School of Medicine
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Nazish Sayed MD, PhD
Assistant Professor (Research) of Surgery (Vascular Surgery) and at the Stanford Cardiovascular Institute
Current Research and Scholarly InterestsThe Sayed Laboratory is focused on the development of novel technologies that drive innovation in regenerative medicine, disease modeling, and drug testing in vascular biology. The lab conducts translational research in vascular biology and aims to understand the role of the vasculature in the development of cardiac diseases, including those due to inherited genetic variants or environmental insults such as type 2 diabetes or hypertension. The lab employs the human induced pluripotent stem cell (iPSC) technology to generate patient-specific vascular cells (endothelial and vascular smooth muscle cells) as an alternative to animal models providing a human tissue surrogate for research that is scalable and sustainable. By employing this unique platform, the lab also investigates the role of chemotherapeutic agents (anti-cancer drugs) on the vasculature. Dr. Sayed’s lab has also established an endothelial regeneration program, where they leverage the innate immune system to regenerate endothelial cells from human fibroblasts.
Work from the lab has led to seminal discoveries in the areas of 1) Nitric oxide (NO) biology, (2) vascular biology, (3) stem cell biology, (4) cardiovascular disease modeling (5) cardio-oncology.
Clinical Associate Professor, Surgery - Vascular Surgery
BioDr. Stern earned his medical degree at The Ohio State University College of Medicine in 2008. He completed his general surgery residency at The University of Chicago in 2015, which included a two-year research fellowship in Translational Systems Biology. He then completed his vascular and endovascular surgery fellowship at New York-Presbyterian Hospital, Columbia University Medical Center/Weill Cornell Medicine, in 2017. Dr. Stern is board certified in both general surgery and vascular surgery.
Dr. Stern joined Stanford Vascular Surgery in 2017 as a Clinical Assistant Professor of Surgery. His primary practice is at Stanford Health Care.
Dr. Stern’s clinical and academic interests are in the treatment of aortic disease. He is involved in the development of novel treatment strategies for complex aortic pathologies, and serves as principal investigator on several clinical trials. He is also involved in clinical research, examining contemporary practice patterns and outcomes from endovascular and open surgical interventions.