Showing 1-10 of 11 Results
Vinit B. Mahajan M.D., Ph.D.
Associate Professor of Ophthalmology at the Stanford University Medical Center
Current Research and Scholarly InterestsOur focus is the development of personalized medicine for eye diseases through translation of our discoveries in proteomics, genomics, and phenomics in humans, mice and tissue culture models.
Associate Professor (Research) of Radiology (Cancer Early Detection-Canary Center)
Current Research and Scholarly InterestsThe Mallick Lab is focused on using integrative, multi-omic approaches to model the processes that govern proteome dynamics and to use those models to discover cancer biomarkers and molecular mechanisms.
David Mulvane Ehrsam and Edward Curtis Franklin Professor in Chemistry and Professor of Photon Science
BioTheoretical chemist Todd Martínez develops and applies new methods that predict and explain how atoms move in molecules. These methods are used both to design new molecules and to understand the behavior of those that already exist. His research group studies the response of molecules to light (photochemistry) and external force (mechanochemistry). Photochemistry is a critical part of human vision, single-molecule spectroscopy, harnessing solar energy (either to make fuels or electricity), and even organic synthesis. Mechanochemistry represents a novel scheme to promote unusual reactions and potentially to create self-healing materials that resist degradation. The underlying tools embody the full gamut of quantum mechanical effects governing molecules, from chemical bond breaking/formation to electron/proton transfer and electronic excited states.
Professor Martínez was born in Amityville, New York, but spent most of his childhood in Central America and the Caribbean. His chemical curiosity benefitted tremendously from the relaxed safety standards in Central American chemical supply houses, giving him unfettered access to strong acids and bases. When he also became interested in computation, limited or nonexistent computer access forced him to write and debug computer programs on paper. Today, Prof. Martínez combines these interests by working toward theoretical and computational modeling and design of molecules. Martínez received his PhD in chemistry from UCLA in 1994. After postdoctoral study at UCLA and the Hebrew University in Jerusalem, he joined the faculty at the University of Illinois in 1996. In 2009, he joined the faculty at Stanford, where he is now the Ehrsam and Franklin Professor of Chemistry and Professor of Photon Science at SLAC National Accelerator Laboratory. He has received numerous awards for his contributions, including a MacArthur Fellowship (commonly known as the “genius award”). He is co-editor of Annual Reviews in Physical Chemistry, associate editor of The Journal of Chemical Physics, and an elected fellow of the American Academy of Arts and Sciences.
Current research in the Martínez lab aims to make molecular modeling both predictive and routine. New approaches to interactive molecular simulation are being developed, in which users interact with a virtual-reality based molecular modeling kit that fully understands quantum mechanics. New techniques to discover heretofore unknown chemical reactions are being developed and tested, exploiting the many efficient methods that the Martínez group has introduced for solving quantum mechanical problems quickly, using a combination of physical/chemical insights and commodity videogaming hardware. For more details, please visit http://mtzweb.stanford.edu.
Associate Professor of Materials Science and Engineering and of Photon Science
BioMelosh's research is focused on developing methods to detect and control chemical processes on the nanoscale, to create materials that are responsive to their local environment. The research goal incorporates many of the hallmarks of biological adaptability, based on feedback control between cellular receptors and protein expression. Similar artificial networks may be achieved by fabricating arrays of nanoscale devices that can detect and influence their local surroundings through ionic potential, temperature, mechanical motion, capacitance, or electrochemistry. These devices are particularly suited as smart biomaterials, where multiple surface-cell interactions must be monitored and adjusted simultaneously for optimal cell adhesion and growth. Other interests include precise control over self-assembled materials, and potential methods to monitor the diagnostics of complicated chemical systems, such as the effect of drug treatments within patients.
Molecular materials at interfaces
Directed dynamic self-assembly
Controlling molecular or biomolecular assembly and behavior
Influence of local electronic, optical or thermal stimuli
Stanford University Professor of Nephrology
Current Research and Scholarly InterestsInadequate removal of uremic solutes contributes to widespread illness in the more than 350,000 Americans maintained on hemodialysis. But we know remarkably little about these solutes. Dr. Meyer's research efforts are focused on identifying which uremic solutes are toxic, how these solutes are made, and how their production could be decreased or their removal could be increased. We should be able to improve treatment if we knew more about what we are trying to remove.
Mrs. George A. Winzer Professor in Cell Biology
Current Research and Scholarly InterestsCELLULAR INFORMATION PROCESSING The main problem in signal transduction is to understand how different receptor-stimuli specifically control diverse cell functions. We are using automated microscopy, live-cell fluorescent biosensors and perturbations of predicted signaling proteins to systematically dissect signaling networks. This allows us to identify signaling modules and to elucidate and ultimately model the flow of cellular information.
The George D. Smith Professor in Translational Medicine
Current Research and Scholarly InterestsTwo areas: 1. Using rationally-designed peptide inhibitors to study protein-protein interactions in cell signaling. Focus: protein kinase C in heart and large GTPases regulating mitochondrial dynamics in neurodegdenration. 2. Using small molecules (identified in a high throughput screens and synthetic chemistry) as activators and inhibitors of aldehyde dehydrogenases, a family of detoxifying enzymes, and glucose-6-phoshate dehydrogenase, in normal cells and in models of human diseases.
W. E. Moerner
Harry S. Mosher Professor and Professor, by courtesy, of Applied Physics
Current Research and Scholarly InterestsLaser spectroscopy and microscopy of single molecules to probe biological systems, one biomolecule at a time. Primary thrusts: fluorescence microscopy far beyond the optical diffraction limit (PALM/STORM/STED), methods for 3D optical microscopy in cells, and trapping of single biomolecules in solution for extended study. We explore protein localization patterns in bacteria, structures of amyloid aggregates in cells, signaling proteins in the primary cilium, and dynamics of DNA and RNA.
Denise M. Monack
Professor of Microbiology and Immunology
Current Research and Scholarly InterestsThe primary focus of my research is to understand the genetic and molecular mechanisms of intracellular bacterial pathogenesis. We use several model systems to study complex host-pathogen interactions in the gut and in immune cells such as macrophages and dendritic cells. Ultimately we would like to understand how Salmonella persists within certain hosts for years in the face of a robust immune response.
Mary Beth Mudgett
Professor of Biology
Current Research and Scholarly InterestsMy laboratory investigates how bacterial pathogens employ proteins secreted by the type III secretion system (TTSS) to manipulate eukaryotic signaling to promote disease. We study TTSS effectors in the plant pathogen Xanthomonas euvesicatoria, the causal agent of bacterial spot disease of pepper and tomato. For these studies, we apply biochemical, cell biological, and genetic approaches using the natural hosts and model pathosystems.