School of Humanities and Sciences
Showing 21-40 of 58 Results
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Nathan McDonald
Basic Life Science Research Associate, Biology
Current Research and Scholarly InterestsI am interested in the fundamental cell biology of neurons. In particular, I study how neuronal synapses are formed and function. Synapses are specialized intercellular junctions that facilitate rapid communication between neurons, and thus form the basis of neural circuits and nervous system function.
Within a synapse, synaptic vesicles containing neurotransmitters are released at a specific region termed the active zone. The active zone is composed of a variety of molecules that coordinate the tethering and priming of synaptic vesicles, the recruitment of ion channels to respond to action potentials, and the stabilization of the synapse through transmembrane connections to a postsynaptic cell.
A wide range of transmembrane proteins are capable of initiating synapse formation during development and provide specificity for targeting the proper postsynaptic cell, including Neurexins/Neuroligins, LRRTMs, DIPs/DPRs, and many Ig domain proteins. However, in all synapses, these molecules must signal to build a common active zone core. I am studying how the conserved active zone core assembles downstream of this complexity, a fundamental unresolved question in developmental neurobiology.
To study this problem, I use the simple and stereotyped nervous system of the nematode Caenorhabditis elegans. I use fluorescent imaging of endogenous proteins at single neuron and single synapse resolution, as well as genetic and biochemical methods. -
Fiorenza Micheli
David and Lucile Packard Professor of Marine Science, Professor of Oceans, Senior Fellow at the Woods Institute for the Environment and Professor, by courtesy, of Biology
Current Research and Scholarly InterestsDr Fiorenza Micheli is a marine ecologist and conservation biologist conducting research and teaching at the Hopkins Marine Station of Stanford University. Micheli’s research focuses on the processes shaping marine communities and incorporating this understanding in the management and conservation of marine ecosystems. She is a Pew Fellow, a fellow of the California Academy of Science and the Aldo Leopold Leadership Program, and past president of the Western Society of Naturalists.