School of Medicine
Showing 101-110 of 4,921 Results
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Manuel R. Amieva
Professor of Pediatrics (Infectious Diseases) and of Microbiology and Immunology
Current Research and Scholarly InterestsMy laboratory studies how bacteria colonize our bodies for long periods of time, and how interactions between bacteria and the epithelial surfaces of the gastrointestinal tract and skin may lead to disease. Epithelial surfaces are the first barrier against infection, but they also where our bodies meet and co-evolve with the microbial world.. Several of our studies have focused on the epithelial junctions as a target for bacterial pathogens. The host epithelium uses its epithelial junctions to form a tight but dynamic barrier with an external surface that is inhospitable to microbial attachment, secretes anti-microbial compounds, and has a rapid rate of self-renewal. The balance in the microbe-epithelial relationship results in silent commensalism or symbiosis; an imbalance results in diseases ranging from acute bacterial invasive disease to chronic ulcers or carcinoma.
Our laboratory has developed novel microscopy applications such as quantitative 3D confocal microscopy, electron microscopy, time-lapse imaging, microinjection and micromanipulation to visualize the interaction of pathogens with epithelial cells in culture and in animal and human tissues. Many of out studies focus on the gastric pathogen Helicobacter pylori, but we have also expanded our investigations to include the intestinal pathogens Listeria monocytogenes and Salmonella enterica, and the skin pathogen and colonizer Staphylococcus aureus. I believe that elucidating how microbes communicate with and alter our epithelial cells at a molecular level will be important for finding novel therapeutic targets to control mucosal colonization and prevent invasive disease.
Using this perspective, we have uncovered several novel concepts of how bacteria colonize and breach our epithelial surfaces. For example, we discovered that Helicobacter pylori target the intercellular junctions, and in particular that the virulence factor CagA affects junction assembly and cell polarity. This confers H. pylori the ability to extract nutrients and grow directly on the epithelial surface. We also found that these properties of CagA have consequences for cellular transformation of the epithelium. For instance, we showed that H. pylori affect the activity and state of epithelial stem cells in the stomach by colonizing the epithelial surface deep in the gastric glands. This gland-associated population is essential for pathological inflammation and hyperplasia in animal models, and confers significant colonization advantages to the bacteria. Our Listeria research uncovered a new mechanism and site where bacteria can breach the gastrointestinal epithelial barrier to invade. We found that Listeria find their receptor for invasion at sites of epithelial senescence, where the epithelial junctions undergo dynamic turnover. To study Salmonella and H. pylori we have developed a human organoid model to study their interactions with human gut epithelium in vitro. To study Staphylococcus aureus pathogenesis, we have developed methods to visualize infection at the scale of a single bacterial microcolony using an organoid culture system of human keratinocytes and fibroblasts that grow into a 3D skin-equivalent. We recently identified several proteins at the eptithelial junctions as host factors involved in the pathogenesis of one of Staphylococcus aureus major toxins. -
Michael Amylon
Professor of Pediatrics (Hematology/Oncology) at the Lucile Salter Packard Children's Hospital, Emeritus
Current Research and Scholarly InterestsBone marrow transplantation (BMT) is a treatment modality which is being broadly applied to a growing number of disorders. Increasing success with BMT is offering improved survival to pediatric and adult patients with acute leukemia, chronic leukemia, lymphomas, and a variety of solid tumors as well as severe aplastic anemia.
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Tonya Wei An, MD
Clinical Assistant Professor, Orthopaedic Surgery
BioDr. An is a fellowship-trained orthopaedic surgeon specializing in foot and ankle surgery. She provides care at Stanford Health Care locations in Emeryville and Pleasanton.
Her practice focuses on the diagnosis and treatment, both nonsurgical and surgical, of foot and ankle conditions, including sports injuries, flatfoot deformity, and ankle arthritis. Working with world-class experts at the Hospital for Specialty Surgery, Dr. An is trained in the latest techniques and technologies, ranging from cartilage repair, minimally invasive bunion correction, to total ankle replacement.
Dr. An is passionate about practicing evidence-based medicine and pursuing research to advance the field of foot and ankle surgery. She works as part of a team with other orthopedic specialists, neurologists, physiatrists, and therapists to help patients achieve the best clinical outcomes. Dr. An believes in understanding each individual’s circumstances and goals to create a personalized care plan. When surgery is deemed the best option, Dr. An guides her patients through every step of getting back on their feet.
Dr. An has been involved in extensive research studying clinical outcomes after surgical correction of foot deformities caused by Charcot-Marie-Tooth disease, a hereditary condition that results in weaker and smaller muscles. Her work has appeared in several peer-reviewed scientific journals, including Foot & Ankle International and the Journal of Foot and Ankle Surgery, among others. She has also written textbook chapters on flatfoot and bunion surgical techniques, metatarsalgia (pain in the ball of the foot), and Lisfranc (midfoot) injuries.
Dr. An is a licensed physician in California and New York. She is a member of the Western Orthopaedic Association, American Orthopaedic Foot and Ankle Society (AOFAS), American Academy of Orthopedic Surgeons, and the American Medical Association. She advocates for diversity in the field of medicine and has served organizations such as the Committee on Inclusion, Equity and Advancement and Women in Orthopaedics Outreach Group at her prior institution. -
Kanwaljeet S. Anand
Professor of Pediatrics (Pediatric Critical Care) and of Anesthesiology, Perioperative and Pain Medicine
Current Research and Scholarly InterestsDr. Anand is a translational clinical researcher who pioneered research on the endocrine-metabolic stress responses of infants undergoing surgery and developed the first-ever scientific rationale for pain perception in early life. This provided a framework for newer methods of pain assessment, numerous clinical trials of analgesia/anesthesia in newborns, infants and older children. His research focus over the past 30+ years has contributed fundamental knowledge about pediatric pain/stress, long-term effects of pain in early life, management of pain, mechanisms for opioid tolerance and withdrawal. Current projects in his laboratory are focused on developing biomarkers for repetitive pain/stress in critically ill children and the mechanisms underlying sedative/anesthetic neurotoxicity in the immature brain. He designed and directed many randomized clinical trials (RCT), including the largest-ever pediatric analgesia trial studying morphine therapy in ventilated preterm neonates. He has extensive experience in clinical and translational research from participating in collaborative networks funded by NIMH, NINDS, or NICHD, a track-record of excellent collaboration across multiple disciplines, while achieving success with large research teams like the Collaborative Pediatric Critical Care Research Network (CPCCRN). He played a leadership roles in CANDLE (Condition Affecting Neuro-Development & Learning in Early infancy) and other activities of the Urban Child Institute and UT Neuroscience Institute. More recently, he led the NeoOpioid Consortium funded by the European Commission, which collected data from 243 NICUs in 18 European countries.
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Shuchi Anand
Associate Professor of Medicine (Nephrology)
Current Research and Scholarly InterestsManagement of CKD and ESRD in low-resource settings
Tubulointerstitial disease
Chronic kidney disease of unknown etiology
ESRD and physical activity
ESRD and vitamin D deficiency -
Christine Anastasiou, MD, MAS
Clinical Assistant Professor, Medicine - Immunology & Rheumatology
BioDr. Anastasiou is a board-certified, fellowship-trained rheumatologist with the Stanford Health Care Immunology and Rheumatology Clinic. She is also a clinical assistant professor in the Department of Medicine, Division of Immunology and Rheumatology at Stanford University School of Medicine.
Dr. Anastasiou specializes in diagnosing and treating patients with rheumatic diseases. She has a special interest in ankylosing spondylitis, systemic lupus erythematosus, rheumatoid arthritis, and idiopathic inflammatory myopathies.
Her scholarly work includes epidemiologic studies and clinical trials focused on improving safety and health outcomes for people with chronic rheumatic diseases. Dr. Anastasiou has served as an investigator and collaborator for clinical trials of new therapies to treat rheumatic disease. She is actively involved in medical education through developing and leading patient, medical student, resident, and fellow educational programs.
Dr. Anastasiou is a member of the American College of Rheumatology (ACR). She has published her research in peer-reviewed journals, including Arthritis Care & Research and Lupus Science & Medicine. She has delivered lectures and presentations across the country and abroad on various topics related to rheumatology. -
Chad Anderson
Clinical Assistant Professor, Medicine - Primary Care and Population Health
BioChad Anderson is a Physician Assistant at Stanford ValleyCare and a Clinical Assistant Professor with the Stanford School of Medicine MSPA program. He is the Assistant Director of PA education at ValleyCare. He is dual credentialed as a Family Nurse Practitioner and a Physician Assistant. He completed his FNP/PA training at the Stanford School of Medicine and his graduate studies at A.T. Still University – Arizona School of Health Sciences. He is passionate about improving our patients hospital experience as well as educating our future providers.
