School of Medicine
Showing 21-30 of 44 Results
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QiLiang “Q” Chen
Instructor, Anesthesiology, Perioperative and Pain Medicine
BioQiLiang “Q” Chen, MD, PhD, is a pain management anesthesiologist and system neuroscientist at Stanford University and VA Palo Alto Healthcare System (VAPAHCS). His research focuses on delineating the basic mechanism of chronic pain and characterizing the physiological changes in the descending pain-modulating circuits after head injury and other forms of trauma, a topic especially relevant to Veterans and other chronic post-traumatic pain sufferers. Clinically, his interests include integrating advanced image guidance in pain procedures and exploring novel pharmacological and minimally invasive interventions for chronic post-traumatic pain, complex headaches, and craniofacial pain conditions.
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Lawrence Chu, MD, MS
Professor of Anesthesiology, Perioperative and Pain Medicine
Current Research and Scholarly InterestsI have two lines of research, one involving educational informatics and use of technology in postgraduate medical education and another involving NIH-funded work in patient-oriented clinical research regarding opioid use and physiologic responses associated with acute and chronic exposure in humans.
For a full description of my educational informatics work, please see my website aim.stanford.edu.
My clinical research focuses on the study opiate-induced hyperalgesia in patients suffering from chronic pain.
I am currently conducting an NIH-funded five year double-blinded randomized controlled clinical study (NIGMS award 1K23GM071400-01) that prospectively examines the following hypotheses: 1) pain patients on chronic opioid therapy develop dose-dependent tolerance and/or hyperalgesia to these medications over time, 2) opiate-induced tolerance and hyperalgesia develop differently with respect to various types of pain, 3) opioid-induced hyperalgesia occurs independently of withdrawal phenomena, and 4) opiate-induced tolerance and hyperalgesia develop differently based on gender and/or ethnicity.
The study is the first quantitative and prospective examination of tolerance and hyperalgesia in pain patients and may have important implications for the rational use of opioids in the treatment of chronic pain.
