Institute for Stem Cell Biology and Regenerative Medicine
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Hiromitsu (Hiro) Nakauchi
Professor of Genetics (Stem Cell)
Current Research and Scholarly InterestsTranslation of discoveries in basic research into practical medical applications
Assistant Professor of Biomedical Data Science
Current Research and Scholarly InterestsOur group focuses on building novel data science tools to better understand the cellular and molecular composition of normal and neoplastic tissues. We are using these tools, together with high throughput sequencing, single cell genomics, and experimental techniques, to study the diversity and clinical significance of (i) cancer cell subtypes involved in tumor initiation, maintenance, and metastasis, and (ii) stromal cell subsets in the tumor microenvironment.
Virginia and Daniel K. Ludwig Professor in Cancer Research and the Reed-Hodgson Professor in Human Biology
Current Research and Scholarly InterestsOur laboratory studies Wnt signaling in development and disease. We found recently that Wnt proteins are unusual growth factors, because they are lipid-modified. We discovered that Wnt proteins promote the proliferation of stem cells of various origins. Current work is directed at understanding the function of the lipid on the Wnt, using Wnt proteins as factors the expand stem cells and on understanding Wnt signaling during repair and regeneration after tissue injury.