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  • Synthesis of Enantioenriched Allylic Silanes via Nickel-Catalyzed Reductive Cross-Coupling JOURNAL OF THE AMERICAN CHEMICAL SOCIETY Hofstra, J. L., Cherney, A. H., Ordner, C. M., Reisman, S. E. 2018; 140 (1): 139–42

    Abstract

    An asymmetric Ni-catalyzed reductive cross-coupling has been developed to prepare enantioenriched allylic silanes. This enantioselective reductive alkenylation proceeds under mild conditions and exhibits good functional group tolerance. The chiral allylic silanes prepared here undergo a variety of stereospecific transformations, including intramolecular Hosomi-Sakurai reactions, to set vicinal stereogenic centers with excellent transfer of chirality.

    View details for DOI 10.1021/jacs.7b11707

    View details for Web of Science ID 000422813300035

    View details for PubMedID 29202243

    View details for PubMedCentralID PMC5851001