School of Medicine


Showing 11-20 of 25 Results

  • Chad S. Weldy, M.D., Ph.D.

    Chad S. Weldy, M.D., Ph.D.

    Instructor, Medicine - Cardiovascular Medicine

    Current Research and Scholarly InterestsAs a physician-scientist in the lab of Dr. Quertermous I work to understand the genetic basis of cardiovascular disease and the transcriptional and epigenomic mechanisms of atherosclerosis. My work is focused across four main areas of cardiovascular genetics and mechanisms of coronary artery disease and smooth muscle biology:
    1.Vascular smooth muscle specific ADAR1 mediated RNA editing of double stranded RNA and activation of the double stranded RNA receptor MDA5
    2.Defining on single cell resolution the cellular and epigenomic features of human vascular disease across vascular beds of differing embryonic origin
    3.CRISPRi screening with targeted perturb seq (TAPseq) to identify novel CAD genes in human coronary artery smooth muscle cells
    4.Investigation of the epigenetic and molecular basis of coronary artery disease and smooth muscle cell transition in mice with conditional smooth muscle genetic deletion of CAD genes Pdgfd and Sox9

    My work with Dr. Quertermous is focused on discovery of causal mechanisms of disease through leveraging human genetics with sophisticated molecular biology, single cell sequencing technologies, and mouse models of disease. This work attempts to apply multiple scientific research arms to ultimately lead to novel understandings of vascular disease and discover important new therapeutic approaches for drug discovery.

    Grant funding received for this work:

    Mentored Clinical Scientist Research Career Development Award (K08)(NIH/NHLBI, 1 K08 HL167699-01), Submitted June, 2022. PI: Weldy, Chad
    •Title of proposal: “ADAR Mediated RNA editing is a causal mechanism in coronary artery disease”.
    •Pending 08/01/2023 Start date
    •$850,000 over 5 years

    Career Development Award, American Heart Association (AHA CDA)(23CDA1042900), July, 2023 – June, 2026. PI: Weldy, Chad
    •Title of proposal: “Linking RNA editing to coronary artery calcification and disease”
    •Activation on 07/01/2023
    •$231,000 over three years

    NIH Loan Repayment Program (LRP) Award (NIH/NHLBI) Renewal Award, July, 2023. PI: Weldy, Chad
    •Title of proposal: “RNA editing is a causal mechanism of coronary artery disease”

    Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (F32) (NIH/NHLBI, 1 F32 HL160067-01), July, 2021. PI: Weldy, Chad
    • Titled, “A transcriptional network which governs smooth muscle transition is mediated by causal coronary artery disease gene PDGFD”
    •*Received perfect score with impact score 10, 1st percentile

    NIH Loan Repayment Program (LRP) Award (NIH/NHLBI), July, 2021. PI: Weldy, Chad
    •Title of proposal: "Single cell transcriptomic and epigenomic features of human atherosclerosis".
    •This will award up to $100,000 towards student loans over the next 24 months with opportunity for renewal after 24 months.

  • Marius Wernig

    Marius Wernig

    Professor of Pathology and, by courtesy, of Chemical and Systems Biology

    Current Research and Scholarly InterestsEpigenetic Reprogramming, Direct conversion of fibroblasts into neurons, Pluripotent Stem Cells, Neural Differentiation: implications in development and regenerative medicine

  • Cornelia Weyand

    Cornelia Weyand

    Professor of Medicine (Immunology and Rheumatology), Emerita

    Current Research and Scholarly InterestsAutoimmunity
    Chronic inflammatory disease
    Metabolic control of immune function

  • Matthew Wheeler

    Matthew Wheeler

    Associate Professor of Medicine (Cardiovascular Medicine)

    Current Research and Scholarly InterestsTranslational research in rare and undiagnosed diseases. Basic and clinical research in cardiomyopathy genetics, mechanisms, screening, and treatment. Investigating novel agents for treatment of hypertrophic cardiomyopathy and new mechanisms in heart failure. Cardiovascular screening and genetics in competitive athletes, disease gene discovery in cardiomyopathy and rare disease. Informatics approaches to rare disease and multiomics. Molecular transducers of physical activity bioinformatics.

  • Jeffrey J. Wine

    Jeffrey J. Wine

    Benjamin Scott Crocker Professor of Human Biology, Emeritus

    Current Research and Scholarly InterestsThe goal is to understand how a defective ion channel leads to the human genetic disease cystic fibrosis. Studies of ion channels and ion transport involved in gland fluid transport. Methods include SSCP mutation detection and DNA sequencing, protein analysis, patch-clamp recording, ion-selective microelectrodes, electrophysiological analyses of transmembrane ion flows, isotopic metho

  • Virginia D. Winn, MD, PhD

    Virginia D. Winn, MD, PhD

    Associate Professor of Obstetrics and Gynecology (Reproductive and Stem Cell Biology)

    Current Research and Scholarly InterestsThe Winn Laboratory seeks to understand the unique biological mechanisms of human placentation. While the placenta itself is one of the key characteristics for defining mammals, the human placenta is different from most available animal models: it is one of the most invasive placentas, and results in the formation of an organ comprised of cells from both the fetus and the mother. In addition to this fascinating chimerism, fetal cells are deeply involved in the remodeling of the maternal vasculature in order to redirect large volumes of maternal blood to the placenta to support the developing fetus. As such, the investigation of this human organ covers a large array of biological processes, and deals not only with understanding its endocrine function, but the physiologic process of immune tolerance, vascular remodeling, and cellular invasion.

  • Paul H. Wise, MD, MPH

    Paul H. Wise, MD, MPH

    Richard E. Behrman, MD, Professor of Child Health and Society, Professor of Health Policy and Senior Fellow at the Freeman Spogli Institute for International Studies
    On Leave from 02/01/2024 To 12/20/2024

    Current Research and Scholarly InterestsHe is a health policy and outcomes researcher whose work has focused on children's health; health-outcomes disparities by race, ethnicity and socioeconomic status; the interaction of genetics and the environment as these factors influence child and maternal health; and the impact of medical technology on disparities in health outcomes.

  • Ronald Witteles

    Ronald Witteles

    Professor of Medicine (Cardiovascular Medicine)

    Current Research and Scholarly Interests1) Amyloidosis -- Optimizing diagnosis/therapy and discovering new treatments
    2) CardioOncology -- Understanding, treating, and preventing cancer therapy-induced cardiotoxicity
    3) Sarcoidosis -- Exploring novel diagnostic modalities and determining optimal treatment, with a focus on cardiac sarcoidosis

  • Wing Hung Wong

    Wing Hung Wong

    Stephen R. Pierce Family Goldman Sachs Professor of Science and Human Health and Professor of Biomedical Data Science

    Current Research and Scholarly InterestsCurrent interest centers on the application of statistics to biology and medicine. We are particularly interested in questions concerning gene regulation, genome interpretation and their applications to precision medicine.