School of Medicine

Showing 51-60 of 124 Results

  • Danish Khan

    Danish Khan

    Postdoctoral Scholar, Biochemistry

    BioDanish is an accomplished researcher who has been working as a postdoctoral research associate at Prof. Onn Brandman's Lab at the Department of Biochemistry for approximately 3.5 years. His primary area of research revolves around unraveling the intricate mechanisms of eukaryotic protein quality control and stress response pathways. Danish's scientific journey at Stanford began as a post-doc under the supervision of Prof. Georgios Skiniotis where he worked briefly before joining Prof. Onn Brandman's group, motivated by his strong interest in investigating ribosome-associated quality control (RQC) pathways and the fascinating phenomenon of "CAT tails," which involves the addition of amino acids to a protein without an mRNA template.

    Motivated by a desire to comprehend how defects in RQC pathways contribute to the development of neurodegenerative diseases in humans, Danish aspires to develop therapeutic interventions for these conditions. Within the Brandman lab, Danish has achieved many accomplishments: he has a first author preview published in Journal of Cell Biology, a second author paper in the eLife journal and a middle author publication in Nature Communications. Currently, Danish is working on two manuscripts that disclose novel and groundbreaking findings concerning the determinants and consequences of CAT tailing in eukaryotes. At Stanford, Danish was awarded the Dean's Fellowship (Bernard Cohen Post Doctoral Fellowship Fund) and Mikitani Cancer Research Fellowship.

    Prior to his time at Stanford, Danish earned his PhD from Texas A&M University at College Station, TX. During his doctoral studies, he delved into the chemical inhibition of a lipid signaling protein, leading to the discovery of a remarkable heme-binding lipid transfer protein. Danish's exceptional work during his graduate school tenure resulted in the publication of three first-author papers in renowned journals such as eLife, Cell Chemical Biology, and the Journal of Lipid Research. Additionally, he made valuable contributions as a middle author to five additional papers. Danish's incredible productivity at Texas A&M was recognized by the 'John Mack Prescott Award For Outstanding Research'.

    Danish's academic journey commenced with a Bachelor's degree in Biochemistry from Presidency College, Kolkata (University of Calcutta), India where he ranked second in college and fourth in university. He then obtained his Master's degree in Biotechnology from Banaras Hindu University in India on Government of India's DBT Fellowship having obtained an All India Rank of 94. Outside of his scientific pursuits, Danish harbors an interest in law and the intersection between law and technology, often immersing himself in related literature.

  • Chaitan Khosla

    Chaitan Khosla

    Wells H. Rauser and Harold M. Petiprin Professor and Professor of Chemistry and, by courtesy, of Biochemistry

    Current Research and Scholarly InterestsResearch in this laboratory focuses on problems where deep insights into enzymology and metabolism can be harnessed to improve human health.

    For the past two decades, we have studied and engineered enzymatic assembly lines called polyketide synthases that catalyze the biosynthesis of structurally complex and medicinally fascinating antibiotics in bacteria. An example of such an assembly line is found in the erythromycin biosynthetic pathway. Our current focus is on understanding the structure and mechanism of this polyketide synthase. At the same time, we are developing methods to decode the vast and growing number of orphan polyketide assembly lines in the sequence databases.

    For more than a decade, we have also investigated the pathogenesis of celiac disease, an autoimmune disorder of the small intestine, with the goal of discovering therapies and related management tools for this widespread but overlooked disease. Ongoing efforts focus on understanding the pivotal role of transglutaminase 2 in triggering the inflammatory response to dietary gluten in the celiac intestine.

  • Peter S. Kim

    Peter S. Kim

    Virginia and D. K. Ludwig Professor of Biochemistry
    On Partial Leave from 09/01/2023 To 06/30/2024

    Current Research and Scholarly InterestsWe are studying the mechanism of viral membrane fusion and its inhibition by drugs and antibodies. We use the HIV envelope protein (gp120/gp41) as a model system. Some of our studies are aimed at creating an HIV vaccine. We are also characterizing protein surfaces that are referred to as "non-druggable". These surfaces are defined empirically based on failure to identify small, drug-like molecules that bind to them with high affinity and specificity.

  • Silvana Maria Konermann

    Silvana Maria Konermann

    Assistant Professor of Biochemistry

    BioSilvana is an Assistant Professor of Biochemistry at Stanford and Executive Director and Core Investigator at Arc Institute. Her research laboratory aims to understand the molecular pathways that drive the development of Alzheimer’s disease using next-generation functional genomics, with the long-term goal of developing rationally targeted therapeutics for neurodegenerative disorders. She received her Ph.D. in Neuroscience from MIT. Silvana’s pioneering work on tools to directly perturb the transcriptomic landscape of the cell using CRISPR has been recognized by her faculty appointment as a Chan Zuckerberg Biohub Investigator and Hanna Gray Fellow of the Howard Hughes Medical Institute.

  • Mark Krasnow

    Mark Krasnow

    Paul and Mildred Berg Professor

    Current Research and Scholarly Interests- Lung development and stem cells
    - Neural circuits of breathing and speaking
    - Lung diseases including lung cancer
    - New genetic model organism for biology, behavior, health and conservation