Wu Tsai Human Performance Alliance
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Angela K. Lumba-Brown
Clinical Associate Professor, Emergency Medicine
Clinical Associate Professor (By courtesy), Neurosurgery
Clinical Associate Professor, Pediatrics
Current Research and Scholarly InterestsCurrent research includes evidence-based guidelines for the management and treatment of traumatic brain injury, research establishing an evidence and targeting treatments for the subtypes of concussion, research identifying the best outcomes in pre-hospital care of patients with traumatic brain injury, research on brain performance via sensorimotor and sensory-cognitive synchronization, and research on dynamic visual synchronization as a biomarker for attentional impairments.
Boston Scientific Applied Biomedical Engineering Professor and Professor of Bioengineering
Current Research and Scholarly InterestsDr. Josh Makower is the Boston Scientific Applied Bioengineering Professor of Medicine and of Bioengineering at the Stanford University Schools of Medicine and Engineering and the Director of the Stanford Byers Center for Biodesign, the program he co-founded with Dr. Paul Yock twenty years ago. Josh helped create the fundamental structure of the Center’s core curriculum and is the chief architect of what is now called “The Biodesign Process.” Over the past 20 years since Josh and Paul founded Biodesign, this curriculum and the associated textbook has been used at Stanford and across the world to train hundreds of thousands of students, faculty and industry leaders on the Biodesign process towards the advancement of medical innovation for the improvement of patient care. Josh has practiced these same techniques directly as the Founder & Executive Chairman of ExploraMed, a medical device incubator, creating 9 companies since 1995. Transactions from the ExploraMed portfolio include NeoTract, acquired by Teleflex, Acclarent, acquired by J&J, EndoMatrix, acquired by C.R. Bard & TransVascular, acquired by Medtronic. Other ExploraMed/NEA ventures include Moximed, NC8 and Willow. Josh is also a Special Partner at NEA where he supports the healthcare team and medtech/healthtech investing practice. Josh serves on the boards of Allay Therapeutics, Revelle Aesthetics, Setpoint Medical, DOTS Technologies, Eargo, ExploraMed, Intrinsic Therapeutics, Moximed, Willow and Coravin. Josh holds over 300 patents and patent applications. He received an MBA from Columbia University, an MD from the NYU School of Medicine, a bachelor’s degree in Mechanical Engineering from MIT. Josh is a Member of the National Academy of Engineering and the College of Fellows of The American Institute for Medical and Biological Engineering and was awarded the Coulter Award for Healthcare Innovation by the Biomedical Engineering Society in 2018.
Maryam S. Makowski, PhD, FACN, NBC-HWC
Clinical Assistant Professor, Psychiatry and Behavioral Sciences
BioMaryam Sarah Makowski, Ph.D., FACN, NBC-HWC is a clinical assistant professor in the Stanford University Department of Psychiatry and Behavioral Sciences, the Associate Director of Scholarship and Health Promotion of the Stanford Medicine WellMD & WellPhD, and a nutrition and physician well-being coach at Stanford University. Dr. Makowski is a member of the WellConnect Program, Lifestyle Psychiatry Clinic, Metabolic Psychiatry Clinic, and Measurement-Based Care (CHOIR) team in the Department of Psychiatry and Behavioral Sciences. She is a member of the Well-being Advisory Committee and a Stanford School of Medicine alternate faculty senate of the Department of Psychiatry and Behavioral Sciences. Dr. Makowski has particular expertise in nutrition and physician well-being. She has been leading many initiatives to promote physician well-being at Stanford via personal and organizational strategies for over 6 years.
Dr. Makowski completed her master's and doctoral studies in clinical nutrition, nutritional epidemiology, and medical science at the University of Toronto in Canada. Prior to joining Stanford, she served as a scientific associate at Toronto General Hospital-University Health Network in Toronto, and as an advisor to Air Canada rouge pilots and cabin crew on optimal nutrition for fatigue mitigation. Over the course of her career, she has authored many highly cited scientific papers on nutrition and well-being.
She is a National Board-Certified Health and Wellness Coach, a Fellow of the American College of Nutrition, a professional member of the Academy of Nutrition and Dietetics, American and Canadian Nutrition Societies, American Nutrition Association, and The Institute of Coaching at McLean (a Harvard Medical School Affiliate).
William J. Maloney, MD
Boswell Chair of Orthopaedics
Current Research and Scholarly InterestsDr. Maloney is nationally and internationally recognized for his contributions to the improved understanding of the causes of failure of surgical joint replacement. For example; he established a critical link between polyethylene wear debris and bony erosion, with resulting significant changes in the materials and design strategies of joint replacement surgery. More recently, he has shown that wear debris particles are coated in vivo with human proteins, such as albumin; this observation has notably improved the validity of in vitro investigation in this area. His research in the area of joint replacement has twice won awards from the Hip Society. Dr. Maloney is currently the President of the American Academy of Orthopaedic Surgeons and has served on numerous AAOS committees, including the Council on Education. Previously, he was chair of the American Joint Replacement Registry Board of Directors (AJRR), and on the board of directors for the Knee Society, the Hip Society, the Western Orthopaedic Association, and the American Association of Hip and Knee Surgeons (AAHKS). Dr. Maloney is a past president of the Hip Society. He has been a Visiting Professor to numerous universities and institutions throughout the United States and Asia.
Douglass M. and Nola Leishman Professor of Cardiovascular Diseases, and Professor of Pediatrics (Cardiology) and of Bioengineering
Current Research and Scholarly InterestsThe Cardiovascular Biomechanics Computation Lab at Stanford develops novel computational methods for the study of cardiovascular disease progression, surgical methods, and medical devices. We have a particular interest in pediatric cardiology, and use virtual surgery to design novel surgical concepts for children born with heart defects.
Michaëlle Ntala Mayalu
Assistant Professor of Mechanical Engineering
BioDr. Michaëlle N. Mayalu is an Assistant Professor of Mechanical Engineering. She received her Ph.D., M.S., and B.S., degrees in Mechanical Engineering at the Massachusetts Institute of Technology. She was a postdoctoral scholar at the California Institute of Technology in the Computing and Mathematical Sciences Department. She was a 2017 California Alliance Postdoctoral Fellowship Program recipient and a 2019 Burroughs Wellcome Fund Postdoctoral Enrichment Program award recipient.
Dr. Michaëlle N. Mayalu's area of expertise is in mathematical modeling and control theory of synthetic biological and biomedical systems. She is interested in the development of control theoretic tools for understanding, controlling, and predicting biological function at the molecular, cellular, and organismal levels to optimize therapeutic intervention.
She is the director of the Mayalu Lab whose research objective is to investigate how to optimize biomedical therapeutic designs using theoretical and computational approaches coupled with experiments. Initial project concepts include: i) theoretical and experimental design of bacterial "microrobots" for preemptive and targeted therapeutic intervention, ii) system-level multi-scale modeling of gut associated skin disorders for virtual evaluation and optimization of therapy, iii) theoretical and experimental design of "microrobotic" swarms of engineered bacteria with sophisticated centralized and decentralized control schemes to explore possible mechanisms of pattern formation. The experimental projects in the Mayalu Lab utilize established techniques borrowed from the field of synthetic biology to develop synthetic genetic circuits in E. coli to make bacterial "microrobots". Ultimately the Mayalu Lab aims to develop accurate and efficient modeling frameworks that incorporate computation, dynamical systems, and control theory that will become more widespread and impactful in the design of electro-mechanical and biological therapeutic machines.
Jennifer A McNab
Associate Professor (Research) of Radiology (Radiological Sciences Laboratory)
Current Research and Scholarly InterestsMy research is focused on developing magnetic resonance imaging (MRI) methods that probe brain tissue microstructure. This requires new MRI contrast mechanisms, strategic encoding and reconstruction schemes, physiological monitoring, brain tissue modeling and validation. Applications of these methods include neuronavigation, neurosurgical planning and the development of improved biomarkers for brain development, degeneration, disease and injury.
Emmanuel Mignot, MD, PhD
Craig Reynolds Professor of Sleep Medicine and Professor, by courtesy, of Genetics and of Neurology
Current Research and Scholarly InterestsThe research focus of the laboratory is the study of sleep and sleep disorders such as narcolepsy and Kleine Levin syndrome. We also study the neurobiological and genetic basis of the EEG and develop new tools to study sleep using nocturnal polysomnography. Approaches mostly involve human genetic studies (GWAS, sequencing), EEG signal analysis, and immunology (as narcolepsy is an autoimmune disease of the brain).
Stephen B. Montgomery
Associate Professor of Pathology, of Genetics, of Biomedical Data Science and, by courtesy, of Computer Science
Current Research and Scholarly InterestsWe focus on understanding the effects of genome variation on cellular phenotypes and cellular modeling of disease through genomic approaches such as next generation RNA sequencing in combination with developing and utilizing state-of-the-art bioinformatics and statistical genetics approaches. See our website at http://montgomerylab.stanford.edu/
Jonathan N. Myers
Clinical Professor (Affiliated), Medicine - Med/Cardiovascular Medicine
BioDr. Myers is a Health Research Scientist at the Palo Alto VA Health Care System; a Clinical Professor at Stanford University (Affiliated), and a Senior Research Career Scientist Award recipient through the VA Rehabilitation Research and Development Program. His research has focused on primary and secondary prevention, and the clinical applications of exercise testing and rehabilitation in patients with cardiovascular disease and other chronic conditions. He has a lengthy history of studying the epidemiology of cardiopulmonary exercise test responses, physical activity patterns, and other lifestyle factors and their relation to health outcomes. He manages the Veterans Exercise Testing Study (VETS), an ongoing, prospective evaluation of Veteran subjects referred for exercise testing for clinical reasons, designed to address exercise test, clinical, and lifestyle factors and their association with health outcomes.
He earned his bachelor’s degree from the University of California, Santa Barbara, his master's degree from San Diego State University, and his doctorate from the University of Southern California. He has been a board member for many organizations including the American Heart Association (AHA), the American Association of Cardiovascular and Pulmonary Rehabilitation (AACVPR), and the American College of Sports Medicine (ACSM), and serves on the editorial board for 9 journals. He is a recipient of the Michael Pollock Established Investigator Award through the AACVPR, a recipient of the Steven N Blair Award for excellence in physical activity research from the AHA Council on Epidemiology and Prevention and is the 2022 recipient of the American College of Sports Medicine Citation Award. He is a fellow of the AACVPR, ACSM, American College of Cardiology, and the AHA, and has authored and co-authored guidelines on exercise testing and rehabilitation for each of these organizations, including the 2021 editions of the ACSM and AACVPR guidelines.
Clinical Professor, Psychiatry and Behavioral Sciences
BioDouglas L. Noordsy, MD, is Clinical Professor and Director of Lifestyle Psychiatry, and psychiatrist on the INSPIRE Early Psychosis Clinic in the Department of Psychiatry & Behavioral Sciences at Stanford University School of Medicine. Dr. Noordsy was previously Professor of Psychiatry, Director of Psychosis Services and Investigator in the Psychopharmacology Research Group at the Geisel School of Medicine at Dartmouth. His research interests include medication and lifestyle interventions for individuals with psychotic disorders; methods to facilitate recovery and promote achievement of optimal outcomes for people with schizophrenia and bipolar disorder; and methods to prevent progression of early psychotic disorders. He is particularly interested in the role of physical exercise for prevention of progression of early psychosis and for potentiating learning in CBTp and supported employment and education. Dr. Noordsy is a member of the Schizophrenia International Research Society, the International Early Psychosis Association, and is a fellow of the American Psychiatric Association. He is a member of the editorial boards for Community Mental Health Journal, Clinical Schizophrenia & Related Psychosis, and Schizophrenia Bulletin. Dr. Noordsy was recognized with the Exemplary Psychiatrist Award from the National Alliance on Mental Illness in 2001, and the Excellence in Leadership Award from the Department of Psychiatry & Behavioral Sciences at Stanford in 2018.
Professor (Research) of PsychologyOn Leave from 10/01/2022 To 03/31/2023
Current Research and Scholarly InterestsVision, development, functional imaging, systems analysis
Assistant Professor of Bioengineering and of Neurosurgery and, by courtesy, of Electrical Engineering
Current Research and Scholarly InterestsOur group explores neuroengineering and its application to both basic and clinical neuroscience. Our goal is to develop brain-machine interfaces as a platform technology for a variety of brain-related medical conditions including stroke and epilepsy.
Associate Professor of Epidemiology and Population Health
Current Research and Scholarly InterestsMultilevel - from cells to society - epidemiologic study of healthy aging
Richard W. Weiland Professor in the School of Engineering and Professor, by courtesy, of Computer Science
Current Research and Scholarly InterestsMy research focuses on developing the principles and tools needed to realize advanced robotic and human-machine systems capable of physical interaction. Application areas include surgery, simulation and training, rehabilitation, prosthetics, neuromechanics, exploration of hazardous and remote environments (e.g. space), design, and education.
Sergiu P. Pasca
Kenneth T. Norris, Jr. Professor of Psychiatry and Behavioral Sciences and Bonnie Uytengsu and Family Director of the Stanford Brain Organogenesis Program
Current Research and Scholarly InterestsA critical challenge in understanding the intricate programs underlying development, assembly and dysfunction of the human brain is the lack of direct access to intact, functioning human brain tissue for detailed investigation by imaging, recording, and stimulation.
To address this, we are developing bottom-up approaches to generate and assemble, from multi-cellular components, human neural circuits in vitro and in vivo.
We introduced the use of instructive signals for deriving from human pluripotent stem cells self-organizing 3D cellular structures named brain region-specific spheroids/organoids. We demonstrated that these cultures, such as the ones resembling the cerebral cortex, can be reliably derived across many lines and experiments, contain synaptically connected neurons and non-reactive astrocytes, and can be used to gain mechanistic insights into genetic and environmental brain disorders. Moreover, when maintained as long-term cultures, they recapitulate an intrinsic program of maturation that progresses towards postnatal stages.
We also pioneered a modular system to integrate 3D brain region-specific organoids and study human neuronal migration and neural circuit formation in functional preparations that we named assembloids. We have actively applied these models in combination with studies in long-term ex vivo brain preparations to acquire a deeper understanding of human physiology, evolution and disease mechanisms.
We have carved a unique research program that combines rigorous in vivo and in vitro neuroscience, stem cell and molecular biology approaches to construct and deconstruct previously inaccessible stages of human brain development and function in health and disease.
We believe science is a community effort, and accordingly, we have been advancing the field by broadly and openly sharing our technologies with numerous laboratories around the world and organizing the primary research conference and the training courses in the area of cellular models of the human brain.
Albert Ray Lang Professor of Psychology
Current Research and Scholarly InterestsOur lab uses the tools of cognitive neuroscience to understand how decision making, executive control, and learning and memory are implemented in the human brain. We also develop neuroinformatics tools and resources to help researchers make better sense of data.