Wu Tsai Human Performance Alliance
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Sean Mackey, M.D., Ph.D.
Redlich Professor, Professor of Anesthesiology, Perioperative, and Pain Medicine and, by courtesy, of Neurology
Current Research and Scholarly InterestsMultiple NIH funded projects to characterize CNS mechanisms of human pain. Comparative effectiveness of cognitive behavioral therapy and chronic pain self-management within the context of opioid reduction (PCORI funded). Single session pain catastrophizing treatment: comparative efficacy & mechanisms (NIH R01). Development and implementation of an open-source learning healthcare system, CHOIR (http://choir/stanford.edu), to optimize pain care and innovative research in real-world patients.
Professor (Research) of Microbiology and Immunology
Current Research and Scholarly InterestsI'm interested in immune monitoring of T cell responses to chronic pathogens and cancer, and the correlation of T cell response signatures with disease protection.
Yock Family Professor and Professor of Bioengineering
Current Research and Scholarly InterestsDr. Josh Makower is the Boston Scientific Applied Bioengineering Professor of Medicine and of Bioengineering at the Stanford University Schools of Medicine and Engineering and the Director of the Stanford Byers Center for Biodesign, the program he co-founded with Dr. Paul Yock twenty years ago. Josh helped create the fundamental structure of the Center’s core curriculum and is the chief architect of what is now called “The Biodesign Process.” Over the past 20 years since Josh and Paul founded Biodesign, this curriculum and the associated textbook has been used at Stanford and across the world to train hundreds of thousands of students, faculty and industry leaders on the Biodesign process towards the advancement of medical innovation for the improvement of patient care. Josh has practiced these same techniques directly as the Founder & Executive Chairman of ExploraMed, a medical device incubator, creating 9 companies since 1995. Transactions from the ExploraMed portfolio include NeoTract, acquired by Teleflex, Acclarent, acquired by J&J, EndoMatrix, acquired by C.R. Bard & TransVascular, acquired by Medtronic. Other ExploraMed/NEA ventures include Moximed, NC8 and Willow. Josh is also a Special Partner at NEA where he supports the healthcare team and medtech/healthtech investing practice. Josh serves on the boards of Allay Therapeutics, Revelle Aesthetics, Setpoint Medical, DOTS Technologies, Eargo, ExploraMed, Intrinsic Therapeutics, Moximed, Willow and Coravin. Josh holds over 300 patents and patent applications. He received an MBA from Columbia University, an MD from the NYU School of Medicine, a bachelor’s degree in Mechanical Engineering from MIT. Josh is a Member of the National Academy of Engineering and the College of Fellows of The American Institute for Medical and Biological Engineering and was awarded the Coulter Award for Healthcare Innovation by the Biomedical Engineering Society in 2018.
Maryam S. Makowski, PhD
Clinical Assistant Professor, Psychiatry and Behavioral Sciences
BioMaryam Sarah Makowski, PhD, is a Clinical Assistant Professor in the Stanford University Department of Psychiatry and Behavioral Sciences and the Associate Director of Scholarship and Health Promotion of the Stanford Medicine WellMD & WellPhD. Dr. Makowski is a member of the WellConnect Program, Lifestyle Psychiatry Clinic, and Measurement-Based Care (CHOIR) team in the Department of Psychiatry and Behavioral Sciences. She is a member of the Well-being Advisory Committee and a Stanford School of Medicine alternate faculty senate of the Department of Psychiatry and Behavioral Sciences.
Dr. Makowski is a nutrition scientist and a National Board-Certified Health and Wellness Coach. The focus of her nutrition research is examining the effects of micro- and macro-nutrients, meal composition, and timing on cognitive function, mood, mental sharpness, and eating behaviors of professionals with high cognitive and physical demands, in particular physicians. As a coach, Maryam uses evidence-based strategies to empower her clients in optimizing their health, energy, focus, and mental sharpness for peak performance.
Maryam completed her master's and doctoral studies in clinical nutrition, nutritional epidemiology, and medical science at the University of Toronto in Canada. Prior to joining Stanford, she served as a scientific associate at Toronto General Hospital-University Health Network in Toronto, and as an advisor to Air Canada rouge pilots and cabin crew on optimal nutrition for fatigue mitigation. Over the course of her career, she has authored highly cited scientific papers on nutrition and well-being.
Nancy Friend Pritzker Professor of Psychiatry and Behavioral Sciences
Current Research and Scholarly InterestsLong-lasting changes in synaptic strength are important for the modification of neural circuits by experience. A major goal of my laboratory is to elucidate the molecular events that trigger various forms of synaptic plasticity and the modifications in synaptic proteins that are responsible for the changes in synaptic efficacy.
William J. Maloney, MD
Boswell Chair of Orthopaedics
Current Research and Scholarly InterestsDr. Maloney is nationally and internationally recognized for his contributions to the improved understanding of the causes of failure of surgical joint replacement. For example; he established a critical link between polyethylene wear debris and bony erosion, with resulting significant changes in the materials and design strategies of joint replacement surgery. More recently, he has shown that wear debris particles are coated in vivo with human proteins, such as albumin; this observation has notably improved the validity of in vitro investigation in this area. His research in the area of joint replacement has twice won awards from the Hip Society. Dr. Maloney is currently the President of the American Academy of Orthopaedic Surgeons and has served on numerous AAOS committees, including the Council on Education. Previously, he was chair of the American Joint Replacement Registry Board of Directors (AJRR), and on the board of directors for the Knee Society, the Hip Society, the Western Orthopaedic Association, and the American Association of Hip and Knee Surgeons (AAHKS). Dr. Maloney is a past president of the Hip Society. He has been a Visiting Professor to numerous universities and institutions throughout the United States and Asia.
Douglass M. and Nola Leishman Professor of Cardiovascular Diseases, and Professor of Pediatrics (Cardiology) and of Bioengineering
Current Research and Scholarly InterestsThe Cardiovascular Biomechanics Computation Lab at Stanford develops novel computational methods for the study of cardiovascular disease progression, surgical methods, and medical devices. We have a particular interest in pediatric cardiology, and use virtual surgery to design novel surgical concepts for children born with heart defects.
Assistant Professor (Research) of Pediatrics, of Medicine (Biomedical Informatics) and, by courtesy, of Epidemiology and Population Health
Current Research and Scholarly InterestsSynthesizing evidence across studies while accounting for biases
Michaëlle Ntala Mayalu
Assistant Professor of Mechanical Engineering and, by courtesy, of Bioengineering
BioDr. Michaëlle N. Mayalu is an Assistant Professor of Mechanical Engineering. She received her Ph.D., M.S., and B.S., degrees in Mechanical Engineering at the Massachusetts Institute of Technology. She was a postdoctoral scholar at the California Institute of Technology in the Computing and Mathematical Sciences Department. She was a 2017 California Alliance Postdoctoral Fellowship Program recipient and a 2019 Burroughs Wellcome Fund Postdoctoral Enrichment Program award recipient.
Dr. Michaëlle N. Mayalu's area of expertise is in mathematical modeling and control theory of synthetic biological and biomedical systems. She is interested in the development of control theoretic tools for understanding, controlling, and predicting biological function at the molecular, cellular, and organismal levels to optimize therapeutic intervention.
She is the director of the Mayalu Lab whose research objective is to investigate how to optimize biomedical therapeutic designs using theoretical and computational approaches coupled with experiments. Initial project concepts include: i) theoretical and experimental design of bacterial "microrobots" for preemptive and targeted therapeutic intervention, ii) system-level multi-scale modeling of gut associated skin disorders for virtual evaluation and optimization of therapy, iii) theoretical and experimental design of "microrobotic" swarms of engineered bacteria with sophisticated centralized and decentralized control schemes to explore possible mechanisms of pattern formation. The experimental projects in the Mayalu Lab utilize established techniques borrowed from the field of synthetic biology to develop synthetic genetic circuits in E. coli to make bacterial "microrobots". Ultimately the Mayalu Lab aims to develop accurate and efficient modeling frameworks that incorporate computation, dynamical systems, and control theory that will become more widespread and impactful in the design of electro-mechanical and biological therapeutic machines.