School of Medicine
Showing 111-120 of 142 Results
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Michael J Rosen, MD, MSCI
Stanford University Endowed Professor for Pediatric IBD and Celiac Disease
BioDr. Rosen is a pediatric gastroenterologist and physician scientist who has been devoted to advancing inflammatory bowel disease (IBD) research and care for 25 years. He is the inaugural Stanford University Endowed Professor for Pediatric IBD and Celiac Disease. He is also Director of the Stanford Medicine Children’s Health Center for IBD and Celiac Disease, which has achieved nationally leading clinical outcomes under his direction. Dr. Rosen’s research expertise crosses mucosal immunology and epithelial biology and clinical and translational investigation. His NIH-funded laboratory has demonstrated the protective role for type 2 cytokines in chronic intestinal inflammation and advanced intestinal organoids as a model to study IBD. His clinical research has demonstrated how proactive therapeutic drug monitoring can be incorporated into clinical practice to optimize ant-TNF therapy treatment response. Dr. Rosen led the multicenter ARCH Study, which demonstrated the importance of intensified anti-TNF drug dosing in pediatric acute severe ulcerative colitis. Presently, he is co-principal investigator for the Crohn's & Colitis Foundation’s Cohort for Pediatric Translational and Clinical Research in IBD (CAPTURE IBD) which will advance precision medicine for children with IBD.
After graduating from Duke University, Dr. Rosen attended Harvard Medical School, followed by pediatrics residency at Boston Children’s Hospital and Boston Medical Center. He pursued his pediatric gastroenterology fellowship at Vanderbilt University Medical Center, where he received a Master of Science in Clinical Investigation. He started his faculty career at Vanderbilt and then moved to Cincinnati Children’s Hospital and the University of Cincinnati College of Medicine. There he rose to Medical Director of the Schubert Martin IBD Center and Associate Director for Faculty Development in the Gastroenterology division before moving to Stanford in 2021. Dr. Rosen serves on the editorial board for Inflammatory Bowel Diseases and the National Scientific Advisory Committee for the Crohn’s & Colitis Foundation. Outside of work, Dr. Rosen enjoys spending time with his wife and two children at their activities, watching movies, downhill skiing, and getting outside. -
Nazish Sayed MD, PhD
Associate Professor (Research) of Surgery (Vascular Surgery)
Current Research and Scholarly InterestsThe Sayed Laboratory investigates how endothelial dysfunction contributes to cardiovascular disease and leverages human stem cell technologies to identify novel therapeutic strategies. Our research integrates patient-derived induced pluripotent stem cells (iPSCs), engineered cardiac tissues, organoids, human biospecimens, and multi-omic technologies to uncover mechanisms underlying inherited and acquired cardiovascular diseases.
A major focus of the laboratory is understanding endothelial–cardiomyocyte communication in cardiomyopathy. Using patient-specific iPSCs, human cardiac organoids, engineered heart tissues, spatial transcriptomics, and single-cell multi-omics, we study how endothelial dysfunction drives myocardial fibrosis, inflammation, and heart failure. Current efforts include investigations into LMNA-related dilated cardiomyopathy, endothelial-to-mesenchymal transition (EndoMT), and mechanisms of fibrotic remodeling.
A second major area of research is cardio-oncology. The laboratory develops human disease models to understand cardiovascular complications associated with cancer therapies, including tyrosine kinase inhibitors and immune checkpoint inhibitors. These studies have identified novel vascular mechanisms underlying treatment-related hypertension, cardiomyopathy, and heart failure.
The laboratory also investigates cardiovascular aging, toxic environmental exposures, rare vascular diseases, and regenerative medicine. By integrating human tissues, advanced stem cell models, genome engineering, spatial biology, and artificial intelligence–enabled multi-omic analyses, our goal is to develop precision therapeutic strategies that improve cardiovascular health and patient outcomes. -
Michael Schumacher
Assistant Professor of Pediatrics (Gastroenterology)
Current Research and Scholarly InterestsThe Schumacher Gut Science Lab is focused on discovering new therapeutic targets for intestinal inflammatory diseases like ulcerative colitis and Crohn’s disease. We study the mucosal immunology and epithelial biology of the gut.
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Zachary M. Sellers, MD, PhD
Adjunct Professor, Pediatrics - Gastroenterology
BioDr. Sellers is a pediatric physician-scientist and research and clinical development consultant. As a pediatric gastroenterologist and ion channel physiologist, Dr. Sellers' work in academia and pharma over the last 20 years has focused on improving the lives of individuals with complex and rare diseases through providing cutting-edge clinical care and advancing research and drug development. Dr. Sellers previously led a basic and translational research laboratory at Stanford, focused on epithelial ion transport and acid-base regulation using a variety of human and animal models. He is a firm believer in the exponential impact of team science and is adept working in multi-disciplinary and cross-functional teams. He seeks out strategic partnerships and opportunities that can leverage his expertise and leadership to advance innovative therapies for areas of high unmet need and to support the development of the next generation of physician-scientists. Dr. Sellers received his BS (Animal Physiology and Neuroscience) and BA (Japanese Studies) from the University of California. San Diego, his MD and PhD (Molecular and Integrative Physiology) from the University of Illinois at Urbana-Champaign, and was trained in Pediatrics and Pediatric Gastroenterology, Hepatology, and Nutrition at Stanford, where he was previously a faculty member and attending physician. He held multiple leadership positions at Stanford, including Associate Chief of Research in Gastroenterology, Director of the Stanford Children's Pancreas Program, Lead Gastroenterologist for the CF Program, Director of the CFTR Phenotyping and Theratyping Program, and Physician-Scientist Advisor for the Pediatrics Residency Program.
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Eric Sibley, M.D., Ph.D.
Professor of Pediatrics (Gastroenterology)
Current Research and Scholarly InterestsMolecular Regulation of Intestinal Development and Maturation. We study transcriptional mechanisms regulating the spatial and temporal restriction of intestine-specific gene expression during gut development. Our approach is to characterize the function of gene-specific DNA cis elements and interacting nuclear proteins in cell culture and in transgenic animals. The goal is to relate the gene-specific control mechanisms to the broader pathways specifying acquisition of gut phenotypes.
