School of Medicine
Showing 701-800 of 1,057 Results
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Lisa Patel
Clinical Associate Professor, Pediatrics
BioLisa Patel received her undergraduate degree in Biological Sciences from Stanford University. After college, she worked in Egypt, Brazil, and India on international development projects with community-based organizations and non-profits, focusing on conservation and development efforts. She then obtained her Master's in Environmental Sciences from the Yale School of the Environment and went on to be a Presidential Management Fellow for the Environmental Protection Agency, coordinating the US Government's efforts on clean air and safe drinking water projects in South Asia in collaboration with the World Health Organization. Realizing the critical and inextricable links between children's health and environmental issues, she obtained her medical degree from Johns Hopkins University and completed her residency in pediatrics at UCSF. For the last several years, she has used her extensive experience working for government, community organizations, and non-profits to advocate for children's health priorities in the US. She is previously the co-chair for the American Academy of Pediatrics Advocacy Committee, California Chapter 1 (AAP-CA1) and in her time helped launch the inaugural Advocating for Children Together conference for Northern California that is now a yearly occurrence. She co-founded the Climate and Health task force for AAP-CA1, and sits on the Executive Committee for the AAP's national Council on Environmental Health and Climate Change. She is formerly the rotation director for the pediatric resident's Community Pediatrics and Child Advocacy Rotation. She is currently the Executive Director for the Medical Society Consortium on Climate and Health and maintains a clinical practice as a pediatric hospitalist caring for newborns, premature infants, and children requiring hospitalization. She also sits on the Board of Our Children's Trust, the legal organization that represented youth in Held v. Montana.
Her work has appeared in the New England Journal of Medicine, the New York Times, the LA Times, Bloomberg News, and multiple state and local outlets. She is interviewed regularly for her expertise on climate, health, and equity for major national media outlets like the Washington Post, US News and World Report, CNN, among others. -
Meghna Patel
Clinical Assistant Professor, Pediatrics - Cardiology
Current Research and Scholarly InterestsMy current academic focus is in chronic heart failure and ventricular assist device.
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Piru Pathmarajah
Postdoctoral Scholar, Dermatology
BioDr Pirunthan Pathmarajah graduated from University College London Medical School in 2016 and intercalated with a first-class Bachelor of Science in Medical Sciences with Physiology. He successfully completed a clinical elective in Allergy and Immunology at Yale New Haven Hospital, USA. He has continued to specialise in Dermatology, training at Broomfield Hospital and Basildon Hospital in the UK. His key academic interests are in medical dermatology with respect to eczema and psoriasis which he continues to pursue as part of the clinical research team at the St John’s Institute of Dermatology. He is currently undertaking a Postdoctoral Fellowship at Stanford University studying genotype-phenotype associations in Epidermolysis Bullosa and validating a novel scoring instrument with the aim of developing novel therapeutics for patients with this rare complex condition.
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Francis Pearman
Assistant Professor of Education
BioFrancis A. Pearman is an Assistant Professor of Education in the Graduate School of Education at Stanford University. His research focuses on how poverty and inequality shape the life chances of children, especially in rapidly changing cities. Pearman holds a Ph.D. and M.Ed. from Vanderbilt University and a B.S. from the University of Virginia.
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Andrea Pedroza Tobias
Postdoctoral Scholar, General Pediatrics
BioDr. Andrea Pedroza is a postdoctoral scholar at Stanford Impact Labs and the Department of Pediatrics in the Partnerships for Research in Child Health Lab. She earned a Ph.D. in Global Health from the University of California, San Francisco (UCSF) and a Master of Science in Nutrition from the National Institute of Public Health in Mexico (INSP). Her research focuses on generating evidence for interventions and policy recommendations aimed at improving the dietary quality of children to impact their health and development. Currently, she is employing a community-engaged approach to design nutrition interventions and policy recommendations that aim to reduce the consumption of ultra-processed foods among low-income children to narrow the gap in health disparities.
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Gary Peltz
Professor of Anesthesiology, Perioperative and Pain Medicine
Current Research and Scholarly InterestsThe laboratory develops and uses state of the art genomic methods to identify genetic factors affecting disease susceptibility, and to translate these findings into new treatments. We have developed a more efficient method for performing mouse genetic analysis, which has been used to analyze the genetic basis for 16 different biomedical traits. We are developing novel methods, and have developed a novel experimental platform that replaces mouse liver with functioning human liver tissue.
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Jon-Paul Pepper, MD
Associate Professor of Otolaryngology - Head & Neck Surgery (OHNS)
Current Research and Scholarly InterestsFacial paralysis is a debilitating condition that affects thousands of people. Despite excellent surgical technique, we are currently limited by the regenerative capacity of the body. The mission of our research is to identify new treatments that improve current facial paralysis treatments. We do this by exploring the regenerative cues that the body uses to restore tissue after nerve injury, in particular through pathways of neurogenesis and nerve repair in small mammals.
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Claudia Katharina Petritsch
Associate Professor (Research) of Neurosurgery
Current Research and Scholarly InterestsThe Petritsch lab broadly investigates underlying causes for the intra-tumoral heterogeneity and immune suppression in brain tumors from a neuro-developmental perspective. Defective cell fate decisions fuel the intra-humoral heterogeneity and plasticity in human brain tumors and may contribute to immune suppression. We use patient-derived models as avatars to study how brain cells control the fate of their progeny, whereby we unravel novel points of vulnerabilities in brain tumor cells.
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Dmitri Petrov
Michelle and Kevin Douglas Professor in the School of Humanities and Sciences
Current Research and Scholarly InterestsEvolution of genomes and population genomics of adaptation and variation
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Martin Pfaller
Instructor, Pediatrics - Cardiology
BioMartin R. Pfaller is an Instructor in the Department of Pediatrics (Cardiology) in the group of Alison L. Marsden. He received his B.Sc., M.Sc., and Ph.D. in Mechanical Engineering from the Technical University of Munich, working with Wolfgang A. Wall. During his Ph.D., he validated an efficient yet physiologically accurate boundary condition to account for the mechanical support of the heart within its surroundings, which has been adopted by various research groups worldwide. He further demonstrated how projection-based model order reduction could speed up model personalization from patient data, such as magnetic resonance imaging or blood pressure measurements. His current work focuses on cardiovascular fluid dynamics. He developed reduced-physics models to make blood flow simulations faster and more reliable. Further, he developed a fluid-solid-growth interaction model in blood vessels. His future research will predict the heart’s long-term function in heart diseases, supported by an NIH Pathway to Independence Award (K99/R00) and Stanford MCHRI Instructor K Award Support. He will quantify the risk of heart failure after a heart attack with a stability analysis validated with imaging data in swine and humans. This research will improve our understanding of biomechanical mechanisms leading to heart failure and help to identify patients at risk, enable personalized therapies, and facilitate the optimal design of medical devices. As an Assistant Professor, Martin will start his research group at Yale University in the Department of Biomedical Engineering in July 2024.
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Trung Hoang Minh Pham
Assistant Professor of Pediatrics (Infectious Diseases)
Current Research and Scholarly InterestsUncovering mechanisms of tissue immunity and immunophysiology during persistent infection
The immune system safeguards the health of complex organisms by rapidly eliminating invading pathogens, curbing infection-induced tissue disruptions, and maintaining tissue homeostasis. Many bacterial pathogens evade host antimicrobial mechanisms and persist in infected tissues at low levels for long periods of time even in the presence of innate and adaptive immune resistance. During persistent infection, the immune system simultaneously orchestrates antimicrobial responses to contain the pathogen, repairs damaged tissue, regulates nutrient resources, and maintains other tissue physiologic functions to ensure host survival. Failure of any of these tasks leads to uncontrolled infection, devastating disease, and even death. The goals of our research are to understand:
1)What are the innate and adaptive immune cellular mechanisms that contain pathogens during persistent infection?
2)How are tissue physiological functions, such as tissue repair and nutrient regulation, maintained during persistent infection?
3)How do pathogens survive innate and adaptive antimicrobial mechanisms in infected tissues?
4)How does persistent infection impact host immunity to secondary infections of a similar or different pathogen?
Through investigating these fundamental questions, we may be able to decode the underlying cellular and molecular mechanisms that can be harnessed to eradicate infections and help restore health after an infectious insult. We employ animal infection models and bring together immunology, tissue biology, microbiology, and genetics to uncover the mechanisms of tissue immunity and immunophysiology during persistent infection from the molecular to organismal level.
Current areas of research:
•Development, maintenance, and plasticity of macrophage functional diversity in infected tissue
•Tissue repair and nutrient regulation during persistent infection
•Cellular dynamics and bacterial persistence in lymphoid organs
We are looking for highly motivated team members who are passionate about making impactful scientific discoveries to join our group at all levels. For opportunities and positions available for pre-doctoral students and postdoctoral fellows, please contact tpham8@stanford.edu! -
Harold Westley Phillips
Assistant Professor of Neurosurgery (Pediatric Neurosurgery)
BioH. Westley Phillips, MD is an Assistant Professor of Neurosurgery at Stanford University where he is a neurosurgeon-scientist specializing in pediatric neurosurgery with a special interest in epilepsy. Dr. Phillips received his undergraduate degree at Yale University where he was a member of the Varsity Football Team and received a Fulbright Scholarship. He completed an MD at the Perelman School of Medicine at the University of Pennsylvania, graduating with a certificate of distinction in the Clinical Neuroscience Training Program. He completed neurosurgical residency at UCLA where he received 2 years of NIH funding to investigate the genetic underpinnings of epilepsy. He received fellowship training in pediatric epilepsy surgery and genetics research at Boston Children’s Hospital as well as pediatric neurosurgery at the University of Pittsburgh Medical Center, Children’s Hospital of Pittsburgh before his arrival at Stanford. At Stanford, Dr. Phillips leads a molecular genetics laboratory and has a particular interest in defining and further understanding somatic mosaicism and its role in epileptogenesis. He has published manuscripts in leading academic journals including Nature: Genetics, JAMA Neurology, Journal of Neuroscience, Scientific Reports, Epilepsia and Neurology. He is dedicated to improving the treatment and outcomes for children with drug resistant epilepsy through innovative research and cutting-edge surgical techniques.
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Benjamin Pinsky
Professor of Pathology, of Medicine (Infectious Diseases) and, by courtesy, of Pediatrics (Infectious Diseases)
Current Research and Scholarly InterestsDevelopment and application of molecular assays for the diagnosis and management of infectious diseases.
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Celeste Poe, Ph.D., LMFT
Clinical Instructor, Psychiatry and Behavioral Sciences - Child & Adolescent Psychiatry and Child Development
BioDr. Celeste Poe is a licensed clinical psychologist and licensed marriage and family therapist. She is a Clinical Instructor and Attending NICU and Perinatal Psychologist at Stanford University School of Medicine. She is the director of the NICU Psychology Program at Lucile Packard Childrens Hospital where she provides psychological consultation and psychotherapy to parents of infants and young children hospitalized in the NICU, CVICU, and other departments of the hospital.
Dr. Poe’s research and clinical specialties include perinatal and early childhood mental health, pediatric behavioral health, ethnic minority mental health, and grief, trauma, and bereavement. Dr. Poe is an alumna of the American Psychological Association’s Minority Fellowship Program and is currently a Zero to Three Fellow. Dr. Poe is a registered Circle of Security Parenting facilitator and is a rostered Child Parent Psychotherapy (CPP) provider.
She also holds an appointment as a Clinical Instructor at the Yale Child Study Center where she works on the Grief-Sensitive Healthcare Project which aims to enhance medical providers’ capacities to meet the needs of grieving families. -
Matthew Porteus
Sutardja Chuk Professor of Definitive and Curative Medicine
BioDr. Porteus was raised in California and was a local graduate of Gunn High School before completing A.B. degree in “History and Science” at Harvard University where he graduated Magna Cum Laude and wrote an thesis entitled “Safe or Dangerous Chimeras: The recombinant DNA controversy as a conflict between differing socially constructed interpretations of recombinant DNA technology.” He then returned to the area and completed his combined MD, PhD at Stanford Medical School with his PhD focused on understanding the molecular basis of mammalian forebrain development with his PhD thesis entitled “Isolation and Characterization of TES-1/DLX-2: A Novel Homeobox Gene Expressed During Mammalian Forebrain Development.” After completion of his dual degree program, he was an intern and resident in Pediatrics at Boston Children’s Hospital and then completed his Pediatric Hematology/Oncology fellowship in the combined Boston Chidlren’s Hospital/Dana Farber Cancer Institute program. For his fellowship and post-doctoral research he worked with Dr. David Baltimore at MIT and CalTech where he began his studies in developing homologous recombination as a strategy to correct disease causing mutations in stem cells as definitive and curative therapy for children with genetic diseases of the blood, particularly sickle cell disease. Following his training with Dr. Baltimore, he took an independent faculty position at UT Southwestern in the Departments of Pediatrics and Biochemistry before again returning to Stanford in 2010 as an Associate Professor. During this time his work has been the first to demonstrate that gene correction could be achieved in human cells at frequencies that were high enough to potentially cure patients and is considered one of the pioneers and founders of the field of genome editing—a field that now encompasses thousands of labs and several new companies throughout the world. His research program continues to focus on developing genome editing by homologous recombination as curative therapy for children with genetic diseases but also has interests in the clonal dynamics of heterogeneous populations and the use of genome editing to better understand diseases that affect children including infant leukemias and genetic diseases that affect the muscle. Clinically, Dr. Porteus attends at the Lucille Packard Children’s Hospital where he takes care of pediatric patients undergoing hematopoietic stem cell transplantation.
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Manu Prakash
Associate Professor of Bioengineering, Senior Fellow at the Woods Institute for the Environment and Associate Professor, by courtesy, of Oceans and of Biology
BioWe use interdisciplinary approaches including theory and experiments to understand how computation is embodied in biological matter. Examples include cognition in single cell protists and morphological computing in animals with no neurons and origins of complex behavior in multi-cellular systems. Broadly, we invent new tools for studying non-model organisms with significant focus on life in the ocean - addressing fundamental questions such as how do cells sense pressure or gravity? Finally, we are dedicated towards inventing and distributing “frugal science” tools to democratize access to science (previous inventions used worldwide: Foldscope, Abuzz), diagnostics of deadly diseases like malaria and convening global citizen science communities to tackle planetary scale environmental challenges such as mosquito surveillance or plankton surveillance by citizen sailors mapping the ocean in the age of Anthropocene.
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Janey S.A. Pratt, MD
Clinical Professor, Surgery - Pediatric Surgery
BioDr. Janey S.A. Pratt, MD, FACS, FASMBS is a general surgeon who specializes in Laparoscopic and Robotic General and Metabolic and Bariatric Surgery (MBS). She began her career in general surgery at Massachusetts General Hospital, where she was a founding member of the MGH Weight Center. As surgical director she introduced minimally invasive MBS and adolescent MBS to MGH in 2001 and 2007 respectively. In 2011 Dr. Pratt took over as Director at the MGH Weight Center and continued to work on several national committees towards improving access and care for adolescents with severe obesity. Dr. Pratt continued to practice general surgery throughout her tenure at MGH seeing patients with breast cancer, hernias, and obesity. She performed advance minimally invasive surgery (MIS) as well as advanced endoscopy.
In 2016 Dr. Pratt moved to California where she began her work at Stanford University, splitting her time between the Lucille Packard Children’s Hospital and the Palo Alto VA. She performs Minimally Invasive MBS as well as endoscopy. Dr. Pratt has trained in robotic surgery as well. As a Clinical Professor of Surgery, Dr. Pratt is involved in training Stanford medical students and residents both in the OR, in clinic, in simulation labs and in the classroom. Dr. Pratt is the Director of the Adolescent Metabolic and Bariatric Surgery Program at Lucille Packard Children's Hospital. This is an MBSAQIP accredited program in a free-standing children's hospital dedicated to the multidisciplinary care of children with obesity. This program is one of the top 5 programs in the country. Dr. Pratt has been involved in creating and updated guidelines for Adolescent MBS since 2005. In 2018 she was first author on the ASMBS Pediatric Metabolic and Bariatric Surgery Guidelines. Her research interests include MIS MBS, pediatric obesity treatment and the use of medications to improve outcomes of MBS. Dr. Pratt frequently lectures on the subject of Adolescent Metabolic and Bariatric Surgery. -
Guillem Pratx
Associate Professor of Radiation Oncology (Radiation Physics)
Current Research and Scholarly InterestsThe Physical Oncology Lab is interested in making a lasting impact on translational cancer research by building novel physical tools and methods.
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James Priest
Adjunct Clinical Assistant Professor, Pediatrics - Cardiology
Current Research and Scholarly InterestsThe Priest lab seeks a better understanding of the genetics and pathogenesis of congenital heart disease using translational genomics, big-data, and vertebrate models of cardiac development.
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Charles G. Prober, MD
Professor of Pediatrics (Infectious Diseases) and, by courtesy, of Microbiology and Immunology
Current Research and Scholarly InterestsMy research interest is in the epidemiology, pathophysiology, prevention, and treatment of infections in children. Much of this research has focused on viral infections, especially those caused by herpes simplex virus (HSV). I have conducted a number of studies concerned with the epidemiology of HSV-2 infections in pregnant women, their partners, and neonates.
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Judith Prochaska
Senior Associate Vice Provost, Clinical Research Governance and Professor of Medicine (Stanford Prevention Research Center)
Current Research and Scholarly InterestsDr. Prochaska's research expertise centers on technology-mediated health behavior change interventions including targets of tobacco, physical activity, and dietary change. Working with Alaska Native and Latino communities, people with serious mental illness, alcohol and drug problems, or heart disease, and jobseekers and the unhoused, Dr. Prochaska’s research combines stage-tailored interventions with pharmacotherapy and utilizes interactive expert system interventions and social media.
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Jochen Profit
Wendy J. Tomlin-Hess Endowed Professor
Current Research and Scholarly InterestsFunded by NIH R01 grants:
1) Development and application of composite measure of NICU quality - Baby-MONITOR
2) High reliability, safety culture and caregiver resilience as modifiers of care quality
3) Modifiable racial/ethnic disparities in quality of care delivery
4) Effectiveness of regionalized care delivery systems for preterm newborns -
Stephanie Pun, MD
Clinical Associate Professor, Orthopaedic Surgery
Current Research and Scholarly InterestsDr. Pun specializes in the treatment of complex hip disorders with surgical hip preservation options for children, adolescents, and adults. Her goal is to enhance hip function in active individuals and to prevent the early development of hip osteoarthritis.
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Lei (Stanley) Qi
Associate Professor of Bioengineering
BioDr. Lei (Stanley) Qi is Associate Professor of Bioengineering, Sarafan ChEM-H, and a Chan Zuckerberg Biohub Investigator. Dr. Qi is a principal contributor to the development of CRISPR technologies for genome engineering beyond gene editing. His lab created the first nuclease-deactivated Cas9 (dCas9) for targeted gene regulation in cells. His lab has invented a CRISPR toolbox for engineering the epigenome, including CRISPRi and CRISPRa for targeted gene repression and activation, epigenome editing, LiveFISH for real-time DNA/RNA imaging, CRISPR-GO for 3D genome manipulation, CasMINI as a compact CRISPR system for gene therapy, hyperCas12a for multi-gene engineering, and CRISPR antivirals aimed at treating broad RNA viruses.
Dr. Qi obtained B.S. in Physics and Math from Tsinghua University in 2005, and Ph.D. in Bioengineering from the University of California, Berkeley in 2012. He was a Systems Biology Faculty Fellow at UCSF between 2012-2014, and joined Stanford faculty in 2014. His research focuses on mammalian synthetic biology, epigenetic engineering, immune cell engineering, directed evolution, and novel approaches for gene therapy. -
Xiaojie Qiu
Assistant Professor of Genetics
Current Research and Scholarly InterestsAt the Qiu Lab, our mission is to unravel and predict the intricacies of gene regulatory networks and cell-cell interactions pivotal in mammalian cell fate transitions over time and space, with a special emphasis on heart evolution, development, and disease. We are a dynamic and interdisciplinary team, harnessing the latest advancements in machine learning as well as single-cell and spatial genomics by integrating the predictive power of systems biology with the scalability of machine learning,
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Thomas Quertermous, MD
William G. Irwin Professor of Cardiovascular Medicine
Current Research and Scholarly InterestsUnderstanding genetic basis of cardiovascular function and disease.
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Jennifer Anne Rabbitts
Professor of Anesthesiology, Perioperative & Pain Medicine (Pediatric Anesthesia) and, by courtesy, of Pediatrics
BioJennifer Rabbitts, MD is Professor and Chief of Pediatric Pain Management at Stanford University School of Medicine. Dr. Rabbitts directs an NIH-funded research laboratory focused on improving long-term pain and health outcomes in children and adolescents undergoing surgery. Her research is devoted to understanding and preventing chronic postsurgical pain, a disabling condition affecting 20% youth undergoing major surgery. Her current research studies investigate the role of biopsychosocial mechanisms including child psychosocial factors, parental/family factors, and psychophysical processes underlying acute to chronic pain transition. Current clinical trials focus on testing feasibility and efficacy of psychosocial and complementary and integrative interventions to improve acute postsurgical pain and prevent transition to chronic pain.
Dr Rabbitts is passionate about mentoring, serving as mentor for the Women's Empowerment and Leadership Initiative and for the Mission Driven Mentoring Program for Diversity, Equity, and Inclusion, of the Society for Pediatric Anesthesia. She serves as section editor for Psychology, Psychiatry and Brain Neuroscience Section for Pain Medicine, on the editorial boards for Pediatric Anesthesia and Journal of Pain, and actively serves on committees in the United States Association for the Study of Pain. -
Marlene Rabinovitch
Dwight and Vera Dunlevie Professor of Pediatric Cardiology
Current Research and Scholarly InterestsOur research program seeks to identify the cellular and molecular programs regulating vascular and lung development, through the use of cultured cells and tissues and mouse and rat models. We then determine how these programs are perturbed by genetic abnormalities or injurious processes associated with disease, focusing on pulmonary arterial hypertension (PAH), a fatal complication in children with heart defects, and a condition of unknown etiology primarily in young women.
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Vasiliki Rahimzadeh
Member, Maternal & Child Health Research Institute (MCHRI)
BioVasiliki (Vaso) Rahimzadeh, PhD is an applied bioethics scholar with research interests at the intersection of precision medicine, data governance and public policy.
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Ram Rajagopal
Associate Professor of Civil and Environmental Engineering and of Electrical Engineering
BioRam Rajagopal is an Associate Professor of Civil and Environmental Engineering at Stanford University, where he directs the Stanford Sustainable Systems Lab (S3L), focused on large-scale monitoring, data analytics and stochastic control for infrastructure networks, in particular, power networks. His current research interests in power systems are in the integration of renewables, smart distribution systems, and demand-side data analytics.
He holds a Ph.D. in Electrical Engineering and Computer Sciences and an M.A. in Statistics, both from the University of California Berkeley, Masters in Electrical and Computer Engineering from University of Texas, Austin and Bachelors in Electrical Engineering from the Federal University of Rio de Janeiro. He is a recipient of the NSF CAREER Award, Powell Foundation Fellowship, Berkeley Regents Fellowship and the Makhoul Conjecture Challenge award. He holds more than 30 patents and several best paper awards from his work and has advised or founded various companies in the fields of sensor networks, power systems, and data analytics. -
Sneha Ramakrishna
Assistant Professor of Pediatrics (Hematology/Oncology)
BioSneha Ramakrishna obtained her B. A. from the University of Chicago and her M.D. from the Cleveland Clinic Lerner College of Medicine at Case Western Reserve University. In medical school, through the Howard Hughes Medical Research Scholar Award, she joined Dr. Crystal Mackall’s laboratory, where she designed and developed various GD2 CAR-Ts and tested them in preclinical models. During her residency training in Pediatrics at the Children’s Hospital of Philadelphia, she cared for some of the first patients treated with CD19 CAR T cells, learning the power of this therapy first-hand. During her fellowship in Pediatric Hematology/Oncology at the Johns Hopkins/National Cancer Institute combined program, she worked with Dr. Terry Fry. She evaluated the mechanism of CD22 CAR T cell relapse in patients by developing an antigen escape model and establishing a deeper understanding of the effects of antigen density on CAR-T phenotype, expansion, and persistence (Fry…Ramakrishna…Mackall Nat Med, 2018; Ramakrishna, et al., Clinical Cancer Research, 2019). Since arriving at Stanford, Dr. Ramakrishna leads an interdisciplinary team that designs, develops, and successfully implements a robust correlative science platform for our novel CAR-T therapies. Analyzing patient samples from our first-in-human GD2 CAR-T trial (NCT04196413) treating a universally fatal cancer, diffuse midline glioma (DMG), we identified that intracerebroventricular CAR-T administration correlates with enhanced pro-inflammatory cytokines and reduced immunosuppressive cell populations in cerebrospinal fluid as compared to intravenous CAR-T administration (Majzner*, Ramakrishna*, et al., Nature 2022 *co-first authors). Her research program evaluates unique sets of patient samples using novel single-cell immune profiling to identify the drivers of CAR-T success or failure. Building on these findings, her team assesses approaches to enhance CAR-T efficacy and translate these findings to the clinic.
Clinically, Dr. Ramakrishna cares for children with solid tumors and treats hematologic, solid, and brain tumor pediatric patients with CAR T cell therapies in the Cancer Cellular Therapies program. -
R J Ramamurthi
Clinical Professor, Anesthesiology, Perioperative and Pain Medicine
Current Research and Scholarly InterestsProspective collection of pediatric regional block procedures and complications on to a national database
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Mahalakshmi Ramamurthy
Postdoctoral Scholar, Developmental Behavioral Pediatrics
BioI am a postdoctoral scholar working with Dr. Jason Yeatman. With a background in vision science, psychophysics and developmental cognitive neuroscience my long-term goal is to study the intersection of basic visual mechanisms and various neurodevelopmental disorders and to extend this understanding in creating effective early screening tools, and in advancing evidence-based therapeutic and remediation programs. Inherent to this interest is the need for developmental data in large and demographically diverse populations. I strongly believe that such inclusive research not only contributes to scientific advancements but can go beyond to bridge health and education disparities.
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Anoop Rao
Clinical Assistant Professor, Pediatrics - Neonatal and Developmental Medicine
Current Research and Scholarly InterestsWearable senors, unobtrusive vital sign monitoring, natural language processing/text mining
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Rameshwar (Ram) Rao MD PhD
Postdoctoral Medical Fellow, Hematology-Oncology
Fellow in Graduate Medical EducationBioMy scientific training spans over a decade of published research in the fields of vascularized bone tissue engineering, biomineralization, gene therapy, and spectral ultrasound. I earned my BS from UC Davis and MS/PhD in Biomedical Engineering at the University of Michigan. I have aimed to form highly collaborative and multidisciplinary research groups at each level of training. This work has resulted in 21 publications, award-winning manuscripts, and multiple national conference research awards. My successful research career began during my undergraduate studies where my work in Prof. Kent Leach’s lab resulted in 3 publications and the Department of Biomedical Engineering Outstanding Undergraduate Research Award. My graduate thesis under the guidance of Prof. Jan Stegemann resulted in 12 publications (7 as first author) in high quality, peer-reviewed journals in the fields of engineering and biotechnology. My graduate studies were funded by an NIH T32 Training grant and the NSF Graduate Research Fellowship. My graduate work culminated in the 2013 Outstanding PhD Research Award from the Society for Biomaterials (SFB) and the 2013 Outstanding Student Award from the Tissue Engineering and Regenerative Medicine Society (TERMIS). Recognizing the gap in translation of bioengineering research into clinical practice, I opted to pursue an MD at the University of Michigan to become the physician-scientist that identifies clinical problems, engineers the solution, and delivers it back to the patient to advance treatments and improve survival outcomes. My success continued through medical school with 4 clinical research manuscripts and Graduation with Distinction in Research, awarded to 10% of the class.
In the next phase of my training, I will complete my fellowship in Pediatric Hematology/Oncology at Stanford through the Accelerated Research Pathway by the American Board of Pediatrics. Prof. Sarah Heilshorn, Associate Chair of Materials Science at Stanford, will be my primary research and career development mentor. Together, we have designed an innovative approach targeting the extracellular matrix to improve survival outcomes in pediatric osteosarcoma. -
Natalie L. Rasgon
Professor of Psychiatry and Behavioral Sciences (General Psychiatry and Psychology-Adult) at the Stanford University Medical Center, Emerita
Current Research and Scholarly InterestsDr. Rasgon has been involved in longitudinal placebo-controlled neuroendocrine studies for nearly two decades, and she has been involved in neuroendocrine and brain imaging studies of estrogen effects on depressed menopausal women for the last eight years. It should be noted that in addition to her duties as a Professor of Psychiatry and Obstetrics & Gynecology, Dr. Rasgon is also the Director of the Behavioral Neuroendocrinology Program and of the Women's Wellness Program.
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Lindsey Rasmussen
Clinical Associate Professor, Pediatrics - Critical Care
Clinical Associate Professor (By courtesy), Neurology & Neurological SciencesCurrent Research and Scholarly InterestsMy research interests reside in the field of Neurocritical Care Medicine. My research focus has included inflammation following traumatic brain injury, outcome prediction after cardiac arrest, and neuro-monitoring in the pediatric intensive care setting. These interests are integrated clinically to focus on the merging of specialized neurologic monitoring and care with prognostic efforts in critically ill patients.
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Caroline E. Rassbach
Clinical Professor, Pediatrics
Clinical Professor, Emergency Medicine
Clinical Professor, Emergency MedicineCurrent Research and Scholarly InterestsMedical education including learner assessment, program development and mentoring and coaching in medicine.
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Kristy Red-Horse
Professor of Biology
Current Research and Scholarly InterestsCardiovascular developmental biology
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Sushma Reddy
Associate Professor of Pediatrics (Cardiology)
Current Research and Scholarly InterestsMy laboratory's expertise in cardiovascular phenotyping has led to the development of mouse models of congenital heart disease that recapitulate abnormal loading conditions on the heart. We have used these models to advance our understanding of the mechanisms of right heart failure in children and adults with congenital heart disease with the long term goal of identifying noninvasive diagnostic tools to better assess right ventricular health and to develop right ventricle specific therapeutics.
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David Rehkopf
Associate Professor of Epidemiology and Population Health, of Medicine (Primary Care and Population Health) and, by courtesy, of Sociology, of Pediatrics and of Health Policy
BioI am a social epidemiologist and serve as an Associate Professor in the Department of Epidemiology and Population Health and in the Department of Medicine in the Division of Primary Care and Population Health. I joined the faculty at Stanford School of Medicine in 2011.
I am Director of the Stanford Center for Population Health Sciences. In this position, I am committed to making high-value data resources available to researchers across disciplines in order to better enable them to answer their most pressing clinical and population health questions.
My own research is focused on understanding the health implications of the myriad decisions that are made by corporations and governments every day - decisions that profoundly shape the social and economic worlds in which we live and work. While these changes are often invisible to us on a daily basis, these seemingly minor actions and decisions form structural nudges that can create better or worse health at a population level. My work demonstrates the health implications of corporate and governmental decisions that can give the public and policy makers evidence to support new strategies for promoting health and well-being. In all of his work, I have a focus on the implications of these exposures for health inequalities.
Since often policy and programmatic changes can take decades to influence health, my work also includes more basic research in understanding biological signals that may act as early warning signs of systemic disease, in particular accelerated aging. I examine how social and economic policy changes influence a range of early markers of disease and aging, with a particular recent focus on DNA methylation. I am supported by several grants from the National Institute on Aging and the National Institute on Minority Health and Health Disparities to develop new more sensitive ways to understand the health implications of social and economic policy changes. -
Richard J. Reimer, MD
Associate Professor of Neurology (Adult Neurology) and, by courtesy, of Molecular and Cellular Physiology
Current Research and Scholarly InterestsReimer Lab interests
A primary interest of our lab is to understand how nerve cells make and recycle neurotransmitters, the small molecules that they use to communicate with each other. In better defining these processes we hope to achieve our long-term goal of identifying novel sites for treatment of diseases such as epilepsy and Parkinson Disease. In our studies on neurotransmitter metabolism we have focused our efforts on transporters, a functional class of proteins that move neurotransmitters and other small molecules across membranes in cells. Transporters have many characteristics that make them excellent pharmacological targets, and not surprisingly some of the most effective treatments for neuropsychiatric disorders are directed at transporters. We are specifically focusing on two groups of transporters vesicular neurotransmitter transporters that package neurotransmitters into vesicles for release, and glutamine transporters that shuttle glutamine, a precursor for two major neurotransmitters glutamate and GABA, to neurons from glia, the supporting cells that surround them. We are pursuing these goals through molecular and biochemical studies, and, in collaboration with the Huguenard and Prince labs, through physiological and biosensor based imaging studies to better understand how pharmacological targeting of these molecules will influence neurological disorders.
A second interest of our lab is to define mechanism underlying the pathology of lysosomal storage disorders. Lysosomes are membrane bound acidic intracellular organelles filled with hydrolytic enzymes that normally function as recycling centers within cells by breaking down damaged cellular macromolecules. Several degenerative diseases designated as lysosomal storage disorders (LSDs) are associated with the accumulation of material within lysosomes. Tay-Sachs disease, Neimann-Pick disease and Gaucher disease are some of the more common LSDs. For reasons that remain incompletely understood, these diseases often affect the nervous system out of proportion to other organs. As a model for LSDs we are studying the lysosomal free sialic acid storage disorders. These diseases are the result of a defect in transport of sialic acid across lysosomal membranes and are associated with mutations in the gene encoding the sialic acid transporter sialin. We are using molecular, genetic and biochemical approaches to better define the normal function of sialin and to determine how loss of sialin function leads to neurodevelopmental defects and neurodegeneration associated with the lysosomal free sialic acid storage disorders. -
Allan L. Reiss
Howard C. Robbins Professor of Psychiatry and Behavioral Sciences and Professor of Radiology
On Partial Leave from 01/01/2024 To 06/30/2024Current Research and Scholarly InterestsMy laboratory, the Center for Interdisciplinary Brain Sciences Research (CIBSR), focuses on multi-level scientific study of individuals with typical and atypical brain structure and function. Data are obtained from genetic analyses, structural and functional neuroimaging studies, assessment of endocrinological status, neurobehavioral assessment, and analysis of pertinent environmental factors. Our overarching focus is to model how brain disorders arise and to develop disease-specific treatments.
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David A. Relman
Thomas C. and Joan M. Merigan Professor and Professor of Microbiology and Immunology
On Leave from 01/15/2024 To 12/20/2024Current Research and Scholarly InterestsMy investigative program focuses on human-microbe interactions and human microbial ecology, and primarily concerns the ecology of human indigenous microbial communities; a secondary interest concerns the classification of humans with systemic infectious diseases, based on features of genome-wide gene transcript abundance patterns and pther aspects of the host response.
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William Rhine
Professor of Pediatrics (Neonatology)
Current Research and Scholarly InterestsNeonatology, extracorporeal membrane oxygenation, nitric oxide therapy, mechanisms of bilirubin toxicity and brain injury, non-invasive biotechnologies to study cellular and organ metabolism.
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Anthony J. Ricci, PhD
Edward C. and Amy H. Sewall Professor in the School of Medicine and Professor of Otolaryngology - Head & Neck Surgery (OHNS) and, by courtesy of Molecular and Cellular Physiology
Current Research and Scholarly InterestsThe auditory sensory cell, the hair cell, detects mechanical stimulation at the atomic level and conveys information regarding frequency and intensity to the brain with high fidelity. Our interests are in identifying specializations associated with mechanotransduction and synaptic transmission leading to the amazing sensitivities of the auditory system. We are also interested in the developmental process, particularly in how development gives insight into repair and regenerative mechanisms.
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Brian Travis Rice
Clinical Associate Professor, Emergency Medicine
Current Research and Scholarly InterestsDeveloping data-driven approaches to defining and comparing chief complaints fro emergency and unscheduled acute care in low- and middle-income countries
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Laura Roberts, MD, MA
Katharine Dexter McCormick and Stanley McCormick Memorial Professor and Professor, by courtesy, of Psychology
Current Research and Scholarly InterestsDr. Roberts has performed numerous empirical studies of contemporary ethics issues in medicine and health policy and has been funded by the National Institutes of Health, the Department of Energy, the National Alliance of Schizophrenia and Depression, the Arnold P. Gold Foundation, and other private and public foundations.
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Tawna L. Roberts, OD, PhD
Associate Professor of Ophthalmology (Pediatric) and, by courtesy, of Pediatrics
Current Research and Scholarly InterestsOur research efforts are funded by grants from the National Eye Institute, Department of Defense, and various foundations to study vision development in infants and young children as well as binocular vision disorders in adolescents and adults with concussions. Our focus is to identify underlying mechanisms that will inform clinical treatment approaches and ultimately leading to the prevention of strabismus, amblyopia, and binocular vision disorders.
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Terry Robinson
Associate Professor of Pediatrics (Pulmonary) at the Lucile Salter Packard Children's Hospital, Emeritus
Current Research and Scholarly InterestsMy research interests focus on detection of early and progressive Cystic fibrosis (CF) structural lung disease by utilizing chest CT imaging and CT post-processing methodology. Current research efforts involve utilization of low dose infant & children CT imaging protocols and quantitative airway and air trapping algorithms to evaluate early and progressive CF disease.
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Thomas Robinson
The Irving Schulman, M.D. Professor of Child Health, Professor of Medicine (Stanford Prevention Research Center) and, by courtesy, of Epidemiology and Population Health
Current Research and Scholarly InterestsDr. Robinson originated the solution-oriented research paradigm and directs the Stanford Solutions Science Lab. He is known for his pioneering obesity prevention and treatment research, including the concept of stealth interventions. His research applies social cognitive models of behavior change to behavioral, social, environmental and policy interventions for children and families in real world settings, making the results relevant for informing clinical and public health practice and policy.
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William H. Robinson, MD PhD
James W. Raitt, M.D. Professor
Current Research and Scholarly InterestsOur lab investigates the molecular mechanisms of and develops therapies to treat autoimmune and rheumatic diseases, with a focus on rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, and osteoarthritis.
The overriding objectives of our laboratory are:
1. To elucidate the mechanisms underlying autoimmune and rheumatic diseases.
2. To investigate the role of innate immune inflammation in osteoarthritis.
3. To develop novel diagnostics and therapeutics -
Eunice Rodriguez
Associate Professor (Teaching) of Pediatrics (General Pediatrics)
Current Research and Scholarly InterestsCurrent program of teaching and research integrates: 1) health disparities and social epidemiology, within the broader area of public health, and 2) program evaluation, as a synthesis of theory and methods applied to the evaluation of health and social programs.
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Samuel Rodriguez, MD
Clinical Professor, Anesthesiology, Perioperative and Pain Medicine
BioDr. Sam Rodriguez is a native of New Jersey and practicing Pediatric Anesthesiologist at Stanford Children's Hospital. He is best known for being the husband of the Stanford Cardiologist Dr. Fatima Rodriguez. Sam was a member of the self proclaimed greatest Anesthesia Residency Class in history (MGH 2012). He is a founder and co-director of the Stanford CHARIOT Program which creates and studies innovative approaches to treating pediatric pain and stress through technology. The CHARIOT Program has positively impacted thousands of children around the world and has grown to include emerging technologies like virtual reality, augmented reality, and interactive video games. Dr. Rodriguez is also highly involved in medical humanities education at Stanford Medical School and teaches courses at the undergraduate and graduate levels on how studying art can make better physicians.
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Stephan Rogalla, M.D. PhD
Clinical Assistant Professor, Medicine - Gastroenterology & Hepatology
Current Research and Scholarly InterestsThe research interest of myself and my lab are in the field of early cancer detection using targeted molecular spies to highlight (pre)cancerous lesions. We as well aim to improve precision medicine in autoimmune disorders like inflammatory bowel disease and oncology.
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Rajat Rohatgi
Professor of Biochemistry and of Medicine (Oncology)
Current Research and Scholarly Intereststhe overall goal of my laboratory is to uncover new regulatory mechanisms in signaling systems, to understand how these mechanisms are damaged in disease states, and to devise new strategies to repair their function.
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Maria Grazia Roncarolo
George D. Smith Professor of Stem Cell and Regenerative Medicine and Professor of Medicine (Blood and Marrow Transplantation and Cellular Therapy)
Current Research and Scholarly InterestsResearch Interests
Immunetolerance: Mechanisms underlying T-cell tolerance, induction of T-cell anergy and regulatory T cells; Immunomodulation: mAbs, proteins and low molecular weight compounds which can modulate T-cell activation; Primary immunodeficiencies: Characterization of molecular and immunological defects; Gene therapy: Gene transduction of hematopoietic cells for gene therapy in primary immunodeficiencies and metabolic diseases; Hematopoiesis: Mechanisms underlying growth and differentiation of hematopoietic stem cells; Transplantation: Immune reconstitution and T-cell tolerance after allogenic stem cell transplantation; Cytokines/Cytokine receptors: Role in regulation of immune and inflammatory responses
Clinical Interests
Primary Immunodeficiencies
Monogenic Autoimmune Disorders
Allogenic Bone Marrow Transplantation
Gene Therapy Clinical Trials
Cell Therapy Clinical Trials
Clinical Trials in Autoimmune Diseases and Organ Transplantation
Clinical Trials in Hemoglobinopathies -
Lisa Goldman Rosas
Assistant Professor (Research) of Epidemiology and Population Health and of Medicine (Primary Care and Population Health) and, by courtesy, of Pediatrics
BioLisa Goldman Rosas, PhD MPH is an Assistant Professor in the Department of Epidemiology and Population Health and the Department of Medicine, Division of Primary Care and Population Health at Stanford School of Medicine. An epidemiologist by training, Dr. Goldman Rosas’ research focuses on addressing disparities in chronic diseases such as diabetes, heart disease, depression, and cancer among racial/ethnic minority families. This research features rigorous quantitative and qualitative methodologies, participatory qualitative approaches, and shared leadership with patient and community partners. She is passionate about integrating patients, caregivers, community organizations, and other key stakeholders in the research process in order to affect the greatest improvements in health and well-being. As a reflection of this passion, Dr. Goldman Rosas serves as the Faculty Director for the School of Medicine Office of Community Engagement, Co-Director of Community-Engaged Research for the Office of Cancer Health Equity, and Director of the Outreach, Recruitment and Engagement Core for the Alzheimer's Disease Research Center. In these roles, she supports other faculty and patient and community partners to develop sustainable and meaningful partnerships to support transformative research. In addition to research, she teaches at the undergraduate and graduate levels and has a special focus on increasing diversity in biomedical research.
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Jessica Rose
Professor of Orthopaedic Surgery
Current Research and Scholarly InterestsDr. Rose's research investigates neuromuscular mechanisms underlying cerebral palsy (CP) early brain and motor development in preterm children and . Research examines neonatal microstructural brain development on DTI and physiological correlates of motor function in preterm children. Dr. Rose served on the NIH Taskforce on Childhood Motor Disorders, the AACPDM Research Committee and Steering Committee to develop CDE for CP neuroimaging diagnostics, and serves on the Board of Directors of SBMT.
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Michael J Rosen, MD, MSCI
Stanford University Endowed Professor for Pediatric IBD and Celiac Disease
BioI am a pediatric gastroenterologist and physician scientist, who has been devoted to inflammatory bowel disease (IBD) research since beginning medical training over 20 years ago. I am also Director of the Stanford Center for Pediatric IBD and Celiac Disease. I have expertise crossing mucosal immunology and epithelial biology, formal training and experience in clinical and translational investigation with human biospecimens, and direct insight regarding the important clinical challenges caring for children with complicated IBD. My translational research program focuses on how the immune system regulates epithelial function in chronic intestinal inflammation as it relates to IBD. My clinical research program has focused on optimization of anti-TNF therapy in pediatric IBD, and in particular acute severe ulcerative colitis (ASUC). My laboratory has demonstrated a protective role for IL33, a cytokine that induces type 2 cytokines from T cells an innate lymphoid cells (ILCs), in acute oxazolone colitis through preservation of epithelial goblet cells and barrier function. In line with this finding, we have also shown in a large prospective patient cohort that mucosal expression of type 2 and type 17 immune response genes distinguishes ulcerative colitis (UC) from colon-only Crohn’s disease, and that type 2 gene expression is associated with superior clinical outcome in pediatric UC. We have now developed an organoid-immune cell in vitro culture system to demonstrate the ILC2-dependent mechanism through which IL33 induces goblet cell differentiation in the intestinal epithelium. I led the multicenter study Anti-TNF for Refractory Colitis in Hospitalized Children (ARCH) Study, which aims to establish determinants of anti-TNF response in pediatric ASUC and currently Co-Chair the Crohn's & Colitis Foundations Cohort for Pediatric Translational and Clinical Research in IBD (CAPTURE IBD) and PRO-KIIDS Pediatric IBD clinical research network.
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David Rosenthal
Professor of Pediatrics (Pediatric Cardiology)
Current Research and Scholarly InterestsResearch interests include the study of Heart Failure, Cardiomyopathy and ventricular dysfunction in children, from a clinical perspective. Investigations include clinical trials of medications, cardiac resynchronization, and mechanical circulatory support.
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Bernard Roth
Professor of Mechanical Engineering, Emeritus
BioRoth is one of the founders of the Hasso Plattner Institute of Design at Stanford (the d.school) and is active in its development: currently, he serves as Academic Director. His design interests include organizing and presenting workshops on creativity, group interactions, and the problem solving process. Formerly he researched the kinematics, dynamics, control, and design of computer controlled mechanical devices. In kinematics, he studied the mathematical theory of rigid body motions and its application to the design of machines.
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Stephen J. Roth
Professor of Pediatrics (Cardiology)
Current Research and Scholarly InterestsRandomized Therapeutic Trials in Pediatric Heart Disease, NIH/U01 GrantNo. HL68285 2001-2006.
Heparin and the Reduction of Thrombosis (HART) Study. Pediatric Health Research Fund Award, Stanford Univ Sch of Medicine, 2005-2006.
A Pilot Trial fo B-type Natriuretic Peptide for Promotion of Urine Output in Diuretic-Resistant Infants Following Cardiovascular Surgery.Pediatric Health Research Fund Award, Stanford Univ Sch of Medicine, 2005-2006. -
Christopher John Russell
Associate Professor of Pediatrics (Hospital Medicine)
BioDr. Russell is an Associate Professor of Pediatrics in the Division of Pediatric Hospital Medicine and a board-certified academic pediatric hospitalist at Lucile Packard Children’s Hospital. His clinical responsibilities include caring for children hospitalized for a variety of illnesses. His research focuses on developing evidence-based care for hospitalized children with medical complexity, including acute respiratory infections (such as pneumonia and bacterial tracheitis). His research efforts have been recognized through receipt of the University of Southern California’s Clinical and Translational Science Institute’s KL2 Mentored Research Career Development Award (2014-16), the Academic Pediatric Association’s Young Investigator Award (2015-16), the NIH Loan Repayment Program (2017-2021) and a large grant from the Gerber Foundation (2020-2022). In August 2021, he received a five-year R01 award from the Agency for Healthcare Research and Quality to study bacterial respiratory infections in child with tracheostomy. Outside of his clinical and research responsibilities, Dr. Russell focuses on research mentorship of medical students, pediatric residents, and pediatric hospital medicine fellows as well as improving representation of underrepresented minorities in medicine throughout the continuum of physician training. Dr. Russell is the chair of the Academic Pediatric Association’s Membership, Diversity, and Inclusion Committee and is on the Executive Committee for the Pediatric Research in Inpatient Settings research network. Dr. Russell is active in the AAP and currently serves as an Associate Editor for the journal Hospital Pediatrics.
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Mirabela Rusu
Assistant Professor of Radiology (Integrative Biomedical Imaging Informatics) and, by courtesy, of Urology and of Biomedical Data Science
Current Research and Scholarly InterestsDr. Mirabela Rusu focuses on developing analytic methods for biomedical data integration, with a particular interest in radiology-pathology fusion. Such integrative methods may be applied to create comprehensive multi-scale representations of biomedical processes and pathological conditions, thus enabling their in-depth characterization.
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Brian Rutt
Professor of Radiology (Radiological Sciences Lab), Emeritus
Current Research and Scholarly InterestsMy research interests center on MRI research, including high-field and high-resolution MRI technology development as well as applications of advanced MRI techniques to studying the brain, cardiovascular system and cancer.
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maura ruzhnikov
Member, Maternal & Child Health Research Institute (MCHRI)
BioChild neurologist and medical geneticist focusing on the diagnosis and management of rare neurologic disorders. Specific interests are in genetic epilepsy syndromes, childhood neurodegenerative and neurometabolic diseases and undiagnosed suspected genetic conditions.
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Raya Saab
Lindhard Family Professor of Pediatric Cancer Biology
BioOur laboratory focuses on investigating molecular mechanisms of oncogene-induced tumorigenesis and tumor suppressor pathways, and oncogenic signaling in the pediatric solid tumor rhabdomyosarcoma. Our earlier work identified the tumor suppressors p53 and p18Ink4c as inhibitors of Cyclin D1-driven tumorigenesis in a pineoblastoma model, through senescence induction, and highlighted distinct roles for the the RB and p53 pathways in induction and maintenance of oncogene-induced senescence. We also identified CDK2 as a potential target for inducing senescence in premalignant lesions to inhibit tumor progression.
Our current focus is on studying oncogenic signaling and tumor suppression in the childhood tumor rhabdomyosarcoma, to identify key mediators of invasion and metastasis, which is the most common cause of treatment failure clinically. We use preclinical in vitro and in vivo models, including murine and human cell lines, and mouse models of disease.
We have recently uncovered a paracrine role for rhabdomyosarcoma-secreted exosomes in impacting biology of stromal cells. Rhabdomyosarcoma-derived exosomes carry specific miRNA cargo that imparts an invasive and migratory phenotype on normal recipient fibroblasts, and proteomic analysis revealed specific and unique pathways relevant to the two different molecular rhabdomyosarcoma subtypes that are driven by distinct oncogenic pathways. We identified that the driver oncogene in fusion-positive rhabdomyosarcoma, PAX3-FOXO1, modulates exosome cargo to promote invasion, migration, and angiogenic properties, and identified specific microRNA and protein cargo acting as effectors of PAX3-FOXO1 exosome-mediated signaling, including modulation of oxidative stress response and cell survival signaling.
Our ongoing work is focused on interrogating specific paracrine signaling pathways and molecular mechanisms of metastatic disease progression in rhabdomyosarcoma, for potential therapeutic targeting. -
Debra Safer
Professor of Psychiatry and Behavioral Sciences (General Psychiatry and Psychology-Adult)
Current Research and Scholarly InterestsPrimary research interests include the nature and treatment of eating disorders
(particularly bulimia nervosa and binge eating disorder), the development and treatment of obesity, and the development and treatment of problematic eating patterns in patients following bariatric surgery. -
Julien Sage
Elaine and John Chambers Professor of Pediatric Cancer and Professor of Genetics
Current Research and Scholarly InterestsWe investigate the mechanisms by which normal cells become tumor cells, and we combine genetics, genomics, and proteomics approaches to investigate the differences between the proliferative response in response to injury and the hyperproliferative phenotype of cancer cells and to identify novel therapeutic targets in cancer cells.
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Manish Saggar
Assistant Professor (Research) of Psychiatry and Behavioral Sciences (Interdisciplinary Brain Science Research)
Current Research and Scholarly InterestsWe are a computational neuropsychiatry lab dedicated to developing computational methods to better understand brain’s overall dynamical organization in healthy and patient populations. We employ algorithms from a wide range of fields, including Applied Mathematics, Econometrics, Machine Learning, Biophysics, and Network Science.
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Kathleen M. Sakamoto
Shelagh Galligan Professor in the School of Medicine
Current Research and Scholarly InterestsMy research focuses on the molecular pathways that regulate normal and aberrant blood cell development, including acute leukemia and bone marrow failure syndromes. We are also studying novel drugs for treatment of cancer.
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Lee M. Sanders, MD, MPH
Professor of Pediatrics (General Pediatrics), of Health Policy and, by courtesy, of Epidemiology and Population Health
Current Research and Scholarly InterestsI conduct interdisciplinary research to understand literacy as potentially modifiable lens for addressing maternal and child health disparities from birth through early adulthood. Applying mixed methods approaches (health-services, epidemiology, ethnography), I have been principal investigator on extramurally-funded research projects (NIH, PCORI, FDA) that aim to examine "natural experiments" in policy and/or to design, implement and test novel system-level interventions.
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Meera N. Sankar
Clinical Professor, Pediatrics - Neonatal and Developmental Medicine
Current Research and Scholarly InterestsPDA in premature infants
Transcutaneous bilirubin use in the NICU Setting
