School of Medicine
Showing 2,081-2,100 of 2,218 Results
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Chad S. Weldy, M.D., Ph.D.
Instructor, Medicine - Cardiovascular Medicine
Current Research and Scholarly InterestsAs a physician-scientist in the lab of Dr. Quertermous I work to understand the genetic basis of cardiovascular disease and the transcriptional and epigenomic mechanisms of atherosclerosis. My work is focused across four main areas of cardiovascular genetics and mechanisms of coronary artery disease and smooth muscle biology:
1.Vascular smooth muscle specific ADAR1 mediated RNA editing of double stranded RNA and activation of the double stranded RNA receptor MDA5
2.Defining on single cell resolution the cellular and epigenomic features of human vascular disease across vascular beds of differing embryonic origin
3.CRISPRi screening with targeted perturb seq (TAPseq) to identify novel CAD genes in human coronary artery smooth muscle cells
4.Investigation of the epigenetic and molecular basis of coronary artery disease and smooth muscle cell transition in mice with conditional smooth muscle genetic deletion of CAD genes Pdgfd and Sox9
My work with Dr. Quertermous is focused on discovery of causal mechanisms of disease through leveraging human genetics with sophisticated molecular biology, single cell sequencing technologies, and mouse models of disease. This work attempts to apply multiple scientific research arms to ultimately lead to novel understandings of vascular disease and discover important new therapeutic approaches for drug discovery.
Grant funding received for this work:
Mentored Clinical Scientist Research Career Development Award (K08)(NIH/NHLBI, 1 K08 HL167699-01), Submitted June, 2022. PI: Weldy, Chad
•Title of proposal: “ADAR Mediated RNA editing is a causal mechanism in coronary artery disease”.
•Pending 08/01/2023 Start date
•$850,000 over 5 years
Career Development Award, American Heart Association (AHA CDA)(23CDA1042900), July, 2023 – June, 2026. PI: Weldy, Chad
•Title of proposal: “Linking RNA editing to coronary artery calcification and disease”
•Activation on 07/01/2023
•$231,000 over three years
NIH Loan Repayment Program (LRP) Award (NIH/NHLBI) Renewal Award, July, 2023. PI: Weldy, Chad
•Title of proposal: “RNA editing is a causal mechanism of coronary artery disease”
Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (F32) (NIH/NHLBI, 1 F32 HL160067-01), July, 2021. PI: Weldy, Chad
• Titled, “A transcriptional network which governs smooth muscle transition is mediated by causal coronary artery disease gene PDGFD”
•*Received perfect score with impact score 10, 1st percentile
NIH Loan Repayment Program (LRP) Award (NIH/NHLBI), July, 2021. PI: Weldy, Chad
•Title of proposal: "Single cell transcriptomic and epigenomic features of human atherosclerosis".
•This will award up to $100,000 towards student loans over the next 24 months with opportunity for renewal after 24 months. -
Wen-Kai Weng, MD, PhD
Associate Professor of Medicine (Blood and Marrow Transplantation and Cellular Therapy) and, by courtesy, of Dermatology
On Partial Leave from 04/10/2024 To 05/21/2024Current Research and Scholarly InterestsMy research interest is on immunotherapy (including allogeneic transplant) of cancer. I have studies the mechanism of monoclonal antibody therapy in lymphoma patients and am currently working on designing new strategy to enhance the clinical efficacy of antibody therapy by infusing expanded NK cells. I am also interested in using tumor vaccine along with hematopoietic cell transplant.
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Yingjie Weng
Biostatistician 3, Med/Quantitative Sciences Unit
Current Role at StanfordResponsibility for Assistant Director, Learning Health Systems Program (LHS):
• Establish and update LHS program resources within QSU
• Host the onboard training program for new QSU hires and training sessions at a regular basis within QSU
• Establish and mentor a core team within QSU for the LHS program
• Guide the process of the projects assignments for quality improvement, pragmatic trials and studies involve real-world evidence generation using electronic health records (EHRs)
• Maintain close relationships with clinical advocators of LHS projects at our collaborating departments under the supports and advocacy of QSU leadership.
• Host an on-board session with department leaders who are interested in the program to communicate our missions of the program.
• Host educational sessions/lectures for clinical investigators across collaborating departments
• Establish close collaborations with a variety of data teams across campus departments under the supports and advocacy of QSU leadership
• Act as the point person for QSU on the LHS Program
Responsibility for Senior Biostatistician:
- Study Design and Study Protocol Development
- Statistical Analysis Plan
- Grant Preparation
- Statistical Methodology Research
- Data Quality Control
- Data Visualization
- Data Cleaning
- Statistical Programming
- Statistical Modeling
- Mentor junior statistician -
Cornelia Weyand
Professor of Medicine (Immunology and Rheumatology), Emerita
Current Research and Scholarly InterestsAutoimmunity
Chronic inflammatory disease
Metabolic control of immune function -
Matthew Wheeler
Associate Professor of Medicine (Cardiovascular Medicine)
Current Research and Scholarly InterestsTranslational research in rare and undiagnosed diseases. Basic and clinical research in cardiomyopathy genetics, mechanisms, screening, and treatment. Investigating novel agents for treatment of hypertrophic cardiomyopathy and new mechanisms in heart failure. Cardiovascular screening and genetics in competitive athletes, disease gene discovery in cardiomyopathy and rare disease. Informatics approaches to rare disease and multiomics. Molecular transducers of physical activity bioinformatics.
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Jennifer Williams
Clinical Assistant Professor, Medicine - Pulmonary, Allergy & Critical Care Medicine
BioDr. Williams is a fellowship-trained pulmonologist specializing in pulmonary critical care medicine. She has board certification in pulmonary medicine, critical care medicine, and internal medicine.
She is a clinical assistant professor in the Department of Medicine, Division of Pulmonary, Allergy & Critical Care Medicine at Stanford University School of Medicine.
For each patient, Dr. Williams develops a comprehensive and compassionate care plan. Her goal is to help every individual achieve the best possible lung health and quality of life.
Patient reviews praise the quality of the care she delivers, her thoroughness, and her patient skills.
Dr. Williams has participated in clinical research studies. She has published articles on autoimmune disease involving interstitial lung disease, COPD, and life-threatening pulmonary complications associated with leukemia. She also co-authored an article on the development of guidelines for identifying and managing post-traumatic stress disorder symptoms associated with critical illness.
Her work has appeared in peer-reviewed journals including the American Journal of Respiratory and Critical Care Medicine, Internal Medicine, and elsewhere. She also has written chapters in books on critical care medicine and clinical decision-making.
Dr. Williams speaks English and both written and oral medical Spanish. In her free time, she enjoys soccer and distance running. -
Marcelle Winget
Sr Res Scholar, Primary Care and Population Health
Current Role at StanfordDirector, Evaluation Sciences Unit
