School of Medicine
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Alison Schroer Vander Roest
Instructor, Pediatrics - Cardiology
BioMy research interests are in the field of cardiac mechanobiology, seeking to understand how the mechanical environment in the heart influences cell behavior and cardiac function throughout pediatric development and disease. I completed my PhD at Vanderbilt working with Dave Merryman focusing on fibroblast activation and inflammatory cell recruitment after myocardial infarction. I was excited for the opportunity to pursue postdoctoral training at Stanford, initially under the mentorship of Dr. Beth Pruitt in mechanical and bioengineering and Dr. Jim Spudich in biochemistry. My postdoctoral project has focused on the effect of myosin mutations which cause hypertrophic cardiomyopathy (HCM) using human induced pluripotent stem cell (hiPSC) derived cardiomyocytes. I have learned techniques for hydrogel micropatterning and quantification of cellular scale forces through traction force and FRET microscopy. I have also participated in many exciting collaborations across Stanford (with Dr. Alex Dunn and Dr. Sean Wu), as well as collaborators at different institutions. My background in biomedical engineering has informed my quantitative and systems-based approach to biological questions, and my current appointment in the medical school working with Dr. Dan Bernstein has provided me with the opportunity to learn more about the realities of clinical care in pediatric cardiology.