School of Medicine
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Mrs. George A. Winzer Professor in Cell Biology
Current Research and Scholarly InterestsCELLULAR INFORMATION PROCESSING. We are using live single-cell microscopy approaches to understand the design principles of cell signaling circuits. Mammalian signaling processes have a unique logic due to the large number of signaling proteins, second messengers and chromatin modifiers involved in each decision process. We are particularly interested in understanding how cells make decisions to enter and exit the cell cycle and how they decide to polarize and move.
Beverly S. Mitchell, M.D.
George E. Becker Professor of Medicine and Professor, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly InterestsBeverly Mitchell's research relates to the development of new therapies for hematologic malignancies, including leukemias and myelodsyplastic syndromes. She is interested in preclinical proof of principle studies on mechanisms inducing cell death and on metabolic targets involving nucleic acid biosynthesis in malignant cells. She is also interested in the translation of these studies into clinical trials.
George D. Smith Professor of Translational Medicine
Current Research and Scholarly InterestsTwo areas: 1. Using rationally-designed peptide inhibitors to study protein-protein interactions in cell signaling. Focus: protein kinase C in heart and large GTPases regulating mitochondrial dynamics in neurodegdenration. 2. Using small molecules (identified in a high throughput screens and synthetic chemistry) as activators and inhibitors of aldehyde dehydrogenases, a family of detoxifying enzymes, and glucose-6-phoshate dehydrogenase, in normal cells and in models of human diseases.