Showing 881-900 of 1,015 Results
Gary K. Steinberg, MD, PhD
Bernard and Ronni Lacroute-William Randolph Hearst Professor of Neurosurgery and Neurosciences and Professor, by courtesy, of Neurology
Current Research and Scholarly InterestsOur laboratory investigates the pathophysiology and treatment of cerebral ischemia, and methods to restore neurologic function after stroke. Treatment strategies include brain hypothermia, stem cell transplantation and optogenetic stimulation. Our clinical research develops innovative surgical, endovascular and radiosurgical approaches for treating difficult intracranial aneurysms, complex vascular malformations and occlusive disease, including Moyamoya disease, as well as stem cell transplant.
Lawrence Steinman, MD
George A. Zimmermann Professor and Professor of Pediatrics
Current Research and Scholarly InterestsOur laboratory is dedicated to understanding the pathogenesis of autoimmune diseases, particularly multiple sclerosis. We have developed several new therapies for autoimmunity, including some in Phase 2 clinical trials, as well as one approved drug, natalizumab. We have developed microarray technology for detecting autoantibodies to myelin proteins and lipids. We employ a diverse range of molecular and celluar approaches to trying to understand multiple sclerosis.
Dieter Schwarz Foundation Endowed Professor and Professor of Genetics
Current Research and Scholarly InterestsWe apply diverse genomic approaches to understand how genetic variation affects health and disease by: 1) functional and mechanistic analyses of gene regulation, 2) studies of meiotic recombination and inheritance, 3) analyses of genetic and environmental interactions, and 4) characterization of diseases in human cells and model organisms. We integrate wet lab and computational genomic, transcriptomic, proteomic and metabolic approaches, and develop technologies to enable personalized medicine.
David A. Stevens
Professor of Medicine, Emeritus
Current Research and Scholarly InterestsImmunology and chemotherapy of human fungal diseases, particularly coccidioidomycosis (Valley Fever) in California and aspergillosis, and the parasitic disease, trypanosomiasis.
Professor of Pediatrics (Genetics)
Current Research and Scholarly InterestsMy research focuses on disorders of the RAS/MAPK pathway (eg. NF1, Noonan, CFC, and Costello syndrome). I am working on understanding the impact of RAS signaling on the musculoskeletal system. I use genomic approaches to identify somatic events and modifiers in the RASopathies. I am also involved in identifying outcome measures for use in clinical trials for the associated orthopedic manifestations. Other areas of research involve vascular anomalies, Prader-Willi syndrome, and hypophosphatasia.
David K. Stevenson, M.D.
Harold K. Faber Professor of Pediatrics, Senior Associate Dean, Maternal and Child Health and Professor, by courtesy, of Obstetrics and Gynecology
Current Research and Scholarly InterestsOur research is focused on the study of the ontogeny and control of heme catabolism and bilirubin production in the developing neonate. A better understanding of the role of increased bilirubin production in neonatal jaundice and the prevention of hemolytic jaundice has remained an overall objective of our program. We are also study the causes of preterm birth and ways to prevent it.
Aaron F. Straight
Pfeiffer and Herold Families Professor, Professor of Biochemistry and, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly InterestsWe study the biology of chromosomes. Our research is focused on understanding how chromosomal domains are specialized for unique functions in chromosome segregation, cell division and cell differentiation. We are particularly interested in the genetic and epigenetic processes that govern vertebrate centromere function, in the organization of the genome in the eukaryotic nucleus and in the roles of RNAs in the regulation of chromosome structure.
Avram Goldstein Professor in the School of Medicine, Professor of Neurosurgery and, by courtesy, of Neurology and of Psychiatry and Behavioral Sciences
Current Research and Scholarly InterestsInformation transfer at synapses mediates information processing in brain, and is impaired in many brain diseases. Thomas Südhof is interested in how synapses are formed, how presynaptic terminals release neurotransmitters at synapses, and how synapses become dysfunctional in diseases such as autism or Alzheimer's disease. To address these questions, Südhof's laboratory employs approaches ranging from biophysical studies to the electrophysiological and behavioral analyses of mutant mice.
Associate Professor of Emergency Medicine
Current Research and Scholarly InterestsDr. Suffoletto is an emergency physician and NIH-funded investigator with a focus on collecting novel forms of longitudinal and remote data to inform temporal risk prediction and inform just-in-time adaptive interventions
Edith Vioni Sullivan
Professor of Psychiatry and Behavioral Sciences (Major Laboratories and Clinical Translational Neurosciences Incubator)On Leave from 10/02/2023 To 12/31/2023
Current Research and Scholarly InterestsApplication of neuroimaging modalities and component process analysis of cognitive, sensory, and motor functions to identify brain structural and functional mechanisms disrupted in diseases affecting the brain: alcohol use disorder, HIV infection, dementia, and normal aging from adolescence to senescence.
Yang Sun, MD, PhD
Professor of Ophthalmology
Current Research and Scholarly InterestsWe are interested in the role of inositol phosphatases in eye development and disease, using both animal models and human disease tissue. We are a translational laboratory seeking to understand the basic function of proteins as well as developing therapeutic strategies for clinical trials.
Professor of Urology, Emeritus
Current Research and Scholarly InterestsWe focus on understanding the molecular mechanism of transcription factors that govern the transformation of normal cells to a neoplastic state. We are especially interested in nuclear hormone action and its interactions with other signaling pathways in tumor development and progression.
John B. Sunwoo, MD
Edward C. and Amy H. Sewall Professor in the School of Medicine and Professor, by courtesy, of Dermatology
Current Research and Scholarly InterestsMy laboratory is focused on two primary areas of research: (1) the immune response to head and neck cancer and to a tumorigenic population of cells within these malignancies called cancer stem cells; (2) the developmental programs of a special lymphocyte population involved in innate immunity called natural killer (NK) cells; and (3) intra-tumor and inter-tumor heterogeneity.
Trisha Suppes, MD, PhD
Professor of Psychiatry and Behavioral Sciences (Public Mental Health and Population Sciences)On Leave from 10/26/2023 To 01/22/2024
Current Research and Scholarly InterestsLong-term treatment strategies for bipolar disorder, treatment for bipolar II disorder, use of treatment algorithms, and treatment of major depression.
Professor of Applied Physics and, by courtesy, of Materials Science and Engineering
Current Research and Scholarly InterestsHer interests are focused on novel ground states and functional properties in condensed matter systems synthesized via atomically precise thin film deposition techniques with a recent emphasis has been on highly correlated electronic systems:
• Emergent interfacial electronic & magnetic phenomena through complex oxide heteroepitaxy
• Low dimensional electron gas systems
• Spin current generation, propagation and control in complex oxide-based ferromagnets
• Multifunctional behavior in complex oxide thin films and heterostructures
Katrin J Svensson
Assistant Professor of Pathology
Current Research and Scholarly InterestsMolecular metabolism
Cell biology and function
James H. Clark Professor in the School of Engineering and Professor of Chemical Engineering and of Bioengineering
Current Research and Scholarly InterestsProgram Overview
The world we enjoy, including the oxygen we breathe, has been beneficially created by biological systems. Consequently, we believe that innovative biotechnologies can also serve to help correct a natural world that non-natural technologies have pushed out of balance. We must work together to provide a sustainable world system capable of equitably improving the lives of over 10 billion people.
Toward that objective, our program focuses on human health as well as planet health. To address particularly difficult challenges, we seek to synergistically combine: 1) the design and evolution of complex protein-based nanoparticles and enzymatic systems with 2) innovative, uniquely capable cell-free production technologies.
To advance human health we focus on: a) achieving the 120 year-old dream of producing “magic bullets”; smart nanoparticles that deliver therapeutics or genetic therapies only to specific cells in our bodies; b) precisely designing and efficiently producing vaccines that mimic viruses to stimulate safe and protective immune responses; and c) providing a rapid point-of-care liquid biopsy that will count and harvest circulating tumor cells.
To address planet health we are pursuing biotechnologies to: a) inexpensively use atmospheric CO2 to produce commodity biochemicals as the basis for a new carbon negative chemical industry, and b) mitigate the intermittency challenges of photovoltaic and wind produced electricity by producing hydrogen either from biomass sugars or directly from sunlight.
More than 25 years ago, Professor Swartz began his pioneering work to develop cell-free biotechnologies. The new ability to precisely focus biological systems toward efficiently addressing new, “non-natural” objectives has proven tremendously useful as we seek to address the crucial and very difficult challenges listed above. Another critical feature of the program is the courage (or naivete) to approach important objectives that require the development and integration of several necessary-but- not-sufficient technology advances.
Karl G. Sylvester
Professor of Surgery (Pediatric Surgery)
Current Research and Scholarly InterestsScholarly interests include investigation of molecular markers of human disease that provide diagnostic function, serve as targets for possible therapeutic manipulation, or provide insight into mechanisms of human disease. Specific diseases of interest include common conditions of pregnancy, gut microbial ecology and Necrotizing Enterocolitis (NEC).
Daniel Sze, MD, PhD
Professor of Radiology (Interventional Radiology)
Current Research and Scholarly InterestsTransarterial administration of chemotherapeutics, radioactive microspheres, and biologics for the treatment of unresectable tumors; management of portal hypertension and complications of cirrhosis (TIPS); treatment of complications of organ transplantation; Venous and pulmonary arterial thrombolysis and reconstruction; Stent and Stent-graft treatment of peripheral vascular diseases, aneurysms, aortic dissections
Christopher N. Ta, MD
Professor of Ophthalmology
BioChristopher N. Ta, MD specializes in the diagnosis and medical treatment of cornea diseases. His areas of expertise are in the treatment of ocular infections, inflammation, dry eyes and ocular surface diseases. He has conducted numerous clinical trials toward the prevention and treatment of ocular infections. Dr. Ta also has extensive clinical experience in the treatment of ocular graft-versus host disease following hematopoietic stem cell transplantation.