School of Medicine
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Professor of Medicine (Gastroenterology and Hepatology) at the Stanford University Medical Center
Current Research and Scholarly InterestsMy laboratory has been focusing on the mechanism of liver fibrogenesis and the role of hepatocyte cell death in fibrogenic injury. We have demonstrated the intricate link between hepatocyte cell death, generation of apoptotic bodies and their phagocytosis by stellate cells triggering fibrogenic activation. Key to this was the activation of the NADPH oxidase and production of reactive oxidative species inducing stellate cell transdifferentiation and collagen I transcription (Gastroenterology, 2010).
We have expanded our work focusing on the role of non-phagocytic NADPH oxidases including NOX4 in dysregulating insulin responses and precipitating stress signaling in non-alcoholic steatohepatitis. (Gastroenterology, 2015). As patients with type II diabetes mellitus develop more progressive liver disease we are now studying how advanced glycation end products (AGEs) engage RAGE signaling in the liver and NADPH oxidase-mediated redox stress.
Our ultimate goal is to translate our findings and develop novel therapeutic approaches that reverse fibrosis in NASH and improve patient outcomes.
Clinical Professor, Medicine - Gastroenterology & Hepatology
Current Research and Scholarly InterestsMy primary research interest concerns factors involved in the pathogenesis of gastro-esophageal reflux disease and its complications, such as Barrett's esophagus and the role of diagnostic and therapeutic modalities in their management.