Honors & Awards


  • Eli Lilly Graduate Fellowship for 2016, Eli Lilly (2016)
  • 2013 UC San Diego Physical Sciences Dean’s Undergraduate Award for Excellence, UCSD (2013)
  • 2012 ACSSA Undergraduate Research Symposium: Excellence in the Use of Chemical Literature, UCSD (2012)
  • 2012 ACSSA Undergraduate Research Symposium: Outstanding Poster Awards in Organic Chemistry, UCSD (2012)

Education & Certifications


  • BS, UCSD, Biochemistry/Chemistry (2013)

Stanford Advisors


Current Research and Scholarly Interests


Asymmetric catalysis and total synthesis

2013-14 Courses


All Publications


  • Direct Catalytic Asymmetric Mannich Reactions for the Construction of Quaternary Carbon Stereocenters. Journal of the American Chemical Society Trost, B. M., Saget, T., Hung, C. J. 2016; 138 (11): 3659-3662

    Abstract

    Herein, we report a Zn-ProPhenol catalyzed Mannich reaction using α-branched ketones as nucleophilic partners for the direct enantio- and diastereoselective construction of quaternary carbon stereocenters. The reaction can be run on a gram-scale with a low catalyst loading without impacting its efficiency. Moreover, the Mannich adducts can be further elaborated with complete diastereocontrol to access molecules possessing complex stereotriads.

    View details for DOI 10.1021/jacs.6b01187

    View details for PubMedID 26952276

  • Direct Catalytic Asymmetric Mannich Reactions for the Construction of Quaternary Carbon Stereocenters JOURNAL OF THE AMERICAN CHEMICAL SOCIETY Trost, B. M., Saget, T., Hung, C. (. 2016; 138 (11): 3659-3662
  • Catalytic Asymmetric Mannich Reactions with Fluorinated Aromatic Ketones: Efficient Access to Chiral beta-Fluoroamines ANGEWANDTE CHEMIE-INTERNATIONAL EDITION Trost, B. M., Saget, T., Lerchen, A., Hung, C. (. 2016; 55 (2): 781-784
  • Broad Spectrum Enolate Equivalent for Catalytic Chemo-, Diastereo-, and Enantioselective Addition to N-Boc Imines JOURNAL OF THE AMERICAN CHEMICAL SOCIETY Trost, B. M., Hung, C. (. 2015; 137 (50): 15940-15946
  • Development of Non-C2-symmetric ProPhenol Ligands. The Asymmetric Vinylation of N-Boc Imines ORGANIC LETTERS Trost, B. M., Hung, C. (., Koester, D. C., Miller, Y. 2015; 17 (15): 3778-3781

    Abstract

    The development and application of a new generation of non-C2-symmetric ProPhenol ligands is reported herein. Rational design of the ProPhenol ligand paved the way to the first catalytic and asymmetric vinylation of N-Boc imines via hydrozirconation giving rise to valuable allylic amines in excellent yields and enantioselectivities. The utility of this method was demonstrated by developing the shortest reported asymmetric synthesis of the selective serotonine reuptake inhibitor (SSRI) (-)-dapoxetine.

    View details for DOI 10.1021/acs.orglett.5b01755

    View details for Web of Science ID 000359393800035

    View details for PubMedID 26200769

  • Fusarisetin A: scalable total synthesis and related studies CHEMICAL SCIENCE Xu, J., Caro-Diaz, E. J., Lacoske, M. H., Hung, C., Jamora, C., Theodorakis, E. A. 2012; 3 (12): 3378-3386

    Abstract

    Fusarisetin A (1) is a recently isolated natural product that displays an unprecedented chemical motif and remarkable bioactivities as a potent cancer migration inhibitor. We describe here our studies leading to an efficient and scalable total synthesis of 1. Essential to the strategy was the development of a new route for the formation of a trans-decalin moiety of this compound and the application of an oxidative radical cyclization (ORC) reaction that produces fusarisetin A (1) from equisetin (2) via a bio-inspired process. TEMPO-induced and metal/O(2)-promoted ORC reactions were evaluated. Biological screening in vitro confirms the reported potency of (+)-1. Importantly, ex vivo studies show that this compound is able to inhibit different types of cell migration. Moreover, the C(5) epimer of (+)-1 was also identified as a potent cancer migration inhibitor, while (-)-1 and 2 were found to be significantly less potent. The optimized synthesis is applicable on gram scale and provides a solid platform for analogue synthesis and methodical biological study.

    View details for DOI 10.1039/c2sc21308g

    View details for Web of Science ID 000311920500005

    View details for PubMedID 23227303