounding sensitivity is possible, we construct computational models of hair-bundle mechanics. By comparing models with experimental observations, we are learning how a hair bundle's geometry, material properties, and ability to move spontaneously determine its function.
Cochlear Mechanics
The cochlea contains the auditory organ that houses the sensory hair cells in mammals. Vibrations in the cochlea arising from sound are amplified more than a thousandfold by the ear's active process. New experimental techniques have additionally revealed that the cochlea vibrates in a complex manner in response to sound. We use computational models to interpret these observations and to make hypotheses about how the cochlea works. -
Lucy Erin O'Brien
Associate Professor of Molecular and Cellular Physiology
Current Research and Scholarly InterestsMany adult organs tune their functional capacity to variable levels of physiologic demand. Adaptive organ resizing breaks the allometry of the body plan that was established during development, suggesting that it occurs through different mechanisms. Emerging evidence points to stem cells as key players in these mechanisms. We use the Drosophila midgut, a stem-cell based organ analogous to the vertebrate small intestine, as a simple model to uncover the rules that govern adaptive remodeling.
-
Lauren O'Connell
Assistant Professor of Biology
Current Research and Scholarly InterestsThe O'Connell lab studies how genetic and environmental factors contribute to biological diversity and adaptation. We are particularly interested in understanding (1) how behavior evolves through changes in brain function and (2) how animal physiology evolves through repurposing existing cellular components.
-
Jelena Obradović
Professor of Education
Current Research and Scholarly InterestsAdaptation, resilience, and developmental psychopathology of disadvantaged children populations; Stress reactivity and biological sensitivity to contextual influences; Executive function and self-regulatory abilities; Effects of risk, adversity, and social status on children’s development.
-
Allison Okamura
Richard W. Weiland Professor in the School of Engineering and Professor, by courtesy, of Computer Science
Current Research and Scholarly InterestsMy research focuses on developing the principles and tools needed to realize advanced robotic and human-machine systems capable of physical interaction. Application areas include surgery, simulation and training, rehabilitation, prosthetics, neuromechanics, exploration of hazardous and remote environments (e.g. space), design, and education.
-
Eric Olcott
Professor of Radiology (Veterans Affairs), Emeritus
Current Research and Scholarly InterestsBody imaging utilizing CT, ultrasound and MRI. Imaging of appendicitis. Imaging of pancreatic and biliary malignancies. Imaging of trauma. Magnetic resonance angiography.
-
Antonio Omuro
Joseph D. Grant Professor
BioDr. Antonio M. Omuro, MD, FAAN, is the Chair of the Department of Neurology and Neurological Sciences at Stanford University School of Medicine.
Dr. Omuro is an internationally renowned neurologist and neuro-oncologist. Before assuming his role at Stanford, he held notable leadership positions at prestigious institutions including Yale University and Memorial Sloan Kettering Cancer Center. His research endeavors are concentrated on clinical and translational studies, where he collaborates closely with basic scientists to pioneer innovative therapies for challenging neuro-oncologic diseases such as gliomas and primary CNS lymphomas. He is also a highly esteemed educator and practicing clinician, delivering state-of-the-art and compassionate care to patients with brain tumors and neurological complications of cancers. -
Lisa A. Orloff, MD, FACS, FACE
Professor of Otolaryngology - Head & Neck Surgery (OHNS)
BioLisa A. Orloff, MD, FACS, FACE, is Director of the Endocrine Head & Neck Surgery Program and Professor in the Department of Otolaryngology — Head & Neck Surgery, Division of Head & Neck Surgery, at Stanford University School of Medicine. She is Director of the Stanford Thyroid Tumor Program within the Stanford Cancer Center. Her clinical practice focuses on the surgical management of thyroid and parathyroid tumors and disorders.
Dr. Orloff is an internationally recognized leader in the field of endocrine head and neck surgery. She is also an expert in the application of ultrasonography to the diagnosis and management of diseases of the head and neck, with an emphasis on thyroid cancer. Dr. Orloff performs minimally invasive ultrasound-guided procedures such as radiofrequency ablation for the nonsurgical management of appropriate thyroid pathology. Her background in microvascular and laryngeal surgical techniques lends a unique level of refinement to her endocrine surgical practice. A major component of her clinical work is the management of persistent or recurrent thyroid cancer. Dr. Orloff’s multidisciplinary approach to the management of endocrine head and neck disease involves collaboration with her colleagues in other specialties at Stanford and throughout the country. Dr. Orloff also studies the regeneration of tissue that has been lost as a result of cancer therapies.
Dr. Orloff received her bachelor’s degree at Stanford, and her medical degree from the University of California, Los Angeles. She completed her residency in Otolaryngology — Head & Neck Surgery at the University of Washington and a visiting fellowship in Microvascular & Reconstructive Surgery at Mount Sinai Medical Center in New York. Prior to joining the faculty at Stanford, she was the Robert K. Werbe Distinguished Professor in Head & Neck Cancer, and Chief of the Division of Head & Neck Surgery at the University of California, San Francisco (UCSF.)
Dr. Orloff served three consecutive terms as the Chair of the American Academy of Otolaryngology — Head & Neck Surgery (AAO-HNS) Endocrine Surgery committee, and served for many years as a voting member of the FDA’s Panel to evaluate medical devices for Otolaryngology. She holds leadership roles within the American Head and Neck Society, the American Thyroid Association, the American Institute of Ultrasound in Medicine, and the American College of Surgeons. She is co-chair of the ACS Thyroid, Parathyroid, and Neck Ultrasound training program and a member of the ACS National Ultrasound Faculty executive board. She is also a member of such influential teams as the National Cancer Institute (NCI) steering committee on Thyroid Cancer Clinical Trials and the Endocrine Surgery Committee of the American Association of Clinical Endocrinology (AACE). She authored the leading textbook, Head and Neck Ultrasonography (Plural Publishing), as a reference for clinicians; the second edition was published in 2017. Dr. Orloff is a former Fulbright scholar. -
Anthony Oro, MD, PhD
Eugene and Gloria Bauer Professor
Current Research and Scholarly InterestsOur lab uses the skin to answer questions about epithelial stem cell biology, differentiation and carcinogenesis using genomics, genetics, and cell biological techniques. We have studied how hedgehog signaling regulates regeneration and skin cancer, and how tumors evolve to develop resistance. We study the mechanisms of early human skin development using human embryonic stem cells. These fundamentals studies provide a greater understanding of epithelial biology and novel disease therapeutics.
-
Nicholas Ouellette
Professor of Civil and Environmental Engineering
Current Research and Scholarly InterestsThe Environmental Complexity Lab studies self-organization in a variety of complex systems, ranging from turbulent fluid flows to granular materials to collective motion in animal groups. In all cases, we aim to characterize the macroscopic behavior, understand its origin in the microscopic dynamics, and ultimately harness it for engineering applications. Most of our projects are experimental, though we also use numerical simulation and mathematical modeling when appropriate. We specialize in high-speed, detailed imaging and statistical analysis.
Our current research includes studies of turbulence in two and three dimensions, with a focus on coherent structures and the geometry of turbulence; the transport of inertial, anisotropic, and active particles in turbulence; the erosion of granular beds by fluid flows and subsequent sediment transport; quantitative measurements of collective behavior in insect swarms and bird flocks; the stability of ocean ecosystems; neural signal processing; and uncovering the natural, self-organized spatiotemporal scales in urban systems. -
Art Owen
Max H. Stein Professor
Current Research and Scholarly InterestsStatistical methods to analyze large data matrices in bioinformatics
-
Doug Owens
Henry J. Kaiser, Jr. Professor, Senior Fellow at the Freeman Spogli Institute for International Studies and Professor, by courtesy, of Management Science and Engineering
Current Research and Scholarly InterestsMy research uses decision modeling, cost-effectiveness analysis, and meta-analysis to evaluate clinical and health policy problems. Much of my work involves development of national guidelines for prevention and treatment.
-
Julia Palacios
Associate Professor of Statistics and of Biomedical Data Science
BioDr. Palacios seek to provide statistically rigorous answers to concrete, data driven questions in evolutionary genetics and public health . My research involves probabilistic modeling of evolutionary forces and the development of computationally tractable methods that are applicable to big data problems. Past and current research relies heavily on the theory of stochastic processes, Bayesian nonparametrics and recent developments in machine learning and statistical theory for big data.
-
Daniel Palanker, PhD
Professor of Ophthalmology and, by courtesy, of Electrical Engineering
Current Research and Scholarly InterestsInteractions of electric field and light with biological cells and tissues and their applications to imaging, diagnostics, therapeutics and prosthetics, primarily in ophthalmology.
Specific fields of interest:
Electronic retinal prosthesis;
Electronic enhancement of tear secretion;
Electronic control of blood vessels;
Non-damaging retinal laser therapy;
Ultrafast laser surgery;
Interferometric imaging of neural signals;
Cell transplantation and retinal plasticity. -
Theo Palmer
Professor of Neurosurgery, Emeritus
Current Research and Scholarly InterestsMembers of the Palmer Lab study the biology of neural stem cells in brain development and in the adult. Our primary goal is to understand how genes and environment synergize in influencing stem cell behavior during development and how mild genetic or environmental risk factors for disease may synergize in their detrimental effects on brain development or in the risk of neuronal loss in age-related degenerative disease.
-
Stephen Palumbi
Jane and Marshall Steel Jr. Professor of Marine Sciences, Professor of Oceans and of Biology
Current Research and Scholarly InterestsWe're interested in ecological, evolutionary, and conservation questions related to marine (and sometimes terrestrial) organisms and ecosystems. We use evolutionary genetics and molecular ecology techniques, and our fieldwork takes us all around the world. Currently, we're studying coral diversity, the adaptive potential of corals in response to climate change, the movement of organisms between marine reserves, genetic changes in abalone in response to environmental.
-
Alan C. Pao
Associate Professor of Medicine (Nephrology) and, by courtesy, of Urology
Current Research and Scholarly InterestsWe are broadly interested in how the kidneys control salt, water, and electrolyte homeostasis in the body. Our disease focus is on kidney stone disease. We use cultured kidney cells, transgenic mice, human plasma/urine samples, and electronic health record data to study the pathogenesis of kidney stone disease. Our therapeutic focus is on the development of small molecule compounds that can be used for kidney stone prevention.
-
Peter Parham
Professor of Structural Biology and, by courtesy, of Microbiology and Immunology
Current Research and Scholarly InterestsThe Parham laboratory investigates the biology, genetics, and evolution of MHC class I molecules and NK cell receptors.
-
Victoria Parikh
Assistant Professor of Medicine (Cardiovascular Medicine)
BioDr. Parikh is a clinician scientist who cares for patients with and studies inherited (genetic) cardiovascular disease. She is the director of the Stanford Center for Inherited Cardiovascular Disease (SCICD) which is one of the largest of its kind in the country. SCICD integrates clinical and basic science with the expert care of patients with genetic cardiovascular conditions (e.g., cardiomyopathies, arrhythmias and vascular diseases). It provides cutting edge care for thousands of patients and families across the lifespan and integrates medical, surgical and genetics care. Our team includes physicians, nurses, advanced practice providers, genetic counselors, exercise physiologists and scientists.
Dr. Parikh's own clinical practice and laboratory are focused on the genetics of cardiomyopathies and their associated arrhythmogenic substrates. She completed clinical cardiology fellowship at Stanford School of Medicine and her medical residency at the University of California, San Francisco. Funded by multiple research grants from the NIH, her lab seeks to identify novel mechanisms and therapeutic technologies for genetic cardiomyopathy as well as better understand the natural histories of patients affected by these diseases. -
Jon Park, MD, FRCSC
Saunders Family Professor
Current Research and Scholarly InterestsNon-fusion dynamic spinal stabilization, artificial disc technologies, and regenerative spinal technologies.
-
Karen J. Parker, PhD
Truong-Tan Broadcom Endowed Professor and Professor, by courtesy, of Comparative Medicine
Current Research and Scholarly InterestsThe Parker Lab conducts research on the biology of social functioning in monkeys, typically developing humans, and patients with social impairments.
-
Josef Parvizi, MD, PhD
Professor of Neurology (Adult Neurology) and, by courtesy, of Neurosurgery
BioDr. Parvizi completed his medical internship at Mayo Clinic, neurology training at Harvard, and subspecialty training in clinical neurophysiology and epilepsy at UCLA before joining the Department of Neurology and Neurological Sciences at Stanford in 2007. Dr. Parvizi directs the Stanford Program for Medication Resistant Epilepsies and specializes in surgical treatments of intractable focal epilepsies. Dr. Parvizi is the principal investigator in the Laboratory of Behavioral and Cognitive Neuroscience, where he leads a team of investigators to study the human brain. http://med.stanford.edu/parvizi-lab.html.
-
Anca M. Pasca, MD
Assistant Professor of Pediatrics
Current Research and Scholarly InterestsThe research focus of the lab is to understand molecular mechanisms underlying neurodevelopmental disorders associated with premature birth, neonatal and fetal brain injury with the long-term goal of translating the lab’s findings into therapeutics. The research team employs a multidisciplinary approach involving genetics, molecular and developmental neurobiology, animal models and neural cells differentiated from patient-derived induced pluripotent stem (iPS) cells. In particular, the lab is using a powerful 3D human brain-region specific organoid system developed at Stanford (Nature Methods, 2015; Nature Protocols, 2018) to ask questions about brain injury during development.
https://www.neopascalab.org/ -
Sergiu P. Pasca
Kenneth T. Norris, Jr. Professor of Psychiatry and Behavioral Sciences and Bonnie Uytengsu and Family Director of the Stanford Brain Organogenesis Program
Current Research and Scholarly InterestsA critical challenge in understanding the intricate programs underlying development, assembly and dysfunction of the human brain is the lack of direct access to intact, functioning human brain tissue for detailed investigation by imaging, recording, and stimulation.
To address this, we are developing bottom-up approaches to generate and assemble, from multi-cellular components, human neural circuits in vitro and in vivo.
We introduced the use of instructive signals for deriving from human pluripotent stem cells self-organizing 3D cellular structures named brain region-specific spheroids/organoids. We demonstrated that these cultures, such as the ones resembling the cerebral cortex, can be reliably derived across many lines and experiments, contain synaptically connected neurons and non-reactive astrocytes, and can be used to gain mechanistic insights into genetic and environmental brain disorders. Moreover, when maintained as long-term cultures, they recapitulate an intrinsic program of maturation that progresses towards postnatal stages.
We also pioneered a modular system to integrate 3D brain region-specific organoids and study human neuronal migration and neural circuit formation in functional preparations that we named assembloids. We have actively applied these models in combination with studies in long-term ex vivo brain preparations to acquire a deeper understanding of human physiology, evolution and disease mechanisms.
We have carved a unique research program that combines rigorous in vivo and in vitro neuroscience, stem cell and molecular biology approaches to construct and deconstruct previously inaccessible stages of human brain development and function in health and disease.
We believe science is a community effort, and accordingly, we have been advancing the field by broadly and openly sharing our technologies with numerous laboratories around the world and organizing the primary research conference and the training courses in the area of cellular models of the human brain. -
Zara Patel, MD
Professor of Otolaryngology - Head & Neck Surgery (OHNS)
BioDr. Zara M. Patel is Director of Endoscopic Skull Base Surgery and a Professor of Otolaryngology and, by courtesy, of Neurosurgery at Stanford. She was born and raised in St. Louis, completed her MD at the Oregon Health and Sciences University in Portland, Oregon and completed her residency training in otolaryngology at Mount Sinai Medical Center in New York, NY. After pursuing fellowship training in rhinology and endoscopic skull base surgery at Stanford University, she was recruited to join the Emory University faculty in Atlanta in 2011. After four years, the rhinology division recruited her back to the West coast to rejoin the department here at Stanford University in 2015.
Dr. Patel is an expert in advanced endoscopic sinus and skull base surgery. She treats patients with a wide variety of rhinologic complaints, including chronic sinus infection or inflammation, sinus disease that has failed medical therapy, sinus disease that has failed prior surgical therapy, cerebrospinal fluid leaks, benign and and malignant sinus and skull base tumors, as well as olfactory disorders.
She has served as Chair of the Education Committee and Member of the Board of Directors for the American Rhinologic Society, is current Chair of the Rhinology and Allergy Education Committee for the American Academy of Otolaryngology - Head and Neck Surgery, and has developed a multitude of educational materials for both physicians and patients to help them better understand rhinologic disorders. She is passionate about educating patients to allow them to make the best decisions about their own care, leading to better outcomes.
Dr. Patel has published widely in topics such as avoiding complications in endoscopic sinus surgery, chronic rhinosinusitis in the immunosuppressed patient population, new devices and techniques for endoscopic skull base surgery, and olfactory dysfunction. She continues to perform research in these areas, and is currently collaborating with neuroscientists and engineers to develop technology that she hopes will eventually help cure patients with smell loss, and potentially even help those with neurodegenerative disorders, such as Alzheimer's and Parkinson's disease. -
John M. Pauly
Reid Weaver Dennis Professor
BioInterests include medical imaging generally, and magnetic resonance imaging (MRI) in particular. Current efforts are focused on medical applications of MRI where real-time interactive imaging is important. Two examples are cardiac imaging, and the interactive guidance of interventional procedures. Specific interests include rapid methods for the excitation and acquisition of the MR signal, and the reconstruction of images from the data acquired using these approaches.
-
Kim Butts Pauly
Professor of Radiology (Radiological Sciences Lab) and, by courtesy, of Electrical Engineering and of Bioengineering
Current Research and Scholarly InterestsWe are investigating and developing, and applying focused ultrasound in neuromodulation, blood brain barrier opening, and ablation for both neuro and body applications.
-
Jonathan Payne
Dorrell William Kirby Professor, Senior Associate Dean for Faculty Affairs, Senior Fellow at the Woods Institute for the Environment and Professor, by courtesy, of Biology,
Current Research and Scholarly InterestsMy goal in research is to understand the interaction between environmental change and biological evolution using fossils and the sedimentary rock record. How does environmental change influence evolutionary and ecological processes? And conversely, how do evolutionary and ecological changes affect the physical environment? I work primarily on the marine fossil record over the past 550 million years.
-
Kabir Peay
Director of the Earth Systems Program, Associate Professor of Biology, of Earth System Science and Senior Fellow at the Woods Institute for the Environment
Current Research and Scholarly InterestsOur lab studies the ecological processes that structure natural communities and the links between community structure and the cycling of nutrients and energy through ecosystems. We focus primarily on fungi, as these organisms are incredibly diverse and are the primary agents of carbon and nutrient cycling in terrestrial ecosystems. By working across multiple scales we hope to build a 'roots-to-biomes' understanding of plant-microbe symbiosis.
-
Donna Peehl, PhD
Professor (Research) of Urology, Emerita
Current Research and Scholarly InterestsMy research focuses on the molecular and cellular biology of the human prostate. Developing realistic experimental models is a major goal, and primary cultures of prostatic epithelial and stromal cells are my main model system. Our discoveries are relevant to prevention, detection, diagnosis and treatment of benign and malignant prostatic diseases.
-
Mark Pegram
Susy Yuan-Huey Hung Professor
Current Research and Scholarly InterestsMolecular mechanisms of targeted therapy resistance in breast and other cancers
-
Norbert Pelc
Boston Scientific Applied Biomedical Engineering Professor and Professor of Radiology, Emeritus
Current Research and Scholarly InterestsBroadly, Dr. Pelc is interested in the physics, engineering and mathematics of medical imaging, especially computed tomography, digital x-ray imaging, magnetic resonance imaging, and hybrid multimodality systems. His current research is concentrated in the development of computed tomography systems with higher image quality and dose efficiency, in the characterization of system performance, and in the development and validation of new clinical applications.
-
Gary Peltz
Professor of Anesthesiology, Perioperative and Pain Medicine
Current Research and Scholarly InterestsThe laboratory develops and uses state of the art genomic methods to identify genetic factors affecting disease susceptibility, and to translate these findings into new treatments. We have developed a more efficient method for performing mouse genetic analysis, which has been used to analyze the genetic basis for 16 different biomedical traits. We are developing novel methods, and have developed a novel experimental platform that replaces mouse liver with functioning human liver tissue.
-
Jon-Paul Pepper, MD
Associate Professor of Otolaryngology - Head & Neck Surgery (OHNS)
Current Research and Scholarly InterestsFacial paralysis is a debilitating condition that affects thousands of people. Despite excellent surgical technique, we are currently limited by the regenerative capacity of the body. The mission of our research is to identify new treatments that improve current facial paralysis treatments. We do this by exploring the regenerative cues that the body uses to restore tissue after nerve injury, in particular through pathways of neurogenesis and nerve repair in small mammals.
-
Claudia Katharina Petritsch
Associate Professor (Research) of Neurosurgery
Current Research and Scholarly InterestsThe Petritsch lab broadly investigates underlying causes for the intra-tumoral heterogeneity and immune suppression in brain tumors from a neuro-developmental perspective. Defective cell fate decisions fuel the intra-humoral heterogeneity and plasticity in human brain tumors and may contribute to immune suppression. We use patient-derived models as avatars to study how brain cells control the fate of their progeny, whereby we unravel novel points of vulnerabilities in brain tumor cells.
-
Dmitri Petrov
Michelle and Kevin Douglas Professor in the School of Humanities and Sciences
Current Research and Scholarly InterestsEvolution of genomes and population genomics of adaptation and variation
-
Suzanne Pfeffer
Emma Pfeiffer Merner Professor of Medical Sciences
Current Research and Scholarly InterestsThe major focus of our research is to understand the molecular basis of inherited Parkinson's Disease (PD). We focus on the LRRK2 kinase that is inappropriately activated in PD and how it phosphorylates Rab GTPases, blocking the formation of primary cilia in specific regions of the brain. The absence of primary cilia renders cells unable to carry out Hedgehog signaling that is critical for neuroprotective pathways that sustain dopamine neurons.
