School of Medicine


Showing 11-20 of 43 Results

  • Josef Parvizi, MD, PhD

    Josef Parvizi, MD, PhD

    Professor of Neurology (Adult Neurology) and, by courtesy, of Neurosurgery

    BioDr. Parvizi completed his medical internship at Mayo Clinic, neurology training at Harvard, and subspecialty training in clinical neurophysiology and epilepsy at UCLA before joining the Department of Neurology and Neurological Sciences at Stanford in 2007. Dr. Parvizi directs the Stanford Program for Medication Resistant Epilepsies and specializes in surgical treatments of intractable focal epilepsies. Dr. Parvizi is the principal investigator in the Laboratory of Behavioral and Cognitive Neuroscience, where he leads a team of investigators to study the human brain. http://med.stanford.edu/parvizi-lab.html.

  • Anca M. Pasca, MD

    Anca M. Pasca, MD

    Assistant Professor of Pediatrics

    Current Research and Scholarly InterestsThe research focus of the lab is to understand molecular mechanisms underlying neurodevelopmental disorders associated with premature birth, neonatal and fetal brain injury with the long-term goal of translating the lab’s findings into therapeutics. The research team employs a multidisciplinary approach involving genetics, molecular and developmental neurobiology, animal models and neural cells differentiated from patient-derived induced pluripotent stem (iPS) cells. In particular, the lab is using a powerful 3D human brain-region specific organoid system developed at Stanford (Nature Methods, 2015; Nature Protocols, 2018) to ask questions about brain injury during development.

    https://www.neopascalab.org/

  • Sergiu P. Pasca

    Sergiu P. Pasca

    Kenneth T. Norris, Jr. Professor of Psychiatry and Behavioral Sciences and Bonnie Uytengsu and Family Director of the Stanford Brain Organogenesis Program

    Current Research and Scholarly InterestsA critical challenge in understanding the intricate programs underlying development, assembly and dysfunction of the human brain is the lack of direct access to intact, functioning human brain tissue for detailed investigation by imaging, recording, and stimulation.
    To address this, we are developing bottom-up approaches to generate and assemble, from multi-cellular components, human neural circuits in vitro and in vivo.
    We introduced the use of instructive signals for deriving from human pluripotent stem cells self-organizing 3D cellular structures named brain region-specific spheroids/organoids. We demonstrated that these cultures, such as the ones resembling the cerebral cortex, can be reliably derived across many lines and experiments, contain synaptically connected neurons and non-reactive astrocytes, and can be used to gain mechanistic insights into genetic and environmental brain disorders. Moreover, when maintained as long-term cultures, they recapitulate an intrinsic program of maturation that progresses towards postnatal stages.
    We also pioneered a modular system to integrate 3D brain region-specific organoids and study human neuronal migration and neural circuit formation in functional preparations that we named assembloids. We have actively applied these models in combination with studies in long-term ex vivo brain preparations to acquire a deeper understanding of human physiology, evolution and disease mechanisms.
    We have carved a unique research program that combines rigorous in vivo and in vitro neuroscience, stem cell and molecular biology approaches to construct and deconstruct previously inaccessible stages of human brain development and function in health and disease.
    We believe science is a community effort, and accordingly, we have been advancing the field by broadly and openly sharing our technologies with numerous laboratories around the world and organizing the primary research conference and the training courses in the area of cellular models of the human brain.

  • Anisha I Patel

    Anisha I Patel

    Professor of Pediatrics (General Pediatrics) and, by courtesy, of Epidemiology and Population Health

    Current Research and Scholarly InterestsDr. Patel's research interests focus on reducing socioeconomic disparities in chronic diseases, including childhood obesity. Over the past 10 years, Dr. Patel has led numerous studies to encourage healthy beverage intake among children and adolescents. These studies include analyses of large national data sets, conduct of randomized controlled trials in schools, child care, and community settings to examine how interventions to increase children’s intake of water instead of sugar-sweetened beverages impact child health, and the evaluation of policy efforts to improve the healthfulness of beverages offered in schools and community settings.

    Dr. Patel has a diverse funding portfolio ranging from the Robert Wood Johnson Foundation Healthy Eating Research Program, the W.K. Kellogg Foundation, and the National Institutes of Health. Dr. Patel has presented her research to local, national and international audiences. She has also been recognized for her research with awards from the American Academy of Pediatrics and the University of North Carolina, Chapel Hill School of Public Health.

  • Lisa Patel

    Lisa Patel

    Clinical Associate Professor, Pediatrics

    BioLisa Patel received her undergraduate degree in Biological Sciences from Stanford University. After college, she worked in Egypt, Brazil, and India on international development projects with community-based organizations and non-profits, focusing on conservation and development efforts. She then obtained her Master's in Environmental Sciences from the Yale School of the Environment and went on to be a Presidential Management Fellow for the Environmental Protection Agency, coordinating the US Government's efforts on clean air and safe drinking water projects in South Asia in collaboration with the World Health Organization. Realizing the critical and inextricable links between children's health and environmental issues, she obtained her medical degree from Johns Hopkins University and completed her residency in pediatrics at UCSF. For the last several years, she has used her extensive experience working for government, community organizations, and non-profits to advocate for children's health priorities in the US. She is previously the co-chair for the American Academy of Pediatrics Advocacy Committee, California Chapter 1 (AAP-CA1) and in her time helped launch the inaugural Advocating for Children Together conference for Northern California that is now a yearly occurrence. She co-founded the Climate and Health task force for AAP-CA1, and sits on the Executive Committee for the AAP's national Council on Environmental Health and Climate Change. She is formerly the rotation director for the pediatric resident's Community Pediatrics and Child Advocacy Rotation. She is currently the Executive Director for the Medical Society Consortium on Climate and Health and maintains a clinical practice as a pediatric hospitalist caring for newborns, premature infants, and children requiring hospitalization. She also sits on the Board of Our Children's Trust, the legal organization that represented youth in Held v. Montana.

    Her work has appeared in the New England Journal of Medicine, the New York Times, the LA Times, Bloomberg News, and multiple state and local outlets. She is interviewed regularly for her expertise on climate, health, and equity for major national media outlets like the Washington Post, US News and World Report, CNN, among others.

  • Meghna Patel

    Meghna Patel

    Clinical Assistant Professor, Pediatrics - Cardiology

    Current Research and Scholarly InterestsMy current academic focus is in chronic heart failure and ventricular assist device.

  • Francis Pearman

    Francis Pearman

    Assistant Professor of Education

    BioFrancis A. Pearman is an Assistant Professor of Education in the Graduate School of Education at Stanford University. His research focuses on how poverty and inequality shape the life chances of children, especially in rapidly changing cities. Pearman holds a Ph.D. and M.Ed. from Vanderbilt University and a B.S. from the University of Virginia.

  • Gary Peltz

    Gary Peltz

    Professor of Anesthesiology, Perioperative and Pain Medicine

    Current Research and Scholarly InterestsThe laboratory develops and uses state of the art genomic methods to identify genetic factors affecting disease susceptibility, and to translate these findings into new treatments. We have developed a more efficient method for performing mouse genetic analysis, which has been used to analyze the genetic basis for 16 different biomedical traits. We are developing novel methods, and have developed a novel experimental platform that replaces mouse liver with functioning human liver tissue.

  • Jon-Paul Pepper, MD

    Jon-Paul Pepper, MD

    Associate Professor of Otolaryngology - Head & Neck Surgery (OHNS)

    Current Research and Scholarly InterestsFacial paralysis is a debilitating condition that affects thousands of people. Despite excellent surgical technique, we are currently limited by the regenerative capacity of the body. The mission of our research is to identify new treatments that improve current facial paralysis treatments. We do this by exploring the regenerative cues that the body uses to restore tissue after nerve injury, in particular through pathways of neurogenesis and nerve repair in small mammals.