School of Medicine
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Oliver O. Aalami, MD
Clinical Professor, Surgery - Vascular Surgery
Current Research and Scholarly InterestsWe launched a national precision medicine PAD trial called, VascTrac (http://vasctrac.stanford.edu/). This trial is mobile phone based and leverages Apple's ResearchKit Platform to monitor a patient's activity both pre- and post-intervention. We are validating mobile phone surveillance for PAD patients and are currently enrolling.
Oscar J. Abilez
Senior Scientist, Cardiothoracic Surgery - Pediatric Cardiac Surgery
Current Research and Scholarly InterestsDr. Abilez' interests are aimed at elucidating how various biophysical and biochemical perturbations regulate early cardiovascular development across time and length scales that span several orders of magnitude, using human pluripotent stem cells as a model system.
Kevin M. Alexander, MD, FACC, FHFSA
Assistant Professor of Medicine (Cardiovascular Medicine) at the Stanford University Medical Center
BioDr. Alexander is an advanced heart failure-trained cardiologist. He is also an Assistant Professor of Cardiovascular Medicine at Stanford University School of Medicine.
Dr. Alexander specializes in the management of advanced heart failure and transplant cases, seeing a wide range of patients. He also has an active research laboratory, studying various forms of heart failure.
Dr. Alexander has expertise in diagnosing and treating transthyretin cardiac amyloidosis, a critical yet underdiagnosed cause of heart failure among African Americans and the elderly. He is conducting extensive research to enhance our understanding of this condition, with grant support from the National Institutes of Health and American Heart Association, among other sources.
Russ B. Altman
Kenneth Fong Professor and Professor of Bioengineering, of Genetics, of Medicine, of Biomedical Data Science, Senior Fellow at the Stanford Institute for HAI and Professor, by courtesy, of Computer Science
Current Research and Scholarly InterestsI refer you to my web page for detailed list of interests, projects and publications. In addition to pressing the link here, you can search "Russ Altman" on http://www.google.com/
Cristina Maria Alvira
Associate Professor of Pediatrics (Critical Care)
Current Research and Scholarly InterestsThe overall objective of the Alvira Laboratory is to elucidate the mechanisms that promote postnatal lung development and repair, by focusing on three main scientific goals: (i) identification of the signaling pathways that direct the transition between the saccular and alveolar stages of lung development; (ii) exploration of the interplay between postnatal vascular and alveolar development; and (iii) determination of developmentally regulated pathways that mediate lung repair after injury.
Professor of Neurology
Current Research and Scholarly InterestsOur research focuses on understanding how immune responses initiate and accelerate synaptic and neuronal injury in age-related neurodegeneration, including models of Alzheimer's disease and Parkinson's disease. We also focus on the role of immune responses in aggravating brain injury in models of stroke. Our goal is the identification of critical immune pathways that function in neurologic disorders and that can be targeted to elicit disease modifying effects.
Lay Teng Ang
Instructor, Institute for Stem Cell Biology and Regenerative Medicine
BioAs a stem cell biologist, I aim to understand the mechanisms through which stem cells differentiate into progressively specialized cell types and to harness this knowledge to artificially generate pure populations of desired cell types from stem cells. My work over the past ten years has centered on pluripotent stem cells (PSCs, which include embryonic and pluripotent stem cells), which can generate any of the hundreds of diverse cell types in the body. However, it has been notoriously challenging to guide PSCs to differentiate into a pure population of a given cell type. Current differentiation strategies typically generate heterogeneous cell populations unsuitable for basic research or clinical applications. To address this challenge, I mapped the cascade of branching lineage choices through which PSCs differentiate into various endodermal and mesodermal cell types. I then developed effective methods to differentiate PSCs into specific lineages by providing the extracellular signal(s) that specify a given lineage while inhibiting the signals that induce the alternate fate(s), enabling the generation of highly-pure human heart and bone (Loh & Chen et al., 2016; Cell) and liver (Loh & Ang et al., 2014; Cell Stem Cell) from PSCs. My laboratory currently focuses on differentiating human PSCs into liver progenitors (Ang et al., 2018; Cell Reports) and blood vessel cells (Ang et al., 2022; Cell).
I earned my Ph.D. jointly from the University of Cambridge and A*STAR and was subsequently appointed as a Research Fellow and, later, a Senior Research Fellow at the Genome Institute of Singapore. I then moved my laboratory to Stanford University as a Siebel Investigator and Instructor at the Stanford Institute for Stem Cell Biology & Regenerative Medicine. My laboratory has been supported by the Siebel Investigatorship, California Institute for Regenerative Medicine, and other sources.
Timothy Angelotti MD, PhD
Clinical Associate Professor, Anesthesiology, Perioperative and Pain Medicine
Current Research and Scholarly InterestsMy research efforts are focused on investigating the pharmacological and physiological interface of the autonomic nervous system with effector organs. Utilizing molecular, cellular, and electrophysiological techniques, we are examining alpha2 adrenergic receptor function in cultured sympathetic neurons. Future research aims will be directed toward understanding neurotransmitter release in general.
Martin S. Angst
Professor of Anesthesiology, Perioperative and Pain Medicine
Current Research and Scholarly InterestsOur laboratory's current transformative research efforts focus on studying immune health in the context of surgery and anesthesia.
Justin P. Annes M.D., Ph.D.
Associate Professor of Medicine (Endocrinology)
Current Research and Scholarly InterestsThe ANNES LABORATORY of Molecular Endocrinology: Leveraging Chemical Biology to Treat Endocrine Disorders
The prevalence of diabetes is increasing at a staggering rate. By the year 2050 an astounding 25% of Americans will be diabetic. The goal of my research is to uncover therapeutic strategies to stymie the ensuing diabetes epidemic. To achieve this goal we have developed a variety of innovate experimental approaches to uncover novel approaches to curing diabetes.
(1) Beta-Cell Regeneration: Diabetes results from either an absolute or relative deficiency in insulin production. Our therapeutic strategy is to stimulate the regeneration of insulin-producing beta-cells to enhance an individual’s insulin secretion capacity. We have developed a unique high-throughput chemical screening platform which we use to identify small molecules that promote beta-cell growth. This work has led to the identification of key molecular pathways (therapeutic targets) and candidate drugs that promote the growth and regeneration of islet beta-cells. Our goal is to utilize these discoveries to treat and prevent diabetes.
(2) The Metabolic Syndrome: A major cause of the diabetes epidemic is the rise in obesity which leads to a cluster of diabetes- and cardiovascular disease-related metabolic abnormalities that shorten life expectancy. These physiologic aberrations are collectively termed the Metabolic Syndrome (MS). My laboratory has developed an original in vivo screening platform t to identify novel hormones that influence the behaviors (excess caloric consumption, deficient exercise and disrupted sleep-wake cycles) and the metabolic abnormalities caused by obesity. We aim to manipulate these hormone levels to prevent the development and detrimental consequences of the MS.
HEREDIATY PARAGAGLIOMA SYNDROME
The Hereditary Paraganglioma Syndrome (hPGL) is a rare genetic cancer syndrome that is most commonly caused by a defect in mitochondrial metabolism. Our goal is to understand how altered cellular metabolism leads to the development of cancer. Although hPGL is uncommon, it serves as an excellent model for the abnormal metabolic behavior displayed by nearly all cancers. Our goal is to develop novel therapeutic strategies that target the abnormal behavior of cancer cells. In the laboratory we have developed hPGL mouse models and use high throughput chemical screening to identify the therapeutic susceptibilities that result from the abnormal metabolic behavior of cancer cells.
As a physician scientist trained in clinical genetics I have developed expertise in hereditary endocrine disorders and devoted my efforts to treating families affected by the hPGL syndrome. By leveraging our laboratory expertise in the hPGL syndrome, our care for individuals who have inherited the hPGL syndrome is at the forefront of medicine. Our goal is to translate our laboratory discoveries to the treatment of affected families.
Associate Professor of Materials Science and Engineering, Senior Fellow at the Woods Institute for the Environment and Associate Professor, by courtesy, of Pediatrics (Endocrinology)
Current Research and Scholarly InterestsThe underlying theme of the Appel Lab at Stanford University integrates concepts and approaches from supramolecular chemistry, natural/synthetic materials, and biology. We aim to develop supramolecular biomaterials that exploit a diverse design toolbox and take advantage of the beautiful synergism between physical properties, aesthetics, and low energy consumption typical of natural systems. Our vision is to use these materials to solve fundamental biological questions and to engineer advanced healthcare solutions.
Associate Professor of Electrical Engineering
Current Research and Scholarly InterestsMy group's research covers RF circuits and system design for (1) biomedical, (2) sensing, and (3) Internet of Things (IoT) applications.
Professor of Surgery (Vascular Surgery)
BioShipra Arya, MD SM FACS is a Professor of Surgery at the Stanford University School of Medicine and section chief of vascular surgery at VA Palo Alto Healthcare System. She has a Master’s degree in epidemiology from the Harvard School of Public Health with focus on research methodology and cardiovascular epidemiology. She completed her General Surgery Residency at Creighton University Medical Center followed by a Vascular Surgery Fellowship at University of Michigan. She has been funded by American Heart Association (AHA), NIH/NIA GEMSSTAR grant, VA Palo Alto Center for Innovation and Implementation (Ci2i), and is currently funded by VA HSR&D for a multicenter stepped wedge cluster randomized clinical trial called “PAtient-centered mUltidiSciplinary Care for vEterans Undergoing Surgery (PAUSE) trial”. Her current work focuses on streamlining frailty evaluation, as well as implementation of patient and system level interventions to improve surgical quality and to provide high-value and patient centered care.
She has multiple administrative roles in surgical quality improvement as Director of Surgical Quality at VAPAHCS; Center director for Stanford University in the Vascular Quality Initiative (VQI); and the Associate Medical Director of the Northern California region for VQI, which is the national registry database and patient safety organization for Society for Vascular Surgery (SVS). Her involvement in SVS VQI also extends to being a member of the steering committee of the Vascular Implant Surveillance and Interventional Outcomes Network (VISION) to improve the quality, safety and effectiveness of vascular care. She also serves as the President of the Surgical Outcomes Club, a national organization of surgical health services researchers, and chairs multiple national committees: VA surgeons committee for the SVS and Diversity and Inclusion Committee for the Association of VA surgeons.
Euan A. Ashley
Associate Dean, School of Medicine, Roger and Joelle Burnell Professor of Genomics and Precision Health, Professor of Medicine (Cardiovascular Medicine), of Genetics, of Biomedical Data Science and, by courtesy, of Pathology
Current Research and Scholarly InterestsThe Ashley lab is focused on precision medicine. We develop methods for the interpretation of whole genome sequencing data to improve the diagnosis of genetic disease and to personalize the practice of medicine. At the wet bench, we take advantage of cell systems, transgenic models and microsurgical models of disease to prove causality in biological pathways and find targets for therapeutic development.
Clinical Professor, Pediatrics - Cardiology
BioI specialize in providing cardiac critical care to infants, children and adults with congenital heart disease and heart failure. I am the Associate Director for the Pulmonary Artery Reconstruction Program at Stanford, helping to coordinate comprehensive multidisciplinary care for children with severe pulmonary artery abnormalities and right ventricular dysfunction. I was a Faculty Fellow at the Stanford Center for Biodesign in 2019-2020 and continue to work on development of new technologies for the unmet needs of pediatric patients. I have an interest in physician wellness and completed the Wellness Director course through the WellMD Center at Stanford.
Themistocles (Tim) Assimes
Associate Professor of Medicine (Cardiovascular Medicine) and, by courtesy, of Epidemiology and Population Health
Current Research and Scholarly InterestsGenetic Epidemiology, Genetic Determinants of Complex Traits related to Cardiovasular Medicine, Coronary Artery Disease related pathway analyses and integrative genomics, Mendelian randomization studies, risk prediction for major adverse cardiovascular events, cardiovascular medicine related pharmacogenomics, ethnic differences in the determinants of Insulin Mediated Glucose Uptake, pharmacoepidemiology of cardiovascular drugs & outcomes
Jennifer Avise, MD
Member, Cardiovascular Institute
BioDr. Avise is a board-certified vascular surgeon specializing in cutting edge treatments of vascular disease. She is a clinical assistant professor in the Department Surgery, Division of Vascular Surgery at Stanford University School of Medicine.
She has helped to expand access to expert vascular surgery in the East Bay, establishing Stanford Health Care’s first vascular surgery practices at the medical center in Emeryville and at the Stanford Health Care – ValleyCare hospital in Pleasanton. Dr. Avise serves as the medical director of the Pleasanton vascular laboratory, an IAC accredited facility, where she advances developments in noninvasive testing to aid in early diagnosis of vascular disease.
Her focus is on early detection and disease prevention, minimally invasive (endovascular) techniques, and complex open surgery. She treats a wide variety of conditions, including aortic aneurysm, limb salvage, varicose veins, peripheral vascular disease, carotid disease, complex wound care, and dialysis access.
David M. Axelrod, MD
Clinical Professor, Pediatrics - Cardiology
Current Research and Scholarly InterestsVirtual Reality Congenital Heart Disease experience: The Stanford Virtual Heart. Currently engaged with 19 academic medical centers across the globe using our Stanford Virtual Heart to educate students and trainees, and research our VR experience as a means for training and education. Also developing next generation modeling and image interaction with Stanford engineers and educators, to promote personalized surgical training in VR and advanced educational programs in congenital heart disease.
Dan E. Azagury, MD, FACS
Associate Professor of Surgery (General Surgery)
Current Research and Scholarly Interests.
Professor of Cardiothoracic Surgery (Thoracic Surgery)
BioLeah Backhus trained in general surgery at the University of Southern California and cardiothoracic surgery at the University of California Los Angeles. She practices at Stanford Hospital and is Chief of Thoracic Surgery at the VA Palo Alto. Her surgical practice consists of general thoracic surgery with special emphasis on thoracic oncology and minimally invasive surgical techniques. She is also Co-Director of the Thoracic Surgery Clinical Research Program, and has grant funding through the Veterans Affairs Administration and NIH. Her current research interests are in imaging surveillance following treatment for lung cancer and cancer survivorship. She is a member of the National Lung Cancer Roundtable of the American Cancer Society serving as Chair of the Task Group on Lung Cancer in Women. She also serves on the Board of Directors of the Society of Thoracic Surgeons. As an educator, Dr. Backhus is the Associate Program Director for the Thoracic Track Residency and is the Chair of the ACGME Residency Review Committee for Thoracic Surgery which is the accrediting body for all cardiothoracic surgery training programs in the US.
Clinical Professor, Medicine - Cardiovascular Medicine
BioNitish Badhwar, MD is Professor of Medicine and Director of Cardiac Electrophysiology Training Program at Stanford University School of Medicine. Dr. Badhwar received his medical degree from Maulana Azad Medical College (University of Delhi, India). After completing his internal medicine training from New York Hospital of Queens (affiliated with Cornell Medical School), he worked as faculty in the Department of Medicine at Hospital of St. Raphael (Yale University School of Medicine). He completed Cardiac Electrophysiology training at UCSF with Dr. Scheinman. After being on faculty at UCSF for 15 years he recently joined the Arrhythmia Service at Stanford Hospital. He is a Fellow of American College of Cardiology and Heart Rhythm Society. He has been named best doctor in cardiac electrophysiology in San Francisco Magazine 3 years in a row (2015-2017). This is nominated by his peers. He was given Excellence in Teaching award in Medical Education by Academy of Medical Educators in 2015. He was an invited speaker at prestigious international meetings including Oriental Congress of Cardiology (OCC) in Shanghai, China; Cardiostim EHRA /Europace in Nice, France; Asia Pacific Heart Rhythm Society (APHRS) in Seoul, S Korea; American Heart Association Annual Scientific Session in New Orleans, LA and Indian Heart Rhythm Society in New Delhi, India.
Clinical Interest: Dr. Badhwar's clinical interest is in complex catheter ablation procedures including mapping and ventricular tachycardia (VT), atrial fibrillation (AF) and supraventricular tachycardia (SVT) including junctional variants of SVT. He started the epicardial ablation program at UCSF and also worked with Dr. Randall Lee to perform the first percutaneous epicardial left atrial appendage (LAA) ligation in the Bay Area in patients with atrial fibrillation. He has also differentiated himself in the field of electrophysiology by performing hybrid procedures with CT surgeons in patients with AF and VT. He is also involved in device implantation including pacemakers, ICD and biventricular pacing for heart failure.
Research Interest: Dr. Badhwar has published electrophysiologic characteristics of SVTs including atrial tachycardia arising from the coronary sinus musculature, para-hisian atrial tachycardia, left sided AVNRT, junctional tachycardia and nodofascicular tachycardia. He has also published on the use of nuclear medicine (ERNA) in assessing left ventricular dyssynchrony as well as optimal pacing sties in patients with heart failure requiring biventricular pacing. He has described the unique clinical characteristics of epicardial idiopathic VT arising from the cardiac crux. He has also published clinical outcomes of combining LAA ligation with catheter ablation of atrial fibrillation perform (first in human percutaneous closed chested Maze procedure) and is now part of a multi-center randomized study comparing standard ablation to ablation plus LAA ligation in patients with persistent atrial fibrillation (aMAZE trial).
Professor of Genetics
Current Research and Scholarly InterestsWe examine how cells communicate and function during fetal development. The work in my laboratory focuses on the establishment of specific cell fates using genomics to decipher interactions between chromatin and developmental signaling cascades, between genomes and rapidly evolving cell types, and between genomic copy number variation and gene expression. In recent years we have focused on the vastly understudied biology of the trophoblast lineage, particularly how this lineage evolved.
Bing Professor of Human Biology, Senior Fellow at the Stanford Institute for Economic Policy Research and Professor, by courtesy, of Economics
Current Research and Scholarly InterestsDr. Baker's research is in the area of health economics, and focuses on the effects of financial incentives, organizational structures, and government policies on the health care delivery system, health care costs, and health outcomes.
K. K. Lee Professor and Professor, by courtesy, of Materials Science and Engineering and of Chemistry
BioZhenan Bao joined Stanford University in 2004. She is currently a K.K. Lee Professor in Chemical Engineering, and with courtesy appointments in Chemistry and Material Science and Engineering. She was the Department Chair of Chemical Engineering from 2018-2022. She founded the Stanford Wearable Electronics Initiative (eWEAR) and is the current faculty director. She is also an affiliated faculty member of Precourt Institute, Woods Institute, ChEM-H and Bio-X. Professor Bao received her Ph.D. degree in Chemistry from The University of Chicago in 1995 and joined the Materials Research Department of Bell Labs, Lucent Technologies. She became a Distinguished Member of Technical Staff in 2001. Professor Bao currently has close to 700 refereed publications and more than 80 US patents with a Google Scholar H-index 201.
Bao is a member of the US National Academy of Engineering, the American Academy of Arts and Sciences and the National Academy of Inventors. Bao was elected a foreign member of the Chinese Academy of Science in 2021. She is a Fellow of AAAS, ACS, MRS, SPIE, ACS POLY and ACS PMSE.
Bao is a member of the Board of Directors for the Camille and Dreyfus Foundation from 2022. She served as a member of Executive Board of Directors for the Materials Research Society and Executive Committee Member for the Polymer Materials Science and Engineering division of the American Chemical Society. She was an Associate Editor for the Royal Society of Chemistry journal Chemical Science, Polymer Reviews and Synthetic Metals. She serves on the international advisory board for Advanced Materials, Advanced Energy Materials, ACS Nano, Accounts of Chemical Reviews, Advanced Functional Materials, Chemistry of Materials, Chemical Communications, Journal of American Chemical Society, Nature Asian Materials, Materials Horizon and Materials Today. She is one of the Founders and currently sits on the Board of Directors of C3 Nano Co. and PyrAmes, both are silicon valley venture funded companies.
Bao was a recipient of the VinFuture Prize Female Innovator 2022, ACS Award of Chemistry of Materials 2022, MRS Mid-Career Award in 2021, AICHE Alpha Chi Sigma Award 2021, ACS Central Science Disruptor and Innovator Prize in 2020, ACS Gibbs Medal in 2020, the Wilhelm Exner Medal from the Austrian Federal Minister of Science in 2018, the L'Oreal UNESCO Women in Science Award North America Laureate in 2017. She was awarded the ACS Applied Polymer Science Award in 2017, ACS Creative Polymer Chemistry Award in 2013 ACS Cope Scholar Award in 2011. She is a recipient of the Royal Society of Chemistry Beilby Medal and Prize in 2009, IUPAC Creativity in Applied Polymer Science Prize in 2008, American Chemical Society Team Innovation Award 2001, R&D 100 Award, and R&D Magazine Editors Choice Best of the Best new technology for 2001.
Assistant Professor of Medicine (Cardiovascular Medicine)
BioTina Baykaner is an Instructor in the Department of Internal Medicine, Division of Cardiovascular Medicine and Electrophysiology. Following internal medicine residency, cardiovascular medicine and advanced heart failure fellowship trainings at University of California, San Diego and electrophysiology fellowship at Stanford University, Dr. Baykaner joined Stanford University faculty in 2018. She has published over 200 papers, book chapters and abstracts including over 80 original peer-reviewed articles, and delivered over 40 invited presentations in national and international meetings. She serves as associate editor, section editor and editorial board member of four electrophysiology journals.
Dr. Baykaner’s current research interests include outcomes research, epidemiology and mechanisms of rhythm disorders. She is currently funded by the National Institutes of Health to study patient related outcomes regarding atrial fibrillation (AF) ablation. She received prior research funding from American Heart Association and Heart Rhythm Society. Dr. Baykaner's clinical practice focuses on ablation of atrial and ventricular arrhythmias, SVTs, inappropriate sinus tachycardia management, device implantation and device extraction.
Dr. Baykaner is an active member of American Heart Association (AHA), American College of Cardiology (ACC), Heart Rhythm Society (HRS) and European Society of Cardiology (ESC). She serves as an elected member of the Communications Committee for HRS, and previously served as an elected member of the ACC Task Force ICD research committee. She also served in the Organizing Committee for Stanford Cardiovascular Institute Annual Postdoctoral Research Meeting in 2017 and 2018 and for Early Career related sessions for HRS Scientific Sessions in 2019 and 2020.
Hans-Christoph Becker, MD, FSABI, FSCCT
Clinical Professor, Radiology
Current Research and Scholarly InterestsMyocardial bridges (MB) with associated upfront atherosclerotic lesions are common findings on coronary computed tomography angiography (CTA). Abnormal septal wall motion in exercise echocardiography (EE) may to be associated with MB. Intravascular ultrasound (IVUS) is considered the gold standard for the detection of MB. We investigate whether CTA is comparable to IVUS for the assessment of MB and upstream plaques in symptomatic patients with suspicion for MB raised by EE.
Professor of Developmental Biology, of Computer Science, of Pediatrics (Genetics) and of Biomedical Data Science
Current Research and Scholarly Interests1. Automating monogenic patient diagnosis.
2. The genomic signatures of independent divergent and convergent trait evolution in mammals.
3. The logic of human gene regulation.
4. The reasons for sequence ultraconservation.
5. Cryptogenomics to bridge medical silos.
6. Cryptogenetics to debate social injustice.
7. Managing patient risk using machine learning.
8. Understanding the flow of money in the US healthcare system.
Clinical Professor, Cardiothoracic Surgery
BioDr. Edward Bender specializes in the treatment of adult cardiac abnormalities, including ischemic heart disease, structural and valvular disease, and arrhythmias. Additionally, he has an interest and expertise in General Thoracic and Vascular surgery. Dr. Bender currently works with organizations within the medical community to develop software to aid in the teaching and practice of medicine.
Alfred Woodley Salter and Mabel G. Salter Endowed Professor of Pediatrics
Current Research and Scholarly Interests1. Using iPSC-derived cardiomyocytes to understand hypertrophic cardiomyopathy and heart failure associated with congenital heart disease.
2. Role of alterations in mitochondrial dycamics and function in normal physiology and disease.
3. Differences between R and L ventricular responses to stress,
4. Immune biomarkers of risk after pediatric VAD implantation.
5. Biomarkers for post-transplant lymphoproliferative disorder.
Richard Kempson, M.D., Professor of Surgical Pathology
Current Research and Scholarly InterestsCardiopulmonary and pulmonary transplant medicine; diagnostic surgical pathology
Mark Francis Berry, MD
Mylavarapu Rogers Professor of Cardiothoracic Surgery
BioDr. Berry joined the Division of Thoracic Surgery at Stanford in August 2014. He came to Stanford from Duke University, where he had most recently served as Associate Professor. He received his medical degree at the University of Pennsylvania School of Medicine after receiving bachelors and masters degrees in Electrical Engineering at the University of Pennsylvania. He completed his residency in Cardiothoracic Surgery at Duke University Medical Center after performing a residency in General Surgery at the Hospital of the University of Pennsylvania. His Cardiothoracic Surgical training included a year dedicated to Minimally Invasive General Thoracic Surgery, a period that also included an American Association for Thoracic Surgery sponsored Traveling Fellowship at the University of Pittsburgh.
Dr. Berry practices all aspects of thoracic surgery, including procedures for benign and malignant conditions of the lung, esophagus, and mediastinum. He has a particular interest in minimally invasive techniques, and has extensive experience in treating thoracic surgical conditions using video-assisted thoracoscopic surgical (VATS), laparoscopic, robotic, endoscopic, and bronchoscopic approaches. He serves as the co-Director of the Stanford Minimally Invasive Thoracic Surgery Center (SMITS), and has both directed and taught in several minimally invasive thoracic surgery courses.
Dr. Berry also has a Masters of Health Sciences in Clinical Research from Duke University. His clinical research activities mirror his clinical interests and activities in optimizing short-term and long-term outcomes of patients with thoracic surgical conditions. He has more than 150 peer-reviewed publications, most of which are related to both the use of minimally invasive thoracic surgical techniques as well as evaluating outcomes after treatment of thoracic malignancies. His clinical practice and his research both focus on choosing the most appropriate treatment and approach for patients based on the individual characteristics of the patient and their disease process.
Vivek Bhalla, MD
Associate Professor of Medicine (Nephrology)
Current Research and Scholarly InterestsDr. Bhalla's two primary research interests are in the role of the kidney in diabetes and hypertension. We use molecular, biochemical, and transgenic approaches to study: (1) mechanisms diabetic kidney disease disease including the role of the endothelium to regulate inflammation and kidney injury; and (2) regulation of tubular transport of glucose, sodium, and potassium. These latter studies have treatment implications in diabetes, kidney disease, and hypertension.
Associate Professor of Medicine (Hematology) and of GeneticsOn Partial Leave from 09/25/2023 To 12/15/2023
Current Research and Scholarly InterestsThe Bhatt lab is exploring how the microbiota is intertwined with states of health and disease. We apply the most modern genetic tools in an effort to deconvolute the mechanism of human diseases.
Y. Katherine Bianco
Clinical Professor, Obstetrics & Gynecology - Maternal Fetal Medicine
BioMy clinical interest in pregnancies complicated with birth defects has led my underlying research interests in genomic abnormalities in the human trophoblast carrying to faulty placentation. The latter began with initial work during K12 and KO8 funding. I took a great interest in the human placenta as it carries potential advantages over other tissues sources: first, this highly metabolically active organ is the potential source of many transcripts. Second, the placenta forms at a very early stage of embryonic development, potentially allowing detection of primary alterations as compared to secondary changes that may mask the underlying causal phenomena. Finally, studying early placentation may provide targets for development of novel molecular approaches, such as up-regulate or down-regulate genes, the protein products of which could potentially serve as molecular surrogates for diagnosis and treatment of pregnancy complication such as miscarriages, pre-eclampsia, pregnancy induced hypertension and intrauterine growth retardation. This work has led to the first Trisomy 21, Trisomy 18, trisomy 13 cell lines established from human placentas making it possible to apply gene editing in the early stages of human trophoblast development.
As my primary clinical responsibility involves treating patients needing medical care and support through their high risk pregnancies, I am interested in factors that may impact outcomes, such as prenatal screening and diagnosis, maternal heart conditions, labor and delivery management, and safety approaches for the second stage of labor. In investigating length of labor and approaches to shorten the second stage, I have found methods of improving perinatal outcomes in diverse maternal populations.
With regards to my interest in fetal medicine, I have worked in collaboration with other specialists such as radiologists and pediatric cardiologists utilizing imagining studies to assess and determine successful perinatal care and fetal survival.
Sandip Biswal, MD
Adjunct Clinical Professor, Radiology
Current Research and Scholarly InterestsThe management of individuals suffering from chronic pain is unfortunately limited by poor diagnostic tests and therapies. Our research group is interested in 'imaging pain' by using novel imaging techniques to study peripheral nociception and inflammation with the goal of accurately identifying the location of pain generators. We are developing new approaches with positron emission tomography (PET) and magnetic resonance imaging (MRI) (PET/MRI) and are currently in clinical trials.
Professor (Research) of Pediatrics (Neonatology), Emeritus
Current Research and Scholarly InterestsOur research focuses on the pathogenesis and treatment of acute and chronic neonatal lung injury and the mechanisms that regulate lung fluid balance and alveolar & pulmonary vascular development after premature birth.
Associate Professor of Radiology (Pediatric Radiology) and, by courtesy, of Pediatrics
Current Research and Scholarly InterestsStudies on apoptotic cell death in vivo using the H MRS phenomenon.
Professor of Medicine and of Molecular Pharmacology, Emeritus
Current Research and Scholarly InterestsClinical pharmacology of antiretroviral drugs
Pharmacokinetic and pharmacodynamic mechanisms of variability in drug response.
Helen M. Blau
Donald E. and Delia B. Baxter Foundation Professor, Director, Baxter Laboratory for Stem Cell Biology and Professor, by courtesy, of Psychiatry and Behavioral Sciences
Current Research and Scholarly InterestsProf. Helen Blau's research area is regenerative medicine with a focus on stem cells. Her research on nuclear reprogramming and demonstrating the plasticity of cell fate using cell fusion is well known and her laboratory has also pioneered the design of biomaterials to mimic the in vivo microenvironment and direct stem cell fate. Current findings are leading to more efficient iPS generation, cell based therapies by dedifferentiation a la newts, and discovery of novel molecules and therapies.
Associate Professor of Medicine (Infectious Diseases) and of Microbiology and Immunology
Current Research and Scholarly InterestsChronic bacterial infections are a major health care problem. Our lab is interested in understanding the host and microbial factors that perpetuate chronic infections and in developing novel therapeutic interventions to improve human health.
Anna Maria Bombardieri
Clinical Assistant Professor, Anesthesiology, Perioperative and Pain Medicine
Masters Student in Epidemiology and Clinical Research, admitted Autumn 2022
Current Research and Scholarly InterestsMy overall research goal is to advance clinical practice by providing anesthesiologists with data to most effectively maintain cerebral blood flow in the perioperative period.
I am interested in the effect of the autonomic nervous system on cerebral blood flow regulation.
I intend to combine regional anesthetic techniques and noninvasive bedside cerebral blood flow monitoring to understand the effect of the sympathetic system on cerebral blood flow.
A secondary goal is to apply this new knowledge to investigate whether cervical sympathetic blocks improve long term neurological outcomes.
Bing Centennial Prof, Freeman-Thornton Chair for Vice Provost for Undergrad Ed, & Dean of Fresh-Soph College, & Prof of Materials Sci & Eng, Emeritus
Instructor, Cardiovascular Institute
Current Research and Scholarly InterestsOne gene can lead to the production of many different RNA isoforms via mechanisms such as alternative promoter usage, splicing, and polyadenylation. The functional significance of many of these isoforms, their impact on cell physiology, and their regulation remain mostly controversial. Understanding the functional consequences of transcript heterogeneity will improve our understanding of gene expression regulation, broadening our ability to intervene when mutations that interfere with this regulation cause human disease.
My goal is to become an independent researcher leading an academic lab that focuses on better understanding human tissue-specific post-transcriptional regulation of gene expression and developing mechanism-based therapeutics. My general strategy is to study the function of regulatory genes and their deregulation in human disease. My specific approach is to understand the molecular mechanisms by which disease-causing mutations alter the gene function and lead to human disease. My hypothesis is that a detailed understanding of the relationship between the gene's molecular function and the disease mechanism will allow the development of first-in-class, personalized therapeutic strategies that target the disease mechanisms rather than manage symptoms independently of disease etiology.
Clinical Associate Professor, Anesthesiology, Perioperative and Pain Medicine
Current Research and Scholarly InterestsClinical Education
Regional Anesthesia for Cardiothoracic Enhanced Recovery (RACER)
Anesthesia for transcatheter and electrophyiology procedures
Michele and Timothy Barakett Endowed Professor
Current Research and Scholarly InterestsOur lab studies the molecular basis of longevity. We are interested in the mechanism of action of known longevity genes, including FOXO and SIRT, in the mammalian nervous system. We are particularly interested in the role of these longevity genes in neural stem cells. We are also discovering novel genes and processes involved in aging using two short-lived model systems, the invertebrate C. elegans and an extremely short-lived vertebrate, the African killifish N. furzeri.
Marion S. Buckwalter, MD, PhD
Professor of Neurology and of Neurosurgery
Current Research and Scholarly InterestsThe goal of the Buckwalter Lab is to improve how people recover after a stroke. We use basic and clinical research to understand the cells, proteins, and genes that lead to successful recovery of function, and also how complications develop that impact quality of life after stroke. Ongoing projects are focused on understanding how inflammatory responses are regulated after a stroke and how they affect short-term brain injury and long term outcomes like dementia and depression.
Professor of Cardiothoracic Surgery (Adult Cardiac Surgery)
Current Research and Scholarly InterestsNew technologies in the area of catheters, clamps, and, visualization devices for aid in cardiac surgery; distribution of, cardioplegia, both anterograde and retrograde as determined by, techniques in technetium pyro-phosphate scans; glucose insulin, potassium as an adjunct in cardiac surgery.
Elan Chanel Burton, MD, MHA
Clinical Associate Professor, Cardiothoracic Surgery
BioDr. Burton is a board-certified cardiothoracic surgeon. She is also a clinical assistant professor in the Stanford University School of Medicine Department of Cardiothoracic Surgery.
She offers her patients exceptional expertise in advanced cardiothoracic surgical techniques. For each patient, she develops a customized, comprehensive, and compassionate care plan.
Dr. Burton has completed specialized training in robotic technique for minimally invasive direct coronary artery bypass (MIDCAB). This procedure enables surgical access to the heart with a smaller incision than other coronary artery bypass graft (CABG) procedures.
In addition to her clinical practice, Dr. Burton has conducted research on health disparities in cardiovascular disease, diversity in radiology and molecular imaging, and other topics. She received an innovation research grant from the National Science Foundation for her work on an app for emotional support during the COVID-19 pandemic.
Dr. Burton has made presentations to her peers as a guest lecturer on subjects including coronary artery disease, primary cardiac tumors, and minimally invasive cardiac surgery. In addition, she has made presentations to the American Heart Association, International Conference on Clinical Ethics and Consultation, and other organizations.
Dr. Burton has published articles on advanced surgical techniques as well as issues such as balancing work and family during the COVID-19 pandemic plus health disparities and social determinants of health. Her work has appeared in the Journal of Cardiac Surgery, JTCVS Techniques, International Social Work, and elsewhere.
Dr. Burton has earned honors including the Coleman Connolly Award in Thoracic Surgery, which recognizes the exemplary efforts of thoracic surgery residents. She also won the Society of Laparoendoscopic Surgeons Resident Achievement Award and the Dr. Albert G. Marrangoni Research Award.
She serves on the Stanford University School of Medicine Taskforce for the Mitigation of the Impact of COVID-19 on Women in Medicine. She is also on the School of Medicine’s Women Faculty Network Steering Committee.
She is a member of the Society of Thoracic Surgeons, American College of Cardiology, American College of Physicians–American Society of Internal Medicine, Lillehei Surgical Society, Women in Thoracic Surgery, Western Thoracic Surgical Association, American Society of Professionals in Patient Safety, Women Health Care Executives, Association of Women Surgeons, Society of Black Academic Surgeons, and American Association of Healthcare Administrative Management.
She has volunteered her time and expertise as a high school medical club faculty mentor, as an elementary school community health nutrition interventionist, and with the Western Pennsylvania Humane Society.
Klaus Bensch Professor of Pathology
Current Research and Scholarly InterestsOur interests include:
1) The physiology and function of lymphocyte homing in local and systemic immunity;
2) Biochemical and genetic studies of molecules that direct leukocyte recruitment;
3) Chemotactic mechanisms and receptors in vascular and immune biology;
4) Vascular control of normal and pathologic inflammation and immunity;
5) Systems biology of immune cell trafficking and programming in tumor immunity.
Professor of Genetics, Emerita
Current Research and Scholarly InterestsMy lab is developing innovative gene and stem cell therapies for genetic diseases, with a focus on gene therapy and regenerative medicine.
We have created novel methods for inserting therapeutic genes into the chromosomes at specific places by using homologous recombination and recombinase enzymes.
We are working on 3 forms of muscular dystrophy.
We created induced pluripotent stem cells from patient fibroblasts, added therapeutic genes, differentiated, and engrafted the cells.
Clinical Professor, Surgery - Vascular Surgery
Clinical Professor (By courtesy), Neurosurgery
BioDr. Chandra is a board certified vascular surgeon who specializes in cutting edge approaches to aortic aneurysmal disease, peripheral vascular disease and limb salvage.
Stephen Chang, MD, PhD
Instructor, Medicine - Cardiovascular Medicine
BioPrior to a career in medicine, Dr. Chang was an English major and subsequent novelist at night. During the days, he taught literature part-time at Rutgers University, and for extra money, worked in a laboratory in NYC washing test tubes. Inspired by his laboratory mentor, he began volunteering at the hospital next door, and developed a love for interacting with patients. Through this experience, he saw how caring for others could form deep bonds between people - even strangers - and connect us in a way that brings grandeur to ordinary life.
In addition to seeing patients, Dr. Chang is a physician-scientist devoted to advancing the field of cardiovascular medicine. His research has been focused on identifying a new genetic organism that better models human heart disease than the mouse. For this purpose, he has been studying the mouse lemur, the smallest non-human primate, performing cardiovascular phenotyping (vital signs, ECG, echocardiogram) on lemurs both in-bred (in France) and in the wild (in Madagascar) to try to identify mutant cardiac traits that may be heritable - and in the process, characterize the first high-throughput primate model of human cardiac disease.
Steven D. Chang, MD
Robert C. and Jeannette Powell Neurosciences Professor and, by courtesy, of Otolaryngology - Head & Neck Surgery (OHNS) and of Neurology
Current Research and Scholarly InterestsClinical research includes studies in the treatment of cerebrovascular disorders, such as aneurysms and AVMs, as well as the use of radiosurgery to treat tumors and vascular malformations of the brain and spine.
Dr. Chang is C0-Director of the Cyberknife Radiosurgery Program.
Dr. Chang is also the head of the The Stanford Neuromolecular Innovation Program with the goal of developing new technologies to improve the diagnosis and treatment of patients affected by neurological conditions.
Tara I. Chang
Professor of Medicine (Nephrology)
Current Research and Scholarly InterestsMy research focuses on issues such as blood pressure control, coronary revascularization, and the comparative effectiveness of cardioprotective medications in patients with chronic kidney disease, with the long-term goal of improving cardiovascular outcomes in these high-risk patients.
Assistant Professor (Research) of Radiology (Integrative Biomedical Imaging Informatics at Stanford) and, by courtesy, of Biomedical Data Science
Current Research and Scholarly InterestsDr. Chaudhari is interested in the application of artificial intelligence techniques to all aspects of medical imaging, including automated schedule and reading prioritization, image reconstruction, quantitative analysis, and prediction of patient outcomes. His interests range from developing novel data-efficient machine learning algorithms to clinical deployment and validation of patient outcomes. He is also exploring combining imaging with clinical, natural language, and time series data.
Associate Professor of Mechanical Engineering and, by courtesy, of BioengineeringOn Partial Leave from 10/01/2023 To 06/30/2024
Current Research and Scholarly InterestsWe study the physics of cell migration, division, and morphogenesis in 3D, as well cell-matrix mechanotransduction, or the process by which cells sense and respond to mechanical properties of the extracellular matrices. For both these areas, we use engineered biomaterials for 3D culture as artificial extracellular matrices.
(Robert) Jeenchen Chen
Clinical Instructor, Cardiothoracic Surgery
Current Research and Scholarly InterestsMy expertise is to interpret clinical data by biostatistics. My pending research are below:
AI Prediction Model of Profound Cardiogenic Shock status post VA-ECMO
Surgical outcomes of pericardiectomy for constrictive pericarditis by national and hospital databases
The effect of hybrid operation on the outcomes of acute type-A aortic dissection by hospital data
Calcium Physiology of Coronary Artery Smooth Muscle — the First Evidence from Human Transplant Cardiectomy (Presented at ISHLT 2017)
Adjunct Professor, Surgery - Vascular Surgery
Current Research and Scholarly InterestsOur research laboratory focuses on understanding the mechanics of the cardiovascular system, especially with respect to interactions between medical devices and the dynamic cardiovascular environment. We use medical imaging, 3D geometric modeling, and custom deformation quantification techniques to investigate disease processes and medical device performance. We are interested in the dynamics of the heart, aorta, and peripheral vasculature, and are always seeking ways to apply our research to current and emerging therapies. While our research pursuits seek to add to the fundamental understanding of cardiovascular biomechanics, all of our projects are directly related to improving medical device design, evaluation, regulation, and their use in clinical practice.
Paul Cheng MD PhD
Assistant Professor of Medicine (Cardiovascular Medicine)
BioDr. Cheng is a Cardiologist at Stanford University School of Medicine in the Department of Medicine and a member of the Cardiovascular Research Institute. Dr. Cheng received his BEng in Chemical Engineering and BSc in biology at MIT. He subsequently completed his MD/PhD at UCSF working in the Srivastava lab studying how extracellular morphogenic signals affect cardiac development and fate determination of cardiac progenitors. Dr. Cheng completed internal medicine residency and cardiology fellowship at Stanford. His current clinical focus is in amyloidosis and cardio-oncology. During his post doctoral research in the Quertermous lab, he pioneered the application of single cell transcriptomic and epigenetic techniques to study human vascular diseases including atherosclerosis and aneurysm, and applied these techniques to investigate molecular mechanisms behind genetic risk factors for several human vascular diseases including atherosclerosis, and aortopathies such as Marfan's and Loey-Dietz syndrome.
The Cheng lab takes a patient-to-bench-to-bedside approach to science. The lab focuses on elucidating new pathogenic mechanisms of human vascular diseases through combing human genetics and primary vascular disease tissues, with high-resolution transcriptomic and epigenetic profiling to generate novel hypothesis that are then tested in a variety of in vitro and in vivo models. The lab is focused on two broad questions: (1) understanding the biological underpinning of the differences in diseases propensities of different arterial segments in an individual (i.e. why do you have atherosclerosis and aneurysms in certain segments but not others), and (2) understanding the role of perivascular fibroblast in human vascular diseases.
Xingxing Shelley Cheng
Assistant Professor of Medicine (Nephrology)
Current Research and Scholarly InterestsDr. Xingxing Cheng's expertise is in applying the tools of decision science to clinical practice and policy analysis. Her current research is in the following areas:
1) the costs, effectiveness, and implementation of work-up before kidney transplantation, including pretransplant cardiovascular screening;
2) ethics of and decision-making in in multi-organ transplantation.
Glenn M. Chertow
Norman S. Coplon/Satellite Healthcare Professor of Medicine and Professor, by courtesy, of Epidemiology and Population Health and of Health Policy
Current Research and Scholarly Interestsclinical epidemiology, health services research, decision sciences, clinical trials in acute and chronic kidney disease
Christina F. Chick
Instructor, Psychiatry and Behavioral Sciences - Child & Adolescent Psychiatry and Child Development
Current Research and Scholarly InterestsMy research examines the mechanistic contributions of sleep, cognition and affect to the onset and course of psychiatric disorders across the lifespan. I am particularly interested in adolescence as a period during which changes in circadian rhythm, sleep architecture, and sleep behavior co-occur with neuroendocrine development, psychosocial changes, and the onset of many psychiatric disorders. Given that sleep is a highly treatable target, increasing our understanding of the specific contributions of sleep to psychiatric symptom onset may facilitate the development of targeted interventions to mitigate the course of illness.
Wallenberg-Bienenstock Professor and Professor of Bioengineering and of Microbiology and Immunology
Current Research and Scholarly InterestsMy research includes methodology improvements in single particle cryo-EM for atomic resolution structure determination of molecules and molecular machines, as well as in cryo-ET of cells and organelles towards subnanometer resolutions. We collaborate with many researchers around the country and outside the USA on understanding biological processes such as protein folding, virus assembly and disassembly, pathogen-host interactions, signal transduction, and transport across cytosol and membranes.
Professor of Pediatrics (Neonatology) and, by courtesy, of Obstetrics and Gynecology (Maternal Fetal Medicine)
Current Research and Scholarly InterestsNeurological monitoring in critically ill infants. Altered hemodynamics in neonates, especially in relation to prematurity, congenital heart disease, and central nervous system injury. Determination of the hemodynamic significance and effects of a patent ductus arteriosus in the preterm infant. Utilizing NIRS (near-infrared spectroscopy) and other technologies for improved monitoring in the NICU.
Danny Hung-Chieh Chou
Assistant Professor of Pediatrics (Endocrinology) and, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly InterestsOur research program integrates concepts of chemical biology, protein engineering and structure biology to design new therapeutic leads and generate probes to study biological processes. A key focus of our lab is insulin, an essential hormone in our body to reduce blood glucose levels. We generate synthetic libraries of insulin analogs to select for chemical probes, and investigate natural insulin molecules (e.g. from the venom of fish-hunting cone snails!) to develop novel therapeutic candidates. We are especially interested in using chemical and enzymatic synthesis to create novel chemical entities with enhanced properties, and leverage the strong expertise of our collaborators to apply our skill sets in the fields of cancer biology, immunology and pain research. Our ultimate goal is to translate our discovery into therapeutic interventions in human diseases.
Daniel Eugene Clark
Clinical Assistant Professor, Medicine - Cardiovascular Medicine
Clinical Assistant Professor, Pediatrics - Cardiology
BioDr. Clark completed a 4-year MD/MPH program at the University of Texas Health Science Center in San Antonio. He subsequently completed all of his post-graduate training at Vanderbilt University Medical Center (VUMC), including Internal Medicine-Pediatrics, Adult Cardiology, and Adult Congenital Heart Disease (ACHD). Additionally, he served as Chief Fellow of the Vanderbilt Cardiovascular Medicine Fellowship, trained in multimodality cardiovascular imaging, and conducted clinical research during a two-year NIH-funded T32 research fellowship at VUMC.
Prior to joining the Stanford ACHD faculty, he was appointed Instructor of Cardiovascular Medicine at Vanderbilt and read cardiac magnetic resonance (CMR) imaging as an attending for two years. He is appointed Assistant Professor of Medicine and Pediatrics at Stanford University School of Medicine.
His academic and investigative interests focus on advanced cardiovascular imaging for ACHD patients, particularly the application of CMR in this population. During the COVID-19 pandemic, Dr. Clark pivoted his scholarly efforts to focus on studying the cardiovascular effects of COVID-19 with CMR. His current clinical investigations include understanding the CMR-derived diastolic patterns of Fontan physiology and the effect of cardiac rehabilitation on functional status among patients with Fontan failure.
Shoa L. Clarke, MD, PhD
Assistant Professor of Medicine (Cardiovascular Medicine) and of Pediatrics
BioDr. Clarke is a preventive cardiologist and a physician-scientist focused on disease prevention. He earned his undergraduate degree in human biology from the Division of Nutritional Sciences at Cornell University before obtaining his MD and PhD (genetics) from Stanford University School of Medicine. He has completed clinical training in internal medicine (Brigham & Women’s Hospital), pediatrics (Boston Children’s Hospital), and cardiovascular medicine (Stanford Hospital), and he is board certified in all three specialties. His research is focused on 1) understanding complex disease genetics in diverse populations, 2) integrating monogenic and polygenic risk with clinical risk, 3) large-scale phenotyping using the electronic health record and medical images. His clinical practice focuses on identifying risk factors for cardiovascular disease with the goal of promoting health and longevity through evidence-based personalized treatment. He is interested in developing family-centric approaches for the treatment of adults and children carrying genetic risk for disease.
William Clusin, MD
Associate Professor of Medicine (Cardiovascular Medicine)
Current Research and Scholarly InterestsCardiac action potentials; tissue culture, voltage, clamp technique; role of calcium in ischemia arrhythmias; coronary, artery disease; myocardial infarction.
Jennifer R. Cochran
Senior Associate Vice Provost for Research, Addie and Al Macovski Professor, Professor of Bioengineering and, by courtesy, of Chemical Engineering
Current Research and Scholarly InterestsMolecular Engineering, Protein Biochemistry, Biotechnology, Cell and Tissue Engineering, Molecular Imaging, Chemical Biology
Associate Professor of Pediatrics (Pulmonary Medicine)On Leave from 08/01/2023 To 12/31/2023
Current Research and Scholarly InterestsI am interested in studying the effects of inflammation in the lung, in particular, how N-acetylcysteine may affect and decrease that in CF patients. I am the PI of a multi-center study researching this question. Additionally, in a separate study involving children who have received lung transplants, I am a participating site in an NIH-sponsored observational and mechanistic multi-center study that will examine the role of viral infections in causing chronic graft rejection.
Christopher H. Contag
Professor of Pediatrics (Neonatology), Emeritus
Current Research and Scholarly InterestsWe develop and use the tools of molecular imaging to understand oncogenesis, reveal patterns of cell migration in immunosurveillance, monitor gene expression, visualize stem cell biology, and assess the distribution of pathogens in living animal models of human biology and disease. Biology doesn't occur in "a vacuum" or on coated plates--it occurs in the living body and that's were we look for biological patterns and responses to insult.
John P. Cooke, MD, PhD
Professor of Medicine (Cardiovascular Medicine), Emeritus
Current Research and Scholarly InterestsOur translational research program in vascular regeneration is focused on generating and characterizing vascular cells from human induced pluripotential stem cells. We are also studying the therapeutic application of these cells in murine models of peripheral arterial disease. In these studies we leverage our longstanding interest in endothelial signaling, eg by nitric oxide synthase (NOS) as well as by nicotinic cholinergic receptors (nAChR).
David N. Cornfield
Anne T. and Robert M. Bass Professor of Pediatric Pulmonary Medicine and Professor, by courtesy, of Surgery
Current Research and Scholarly InterestsOver the past 20 years, the Cornfield Laboratory has focused upon basic, translational and clinical research, with a primary focus on lung biology. As an active clinician-scientist, delivering care to acutely and chronically ill infants and children, our lab focuses on significant clinical challenges and tried to use science to craft novel solutions to difficult clinical problems.
Shriram Chair of the Department of Bioengineering, Professor of Bioengineering and, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly InterestsOur focus is on building computational models of complex biological processes, and using them to guide an experimental program. Such an approach leads to a relatively rapid identification and validation of previously unknown components and interactions. Biological systems of interest include metabolic, regulatory and signaling networks as well as cell-cell interactions. Current research involves the dynamic behavior of NF-kappaB, an important family of transcription factors.
David Korn, MD, Professor of Pathology and Professor of Developmental Biology
Current Research and Scholarly InterestsChromatin regulation and its roles in human cancer and the development of the nervous system. Engineering new methods for studying and controlling chromatin and epigenetic regulation in living cells.
Job and Gertrud Tamaki Professor of Chemistry
Current Research and Scholarly InterestsOur objective is to develop new biophysical methods to advance current understandings of cellular machinery in the complicated environment of living cells. Currently, we are focusing on four research areas: (1) Membrane curvature at the nano-bio interface; (2) Nanoelectrode arrays (NEAs) for scalable intracellular electrophysiology; (3) Electrochromic optical recording (ECORE) for neuroscience; and (4) Optical control of neurotrophin receptor tyrosine kinases.
Maria Elizabeth Currie, MD, PhD
Clinical Assistant Professor, Cardiothoracic Surgery
BioDr. Currie is a board-certified, fellowship-trained cardiothoracic surgeon. She is also a clinical assistant professor at Stanford University School of Medicine. With subspecialty training in heart failure, Dr. Currie treats all forms of cardiomyopathy, ischemic heart disease, and valvular heart disease. She performs heart transplant, lung transplant, and combined heart-lung transplant procedures as part of a multidisciplinary team. She excels at valve surgery and the implantation of mechanical circulatory support systems.
Dr. Currie welcomes referrals from cardiologists and primary care physicians as early as possible when cardiovascular disease is suspected. Understanding that early intervention can prevent later complications, she invites communication about screening, diagnostics, and treatment strategies.
For each patient, Dr. Currie’s goal is to achieve the best possible outcome using the most advanced minimally invasive cardiac care techniques and technology available. Combined with technical expertise and a focus on excellent clinical outcomes, Dr. Currie delivers empathetic, thoughtful patient care. She ensures that patients are well informed about what they can expect both before and after their surgical procedure.
Dr. Currie is passionate about improving the safety of cardiac surgery. Her research includes translational studies on new ways to visualize anatomic structures that are difficult to see during minimally invasive surgery. One published study investigated the use of augmented reality (AR) guided by transesophageal echocardiography in minimally invasive mitral valve repair. Her work has appeared in The Journal of Thoracic and Cardiovascular Surgery, The Annals of Thoracic Surgery, The International Journal of Medical Robotics and Computer Assisted Surgery, Transplant Immunology, and other peer reviewed publications.
Dr. Currie’s interest in technological advances is rooted in her commitment to the evolution of technology and technique in the fast-changing, relatively young field of cardiac surgery. Also driving her interest is her PhD background in biomedical engineering. She has made presentations on the use of AR systems, 3D visualization technology, and robotics-assisted surgical procedures at the American Association for Thoracic Surgery Annual Meeting, International Society for Minimally Invasive Surgery Annual Scientific Meeting, and other conferences.
Dr. Currie has won numerous awards for her research achievements and scholarship. She is a Fellow of the Royal College of Surgeons of Canada. She is also a member of The Society of Thoracic Surgeons, the International Society for Heart and Lung Transplantation, the International Society for Minimally Invasive Cardiothoracic Surgery, Women in Thoracic Surgery, and the Association of Women Surgeons. With its long legacy of leadership in cardiac surgery and research, Dr. Currie feels Stanford Health Care enables her to pursue her research interests and offers her patients access to the latest innovations, along with expertise across specialties including engineering and statistics.
Martha S. Cyert
Dr. Nancy Chang Professor
Current Research and Scholarly InterestsThe Cyert lab is identifying signaling networks for calcineurin, the conserved Ca2+/calmodulin-dependent phosphatase, and target of immunosuppressants FK506 and cyclosporin A, in yeast and mammals. Cell biological investigations of target dephosphorylation reveal calcineurin’s many physiological functions. Roles for short linear peptide motifs, or SLiMs, in substrate recognition, network evolution, and regulation of calcineurin activity are being studied.
Associate Professor of Radiology (Pediatric Radiology)
Current Research and Scholarly InterestsUltrasonic beamforming, imaging methods, systems, and devices.
The J.G. Jackson and C.J. Wood Professor of Chemistry, Emeritus
BioProfessor Dai’s research spans chemistry, physics, and materials and biomedical sciences, leading to materials with properties useful in electronics, energy storage and biomedicine. Recent developments include near-infrared-II fluorescence imaging, ultra-sensitive diagnostic assays, a fast-charging aluminum battery and inexpensive electrocatalysts that split water into oxygen and hydrogen fuels.
Born in 1966 in Shaoyang, China, Hongjie Dai began his formal studies in physics at Tsinghua U. (B.S. 1989) and applied sciences at Columbia U. (M.S. 1991). He obtained his Ph.D. from Harvard U and performed postdoctoral research with Dr. Richard Smalley. He joined the Stanford faculty in 1997, and in 2007 was named Jackson–Wood Professor of Chemistry. Among many awards, he has been recognized with the ACS Pure Chemistry Award, APS McGroddy Prize for New Materials, Julius Springer Prize for Applied Physics and Materials Research Society Mid-Career Award. He has been elected to the American Academy of Arts and Sciences, National Academy of Sciences (NAS), National Academy of Medicine (NAM) and Foreign Member of Chinese Academy of Sciences.
The Dai Laboratory has advanced the synthesis and basic understanding of carbon nanomaterials and applications in nanoelectronics, nanomedicine, energy storage and electrocatalysis.
The Dai Lab pioneered some of the now-widespread uses of chemical vapor deposition for carbon nanotube (CNT) growth, including vertically aligned nanotubes and patterned growth of single-walled CNTs on wafer substrates, facilitating fundamental studies of their intrinsic properties. The group developed the synthesis of graphene nanoribbons, and of nanocrystals and nanoparticles on CNTs and graphene with controlled degrees of oxidation, producing a class of strongly coupled hybrid materials with advanced properties for electrochemistry, electrocatalysis and photocatalysis. The lab’s synthesis of a novel plasmonic gold film has enhanced near-infrared fluorescence up to 100-fold, enabling ultra-sensitive assays of disease biomarkers.
Nanoscale Physics and Electronics
High quality nanotubes from his group’s synthesis are widely used to investigate the electrical, mechanical, optical, electro-mechanical and thermal properties of quasi-one-dimensional systems. Lab members have studied ballistic electron transport in nanotubes and demonstrated nanotube-based nanosensors, Pd ohmic contacts and ballistic field effect transistors with integrated high-kappa dielectrics.
Nanomedicine and NIR-II Imaging
Advancing biological research with CNTs and nano-graphene, group members have developed π–π stacking non-covalent functionalization chemistry, molecular cellular delivery (drugs, proteins and siRNA), in vivo anti-cancer drug delivery and in vivo photothermal ablation of cancer. Using nanotubes as novel contrast agents, lab collaborations have developed in vitro and in vivo Raman, photoacoustic and fluorescence imaging. Lab members have exploited the physics of reduced light scattering in the near-infrared-II (1000-1700nm) window and pioneered NIR-II fluorescence imaging to increase tissue penetration depth in vivo. Video-rate NIR-II imaging can measure blood flow in single vessels in real time. The lab has developed novel NIR-II fluorescence agents, including CNTs, quantum dots, conjugated polymers and small organic dyes with promise for clinical translation.
Electrocatalysis and Batteries
The Dai group’s nanocarbon–inorganic particle hybrid materials have opened new directions in energy research. Advances include electrocatalysts for oxygen reduction and water splitting catalysts including NiFe layered-double-hydroxide for oxygen evolution. Recently, the group also demonstrated an aluminum ion battery with graphite cathodes and ionic liquid electrolytes, a substantial breakthrough in battery science.
Ronald L. Dalman MD
Dr. Walter C. Chidester Professor
Current Research and Scholarly InterestsVascular biology, arterial remodeling, aneurysm development; innovative treatment strategies for AAA, animal models of arterial disease, arterial remodeling and flow changes in spinal cord injury, genetic regulation of arterial aneurysm formation
Rajesh Dash, MD PhD; Director of SSATHI & CardioClick
Associate Professor of Medicine (Cardiovascular Medicine)
Current Research and Scholarly InterestsI have two research areas:
1) Heart disease in South Asians - genetic, metabolic, & behavioral underpinnings of an aggressive phenotype.
2) Imaging cell injury & recovery in the heart. Using Cardiac MRI to visualize signals of early injury and facilitating preventive medical therapy. Optimizing new imaging methods for viable cells to delineate live heart cells or transplanted stem cells.