School of Medicine
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Hector Rodrigo Mendez
Postdoctoral Scholar, Cardiovascular Medicine
BioDr. Hector Rodrigo Mendez is a Medical Geneticist from Argentina. Rodrigo completed a residency program in Medical Genetics at Centro Nacional de Genetica Medica – ANLIS (Buenos Aires, Argentina) and a Master’s program in Medical Molecular Biology at Buenos Aires University.
Rodrigo continued his scientific career at a German Genomic Start-up, working as a human geneticist and providing his experience in rare disorders, genomic data (WGS/WES/gene panels) analysis, variant interpretation, and its integration with a deep focus on genotype-phenotype correlation.
Rodrigo’s areas of expertise are rare disorders, NGS technology, Whole Genome Sequencing analysis, and ACMG interpretation guidelines, and his research aims are:
- Collection and analysis of clinical data through deep-learning phenotyping approaches.
- Multi-omic data integration to elucidate complex and rare genetic disorders.
- International collaborations to break down barriers to research participation amongst those who have been under-represented.
At Stanford University, under the supervision of Dr. Matthew Wheeler, he is conducting his postdoctoral research studies to achieve his scientific goals. -
Samuel Montalvo Hernandez
Postdoctoral Scholar, Cardiovascular Medicine
BioAs a clinical exercise physiologist and sport biomechanist, I am dedicated to advancing human exercise and sports performance. I hold certifications as a Performance and Sport Scientist (CPSS) and as a Strength and Conditioning Specialist with Distinction (CSCS, *D) from the National Strength and Conditioning Association (NSCA). In 2022, I was honored with the Wu Tsai Human Performance Alliance Post-Doctoral Research Fellowship and a T32 Post-Doctoral Fellowship, Research Training in Myocardial Biology (TIMBS) at Stanford University.
My research focuses on understanding the mechanical, molecular, and physiological mechanisms that underpin human performance. I am also committed to developing innovative and practical training methods to enhance exercise and sports performance. Currently, I am a member of the Stanford Bioinformatics Core, contributing to the NIH-funded Molecular Transducers of Physical Activity Consortium (MoTrPAC) project. In this capacity, I analyze extensive clinical and exercise datasets, as well as multi-omic, multi-tissue, multi-exercise modality, and multi-species data, to uncover new insights into the biological mechanisms of physical activity and its impact on human health and performance.
In addition to my primary research focus, I collaborate with several teams at Stanford on projects involving Sports and Electrocardiography, Cardiopulmonary Exercise Testing, Exercise and Neuromuscular Disease, and the Stanford Baseball Team.
Beyond research, I am deeply committed to teaching, mentoring, and promoting diversity. As a first-generation college graduate and a Mexican-American with Indigenous heritage, I bring a unique perspective to my work, which informs my dedication to creating supportive and inclusive spaces for underrepresented groups in science and education. I serve as a Post-Doc Mentoring Coach in collaboration with the Stanford Office of Postdoctoral Affairs, where I facilitate bi-weekly workshops on mentoring for postdocs. I am also part of the Stanford PRISM program, which promotes inclusion and diversity among postdoctoral scholars. Furthermore, I mentor prospective and current medical students through the MAVERICs program (Metascience Analyses and Explorations of Reproducibility in Cardiovascular Science) as part of the Stanford Cardiovascular Institute, supporting their growth in cardiovascular research.
These experiences reflect my dedication to fostering an inclusive and supportive academic environment. My long-term goal is to become a professor, combining my passion for research, education, and mentoring the next generation of scientists to advance the fields of exercise physiology and sports science. -
Connor Galen O'Brien
Postdoctoral Medical Fellow, Cardiovascular Medicine
BioDr. O'Brien is a native of Menlo Park, CA. He attended medical school at Columbia University College of Physicians and Surgeons. At Columbia he was elected to both Alpha Omega Alpha and Gold Humanism Honors Societies. He completed an Internal Medicine residency as well as fellowship in Cardiovascular Medicine at Stanford University. In his third year of fellowship, he was selected Chief Cardiology Fellow.
He is currently a post-doctoral fellow performing regenerative medicine research, specifically studying the role of exosomes in treating cardiomyopathy. In addition to his basic science research, he is also involved in human clinical trials investigating the role of stem cells in treating various forms of cardiomyopathy. -
Disha Sharma
Postdoctoral Scholar, Cardiovascular Medicine
BioI am currently a Postdoctoral Fellow with Dr. Thomas Quertermous at Stanford University. I have joined the lab with more than 7 years of research experience in the field of computational biology wherein I have worked with multi-omics data for multiple diseases to get a deeper understanding of the disease identification and progression.
My background in engineering and bioinformatics provide an excellent background for the studies proposed in this application, which proposes to investigate the genetics and genomics of smooth muscle cell biology in the context of vascular disease. I first pursued a Bachelor's in Biotechnology program at one of the premier institutes in India, Banasthali Vidyapeeth and received my degree in 2007. After qualifying with the IIT-JAM exam in 2010, I joined the Master’s in Science (Biotechnology) program at the prestigious Indian Institute of Technology Roorkee in a program of engineering and technology. After my Master's, I joined Dr. Vinod Scaria’s lab at CSIR-IGIB as a Project Fellow. During the tenure as Project fellow from 2012-2014, I had the opportunity to work with different transcriptomics data from model organisms including zebrafish, rat and human cell lines to understand the role of long non-coding RNAs and miRNAs. I also worked on clinical datasets of autoimmune disorders. With one and half years of research experience and a UGC fellowship awarded through the NET-JRF examination, I continued working with Dr. Vinod Scaria to pursue my PhD. My research interest for the degree focused on the identification and characterization of circular RNAs, and this work has now been published in multiple manuscripts listed below. Over the years at CSIR-IGIB, I have had the chance to work on interesting ideas with multiple collaborating groups. One of them was Dr. Sridhar Sivasubbu, with whom I worked to understand the transcript-level interactions between mitochondria and the nucleus, using zebrafish as a model organism.
In view of my interest in the translational aspects of biology, I obtained the opportunity to work as part of the GUaRDIAN Consortium with Dr. Vinod Scaria and Dr. Sridhar Sivasubbu at CSIR-IGIB. This pioneering project is the largest network of researchers and clinicians in India pursuing sequencing patient DNAs to identify rare SNVs and structural variants responsible for muscular dystrophy in these patients. In the interest of advancing genomics in clinical and healthcare settings, I was selected as Intel Fellow 2019 to work for the Intel-IGIB collaboration focussing on “Accelerating Clinical Analysis and Interpretation of Genomic Data through advanced tools/libraries”. Our project was selected among top 3 from 50 premier research institutes and I was awarded the Intel-India Fellowship for a year to pursue this project. I was also part of the core team of IndiGen (Genomes for Public Health in India). With the spread of COVID-19 around the world, our group contributed by sequencing and analysing COVID19 genomes to get a better understanding of the disease and I had the opportunity to be part of the core team to analyse the viral sequencing datasets and viral assembly.
I am extremely pleased to have joined the Quertermous lab at Stanford to the study of the molecular mechanisms of cardiovascular disease. Work that I am pursuing in this laboratory, and proposed in this application, are directly in line with my personal aspiration to start an independent career in the field of scientific research to work on projects with high translational value and of interest to the public health.
