School of Medicine


Showing 1-50 of 56 Results

  • Steven Artandi

    Steven Artandi

    Director, Stanford Cancer Institute, Jerome and Daisy Low Gilbert Professor and Professor of Biochemistry

    Current Research and Scholarly InterestsTelomeres are nucleoprotein complexes that protect chromosome ends and shorten with cell division and aging. We are interested in how telomere shortening influences cancer, stem cell function, aging and human disease. Telomerase is a reverse transcriptase that synthesizes telomere repeats and is expressed in stem cells and in cancer. We have found that telomerase also regulates stem cells and we are pursuing the function of telomerase through diverse genetic and biochemical approaches.

  • Philip Beachy

    Philip Beachy

    The Ernest and Amelia Gallo Professor in the School of Medicine, Professor of Urology, of Developmental Biology and, by courtesy, of Chemical and Systems Biology

    Current Research and Scholarly InterestsFunction of Hedgehog proteins and other extracellular signals in morphogenesis (pattern formation), in injury repair and regeneration (pattern maintenance). We study how the distribution of such signals is regulated in tissues, how cells perceive and respond to distinct concentrations of signals, and how such signaling pathways arose in evolution. We also study the normal roles of such signals in stem-cell physiology and their abnormal roles in the formation and expansion of cancer stem cells.

  • Dominique Bergmann

    Dominique Bergmann

    Professor of Biology

    Current Research and Scholarly InterestsWe use genetic, genomic and cell biological approaches to study cell fate acquisition, focusing on cases where cell fate is correlated with asymmetric cell division.

  • Helen M. Blau

    Helen M. Blau

    The Donald E. and Delia B. Baxter Foundation Professor and Director, Baxter Laboratory for Stem Cell Biology
    On Partial Leave from 01/01/2020 To 12/31/2020

    Current Research and Scholarly InterestsProf. Helen Blau's research area is regenerative medicine with a focus on stem cells. Her research on nuclear reprogramming and demonstrating the plasticity of cell fate using cell fusion is well known and her laboratory has also pioneered the design of biomaterials to mimic the in vivo microenvironment and direct stem cell fate. Current findings are leading to more efficient iPS generation, cell based therapies by dedifferentiation a la newts, and discovery of novel molecules and therapies.

  • Anne Brunet

    Anne Brunet

    Michele and Timothy Barakett Endowed Professor

    Current Research and Scholarly InterestsOur lab studies the molecular basis of longevity. We are interested in the mechanism of action of known longevity genes, including FOXO and SIRT, in the mammalian nervous system. We are particularly interested in the role of these longevity genes in neural stem cells. We are also discovering novel genes and processes involved in aging using two short-lived model systems, the invertebrate C. elegans and an extremely short-lived vertebrate, the African killifish N. furzeri.

  • Howard Y. Chang, MD, PhD

    Howard Y. Chang, MD, PhD

    Virginia and D. K. Ludwig Professor of Cancer Genomics and of Genetics

    Current Research and Scholarly InterestsOur research is focused on how the activities of hundreds or even thousands of genes (gene parties) are coordinated to achieve biological meaning. We have pioneered methods to predict, dissect, and control large-scale gene regulatory programs; these methods have provided insights into human development, cancer, and aging.

  • Katrin Chua

    Katrin Chua

    Associate Professor of Medicine (Endocrinology, Gerontology and Metabolism)

    Current Research and Scholarly InterestsOur lab is interested in understanding molecular processes that underlie aging and age-associated pathologies in mammals. We focus on a family of genes, the SIRTs, which regulate stress resistance and lifespan in lower organisms such as yeast, worms, and flies. In mammals, we recently uncovered a number of ways in which SIRT factors may contribute to cellular and organismal aging by regulating resistance to various forms of stress. We have now begun to characterize the molecular mechanisms by which these SIRT factors function. In particular, we are interested in how SIRT factors regulate chromatin, the molecular structure in which the DNA of mammalian genomes is packaged, and how such functions may link genome maintenance to stress resistance and aging.

  • Michael F. Clarke, M.D.

    Michael F. Clarke, M.D.

    Karel H. and Avice N. Beekhuis Professor in Cancer Biology

    Current Research and Scholarly InterestsDr. Clarke maintains a laboratory focused on two areas of research: i) the control of self-renewal of normal stem cells and diseases such as cancer and hereditary diseases; and ii) the identification and characterization of cancer stem cells. His laboratory is investigating how perturbations of stem cell regulatory machinery contributes to human disease. In particular, the laboratory is investigating epigenetic regulators of self renewal, the process by which stem cells regenerate themselves.

  • Gerald Crabtree

    Gerald Crabtree

    Department of Pathology Professor in Experimental Pathology and Professor of Developmental Biology

    Current Research and Scholarly InterestsChromatin regulation and its roles in human cancer and the development of the nervous system. Engineering new methods for studying and controlling chromatin in living cells.

  • Tushar Desai

    Tushar Desai

    Associate Professor of Medicine (Pulmonary and Critical Care)
    On Leave from 01/01/2020 To 07/31/2020

    Current Research and Scholarly InterestsWe investigate the cellular and molecular events that regulate proper development of the lungs, including how the gas exchange region is maintained and renewed throughout life. We apply this knowledge to dissect how dysregulation of these normal processes can cause or contribute to specific lung diseases like pulmonary fibrosis, emphysema, and lung cancer, and we are interested in uncovering how lung stem cells are regulated in the hopes of harnessing them as a regenerative therapy for patients.

  • James Ferrell

    James Ferrell

    Professor of Chemical and Systems Biology and of Biochemistry
    On Leave from 04/01/2020 To 08/31/2020

    Current Research and Scholarly InterestsMy lab has two main goals: to understand the regulation of mitosis and to understand the systems-level logic of simple signaling circuits. We often make use of Xenopus laevis oocytes, eggs, and cell-free extracts for both sorts of study. We also carry out single-cell fluorescence imaging studies on mammalian cell lines. Our experimental work is complemented by computational and theoretical studies aimed at understanding the design principles and recurring themes of regulatory circuits.

  • Hunter Fraser

    Hunter Fraser

    Associate Professor of Biology

    Current Research and Scholarly InterestsWe study the regulation and evolution of gene expression using a combination of experimental and computational approaches.

    Our work brings together quantitative genetics, genomics, epigenetics, and evolutionary biology to achieve a deeper understanding of how genetic variation within and between species affects genome-wide gene expression and ultimately shapes the phenotypic diversity of life.

  • Judith Frydman

    Judith Frydman

    Donald Kennedy Chair in the School of Humanities and Sciences and Professor of Genetics

    Current Research and Scholarly InterestsThe long term goal of our research is to understand how proteins fold in living cells. My lab uses a multidisciplinary approach to address fundamental questions about molecular chaperones, protein folding and degradation. In addition to basic mechanistic principles, we aim to define how impairment of cellular folding and quality control are linked to disease, including cancer and neurodegenerative diseases and examine whether reengineering chaperone networks can provide therapeutic strategies.

  • Margaret T. Fuller

    Margaret T. Fuller

    Reed-Hodgson Professor in Human Biology and Professor of Genetics and of Obstetrics/Gynecology (Reproductive and Stem Cell Biology)

    Current Research and Scholarly InterestsRegulation of self-renewal, proliferation and differentiation in adult stem cell lineages. Developmental tumor suppressor mechanisms and regulation of the switch from proliferation to differentiation. Cell type specific transcription machinery and regulation of cell differentiation. Developmental regulation of cell cycle progression during male meiosis.

  • Or Gozani

    Or Gozani

    Dr. Morris Herzstein Professor of Biology

    Current Research and Scholarly InterestsWe study the molecular mechanisms by which chromatin-signaling networks effect nuclear and epigenetic programs, and how dysregulation of these pathways leads to disease. Our work centers on the biology of lysine methylation, a principal chromatin-regulatory mechanism that directs epigenetic processes. We study how lysine methylation events are generated, sensed, and transduced, and how these chemical marks integrate with other nuclear signaling systems to govern diverse cellular functions.

  • William Greenleaf

    William Greenleaf

    Associate Professor of Genetics and, by courtesy, of Applied Physics

    Current Research and Scholarly InterestsOur lab focuses on developing methods to probe both the structure and function of molecules encoded by the genome, as well as the physical compaction and folding of the genome itself. Our efforts are split between building new tools to leverage the power of high-throughput sequencing technologies and cutting-edge optical microscopies, and bringing these technologies to bear against basic biological questions by linking DNA sequence, structure, and function.

  • Daniel Herschlag

    Daniel Herschlag

    Professor of Biochemistry and, by courtesy, of Chemical Engineering and of Chemistry

    Current Research and Scholarly InterestsOur research is aimed at understanding the chemical and physical behavior underlying biological macromolecules and systems, as these behaviors define the capabilities and limitations of biology. Toward this end we study folding and catalysis by RNA, as well as catalysis by protein enzymes.

  • Andrew R. Hoffman

    Andrew R. Hoffman

    Professor of Medicine (Endocrinology)

    Current Research and Scholarly InterestsMechanism of genomic imprinting of insulin like growth factor-2 and other genes.Long range chromatin interactions Role of histone modifications and DNA methylation in gene expression.

  • Peter K.  Jackson

    Peter K.  Jackson

    Professor of Microbiology and Immunology (Baxter Labs)

    Current Research and Scholarly InterestsCell cycle and cyclin control of DNA replication .

  • Daniel Jarosz

    Daniel Jarosz

    Associate Professor of Chemical and Systems Biology and of Developmental Biology
    On Leave from 02/07/2020 To 07/31/2020

    Current Research and Scholarly InterestsMy laboratory studies conformational switches in evolution, disease, and development. We focus on how molecular chaperones, proteins that help other biomolecules to fold, affect the phenotypic output of genetic variation. To do so we combine classical biochemistry and genetics with systems-level approaches. Ultimately we seek to understand how homeostatic mechanisms influence the acquisition of biological novelty and identify means of manipulating them for therapeutic and biosynthetic benefit.

  • Hanlee P. Ji

    Hanlee P. Ji

    Associate Professor of Medicine (Oncology) and, by courtesy, of Electrical Engineering

    Current Research and Scholarly InterestsCancer genomics and genetics, translational applications of next generation sequencing technologies, development of molecular signatures as prognostic and predictive biomarkers in oncology, primary genomic and proteomic technology development, cancer rearrangements, genome sequencing, big data analysis

  • Paul A. Khavari, MD, PhD

    Paul A. Khavari, MD, PhD

    Carl J. Herzog Professor in Dermatology in the School of Medicine

    Current Research and Scholarly InterestsWe work in epithelial tissue as a model system to study stem cell biology, cancer and new molecular therapeutics. Epithelia cover external and internal body surfaces and undergo constant self-renewal while responding to diverse environmental stimuli. Epithelial homeostasis precisely balances stem cell-sustained proliferation and differentiation-associated cell death, a balance which is lost in many human diseases, including cancer, 90% of which arise in epithelial tissues.

  • Seung K. Kim  M.D., Ph.D.

    Seung K. Kim M.D., Ph.D.

    Professor of Developmental Biology and, by courtesy, of Medicine (Endocrinology)

    Current Research and Scholarly InterestsWe study the genetics of pancreatic islet cell differentiation using molecular, embryologic and genetic methods in several model systems, including mice, embryonic stem cells, and Drosophila. Our work suggests that critical factors required for islet development are also needed to maintain essential functions of the mature islet. Our knowledge of genetic and cellular pathways governing islet formation has allowed us to use stem cell lines to produce islet replacements in vitro.

  • Mark Krasnow

    Mark Krasnow

    Professor of Biochemistry

    Current Research and Scholarly Interests- Lung development and stem cells
    - Neural circuits of breathing and speaking
    - Lung diseases including lung cancer
    - New genetic model organism for biology, behavior, health and conservation

  • Calvin Kuo

    Calvin Kuo

    Maureen Lyles D'Ambrogio Professor

    Current Research and Scholarly InterestsWe study cancer biology, intestinal stem cells (ISC), and angiogenesis. We use primary organoid cultures of diverse tissues and tumor biopsies for immunotherapy modeling, oncogene functional screening and stem cell biology. Angiogenesis projects include blood-brain barrier regulation, stroke therapeutics and anti-angiogenic cancer therapy. ISC projects apply organoid culture and ko mice to injury-inducible vs homeostatic stem cells and symmetric division mechanisms.

  • Joseph (Joe) Lipsick

    Joseph (Joe) Lipsick

    Professor of Pathology, of Genetics and, by courtesy, of Biology

    Current Research and Scholarly InterestsFunction and evolution of the Myb oncogene family; function and evolution of E2F transcriptional regulators and RB tumor suppressors; epigenetic regulation of chromatin and chromosomes; cancer genetics.

  • Kyle Loh

    Kyle Loh

    Assistant Professor of Developmental Biology (Stem Cell)

    Current Research and Scholarly InterestsWe have developed a strategy to generate fairly pure populations of various human tissue progenitors in a dish from embryonic stem cells (ESCs). We have delineated the sequential lineage steps through which ESCs diversify into various tissues, and in so doing, developed methods to exclusively induce certain fates at the expense of others. The resultant pure populations of tissue progenitors are the fundamental building blocks for regenerative medicine.

  • M. Peter Marinkovich, MD

    M. Peter Marinkovich, MD

    Associate Professor of Dermatology

    Current Research and Scholarly InterestsThe Marinkovich lab studies the function of epithelial extracellular matrix molecules, including integrins, collagens and laminins in epithelial development and carcinoma progression. We apply our discoveries in this area towards development of molecular therapies for carcinomas, hair disease and inherited epithelial adhesive disorders.

  • Tobias Meyer

    Tobias Meyer

    Mrs. George A. Winzer Professor in Cell Biology

    Current Research and Scholarly InterestsCELLULAR INFORMATION PROCESSING. We are using live single-cell microscopy approaches to understand the design principles of cell signaling circuits. Mammalian signaling processes have a unique logic due to the large number of signaling proteins, second messengers and chromatin modifiers involved in each decision process. We are particularly interested in understanding how cells make decisions to enter and exit the cell cycle and how they decide to polarize and move.

  • William Nelson

    William Nelson

    Rudy J. and Daphne Donohue Munzer Professor in the School of Medicine, Emeritus

    Current Research and Scholarly InterestsOur research objectives are to understand the cellular mechanisms involved in the development and maintenance of epithelial cell polarity. Polarized epithelial cells play fundamental roles in the ontogeny and function of a variety of tissues and organs.

  • Aaron Newman

    Aaron Newman

    Assistant Professor of Biomedical Data Science

    Current Research and Scholarly InterestsOur group develops computational strategies to study the phenotypic diversity, differentiation hierarchies, and clinical significance of tumor cell subsets. Key results are further explored experimentally, both in our lab and through collaboration, with the ultimate goal of translating promising findings into the clinic.

  • Roeland Nusse

    Roeland Nusse

    Virginia and Daniel K. Ludwig Professor in Cancer Research and the Reed-Hodgson Professor in Human Biology

    Current Research and Scholarly InterestsOur laboratory studies Wnt signaling in development and disease. We found recently that Wnt proteins are unusual growth factors, because they are lipid-modified. We discovered that Wnt proteins promote the proliferation of stem cells of various origins. Current work is directed at understanding the function of the lipid on the Wnt, using Wnt proteins as factors the expand stem cells and on understanding Wnt signaling during repair and regeneration after tissue injury.

  • Anthony Oro, MD, PhD

    Anthony Oro, MD, PhD

    Eugene and Gloria Bauer Professor

    Current Research and Scholarly InterestsOur lab uses the skin to answer questions about epithelial stem cell biology, differentiation and carcinogenesis using genomics, genetics, and cell biological techniques. We have studied how hedgehog signaling regulates regeneration and skin cancer, and how tumors evolve to develop resistance. We study the mechanisms of early human skin development using human embryonic stem cells. These fundamentals studies provide a greater understanding of epithelial biology and novel disease therapeutics.

  • Donna Peehl, PhD

    Donna Peehl, PhD

    Professor (Research) of Urology, Emerita

    Current Research and Scholarly InterestsMy research focuses on the molecular and cellular biology of the human prostate. Developing realistic experimental models is a major goal, and primary cultures of prostatic epithelial and stromal cells are my main model system. Our discoveries are relevant to prevention, detection, diagnosis and treatment of benign and malignant prostatic diseases.

  • Suzanne Pfeffer

    Suzanne Pfeffer

    Emma Pfeiffer Merner Professor in the Medical Sciences

    Current Research and Scholarly InterestsThe major focuses of our research is to understand the molecular basis of inherited Parkinson's Disease (PD) and to elucidate the molecular mechanisms by which proteins and cholesterol are transported between specific membrane compartments. We focus on the LRRK2 kinase that is inappropriately activated in PD and how it phosphorylates Rab GTPases, blocking the formation of primary cilia in culture and specific regions of the brain.

  • Sylvia K. Plevritis, PhD

    Sylvia K. Plevritis, PhD

    Professor of Biomedical Data Science and of Radiology (Integrative Biomedical Imaging Informatics at Stanford)

    Current Research and Scholarly InterestsMy research program focuses on computational modeling of cancer biology and cancer outcomes. My laboratory develops stochastic models of the natural history of cancer based on clinical research data. We estimate population-level outcomes under differing screening and treatment interventions. We also analyze genomic and proteomic cancer data in order to identify molecular networks that are perturbed in cancer initiation and progression and relate these perturbations to patient outcomes.

  • Jonathan Pollack

    Jonathan Pollack

    Professor of Pathology

    Current Research and Scholarly InterestsResearch in the Pollack lab centers on translational genomics, with a focus on human cancer. The lab employs next-generation sequencing, single-cell genomics, genome editing, and cell/tissue-based modeling to uncover disease mechanisms, biomarkers and therapeutic targets. Current areas of emphasis include diseases of the prostate (prostate cancer and benign prostatic hyperplasia), as well as odontogenic neoplasms.

  • Matthew Porteus

    Matthew Porteus

    Professor of Pediatrics (Stem Cell Transplantation)

    Current Research and Scholarly InterestsGenome Editing and Population Dynamics for Gene Therapy and Cancer Research

  • Stanley Qi

    Stanley Qi

    Assistant Professor of Bioengineering and of Chemical and Systems Biology

    BioDr. Lei Qi (Stanley) is Assistant Professor in the Department of Bioengineering (School of Engineering), Department of Chemical and Systems Biology (School of Medicine), and a core faculty member in Stanford ChEM-H Institute. He is one pioneer in the CRISPR technology development for genome engineering. He has developed the CRISPRi/a technologies for purposes beyond gene editing: gene regulation using CRISPR interference (CRISPRi, gene repression) and CRISPR activation (CRISPRa, gene activation), CRISPR dynamic imaging of chromatin in living cells, and CRISPRi/a high-throughput single or combinatorial genetic screens. He is also active in the field of Synthetic Biology and has developed synthetic noncoding RNAs for controlling transcription and translation. He obtained his Ph.D. in Bioengineering from the University of California Berkeley/UCSF in 2012. He joined UCSF as faculty fellow between 2012 to 2014, and joined the faculty at Stanford University since 2014. His lab currently is applying genetic engineering to rational cell design for understanding genomics and cell therapy.

  • Stephen Quake

    Stephen Quake

    Lee Otterson Professor in the School of Engineering and Professor of Bioengineering, of Applied Physics and, by courtesy, of Physics

    Current Research and Scholarly InterestsSingle molecule biophysics, precision force measurement, micro and nano fabrication with soft materials, integrated microfluidics and large scale biological automation.

  • Rajat Rohatgi

    Rajat Rohatgi

    Associate Professor of Biochemistry and of Medicine (Oncology)

    Current Research and Scholarly Intereststhe overall goal of my laboratory is to uncover new regulatory mechanisms in signaling systems, to understand how these mechanisms are damaged in disease states, and to devise new strategies to repair their function.

  • Julien Sage

    Julien Sage

    Professor of Pediatrics (Hematology/Oncology) and of Genetics

    Current Research and Scholarly InterestsWe investigate the mechanisms by which normal cells become tumor cells, and we combine genetics, genomics, and proteomics approaches to investigate the differences between the proliferative response in response to injury and the hyperproliferative phenotype of cancer cells and to identify novel therapeutic targets in cancer cells.

  • Julia Salzman

    Julia Salzman

    Assistant Professor of Biochemistry and of Biomedical Data Science

    Current Research and Scholarly InterestsCircular RNA regulation and function; computational and experimental approaches

  • Jan Skotheim

    Jan Skotheim

    Professor of Biology and, by courtesy, of Chemical and Systems Biology

    Current Research and Scholarly InterestsMy overarching goal is to understand how cell growth triggers cell division. Linking growth to division is important because it allows cells to maintain specific size range to best perform their physiological functions. For example, red blood cells must be small enough to flow through small capillaries, whereas macrophages must be large enough to engulf pathogens. In addition to being important for normal cell and tissue physiology, the link between growth and division is misregulated in cancer.

  • Tim Stearns

    Tim Stearns

    Frank Lee and Carol Hall Professor, Senior Associate Dean for Research and Professor of Genetics

    Current Research and Scholarly InterestsWe use the tools of genetics, microscopy, and biochemistry to understand fundamental questions of cell biology: How are cells organized by the cytoskeleton? How do the centrosome and cilium control cell control cell signaling? How is cell division coordinated with duplication of the centrosome, and what goes wrong in cancer cells defective in this coordination?

  • Aaron Straight

    Aaron Straight

    Professor of Biochemistry and, by courtesy, of Chemical and Systems Biology

    Current Research and Scholarly InterestsWe study the biology of chromosomes. Our research is focused on understanding how chromosomal domains are specialized for unique functions in chromosome segregation, cell division and cell differentiation. We are particularly interested in the genetic and epigenetic processes that govern vertebrate centromere function, in the organization of the genome in the eukaryotic nucleus and in the roles of RNAs in the regulation of chromosome structure.

  • Zijie Sun

    Zijie Sun

    Professor of Urology, Emeritus

    Current Research and Scholarly InterestsWe focus on understanding the molecular mechanism of transcription factors that govern the transformation of normal cells to a neoplastic state. We are especially interested in nuclear hormone action and its interactions with other signaling pathways in tumor development and progression.

  • Alice Ting

    Alice Ting

    Professor of Genetics, of Biology and, by courtesy, of Chemistry

    Current Research and Scholarly InterestsWe develop chemogenetic and optogenetic technologies for probing and manipulating protein networks, cellular RNA, and the function of mitochondria and the mammalian brain. Our technologies draw from enzyme engineering, directed evolution, chemical biology, organic synthesis, high-resolution microscopy, genetics, and computational analysis.

  • Tom Wandless

    Tom Wandless

    Professor of Chemical and Systems Biology and, by courtesy, of Chemistry

    Current Research and Scholarly InterestsWe employ an interdisciplinary approach to studies of biological systems, combining synthetic chemistry with biochemistry, cell biology, and structural biology. We invent tools for biology and we are motivated by approaches that enable new experiments with unprecedented control. These new techniques may also provide a window into mechanisms involved in maintaining cellular homeostasis. Protein quality control is a particular interest at present.