Pediatrics
Showing 51-60 of 107 Results
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Yunkyeong Lee
Postdoctoral Scholar, Endocrinology and Metabolism
BioYun is a postdoctoral research scholar in the Translational Genomics of Diabetes Laboratory under the mentorship of Dr. Anna Gloyn. Since joining the lab in August 2022, she has been investigating type 2 diabetes (T2D) susceptible genes and their molecular mechanisms in pancreatic β-cell dysfunction and the development of T2D. Her primary focus is on how T2D effector transcripts alter autophagy/mitophagy pathways in human pancreatic β-cells, contributing to β-cell failure, mitochondrial dysfunction, and T2D pathology. She also investigated the impact of genetic mutations underlying neonatal diabetes using CRISPR HDR knockin genome editing in human induced pluripotent stem cell (hiPSC) models and their derivatives.
During her PhD, she explored the role of an epigenetic regulator and its molecular machinery in the pathogenesis of non-alcoholic fatty liver disease (NAFLD), now termed metabolic dysfunction-associated steatotic liver disease (MASLD). In parallel, she studied the interplay between endoplasmic reticulum (ER) stress-mediated unfolded protein response (UPR) signalling and autophagy, and examined how these processes are modulated by bioactive plant extracts in various cellular contexts.
She is particularly interested in exploring inter-organ communication, such as pancreas-liver-heart crosstalk, and how these interactions influence systemic metabolism and contribute to the onset and progression of T2D, along with its complications. Her long-term research goal is to advance our understanding of the cellular and molecular mechanisms driving T2D and to identify novel therapeutic targets and strategies. -
Devin Malloy McCauley
Postdoctoral Scholar, Adolescent Medicine
BioDevin McCauley earned his PhD in Human Development and Family Studies from The Pennsylvania State University in 2021, where his research applied intensive longitudinal methods and time-varying effect modeling to investigate family, school, and peer influences on adolescent mental health and well-being. A second focus of his research applies a developmental framework in study of adolescent e-cigarette use. He is particularly interested in identifying sociodemographic (e.g., race/ethnicity, sexual identity) disparities in risk factors for e-cigarette use. His long-term goal is to inform, develop, and evaluate family and school-based prevention programs which support healthy adolescent development and address health disparities related to e-cigarette use.
