Bio-X


Showing 41-50 of 1,060 Results

  • Christopher O. Barnes

    Christopher O. Barnes

    Assistant Professor of Biology and, by courtesy, of Structural Biology

    Current Research and Scholarly InterestsResearch in our lab is aimed at defining the structural correlates of broad and potent antibody-mediated neutralization of viruses. We combine biophysical and structural methods (e.g., cryo-EM), protein engineering, and in vivo approaches to understand how enveloped viruses infect host cells and elicit antigen-specific immune responses. We are particularly interested in the co-evolution of HIV-1 and broadly-neutralizing IgG antibodies (bNAbs), which may hold the key to the development of an effective HIV-1 vaccine. In addition, we are investigating antibody responses to SARS-CoV-2 and related zoonotic coronaviruses (CoV), with the related goal of developing broadly-protective immunotherapies and vaccines against variants of concern and emerging CoV threats.

    HIV-1; SARS-CoV-2; coronaviruses; cryo-EM; crystallography; vaccines; directed evolution

  • Annelise E. Barron

    Annelise E. Barron

    Associate Professor of Bioengineering

    Current Research and Scholarly InterestsBiophysical mechanisms of host defense peptides (a.k.a. antimicrobial peptides) and their peptoid mimics; also, molecular and cellular biophysics of human innate immune responses.

  • Greg Barsh

    Greg Barsh

    Professor of Genetics and of Pediatrics, Emeritus

    Current Research and Scholarly InterestsGenetics of color variation

  • Michael Bassik

    Michael Bassik

    Associate Professor of Genetics

    Current Research and Scholarly InterestsWe are an interdisciplinary lab focused on two major areas:(1) we seek to understand mechanisms of cancer growth and drug resistance in order to find new therapeutic targets(2) we study mechanisms by which macrophages and other cells take up diverse materials by endocytosis and phagocytosis; these substrates range from bacteria, viruses, and cancer cells to drugs and protein toxins. To accomplish these goals, we develop and use new technologies for high-throughput functional genomics.

  • Glaivy Batsuli, MD

    Glaivy Batsuli, MD

    Assistant Professor of Pediatrics (Hematology/Oncology)

    Current Research and Scholarly InterestsHemophilia is a rare inherited X-linked bleeding disorder characterized by the deficiency of blood clotting proteins factor VIII or factor IX. These individuals are at risk for spontaneous bleeds and trauma or surgery-induced bleeding. There have been remarkable advancements in the management of hemophilia to prevent these bleeding episodes and improve quality of life. However, the presence of neutralizing antibodies, called inhibitors, still dictates access to novel therapies such as factor replacement for bleed management and now FDA-approved gene therapies. The Batsuli Lab is focused on elucidating mechanisms of the immune response to blood coagulation proteins in bleeding disorders in order to develop strategies and therapeutics for inhibitor prevention and tolerance induction.

    Dr. Batsuli's clinical research interests also include clinical trial participation for novel therapeutics & interventions in bleeding disorders such as hemophilia and von Willebrand disease in addition to coagulation issues & outcomes in ultra-rare bleeding disorders and sickle cell disease.

  • Fiona Baumer

    Fiona Baumer

    Assistant Professor of Neurology (Pediatric Neurology) and of Pediatrics

    Current Research and Scholarly InterestsCauses of Disturbed Cognition in Pediatric Epilepsy

  • Mohsen Bayati

    Mohsen Bayati

    Professor of Operations, Information and Technology at the Graduate School of Business and, by courtesy, of Electrical Engineering

    Current Research and Scholarly Interests1) Healthcare management: I am interested in improving healthcare delivery using data-driven modeling and decision-making.

    2) Network models and message-passing algorithms: I work on graphical modeling ideas motivated from statistical physics and their applications in statistical inference.

    3) Personalized decision-making: I work on machine learning and statistical challenges of personalized decision-making. The problems that I have worked on are primarily motivated by healthcare applications.

  • Philip Beachy

    Philip Beachy

    The Ernest and Amelia Gallo Professor, Professor of Urology, of Developmental Biology and, by courtesy, of Chemical and Systems Biology

    Current Research and Scholarly InterestsFunction of Hedgehog proteins and other extracellular signals in morphogenesis (pattern formation), in injury repair and regeneration (pattern maintenance). We study how the distribution of such signals is regulated in tissues, how cells perceive and respond to distinct concentrations of signals, and how such signaling pathways arose in evolution. We also study the normal roles of such signals in stem-cell physiology and their abnormal roles in the formation and expansion of cancer stem cells.

  • Christopher Beaulieu M.D., Ph.D.

    Christopher Beaulieu M.D., Ph.D.

    Professor of Radiology (Musculoskeletal Imaging) and, by courtesy, of Orthopaedic Surgery

    Current Research and Scholarly InterestsInformatics and image processing techniques that provide infrastructure for diagnosis in musculoskeletal imaging. Decision support for improving accuracy of bone tumor diagnosis. Improved methods for MRI in the musculoskeletal system.