School of Medicine
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Postdoctoral Research Fellow, Psychiatry
Current Research and Scholarly InterestsI have been venturing the career of characterizing insulin resistance genes, as the underlying risk factor of type 2 diabetes and metabolic syndrome. My earlier postdoctoral fellowship at the Department of Cardiovascular Medicine involved the functional genomic of diabetes and glycemic traits loci by using deep phenotyping approach i.e., multi-OMICs and transgenic mice.
At my current research, I am harnessing the epigenomic analysis in the global birth cohorts. I aim to unravel the origin of insulin resistance in the etiology of diabetes, mild cognitive impairment, and Alzheimer's diseases. Certain ethnicities develop insulin resistance and diabetes even with the normal weight and at younger ages. Therefore, it is essential to distinguish genes that predispose high-risk individuals to insulin resistance in the presence or absence (lipodystrophy) of obesity.
The main plan of my research is to expand follow-up studies on the global birth cohorts from diverse ethnic groups to eventually enable precise screening. This aim is aligned with the missions of Stanford Long-Range Planning and Precision Health to diminish health disparities. Therefore, our research supports the University mission of deep phenotyping and care of diverse patients and populations. These studies have the potential to specify mechanistic and causality insights from the drivers of diabetes and insulin resistance risk in different ethnicities. The ultimate goal of my research is to pave the way for opportunities to prevent insulin resistance as early as 10-20 years before the onset of diabetes and the age-related adverse outcomes such as vascular dementia and to reduce the widening ethnic inequalities.
My overall goal is to promote the field of global precision medicine with an eye toward the minority and under-represented communities in genomic medicine.