School of Medicine


Showing 11-20 of 28 Results

  • Andrew Fire

    Andrew Fire

    George D. Smith Professor of Molecular and Genetic Medicine and Professor of Pathology and of Genetics

    Current Research and Scholarly InterestsWe study natural cellular mechanisms for adapting to genetic change. These include systems activated during normal development and those for detecting and responding to foreign or unwanted genetic activity. Underlying these studies are questions of how a cells can distinguish information as "self" versus "nonself" or "wanted" versus "unwanted".

  • Michael Fischbach

    Michael Fischbach

    Liu (Liao) Family Professor

    Current Research and Scholarly InterestsThe microbiome carries out extraordinary feats of biology: it produces hundreds of molecules, many of which impact host physiology; modulates immune function potently and specifically; self-organizes biogeographically; and exhibits profound stability in the face of perturbations. Our lab studies the mechanisms of microbiome-host interactions. Our approach is based on two technologies we recently developed: a complex (119-member) defined gut community that serves as an analytically manageable but biologically relevant system for experimentation, and new genetic systems for common species from the microbiome. Using these systems, we investigate mechanisms at the community level and the strain level.

    1) Community-level mechanisms. A typical gut microbiome consists of 200-250 bacterial species that span >6 orders of magnitude in relative abundance. As a system, these bacteria carry out extraordinary feats of metabolite consumption and production, elicit a variety of specific immune cell populations, self-organize geographically and metabolically, and exhibit profound resilience against a wide range of perturbations. Yet remarkably little is known about how the community functions as a system. We are exploring this by asking two broad questions: How do groups of organisms work together to influence immune function? What are the mechanisms that govern metabolism and ecology at the 100+ strain scale? Our goal is to learn rules that will enable us to design communities that solve specific therapeutic problems.

    2) Strain-level mechanisms. Even though gut and skin colonists live in communities, individual strains can have an extraordinary impact on host biology. We focus on two broad (and partially overlapping) categories:

    Immune modulation: Can we redirect colonist-specific T cells against an antigen of interest by expressing it on the surface of a bacterium? How do skin colonists induce high levels of Staphylococcus-specific antibodies in mice and humans?

    Abundant microbiome-derived molecules: By constructing single-strain/single-gene knockouts in a complex defined community, we will ask: What are the effects of bacterially produced molecules on host metabolism and immunology? Can the molecular output of low-abundance organisms impact host physiology?

    3) Cell and gene therapy. We have begun two new efforts in mammalian cell and gene therapies. First, we are developing methods that enable cell-type specific delivery of genome editing payloads in vivo. We are especially interested in delivery vehicles that are customizable and easy to manufacture. Second, we have begun a comprehensive genome mining effort with an emphasis on understudied or entirely novel enzyme systems with utility in mammalian genome editing.

  • Paul Graham Fisher, MD

    Paul Graham Fisher, MD

    Beirne Family Professor of Pediatric Neuro-Oncology, Professor of Pediatrics and, by courtesy, of Neurosurgery and of Epidemiology and Population Health
    On Partial Leave from 07/15/2024 To 07/13/2025

    Current Research and Scholarly InterestsClinical neuro-oncology: My research explores the epidemiology, natural history, and disease patterns of brain tumors and other cancers in childhood, as well as prospective clinical trials for treating these neoplasms. Research interests also include neurologic effects of cancer and its therapies.

  • Robert Fisher, MD, PhD

    Robert Fisher, MD, PhD

    The Maslah Saul, MD, Professor and Professor, by courtesy, of Neurosurgery

    Current Research and Scholarly InterestsDr. Fisher is interested in clincal, laboratory and translational aspects of epilepsy research. Prior work has included: electrical deep brain stimulation for epilepsy, studied in laboratory models and clinical trials; drug delivery to a seizure focus; mechanisms of absence epilepsy studied with in vitro slices of brain thalamus; hyperthermic seizures; diagnosis and treatment of non-epileptic seizures, the post-ictal state; driving and epilepsy; new antiepileptic drugs; surgery for epilepsy.

  • Matthew Fitzgerald, PhD

    Matthew Fitzgerald, PhD

    Assistant Professor of Otolaryngology - Head & Neck Surgery (OHNS)

    Current Research and Scholarly InterestsMy research encompasses several translational projects. One focus is to modify the routine audiologic test battery such that it places equal weight on hearing acuity and hearing function. This work includes measures of speech in noise, or electrophysiologic responses such as the FFR. I also explore tools to better assess and maximize performance in users of hearing aids and cochlear implants. Finally, I am also investigating the benefits of telemedicine, and new treatments for tinnitus.

  • Pamela Flood

    Pamela Flood

    Adjunct Clinical Professor, Anesthesiology, Perioperative and Pain Medicine

    BioDr. Flood is a Professor at Stanford University who is fellowship trained in Pain Medicine and Obstetric Anesthesiology. She specializes in the treatment of chronic pelvic pain and multiple aspects of women's health including the prevention of chronic pain after childbirth. Research interests include the role of multimodal treatment in chronic pain conditions and prevention of persistent opioid use. Her research has spanned from detailed pharmacodynamic analysis, clinical trials to population health.

  • Eric Foote

    Eric Foote

    Clinical Assistant Professor, Pediatrics - Neonatal and Developmental Medicine

    BioEric Foote is a pediatric hospitalist with experience conducting clinical and public health research around the world. His research focuses on identifying and intervening on health disparities in low income countries and in low resource settings. Currently, he is developing and evaluating a community health worker-led household phototherapy intervention to extend access to neonatal jaundice care for newborns in rural Bangladesh. He is also working to improve SARS-CoV-2 testing and genomic surveillance across California and worldwide.

  • Michael Frank

    Michael Frank

    Benjamin Scott Crocker Professor of Human Biology and Professor, by courtesy, of Linguistics

    Current Research and Scholarly InterestsHow do we learn to communicate using language? I study children's language learning and how it interacts with their developing understanding of the social world. I use behavioral experiments, computational tools, and novel measurement methods like large-scale web-based studies, eye-tracking, and head-mounted cameras.

  • Jennifer Frankovich

    Jennifer Frankovich

    Clinical Professor, Pediatrics - Rheumatology

    Current Research and Scholarly InterestsMy primary interest and role at Stanford is to evaluate and treat children with both systemic and organ specific autoimmune disease. In October of 2012, we started a multidisciplinary clinic dedicated to treating patients with PANS (Pediatric Acute-onset Neuropsychiatric Syndromes). I am currently the clinical and research director for the PANS program.