Wu Tsai Neurosciences Institute
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Professor of Psychiatry and Behavioral Sciences (Major Laboratories and Clinical Translational Neurosciences Incubator), of Neurobiology and, by courtesy, of Obstetrics and Gynecology
Current Research and Scholarly InterestsWe study how our brains generate social interactions that differ between the sexes. Such gender differences in behavior are regulated by sex hormones, experience, and social cues. Accordingly, we are characterizing how these internal and external factors control gene expression and neuronal physiology in the two sexes to generate behavior. We are also interested in understanding how such sex differences in the healthy brain translate to sex differences in many neuro-psychiatric illnesses.
Professor (Research) of Neurosurgery and, by courtesy, of Neurology
Current Research and Scholarly InterestsThe ultimate goal of the Shamloo laboratory is to rapidly advance our understanding of brain function at the molecular, cellular, circuit and behavioral levels, and to elucidate the pathological process underlying malfunction of the nervous system following injury and neurologic disorders such as stroke, Alzheimer's disease, Parkinson’s disease, and autism. We have been focusing on the noradrenergic system and approaches leading to restoration of brain adrenergic signaling in these disorders.
Sapp Family Provostial Professor, The Catherine Holman Johnson Director of Stanford Bio-X and Professor of Biology and of Neurobiology
Current Research and Scholarly InterestsThe goal of research in the Shatz Laboratory is to discover how brain circuits are tuned up by experience during critical periods of development both before and after birth by elucidating cellular and molecular mechanisms that transform early fetal and neonatal brain circuits into mature connections. To discover mechanistic underpinnings of circuit tuning, the lab has conducted functional screens for genes regulated by neural activity and studied their function for vision, learning and memory.
Vincent V.C. Woo Director, Wu Tsai Neuroscience Institute and Professor of Biology and of Pathology
Current Research and Scholarly InterestsThe connectivity of a neuron (its unique constellation of synaptic inputs and outputs) is essential for its function. Neuronal connections are made with exquisite accuracy between specific types of neurons. How each neuron finds its synaptic partners has been a central question in developmental neurobiology. We utilize the relatively simple nervous system of nematode C. elegans, to search for molecules that can specify synaptic connections and understand the molecular mechanisms of synaptic as
Hong Seh and Vivian W. M. Lim Professor and Professor, by courtesy, of Neurobiology, of Bioengineering and of Neurosurgery
Current Research and Scholarly InterestsWe conduct neuroscience, neuroengineering and translational research to better understand how the brain controls movement, and to design medical systems to assist people with paralysis. These are referred to as brain-machine interfaces (BMIs), brain-computer interfaces (BCIs) and intra-cortical neural prostheses. We conduct this research as part of our Neural Prosthetic Systems Lab (NPSL) and our Neural Prosthetics Translational Lab (NPTL), which I co-direct with Prof. Jaimie Henderson, M.D.
Professor of Anesthesiology, Perioperative and Pain Medicine (Pediatric)
Current Research and Scholarly InterestsThe primary goal of my research is to promote the health and well being of children and adolescents with chronic pain and their families. In line with this goal, research projects focus on biological, neurological, cognitive, affective, and social risk and resiliency factors of the pain experience. Projects include brain imaging, longitudinal clinical cohort, and treatment interventions studies.
Some current research orojects include:
Learning and Memory in Pediatric Chronic Pain
Funding: NIH/NICHD R01
Description: Investigating the mechanisms underlying fear learning, extinction and disruption of fear reconsolidation in adolescents with chronic pain and health controls using behavioral and neuroimaging measures. Multi-site study with Boston Children's Hospital (Collaborator: David Borsook, MD).
Children Pain Behaviors in Context: A functional-cognitive perspective
Leading Site: University of Ghent (Collaborator: Liesbet Goubert, PhD)
Description: Identifying key antecedents and consequences that give rise to and maintain children's pain-related behaviors and investigate impact these antecedents on children's behavior and functioning through daily surveys and activity monitoring.
Manpreet K. Singh, MD MS
Associate Professor of Psychiatry and Behavioral Sciences (Child and Adolescent Psychiatry and Child Development)
Current Research and Scholarly InterestsDr. Singh conducts research in the phenomenology, neurobiology, pharmacology, and genetic aspects of depression and bipolar disorder in children. These studies include brain imaging (MRI, MRS, fMRI), medication, and psychotherapy trials. She is particularly interested in risk factors for the development of major mood disorders and associated morbidities, and early intervention strategies to delay the onset and progression of symptoms.
Professor of Medicine (Infectious Diseases & Geographic Medicine) and of Microbiology and Immunology
Current Research and Scholarly InterestsOur lab elucidates the molecular basis of pathogenesis of the protozoan parasite Entamoeba histolytica. We use genetic and genomic approaches to identify novel virulence determinants and to characterize the global epidemiology of the parasite.