Wu Tsai Neurosciences Institute
Showing 21-33 of 33 Results
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Tino Pleiner
Assistant Professor of Molecular and Cellular Physiology
Current Research and Scholarly InterestsThe Pleiner lab combines mechanistic cell biology, structural biochemistry and protein engineering to dissect the pathways and molecular machines that mature human membrane proteins to a fully functional state. We also develop alpaca-derived and synthetic nanobodies as tools to modulate intracellular pathways that globally regulate protein homeostasis in health and disease.
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Sylvia K. Plevritis, PhD
William M. Hume Professor in the School of Medicine, Professor of Biomedical Data Science and of Radiology
Current Research and Scholarly InterestsMy research program focuses on computational modeling of cancer biology and cancer outcomes. My laboratory develops stochastic models of the natural history of cancer based on clinical research data. We estimate population-level outcomes under differing screening and treatment interventions. We also analyze genomic and proteomic cancer data in order to identify molecular networks that are perturbed in cancer initiation and progression and relate these perturbations to patient outcomes.
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Kilian M Pohl
Professor (Research) of Psychiatry and Behavioral Sciences (Major Labs and Incubator) and, by courtesy, of Electrical Engineering
Current Research and Scholarly InterestsThe foundation of the laboratory of Associate Professor Kilian M. Pohl, PhD, is computational science aimed at identifying biomedical phenotypes improving the mechanistic understanding, diagnosis, and treatment of neuropsychiatric disorders. The biomedical phenotypes are discovered by unbiased, machine learning-based searches across biological, neuroimaging, and neuropsychological data. This data-driven discovery currently supports the adolescent brain research of the NIH-funded National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA) and the Adolescent Brain Cognitive Development (ABCD), the largest long-term study of brain development and child health in the US. The laboratory also investigates brain patterns specific to alcohol use disorder and the human immunodeficiency virus (HIV) across the adult age range, and have advanced the understanding of a variety of brain diseases including schizophrenia, Alzheimer’s disease, glioma, and aging.
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Russell Poldrack
Albert Ray Lang Professor of Psychology
Current Research and Scholarly InterestsOur lab uses the tools of cognitive neuroscience to understand how decision making, executive control, and learning and memory are implemented in the human brain. We also develop neuroinformatics tools and resources to help researchers make better sense of data.
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Ada Poon
Associate Professor of Electrical Engineering
Current Research and Scholarly InterestsOur research focuses on providing theoretical foundations and engineering platforms for realizing electronics that seamlessly integrate with the body. Such systems will allow precise recording or modulation of physiological activity, for advancing basic scientific discovery and for restoring or augmenting biological functions for clinical applications.
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Matthew Porteus
Sutardja Chuk Professor of Definitive and Curative Medicine
BioDr. Porteus was raised in California and was a local graduate of Gunn High School before completing A.B. degree in “History and Science” at Harvard University where he graduated Magna Cum Laude and wrote an thesis entitled “Safe or Dangerous Chimeras: The recombinant DNA controversy as a conflict between differing socially constructed interpretations of recombinant DNA technology.” He then returned to the area and completed his combined MD, PhD at Stanford Medical School with his PhD focused on understanding the molecular basis of mammalian forebrain development with his PhD thesis entitled “Isolation and Characterization of TES-1/DLX-2: A Novel Homeobox Gene Expressed During Mammalian Forebrain Development.” After completion of his dual degree program, he was an intern and resident in Pediatrics at Boston Children’s Hospital and then completed his Pediatric Hematology/Oncology fellowship in the combined Boston Chidlren’s Hospital/Dana Farber Cancer Institute program. For his fellowship and post-doctoral research he worked with Dr. David Baltimore at MIT and CalTech where he began his studies in developing homologous recombination as a strategy to correct disease causing mutations in stem cells as definitive and curative therapy for children with genetic diseases of the blood, particularly sickle cell disease. Following his training with Dr. Baltimore, he took an independent faculty position at UT Southwestern in the Departments of Pediatrics and Biochemistry before again returning to Stanford in 2010 as an Associate Professor. During this time his work has been the first to demonstrate that gene correction could be achieved in human cells at frequencies that were high enough to potentially cure patients and is considered one of the pioneers and founders of the field of genome editing—a field that now encompasses thousands of labs and several new companies throughout the world. His research program continues to focus on developing genome editing by homologous recombination as curative therapy for children with genetic diseases but also has interests in the clonal dynamics of heterogeneous populations and the use of genome editing to better understand diseases that affect children including infant leukemias and genetic diseases that affect the muscle. Clinically, Dr. Porteus attends at the Lucille Packard Children’s Hospital where he takes care of pediatric patients undergoing hematopoietic stem cell transplantation.
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Kathleen Poston, MD, MS
Edward F. and Irene Thiele Pimley Professor of Neurology and the Neurological Sciences and Professor, by courtesy, of Neurosurgery
Current Research and Scholarly InterestsMy research addresses one of the most devastating and poorly treated symptoms that can develop in people with Parkinson's disease - Dementia. We use biological markers, multi-modal neuroimaging and genetics to understand the different underlying causes of dementia and to understand why dementia develops more quickly in some patients, but not others.
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Manu Prakash
Associate Professor of Bioengineering, Senior Fellow at the Woods Institute for the Environment and Associate Professor, by courtesy, of Oceans and of Biology
BioWe use interdisciplinary approaches including theory and experiments to understand how computation is embodied in biological matter. Examples include cognition in single cell protists and morphological computing in animals with no neurons and origins of complex behavior in multi-cellular systems. Broadly, we invent new tools for studying non-model organisms with significant focus on life in the ocean - addressing fundamental questions such as how do cells sense pressure or gravity? Finally, we are dedicated towards inventing and distributing “frugal science” tools to democratize access to science (previous inventions used worldwide: Foldscope, Abuzz), diagnostics of deadly diseases like malaria and convening global citizen science communities to tackle planetary scale environmental challenges such as mosquito surveillance or plankton surveillance by citizen sailors mapping the ocean in the age of Anthropocene.
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James Priest
Adjunct Clinical Assistant Professor, Pediatrics - Cardiology
Current Research and Scholarly InterestsThe Priest lab seeks a better understanding of the genetics and pathogenesis of congenital heart disease using translational genomics, big-data, and vertebrate models of cardiac development.
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David Prince
Edward F. and Irene Thiele Pimley Professor of Neurology and the Neurological Sciences, Emeritus
Current Research and Scholarly InterestsExperiments examine
1)intrinsic properties of neuronal membranes; actions of neurotransmitters that regulate neocortical and thalamic excitability
2) chronic epileptogenesis following cortical injury; changes in intracortical connectivity and receptors;
3) effects of early injury and activity on cortical development/maldevelopment Electrophysiological, anatomical and pharmacological techniques employed.
4. prophylaxis of postraumatic epilepsy
5. Neocortical interneuronal function/modulation -
Patrick Lee Purdon
Professor of Anesthesiology, Perioperative and Pain Medicine (Department Research) and, by courtesy, of Bioengineering
BioMy research integrates neuroimaging, biomedical signal processing, and the systems neuroscience of general anesthesia and sedation.
My group conducts human studies of anesthesia-induced unconsciousness, using a variety of techniques including multimodal neuroimaging, high-density EEG, and invasive neurophysiological recordings used to diagnose medically refractory epilepsy. We also develop novel methods in neuroimaging and biomedical signal processing to support these studies, as well as methods for monitoring level of consciousness under general anesthesia using EEG.
