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Sergiu P. Pasca
Assistant Professor of Psychiatry and Behavioral Sciences (Sleep Disorder/Sleep Center)
Current Research and Scholarly InterestsA critical challenge in understanding the intricate programs underlying development, assembly and dysfunction of the human brain is the lack of direct access to intact, functioning human brain tissue for detailed investigation by imaging, recording, and stimulation.
Our lab is using pluripotent stem cells derived non-invasively from human individuals to generate in a dish specific regions of the human brain in a functional 3D preparation we have developed. We are using months-to-years long ‘brain-a-dish’ cultures (also known as brain region-specific organoids or spheroids) to understand how neurons find their final position in the brain and how they mature functionally. To investigate how different brain regions talk to each-other in normal and diseased states, we introduced a new approach for in vitro assembly of neural circuits, also known as assembloids.
We employ state-of-the-art stem cell biology, genome engineering, imaging and neuroscience approaches to identify the dynamical processes that go awry in neural cells derived from patients with neuropsychiatric disorders, such as autism or schizophrenia, and what should be therapeutically targeted in these conditions.
Emma Pfeiffer Merner Professor in the Medical Sciences
Current Research and Scholarly InterestsThe goal of our research is to elucidate the molecular mechanisms by which proteins and cholesterol are transported between specific membrane compartments. We are trying to understand how phosphorylation of Rabs may trigger Parkinson's Disease. We also study how cells acquire cholesterol from the diet and from LDL; cholesterol export from lysosomes is critical for normal cell function.
Associate Director, ChEM-H Operations
BioDr. Elizabeth Ponder joined Stanford ChEM-H in 2014 as the Associate Director. She leads planning and operations for ChEM-H in partnership with the faculty executive committee. Dr. Ponder completed her Ph.D. and postdoctoral training at Stanford University in the laboratory of Dr. Matthew Bogyo. Her past work has included promoting public-private partnerships in the non-profit sector, managing multidisciplinary research in the higher education sector, and business development consulting in the for-profit biotech sector. Dr. Ponder joined ChEM-H from the University of California, Berkeley where she served as the Executive Director of the Henry Wheeler Center for Emerging & Neglected Diseases (CEND).
Professor of Pediatrics (Stem Cell Transplantation)
Current Research and Scholarly InterestsGenome Editing and Population Dynamics for Gene Therapy and Cancer Research
Associate Professor of Bioengineering
BioWe are a curiosity driven research group working in the field of physical biology. Our approach brings together experimental and theoretical techniques from soft-condensed matter physics, fluid dynamics, theory of computation and unconventional micro and nano-fabrication to open problems in biology: from organismal to cellular and molecular scale. We design and build precision instrumentation including droplet microfluidic tools to probe and perturb biological machines and their synthetic analogues. Along the way, we invent novel technologies in global health context with clinical applications in extreme resource poor settings.
Assistant Professor of Radiation Oncology (Radiation Physics)
Current Research and Scholarly InterestsThe Physical Oncology Lab is interested in making a lasting impact on translational cancer research by building novel physical tools and methods.