School of Medicine
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Muhammad Murtaza Hassan
Postdoctoral Scholar, Chemical and Systems Biology
BioMurtaza is a chemical biologist that joined the Gray Lab in July 2021 as a postdoctoral researcher. He developed his love for medicinal chemistry and chemical biology at the undergraduate level at the University of Toronto Mississauga which then motivated him to pursue an MSc (York University, Supervisor: Prof. Edward Lee-Ruff, 2017) and PhD (University of Toronto Mississauga, Supervisor: Patrick T. Gunning, 2021) in the field. His PhD work involved the development of some of the most potent and selective HDAC8 inhibitors known-to-date. It incorporated inhibitors with L-shaped conformational constraints to compliment the L-shaped HDAC8 pocket. His current work at the Gray Lab revolves around the development of first-in-class covalent inhibitors for recently discovered epigenetic targets that have been shown to synergize with anticancer immunotherapy. Additionally, he is interested in developing small-molecule chemoproteomic tools that can potentially expand our ability to target otherwise undruggable proteins, by using protein-protein interactions for cross-labelling/drugging interacting proteins.
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Cellas Ari'ka Hayes
Postdoctoral Scholar, Epidemiology
BioCellas is currently a postdoctoral fellow/Propel scholar at Stanford University in the Department of Neurology and Neurological Sciences in a laboratory utilizing longitudinal data analysis and neuroimaging modalities to understand the aging brain, neuropathology, cognition, and Alzheimer’s Disease. Postdoctoral experience includes using R, Linux, and Python to perform data preprocessing, multivariate statistical analysis, and applying novel models for longitudinal continuous outcomes. Cellas received his Bachelor’s in Biology (2015-2019) and Doctor of Philosophy in Pharmaceutical Sciences with an emphasis in Pharmacology (2019-2022) from the University of Mississippi. As a doctoral candidate, his research focused on using both in vitro and in vivo approaches to further elucidate how neuroendocrine modulation specifically insulin-like growth factor-1 alters learning and memory performance along with ischemic stroke outcomes. Skills gained during doctoral training included in vitro cell culture, pharmacological experimental design of both in vitro and in vivo studies, development of transgenic mouse models, a wide array of rodent behavioral paradigms, stereotaxic surgery, photothrombosis, and numerous ex vivo cellular, molecular, and microscopy techniques.
My primary interests lie at the intersection of aging, neurodegenerative disease, and using longitudinal epidemiological data sets to investigate hypotheses. All around neuroscientist seeking sci-comm, industry, and academic opportunities to strengthen skills to become an independent investigator.