School of Medicine
Showing 951-960 of 980 Results
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Jian Xiong
Postdoctoral Scholar, Chemical Engineering
BioI thrive to understand the roles of lysosomes in physiological and pathological conditions. Lysosomes are both degradation compartment and metabolic controlling hub, and dysregulation of lysosomal functions are frequently implicated in a vast number of diseases including neurodegenerative diseases, however, the systematic knowledge of the molecular mechanism by which lysosomal contributes to these diseases is lacking. Ion channels are the primary mediators of neuronal activity, defects in neuronal ion channel activity are linked with many kinds of neurodegenerative diseases. Interestingly, besides typical ion channels that are involved in the neuronal activity, defects in lysosomal ion channels, such as TRPML1, CLN7 and CLC-7 are also implicated in neuropathy. My previous work as Ph.D student in University of Texas MD Anderson Cancer Center focused on regulation of lysosomal function by ion channels and metabolites. I discovered a mechanism of lysosomal Na+ channel regulate mTORC1 activation by regulating lysosomal amino acid accumulation. I also discovered role of glutamine in controlling lysosomal degradation capacity. In the meantime, I developed novel methods to isolate organelles. My ultimate research goal is to understand the key developmental pathways and how alterations in gene sequences and expression contribute to human disease, therefore, I am pursuing independent academic researcher as my career goal. Starting Feb 2022, I work with Dr. Monther Abu-Remaileh at Stanford University on role of lysosomes in neurodegenerative diseases. I use genetics, chemical biology and omics approaches to study lysosome function under various physiological and pathological conditions, especially age-associated neurodegenerative disorders, and monogenic neurodegenerative lysosome storage diseases. In Stanford, I aim to integrate ionic regulation, metabolomic regulation and functional proteomic regulation to systematically understand the biology of lysosome in physiological conditions and pathological conditions.
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Fan Yang
Associate Professor of Orthopaedic Surgery and of Bioengineering
Current Research and Scholarly InterestsOur research seeks to understand how microenvironmental cues regulate stem cell fate, and to develop novel biomaterials and stem cell-based therapeutics for tissue engineering and regenerative medicine. Our work spans from fundamental science, technology development, to translational research.We are particularly interested in developing better therapies for treating musculoskeletal diseases, cardiovascular diseases and cancer.
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Samuel Yang, MD, FACEP
Associate Professor of Emergency Medicine
Current Research and Scholarly InterestsDr. Yang's research is focused on bridging the translational gap at the interface of molecular biology, genome science, engineering, and acute care medicine. The investigative interest of the Yang lab falls within the general theme of developing integrative systems-level approaches for precision diagnostics, as well as data driven knowledge discoveries, to improve the health outcome and our understanding of complex critical illnesses. Using sepsis and COVID-19 as the disease models with complex host-pathogen dynamics, the goals of the Yang lab are divided into 2 areas:
1) Developing high-content, near-patient, diagnostic system for rapid broad pathogen detection and characterization.
2) Integrating multi-omics molecular and phenotypic data layers with novel computational approaches into advanced diagnostics and predictive analytics for acute infections. -
Yanmin Yang
Associate Professor of Neurology
Current Research and Scholarly InterestsElucidate biological functions of cytoskeletal associated proteins in neurons. Define the cellular and molecular mechanisms underlying neurodegeneration in null mice.
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Yunzhi Peter Yang
Professor of Orthopaedic Surgery and, by courtesy, of Materials Science and Engineering and of Bioengineering
Current Research and Scholarly InterestsYangÂ’ lab's research interests are in the areas of bio-inspired biomaterials, medical devices, and 3D printing approaches for re-creating a suitable microenvironment for cell growth and tissue regeneration for musculoskeletal disease diagnosis and treatment, including multiple tissue healing such as rotator cuff injury, orthopedic diseases such as osteoporosis and osteonecrosis, and orthopedic traumas such as massive bone and muscle injuries.
