School of Medicine
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Yiyun Chen
Postdoctoral Scholar, Stanford Cancer Institute
BioYiyun Chen is a computational cancer immunologist whose interdisciplinary training spans structural biology, computational genomics, and cancer immunotherapy. During her doctoral training at HKUST, she developed multi-omic frameworks to decode the molecular landscape of brain tumors, gastric cancer, and B cell lymphoma — including the discovery of a tumor-associated monocyte population in the glioma microenvironment that drives mesenchymal transformation through the FOSL2-EREG/AREG-EGFR signaling axis.
As a postdoctoral fellow in the Crystal Mackall Laboratory at Stanford Cancer Institute, she extended this focus to the co-evolution of glioma and the immune system during CAR T cell therapy, uncovering multiple mechanisms of acquired resistance: anti-CAR humoral and cellular immunity, proinflammatory-to-immunosuppressive phenotypic shifts in macrophages, and tumor antigen escape. Her future research program will build an AI-powered platform that integrates longitudinal single-cell and spatial transcriptomics to model tumor-immune co-evolution in silico — constructing patient-level digital twins that simulate treatment trajectories, predict resistance, and identify real-time monitoring biomarkers. -
Jordan C. Cheng, DMD, PhD
Postdoctoral Scholar, Stanford Cancer Institute
Current Research and Scholarly InterestsMy research direction involves the evalutation of single-stranded library prepartion methods versus conventional double-stranded methods of cell-free DNA for non-invasive cancer profiling applications. The exploration of these technologies allow for the inference of the genomic and epigenetic features of both local and distant cell types associated with a biofluid.
