School of Medicine
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Postdoctoral Scholar, Neurosurgery
Current Research and Scholarly InterestsMyelin is required for rapid nerve signaling by insulating axons to accelerate action potential propagation. Myelin-forming cells of the central nervous system, called oligodendrocytes, orchestrate one of the most complex morphological transformations in neurobiology. Each oligodendrocyte can extend multiple processes that selectively wrap axons in tens to hundreds of spiraling membrane layers, forming myelin sheaths that vary in thickness and length. Furthermore, oligodendrocytes can respond to neural activity by adding new sheaths or by changing the geometry of pre-existing sheaths to tune neural circuitry, a process known as adaptive myelination.
What are the membrane trafficking mechanisms that drive adaptive myelination in oligodendrocytes?
How can these mechanisms be stimulated to promote myelin regeneration in disease?
By using transgenic mouse models and primary oligodendrocytes, we have found that SNARE-mediated exocytosis drives membrane addition in myelin sheaths. Current research is focused on how these pathways in oligodendrocytes may be regulated during adaptive myelination.
Maarten Lansberg, MD, PhD
Professor of Neurology and, by courtesy, of Neurosurgery
Current Research and Scholarly InterestsMy research involves the design and conduct of clinical trials to discover new treatments for patients who have suffered a stroke. These trials span treatment of acute stroke, stroke recovery, and stroke prevention. My research in acute stroke is primarily focused on the use of advanced neuroimaging methods (CT and MRI) to select patients who are most likely to benefit from therapies aimed at restoring blood flow to the brain in patients who have suffered a stroke.
Christine Kyuyoung Lee
Clinical Instructor, Neurosurgery
BioDr. Lee is a Clinical Instructor in the Department of Neurosurgery. After receiving her A.B. in Biology at Harvard College and M.S.E. in Biomedical Engineering at Johns Hopkins University, Dr. Lee obtained her MD and PhD in Neuroscience at Stanford University. Dr. Lee completed neurosurgery residency at Massachusetts General Hospital in Boston with a clinical focus on skull base pathology and research on tumor-neuron interactions. In her fellowship at Stanford, Dr. Lee will be working with Dr. Juan Fernandez-Miranda to obtain specialized surgical training in advanced endoscopic endonasal and open skull base techniques, with the ultimate goal of providing comprehensive treatment to patients with a range of brain tumors, skull base pathology and pituitary lesions.
Jin Hyung Lee
Associate Professor of Neurology, of Neurosurgery and of Bioengineering and, by courtesy, of Electrical Engineering
Current Research and Scholarly InterestsIn vivo visualization and control of neural circuits
Clinical Professor, Anesthesiology, Perioperative and Pain Medicine
Clinical Professor (By courtesy), Neurosurgery
Current Research and Scholarly Interests- Intrathecal / Intraspinal Analgesics
- Ziconotide (Prialt)
- Industry-supported clinical trials
Joshua Levin, MD
Clinical Associate Professor, Orthopaedic Surgery
Clinical Associate Professor, Neurosurgery
BioDr. Levin completed a residency in physical medicine and rehabilitation at the University of Michigan in 2007, and a pain medicine fellowship at the Virginia Commonwealth University in 2008. Currently, he is a member of both the departments of orthopedic surgery and neurosurgery at Stanford University, where he also is the director of the PM&R interventional spine fellowship and the interim director of the PM&R residency program.
Affiliate, Dean's Office Operations - Dean Other
Resident in Neurosurgery
BioSimon was born and raised in and around New York City. He moved to California to attend the University of California, Los Angeles (UCLA) where he obtained undergraduate degrees in both political theory and neuroscience. Simon continued his education at UCLA where he attended the David Geffen School of Medicine. While a medical student he worked under the mentorship of Dr. Carlos Cepeda to investigate the cellular mechanisms underlying pediatric epilepsy. Additionally, under the mentorship of Dr. Ausaf Bari he created an MRI based structural atlas of the human brainstem. Simon is currently undergoing clinical training in neurologic surgery at Stanford University. He is interested in understanding how neural networks function and contribute to disease and how they can aid in developing novel treatment therapies. Outside of medicine, Simon enjoys spending time with his wife, going for hikes with their dog, traveling, listening to audiobooks, and running.
Please see complete publication list on Google scholar profile: https://scholar.google.com/citations?view_op=list_works&hl=en&user=eEX91cwAAAAJ
Gordon Li, MD
Professor of Neurosurgery and, by courtesy, of Neurology and of Otolaryngology - Head & Neck Surgery (OHNS)
Current Research and Scholarly Interests1.) My laboratory studies the biology of brain tumors with the goal of developing novel therapeutics for the treatment of malignant brain tumors and translating that research into clinical trials.
2.) My clinical interests include improving surgical techniques for brain tumor surgery, immunotherapy for the treatment of glioblastoma, and novel uses for stereotactic radiosurgery.
Michael Lim, M.D.
Professor of Neurosurgery and, by courtesy, of Radiation Oncology (Radiation Therapy), of Medicine (Oncology), of Otolaryngology - Head & Neck Surgery (OHNS) and of Neurology
BioDr. Lim is the Chair of the Department of Neurosurgery and a board-certified neurosurgeon specializing in brain tumors and trigeminal neuralgia.
Dr. Lim’s clinical interests include the treatment of benign and malignant brain tumors, with special interest in gliomas, meningiomas, metastatic tumors, and skull base tumors. Dr. Lim also specializes in surgical treatments for trigeminal neuralgia. During his time at Johns Hopkins, Dr. Lim built one of the largest brain tumor and trigeminal neuralgia practices and utilized the most advanced surgical technologies and techniques for his patients. As a passionate voice for patient experience, he has been recognized by his peers and patients for his integrity and compassionate care, including a Service Excellence Award from HealthNetwork Foundation.
As a mentor, he has garnered numerous teaching awards, including being honored as an outstanding teacher by Johns Hopkins University School of Medicine. He is actively involved in shaping education for neurosurgery and oncology across the United States and around the world.
Dr. Lim’s research interests focus on harnessing the immune system to fight cancer. His laboratory focuses on understanding mechanisms of immune evasion by cancer cells. He has successfully translated his findings from the laboratory to the clinics and has conducted and led several large national immunotherapy clinical trials for brain tumors.
Dr. Lim’s bibliography contains well over 200 articles on topics such as immunotherapy for glioblastoma, long-term survival of glioma patients treated with stereotactic radiation, and treatment of neuropathic pain. His work has appeared in Science Translational Medicine, Clinical Cancer Research, Lancet Oncology, Nature Immunology, and many more publications. He also has written 20 book chapters and monographs.
Dr. Lim is a world leader in immunotherapy for brain tumors. In addition to being invited world-wide to give lectures and seminars, he has given platform presentations on the topics of immunotherapy for brain tumors, neurosurgical techniques and management of brain tumors at the American Society of Clinical Oncologists, American Academy of Neurological Surgeons, Radiological Society of North America, Annual Symposium on Brain and Spine Metastases, Congress of Neurological Surgeons, and other meetings. In addition, he has served as platform chairman of the CNS session at the American Society for Clinical Oncology conference.
Dr. Lim is a member of the American Society for Clinical Oncology, Congress of Neurological Surgeons, American Association of Neurological Surgeons, and Society for Neuro-Oncology. Dr. Lim served as the program co-chair of the Society for Neuro-Oncology and CNS section of the American Society for Clinical Oncology. He also served on many executive committees, including the Executive Committee for the Joint Tumor Section of the American Association of Neurological Surgeons and Congress of Neurological Surgeons.
Frank M. Longo, MD, PhD
George E. and Lucy Becker Professor of Medicine and Professor, by courtesy, of Neurosurgery
Current Research and Scholarly InterestsClinical interests include Alzheimer's disease and Huntington's disease and the development of effective therapeutics for these disorders. Laboratory interests encompass the elucidation of signaling mechanisms relevant to neurodegenerative disorders and the development of novel small molecule approaches for the treatment of neurodegenerative and other neurological disorders.
Jaime Lopez, MD
Professor of Neurology and, by courtesy, of Neurosurgery
Current Research and Scholarly InterestsMy clinical interests are in the areas of Intraoperative Neurophysiologic Monitoring (IOM), clinical neurophysiology, electromyopgraphy and in the use of botulinum toxins in the treatment of neurologic disorders. Our IOM groups research is in the development of new and innovative techniques for monitoring the nervous system during surgical and endovascular procedures and how these alter surgical management and patient outcomes. I am also active in formulating national IOM practice guidelines.
Irene L. Llorente
Assistant Professor of Neurosurgery
BioOriginally from Spain, Irene L. Llorente joined the Neurosurgery Department at Stanford University in 2022. Following her undergraduate degree in Molecular Biology at the University of Leon in Spain, Dr. Llorente completed a MS in Molecular Biology and Biomedicine and a Ph.D. in Neuroscience between the Universities of Leon (Spain) and Florence (Italy). She conducted a postdoctoral fellowship in the Neurology Department at the David Geffen School of Medicine at UCLA where she also started her independent career as a Research Assistant Professor. Her research interests are largely directed toward understanding the biology of white matter repair in central nervous system (CNS) disorders, with a special emphasis on human glial biology. She is particularly interested in leveraging the current technologies emerging in the stem cell field to develop more efficient and effective stem cell-based therapies for stroke and vascular dementia patients. These stem cell-based therapies will also apply to other CNS disorders including spinal cord injury, multiple sclerosis, and traumatic brain injury in the future.
Angela K. Lumba-Brown
Clinical Associate Professor, Emergency Medicine
Clinical Associate Professor (By courtesy), Neurosurgery
Clinical Associate Professor, Pediatrics
Current Research and Scholarly InterestsCurrent research includes evidence-based guidelines for the management and treatment of traumatic brain injury, research establishing an evidence and targeting treatments for the subtypes of concussion, research identifying the best outcomes in pre-hospital care of patients with traumatic brain injury, research on brain performance via sensorimotor and sensory-cognitive synchronization, and research on dynamic visual synchronization as a biomarker for attentional impairments.
BioDr. Lyu is an instructor at the Department of Neurosurgery, Stanford University School of Medicine. He obtained his PhD at Soochow University, China, where he gained training in designing biomaterials to modulate stem cell behaviors and led multidisciplinary research under the advice of Prof. Hong Chen. During his PhD, he worked as a visiting student researcher at Canary Center for Early Cancer Detection at Stanford University School of Medicine where he gained training in microfluidics and cancer metastasis. Dr. Lyu carried out his postdoctoral research under the guidance of Prof. Jon Park and Wonjae Lee at the Department of Neurosurgery, Stanford University School of Medicine. He developed an in vitro microphysiological model of ischaemic stroke and used it as a platform to systematically evaluate the restorative potential of stem cell therapy.
As an instructor, Dr. Lyu's main research interest is to develop in vitro tissue/organ models to mimic human diseases including neurological diseases and cancer metastases. The goal is to use these models to evaluate the safety and efficacy of existing drugs and to look for new therapeutic targets.