Synthesis of Enantioenriched Allylic Silanes via Nickel-Catalyzed Reductive Cross-Coupling
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
2018; 140 (1): 139–42
An asymmetric Ni-catalyzed reductive cross-coupling has been developed to prepare enantioenriched allylic silanes. This enantioselective reductive alkenylation proceeds under mild conditions and exhibits good functional group tolerance. The chiral allylic silanes prepared here undergo a variety of stereospecific transformations, including intramolecular Hosomi-Sakurai reactions, to set vicinal stereogenic centers with excellent transfer of chirality.
View details for DOI 10.1021/jacs.7b11707
View details for Web of Science ID 000422813300035
View details for PubMedID 29202243
View details for PubMedCentralID PMC5851001